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Conserved domains on  [gi|751557640|ref|NP_001291454|]
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mitotic spindle assembly checkpoint protein MAD1 isoform c [Homo sapiens]

Protein Classification

mitotic spindle assembly checkpoint protein MAD1( domain architecture ID 1000521)

mitotic spindle assembly checkpoint protein MAD1 is a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate

CATH:  1.20.5.1310
Gene Ontology:  GO:0007094|GO:0043515|GO:0051301|GO:0090267|GO:0005515

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAD super family cl37733
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1-172 6.54e-72

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


The actual alignment was detected with superfamily member pfam05557:

Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 228.47  E-value: 6.54e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557640    1 MSLNPTSVARQRLREDHSQLQAECERLRGLLRAMErggtvpADLEAAAASLPSS-----KEVAELKKQVESAELKNQRLK 75
Cdd:pfam05557 490 LSMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLE------DDLEQVLRLPETTstmnfKEVLDLRKELESAELKNQRLK 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557640   76 EVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDS 155
Cdd:pfam05557 564 EVFQAKIQEFRDVCYMLTGYQIDITTNSQYRLTSMYAEHPDDYLLFKLSGSNGSTMQLLETPFSRTLEPLIDLHLAAQKS 643

                         170
                  ....*....|....*..
gi 751557640  156 IPAFLSSLTLELFSRQT 172
Cdd:pfam05557 644 IPAFLSALTLELFSRQT 660
 
Name Accession Description Interval E-value
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1-172 6.54e-72

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 228.47  E-value: 6.54e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557640    1 MSLNPTSVARQRLREDHSQLQAECERLRGLLRAMErggtvpADLEAAAASLPSS-----KEVAELKKQVESAELKNQRLK 75
Cdd:pfam05557 490 LSMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLE------DDLEQVLRLPETTstmnfKEVLDLRKELESAELKNQRLK 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557640   76 EVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDS 155
Cdd:pfam05557 564 EVFQAKIQEFRDVCYMLTGYQIDITTNSQYRLTSMYAEHPDDYLLFKLSGSNGSTMQLLETPFSRTLEPLIDLHLAAQKS 643

                         170
                  ....*....|....*..
gi 751557640  156 IPAFLSSLTLELFSRQT 172
Cdd:pfam05557 644 IPAFLSALTLELFSRQT 660
 
Name Accession Description Interval E-value
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1-172 6.54e-72

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 228.47  E-value: 6.54e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557640    1 MSLNPTSVARQRLREDHSQLQAECERLRGLLRAMErggtvpADLEAAAASLPSS-----KEVAELKKQVESAELKNQRLK 75
Cdd:pfam05557 490 LSMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLE------DDLEQVLRLPETTstmnfKEVLDLRKELESAELKNQRLK 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557640   76 EVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDS 155
Cdd:pfam05557 564 EVFQAKIQEFRDVCYMLTGYQIDITTNSQYRLTSMYAEHPDDYLLFKLSGSNGSTMQLLETPFSRTLEPLIDLHLAAQKS 643

                         170
                  ....*....|....*..
gi 751557640  156 IPAFLSSLTLELFSRQT 172
Cdd:pfam05557 644 IPAFLSALTLELFSRQT 660
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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