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Conserved domains on  [gi|765099199|ref|NP_001292162|]
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denticleless protein homolog isoform 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-265 2.20e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 2.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  22 CVTPHSQISVFSTGGRDGNIMIWDTRCNKkdgfyrQVNQISGaHNtadkqtpskpkkkqnskglapavdsqQSVTVVLFQ 101
Cdd:cd00200   98 SVAFSPDGRILSSSSRDKTIKVWDVETGK------CLTTLRG-HT--------------------------DWVNSVAFS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 102 DENTLVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGtstRKLGYSSLVLDSTGSTLFANCTDDNIYMFNMTGLKT 181
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 182 spVAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVsMPWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTL 261
Cdd:cd00200  212 --LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTI 285


                 ....
gi 765099199 262 KIWR 265
Cdd:cd00200  286 RIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-265 2.20e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 2.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  22 CVTPHSQISVFSTGGRDGNIMIWDTRCNKkdgfyrQVNQISGaHNtadkqtpskpkkkqnskglapavdsqQSVTVVLFQ 101
Cdd:cd00200   98 SVAFSPDGRILSSSSRDKTIKVWDVETGK------CLTTLRG-HT--------------------------DWVNSVAFS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 102 DENTLVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGtstRKLGYSSLVLDSTGSTLFANCTDDNIYMFNMTGLKT 181
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 182 spVAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVsMPWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTL 261
Cdd:cd00200  212 --LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTI 285


                 ....
gi 765099199 262 KIWR 265
Cdd:cd00200  286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
34-267 6.09e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 6.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  34 TGGRDGNIMIWDTRCNKK----DGFYRQVNQIS-----------GAHNTA---DKQTPskpkkkqnsKGLAPAVDSQQSV 95
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLlrtlTGHTGAVRSVAfspdgkllasgSADGTVrlwDLATG---------KLLRTLTGHSGSV 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  96 TVVLF-QDENTLVSAGAvDGIIKVWDLRknytayrqepiasksflyPGTSTRKLGY-----SSLVLDSTGSTLFANCTDD 169
Cdd:COG2319  250 RSVAFsPDGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 170 NIYMFNMTGLKtsPVAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVSmPWHPPTVLLGHSQEVTSVCWCPsDF 249
Cdd:COG2319  311 TVRLWDLATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSP-DG 384

                        250
                 ....*....|....*...
gi 765099199 250 TKIATCSDDNTLKIWRLN 267
Cdd:COG2319  385 RTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-264 3.06e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 765099199   225 PWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 264
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 107-287 2.31e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 107 VSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFlypgtstrklgysSLVLDSTGSTLFANCTDDNiymfnmtglKTSPVAV 186
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVW-------------SIDYSSADPTLLASGSDDG---------SVKLWSI 605

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 187 FNGHQNSTFYVKSSL------SPDDQFLISGSSDEAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNT 260
Cdd:PLN00181 606 NQGVSIGTIKTKANIccvqfpSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNT 683

                        170       180       190
                 ....*....|....*....|....*....|
gi 765099199 261 LKIWRLN---RGLEEKPgdKHSIVGWTSQK 287
Cdd:PLN00181 684 LKLWDLSmsiSGINETP--LHSFMGHTNVK 711
WD40 pfam00400
WD domain, G-beta repeat;
226-264 7.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 7.31e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 765099199  226 WHPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 264
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-265 2.20e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 2.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  22 CVTPHSQISVFSTGGRDGNIMIWDTRCNKkdgfyrQVNQISGaHNtadkqtpskpkkkqnskglapavdsqQSVTVVLFQ 101
Cdd:cd00200   98 SVAFSPDGRILSSSSRDKTIKVWDVETGK------CLTTLRG-HT--------------------------DWVNSVAFS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 102 DENTLVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGtstRKLGYSSLVLDSTGSTLFANCTDDNIYMFNMTGLKT 181
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 182 spVAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVsMPWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTL 261
Cdd:cd00200  212 --LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTI 285


                 ....
gi 765099199 262 KIWR 265
Cdd:cd00200  286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
34-267 6.09e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 6.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  34 TGGRDGNIMIWDTRCNKK----DGFYRQVNQIS-----------GAHNTA---DKQTPskpkkkqnsKGLAPAVDSQQSV 95
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLlrtlTGHTGAVRSVAfspdgkllasgSADGTVrlwDLATG---------KLLRTLTGHSGSV 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  96 TVVLF-QDENTLVSAGAvDGIIKVWDLRknytayrqepiasksflyPGTSTRKLGY-----SSLVLDSTGSTLFANCTDD 169
Cdd:COG2319  250 RSVAFsPDGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 170 NIYMFNMTGLKtsPVAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVSmPWHPPTVLLGHSQEVTSVCWCPsDF 249
Cdd:COG2319  311 TVRLWDLATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSP-DG 384

                        250
                 ....*....|....*...
gi 765099199 250 TKIATCSDDNTLKIWRLN 267
Cdd:COG2319  385 RTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
85-279 2.00e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 2.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  85 LAPAVDSQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASksflypgtstrklGYSSLVLDSTGSTLFA 164
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG-------------AVRSVAFSPDGKTLAS 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 165 NCTDDNIYMFNMTGLKtsPVAVFNGHQNStfyVKS-SLSPDDQFLISGSSDEAAYIWKVSmPWHPPTVLLGHSQEVTSVC 243
Cdd:COG2319  138 GSADGTVRLWDLATGK--LLRTLTGHSGA---VTSvAFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVA 211

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 765099199 244 WCPsDFTKIATCSDDNTLKIWRLNRGLEEKPGDKHS 279
Cdd:COG2319  212 FSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-269 2.34e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 2.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  22 CVTPHSQISVFSTGGRDGNIMIWDT------RCNK-KDGFYRQVNQISGAHNTA----DKQTpsKPKKKQNSKGLAPAVD 90
Cdd:cd00200   14 CVAFSPDGKLLATGSGDGTIKVWDLetgellRTLKgHTGPVRDVAASADGTYLAsgssDKTI--RLWDLETGECVRTLTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  91 SQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASksflypgtstrklGYSSLVLDSTGSTLFANCTDDN 170
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD-------------WVNSVAFSPDGTFVASSSQDGT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 171 IYMFNMTGLKtsPVAVFNGHQNstfYVKS-SLSPDDQFLISGSSDEAAYIWKVSMpWHPPTVLLGHSQEVTSVCWCPSDF 249
Cdd:cd00200  159 IKLWDLRTGK--CVATLTGHTG---EVNSvAFSPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGY 232

                        250       260
                 ....*....|....*....|
gi 765099199 250 TkIATCSDDNTLKIWRLNRG 269
Cdd:cd00200  233 L-LASGSEDGTIRVWDLRTG 251
WD40 COG2319
WD40 repeat [General function prediction only];
80-279 7.34e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 7.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  80 QNSKGLAPAVDSQQSVTVVLF-QDENTLVSAGAvDGIIKVWDLRknytayRQEPIASksflYPGTSTRklgYSSLVLDST 158
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFsPDGKTLASGSA-DGTVRLWDLA------TGKLLRT----LTGHSGA---VTSVAFSPD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 159 GSTLFANCTDDNIYMFNMTGLKtsPVAVFNGHQNStfyVKS-SLSPDDQFLISGSSDEAAYIWKVSmPWHPPTVLLGHSQ 237
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGA---VRSvAFSPDGKLLASGSADGTVRLWDLA-TGKLLRTLTGHSG 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 765099199 238 EVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLEEKPGDKHS 279
Cdd:COG2319  248 SVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHS 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-269 1.36e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 1.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199  94 SVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQE----PIASKSF-----------------LYP---GTSTRKL- 148
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgPVRDVAAsadgtylasgssdktirLWDletGECVRTLt 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 149 GYSSLVLD---STGSTLFANCTDDN-IYMFNMTglKTSPVAVFNGHQNStfyVKS-SLSPDDQFLISGSSDEAAYIWKVS 223
Cdd:cd00200   91 GHTSYVSSvafSPDGRILSSSSRDKtIKVWDVE--TGKCLTTLRGHTDW---VNSvAFSPDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 765099199 224 mPWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRG 269
Cdd:cd00200  166 -TGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG 209
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 183-269 1.09e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 183 PVAVFNGHQNSTFYVKssLSPDDQFLISGSSDEAAYIWKVSMPWhPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLK 262
Cdd:cd00200    1 LRRTLKGHTGGVTCVA--FSPDGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIR 76


                 ....*..
gi 765099199 263 IWRLNRG 269
Cdd:cd00200   77 LWDLETG 83
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-264 3.06e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 765099199   225 PWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 264
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 107-287 2.31e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 107 VSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFlypgtstrklgysSLVLDSTGSTLFANCTDDNiymfnmtglKTSPVAV 186
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVW-------------SIDYSSADPTLLASGSDDG---------SVKLWSI 605

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 187 FNGHQNSTFYVKSSL------SPDDQFLISGSSDEAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNT 260
Cdd:PLN00181 606 NQGVSIGTIKTKANIccvqfpSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNT 683

                        170       180       190
                 ....*....|....*....|....*....|
gi 765099199 261 LKIWRLN---RGLEEKPgdKHSIVGWTSQK 287
Cdd:PLN00181 684 LKLWDLSmsiSGINETP--LHSFMGHTNVK 711
WD40 pfam00400
WD domain, G-beta repeat;
226-264 7.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 7.31e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 765099199  226 WHPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 264
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 231-273 1.43e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 1.43e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 765099199 231 VLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLEEK 273
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR 45
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 105-259 6.63e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.77  E-value: 6.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 105 TLVSAGAVDGIIKVWDLR----------KNYTAYRQEPIASKSFLYPGTSTRKLGYSSL--------------------- 153
Cdd:PLN00181 589 TLLASGSDDGSVKLWSINqgvsigtiktKANICCVQFPSESGRSLAFGSADHKVYYYDLrnpklplctmighsktvsyvr 668

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765099199 154 VLDStgSTLFANCTDDNIYMFNMT----GLKTSPVAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVSMPWHPP 229
Cdd:PLN00181 669 FVDS--STLVSSSTDNTLKLWDLSmsisGINETPLHSFMGHTNVKNFV--GLSVSDGYIATGSETNEVFVYHKAFPMPVL 744

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 765099199 230 TVLLGH------------SQEVTSVCWCPSDFTKIATCSDDN 259
Cdd:PLN00181 745 SYKFKTidpvsglevddaSQFISSVCWRGQSSTLVAANSTGN 786
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 182-221 7.78e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 7.78e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 765099199   182 SPVAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWK 221
Cdd:smart00320   3 ELLKTLKGHTGPVTSV--AFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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