NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|807201118|ref|NP_001293129|]
View 

histone-lysine N-methyltransferase SETD7 isoform 3 [Homo sapiens]

Protein Classification

MORN repeat-containing protein( domain architecture ID 1003622)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  35568981|33296386

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
19-124 5.42e-18

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 77.30  E-value: 5.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  19 DGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEY 98
Cdd:COG4642  156 NGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235

                         90       100
                 ....*....|....*....|....*.
gi 807201118  99 DTDGRlIFKGQYKDNIRHGVCWIYYP 124
Cdd:COG4642  236 YADGD-RYEGEFKNGKRHGQGTMTYA 260
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
19-124 5.42e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 77.30  E-value: 5.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  19 DGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEY 98
Cdd:COG4642  156 NGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235

                         90       100
                 ....*....|....*....|....*.
gi 807201118  99 DTDGRlIFKGQYKDNIRHGVCWIYYP 124
Cdd:COG4642  236 YADGD-RYEGEFKNGKRHGQGTMTYA 260
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-104 1.85e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 48.68  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  19 DGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEY 98
Cdd:PLN03185 109 QGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVFY 188


                 ....*.
gi 807201118  99 DTDGRL 104
Cdd:PLN03185 189 PAGSRV 194
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
19-124 5.42e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 77.30  E-value: 5.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  19 DGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEY 98
Cdd:COG4642  156 NGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235

                         90       100
                 ....*....|....*....|....*.
gi 807201118  99 DTDGRlIFKGQYKDNIRHGVCWIYYP 124
Cdd:COG4642  236 YADGD-RYEGEFKNGKRHGQGTMTYA 260
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
19-112 3.94e-17

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 3.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  19 DGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEY 98
Cdd:COG4642  179 NGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMT 258

                         90
                 ....*....|....
gi 807201118  99 DTDGRlIFKGQYKD 112
Cdd:COG4642  259 YADGS-VYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
6-117 1.14e-14

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 68.44  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118   6 EMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGT 85
Cdd:COG4642  120 EGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGE 199

                         90       100       110
                 ....*....|....*....|....*....|..
gi 807201118  86 YVDGELNGPAQEYDTDGRlIFKGQYKDNIRHG 117
Cdd:COG4642  200 FKNGQRHGQGTYTYADGD-RYEGEFKNGKRHG 230
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
37-123 4.42e-12

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 59.70  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  37 EGNFVHGEKNGRGKFFFFDGSTL-EGYYVDDALQGQGVYTYEDGGVLQ-GTYVDGELNGPAQEYDTDGRLIFKGQYKDNI 114
Cdd:COG2849   58 GLGKYKKGKLGEWKTYYPNGQLKsEGTYKNGKLEGEWKEYYENGKLKSeGNYKNGKLHGEWKEYYENGKLKEEGNYKNGK 137


                 ....*....
gi 807201118 115 RHGVcWIYY 123
Cdd:COG2849  138 KDGV-WKYY 145
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
35-116 5.87e-12

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 59.31  E-value: 5.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  35 RFEGNFVHGEKNGRGKFFFFDGS-TLEGYYVDDALQGQGVYTYEDGGVL-QGTYVDGELNGPAQEYDTDGRLIFKGQYKD 112
Cdd:COG2849   80 KSEGTYKNGKLEGEWKEYYENGKlKSEGNYKNGKLHGEWKEYYENGKLKeEGNYKNGKKDGVWKYYDENGKLVKEEEYKN 159


                 ....
gi 807201118 113 NIRH 116
Cdd:COG2849  160 GKKV 163
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
33-124 1.13e-09

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 53.15  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  33 TDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVL-QGTYVDGELNGPAQEYDTDGRLIFKGQYK 111
Cdd:COG2849   31 GYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQLKsEGTYKNGKLEGEWKEYYENGKLKSEGNYK 110

                         90
                 ....*....|...
gi 807201118 112 DNIRHGVCWIYYP 124
Cdd:COG2849  111 NGKLHGEWKEYYE 123
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
19-117 4.27e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 53.04  E-value: 4.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  19 DGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEY 98
Cdd:COG4642  110 GGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLT 189

                         90
                 ....*....|....*....
gi 807201118  99 DTDGRlIFKGQYKDNIRHG 117
Cdd:COG4642  190 YANGD-VYEGEFKNGQRHG 207
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-104 1.85e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 48.68  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  19 DGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEY 98
Cdd:PLN03185 109 QGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVFY 188


                 ....*.
gi 807201118  99 DTDGRL 104
Cdd:PLN03185 189 PAGSRV 194
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 31-124 4.96e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 44.44  E-value: 4.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  31 SSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGrLIFKGQY 110
Cdd:PLN03185   6 SNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDG-TTYKGRW 84

                         90
                 ....*....|....
gi 807201118 111 KDNIRHGVCWIYYP 124
Cdd:PLN03185  85 RLNLKHGLGYQRYP 98
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 20-96 6.55e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 44.05  E-value: 6.55e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 807201118  20 GLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQ 96
Cdd:PLN03185  41 GMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGK 117
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
43-124 2.06e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 41.98  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  43 GEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIY 122
Cdd:COG2849   18 LKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQLKSEGTYKNGKLEGEWKEY 97


                 ..
gi 807201118 123 YP 124
Cdd:COG2849   98 YE 99
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
13-117 2.14e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 39.55  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  13 EGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELN 92
Cdd:COG4642   81 GGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPH 160

                         90       100
                 ....*....|....*....|....*
gi 807201118  93 GPAQEYDTDGRlIFKGQYKDNIRHG 117
Cdd:COG4642  161 GQGTLTYADGD-RYEGEFKNGKRHG 184
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 20-118 2.36e-04

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 39.82  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807201118  20 GLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYD 99
Cdd:PLN03185  64 GYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTW 143

                         90
                 ....*....|....*....
gi 807201118 100 TDGRlIFKGQYKDNIRHGV 118
Cdd:PLN03185 144 VSGD-SYEGQWLDGMMHGF 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH