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Conserved domains on  [gi|735997337|ref|NP_001290184|]
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leucine-rich repeat-containing protein 37A3 isoform 2 [Homo sapiens]

Protein Classification

LRR_8 and LRRC37AB_C domain-containing protein( domain architecture ID 12158233)

LRR_8 and LRRC37AB_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 586-708 7.34e-67

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


:

Pssm-ID: 464370  Cd Length: 147  Bit Score: 217.29  E-value: 7.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997337  586 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 665
Cdd:pfam14914   1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 735997337  666 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 708
Cdd:pfam14914  81 NENYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
LRR_8 pfam13855
Leucine rich repeat;
61-113 6.18e-10

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 6.18e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 735997337   61 EKLILRENNLTELHKDSFEGLLSLQYLILNHNPLTTVEDPYLFKLPALKYLDM 113
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 586-708 7.34e-67

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 217.29  E-value: 7.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997337  586 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 665
Cdd:pfam14914   1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 735997337  666 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 708
Cdd:pfam14914  81 NENYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
LRR_8 pfam13855
Leucine rich repeat;
61-113 6.18e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 6.18e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 735997337   61 EKLILRENNLTELHKDSFEGLLSLQYLILNHNPLTTVEDPYLFKLPALKYLDM 113
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-126 4.08e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 4.08e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997337  61 EKLILRENNLTELhKDSFEGLLSLQYLILNHNPLTTVedPYLFKLPALKYLDMG----TTLVPLTTLKNI 126
Cdd:COG4886  208 EELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSnnqlTDLPPLANLTNL 274
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 586-708 7.34e-67

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 217.29  E-value: 7.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997337  586 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 665
Cdd:pfam14914   1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 735997337  666 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 708
Cdd:pfam14914  81 NENYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
LRR_8 pfam13855
Leucine rich repeat;
61-113 6.18e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 6.18e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 735997337   61 EKLILRENNLTELHKDSFEGLLSLQYLILNHNPLTTVEDPYLFKLPALKYLDM 113
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-126 4.08e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 4.08e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997337  61 EKLILRENNLTELhKDSFEGLLSLQYLILNHNPLTTVedPYLFKLPALKYLDMG----TTLVPLTTLKNI 126
Cdd:COG4886  208 EELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSnnqlTDLPPLANLTNL 274
LRR_8 pfam13855
Leucine rich repeat;
61-94 9.42e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 9.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 735997337   61 EKLILRENNLTELHKDSFEGLLSLQYLILNHNPL 94
Cdd:pfam13855  28 KVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-138 6.24e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 6.24e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 735997337  61 EKLILRENNLTELhKDSFEGLLSLQYLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTVELEKLIV 138
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN--QLTDLPEELGNLTNLKELDL 189
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-126 9.64e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 9.64e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 735997337  61 EKLILRENNLTELhKDSFEGLLSLQYLILNHNPLTTVEDPyLFKLPALKYLDMG----TTL-VPLTTLKNI 126
Cdd:COG4886  162 KSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSgnqlTDLpEPLANLTNL 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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