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Conserved domains on  [gi|808154260|ref|NP_001294881|]
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hyaluronan and proteoglycan link protein 3 isoform 1 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 10147181)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 114-230 2.74e-65

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


:

Pssm-ID: 409461  Cd Length: 117  Bit Score: 204.48  E-value: 2.74e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 114 ETPEETLFTYQGASVILPCRYRYEPALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGRVHLRQDKEHDVSL 193
Cdd:cd05877    1 ETVQAKVFSHRGGNVTLPCRYHYEPELSAPRKIRVKWTKLEVDYAKEEDVLVAIGTRHKSYGSYQGRVFLRRADDLDASL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 808154260 194 EIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVF 230
Cdd:cd05877   81 VITDLRLEDYGRYRCEVIDGLEDESVVVALRLRGVVF 117
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 329-419 1.07e-58

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


:

Pssm-ID: 239596  Cd Length: 91  Bit Score: 186.47  E-value: 1.07e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 329 RVYYLEHPEKLTLTEAREACQEDDATIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGFPD 408
Cdd:cd03519    1 GVFYLLHPGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFGFPD 80

                         90
                 ....*....|.
gi 808154260 409 PQSRLYGVYCY 419
Cdd:cd03519   81 KKHKLYGVYCY 91
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 228-322 1.66e-56

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


:

Pssm-ID: 239595  Cd Length: 95  Bit Score: 181.09  E-value: 1.66e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 228 VVFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLAPGVRSY 307
Cdd:cd03518    1 VVFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTVPGLRSY 80

                         90
                 ....*....|....*
gi 808154260 308 GPRHRRLHRYDVFCF 322
Cdd:cd03518   81 GERDKMLSRYDAFCF 95
 
Name Accession Description Interval E-value
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 114-230 2.74e-65

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 204.48  E-value: 2.74e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 114 ETPEETLFTYQGASVILPCRYRYEPALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGRVHLRQDKEHDVSL 193
Cdd:cd05877    1 ETVQAKVFSHRGGNVTLPCRYHYEPELSAPRKIRVKWTKLEVDYAKEEDVLVAIGTRHKSYGSYQGRVFLRRADDLDASL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 808154260 194 EIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVF 230
Cdd:cd05877   81 VITDLRLEDYGRYRCEVIDGLEDESVVVALRLRGVVF 117
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 329-419 1.07e-58

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 186.47  E-value: 1.07e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 329 RVYYLEHPEKLTLTEAREACQEDDATIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGFPD 408
Cdd:cd03519    1 GVFYLLHPGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFGFPD 80

                         90
                 ....*....|.
gi 808154260 409 PQSRLYGVYCY 419
Cdd:cd03519   81 KKHKLYGVYCY 91
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 228-322 1.66e-56

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 181.09  E-value: 1.66e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 228 VVFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLAPGVRSY 307
Cdd:cd03518    1 VVFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTVPGLRSY 80

                         90
                 ....*....|....*
gi 808154260 308 GPRHRRLHRYDVFCF 322
Cdd:cd03518   81 GERDKMLSRYDAFCF 95
Xlink pfam00193
Extracellular link domain;
329-419 5.41e-42

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 143.10  E-value: 5.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260  329 RVYYLEHPE--KLTLTEAREACQEDDATIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGF 406
Cdd:pfam00193   1 GVFHLESPGryKLTFQEAQAACAALGATLATPEQLYAAWKA-GLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                          90
                  ....*....|...
gi 808154260  407 PDPQSRLYGVYCY 419
Cdd:pfam00193  80 RDPLSERYDAYCY 92
Xlink pfam00193
Extracellular link domain;
228-322 8.08e-42

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 142.71  E-value: 8.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260  228 VVFPYQSPNgRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGlaPGVRSY 307
Cdd:pfam00193   1 GVFHLESPG-RYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNM--PGVRQY 77

                          90
                  ....*....|....*
gi 808154260  308 GPRHRRLHRYDVFCF 322
Cdd:pfam00193  78 GFRDPLSERYDAYCY 92
LINK smart00445
Link (Hyaluronan-binding);
327-420 1.58e-41

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 142.10  E-value: 1.58e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260   327 KGRVYYLEH--PEKLTLTEAREACQEDDATIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSF 404
Cdd:smart00445   1 DGGVFHVEKngRYKLTFAEAREACRAQGATLATVGQLYAAWQD-GFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                           90
                   ....*....|....*.
gi 808154260   405 GFPDPQSRlYGVYCYR 420
Cdd:smart00445  80 GFPDPTSR-YDAYCFN 94
LINK smart00445
Link (Hyaluronan-binding);
226-323 1.25e-33

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 121.30  E-value: 1.25e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260   226 RGVVFPYQsPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGlaPGVR 305
Cdd:smart00445   1 DGGVFHVE-KNGRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNL--PGVR 77

                           90
                   ....*....|....*...
gi 808154260   306 SYGPRHRRlHRYDVFCFA 323
Cdd:smart00445  78 QYGFPDPT-SRYDAYCFN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 115-212 1.17e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 58.24  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260  115 TPEETLFTYQGASVILPCRYryePALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFgdYQGRVHLRQDKE-HDVSL 193
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTY---SSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGV--KKGRFSGRGDPSnGDGSL 75

                          90
                  ....*....|....*....
gi 808154260  194 EIQDLRLEDYGRYRCEVID 212
Cdd:pfam07686  76 TIQNLTLSDSGTYTCAVIP 94
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 125-224 2.13e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 48.27  E-value: 2.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260   125 GASVILPCRYRYEPAlvsprrVRVKWWKlsengapEKDVLVAiglrhrsfgdYQGRVHLRQDKeHDVSLEIQDLRLEDYG 204
Cdd:smart00410   9 GESVTLSCEASGSPP------PEVTWYK-------QGGKLLA----------ESGRFSVSRSG-STSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|
gi 808154260   205 RYRCEVIDGLEDESGLVELE 224
Cdd:smart00410  65 TYTCAATNSSGSASSGTTLT 84
 
Name Accession Description Interval E-value
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 114-230 2.74e-65

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 204.48  E-value: 2.74e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 114 ETPEETLFTYQGASVILPCRYRYEPALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGRVHLRQDKEHDVSL 193
Cdd:cd05877    1 ETVQAKVFSHRGGNVTLPCRYHYEPELSAPRKIRVKWTKLEVDYAKEEDVLVAIGTRHKSYGSYQGRVFLRRADDLDASL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 808154260 194 EIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVF 230
Cdd:cd05877   81 VITDLRLEDYGRYRCEVIDGLEDESVVVALRLRGVVF 117
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 329-419 1.07e-58

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 186.47  E-value: 1.07e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 329 RVYYLEHPEKLTLTEAREACQEDDATIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGFPD 408
Cdd:cd03519    1 GVFYLLHPGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFGFPD 80

                         90
                 ....*....|.
gi 808154260 409 PQSRLYGVYCY 419
Cdd:cd03519   81 KKHKLYGVYCY 91
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 228-322 1.66e-56

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 181.09  E-value: 1.66e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 228 VVFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLAPGVRSY 307
Cdd:cd03518    1 VVFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTVPGLRSY 80

                         90
                 ....*....|....*
gi 808154260 308 GPRHRRLHRYDVFCF 322
Cdd:cd03518   81 GERDKMLSRYDAFCF 95
Xlink pfam00193
Extracellular link domain;
329-419 5.41e-42

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 143.10  E-value: 5.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260  329 RVYYLEHPE--KLTLTEAREACQEDDATIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGF 406
Cdd:pfam00193   1 GVFHLESPGryKLTFQEAQAACAALGATLATPEQLYAAWKA-GLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                          90
                  ....*....|...
gi 808154260  407 PDPQSRLYGVYCY 419
Cdd:pfam00193  80 RDPLSERYDAYCY 92
Xlink pfam00193
Extracellular link domain;
228-322 8.08e-42

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 142.71  E-value: 8.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260  228 VVFPYQSPNgRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGlaPGVRSY 307
Cdd:pfam00193   1 GVFHLESPG-RYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNM--PGVRQY 77

                          90
                  ....*....|....*
gi 808154260  308 GPRHRRLHRYDVFCF 322
Cdd:pfam00193  78 GFRDPLSERYDAYCY 92
LINK smart00445
Link (Hyaluronan-binding);
327-420 1.58e-41

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 142.10  E-value: 1.58e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260   327 KGRVYYLEH--PEKLTLTEAREACQEDDATIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSF 404
Cdd:smart00445   1 DGGVFHVEKngRYKLTFAEAREACRAQGATLATVGQLYAAWQD-GFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                           90
                   ....*....|....*.
gi 808154260   405 GFPDPQSRlYGVYCYR 420
Cdd:smart00445  80 GFPDPTSR-YDAYCFN 94
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 330-419 1.05e-37

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 132.05  E-value: 1.05e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 330 VYYLEHPEKLTLTEAREACQEDDATIAKVGQLFAAWKfHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSF----- 404
Cdd:cd03520    2 VFYATAPEKFTFQEARAECRSLGAVLATTGQLYAAWR-QGLDQCDPGWLADGSVRYPISTPRPQCGGGLPGVRTLyrfpn 80

                         90
                 ....*....|....*..
gi 808154260 405 --GFPDPQSRlYGVYCY 419
Cdd:cd03520   81 qtGFPDPHSR-FDAYCF 96
LINK smart00445
Link (Hyaluronan-binding);
226-323 1.25e-33

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 121.30  E-value: 1.25e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260   226 RGVVFPYQsPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGlaPGVR 305
Cdd:smart00445   1 DGGVFHVE-KNGRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNL--PGVR 77

                           90
                   ....*....|....*...
gi 808154260   306 SYGPRHRRlHRYDVFCFA 323
Cdd:smart00445  78 QYGFPDPT-SRYDAYCFN 94
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 329-419 9.52e-33

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 118.68  E-value: 9.52e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 329 RVYYLEH---PEKLTLTEAREACQEDDATIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFG 405
Cdd:cd01102    1 VVFHLESqngRYKLTFAEAALACKARGAHLATPGQLEAAWQD-GFDVCTAGWLADGSVRYPIVTSRPNCGGRNPGVRSYG 79

                         90
                 ....*....|....
gi 808154260 406 FPDPQSRlYGVYCY 419
Cdd:cd01102   80 NPAPSGR-YDAYCF 92
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 228-322 4.34e-32

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 117.13  E-value: 4.34e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 228 VVFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPglAPGVRSY 307
Cdd:cd01102    1 VVFHLESQNGRYKLTFAEAALACKARGAHLATPGQLEAAWQDGFDVCTAGWLADGSVRYPIVTSRPNCGGR--NPGVRSY 78

                         90
                 ....*....|....*
gi 808154260 308 GPRHRRlHRYDVFCF 322
Cdd:cd01102   79 GNPAPS-GRYDAYCF 92
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 228-322 1.34e-26

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 102.49  E-value: 1.34e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 228 VVFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPC-GGPGLAPGVRS 306
Cdd:cd03517    1 VVFHYRDATARYALTFPRAQRACLDISAQIATPEQLLAAYEDGFEQCDAGWLADQTVRYPIQTPREGCyGDMDGFPGVRN 80

                         90
                 ....*....|....*.
gi 808154260 307 YGPRHRRlHRYDVFCF 322
Cdd:cd03517   81 YGVRDPD-ELYDVYCY 95
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
 120-230 3.96e-23

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 93.81  E-value: 3.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 120 LFTYQGASVILPCRYRYEPALVSPRR--VRVKWWKLSENGA--PEKDVLVAIGLRHRSFGDYQGRVHL--RQDKEHDVSL 193
Cdd:cd05714    7 VFSHLGGNVTLPCKFYRDPTAFGSGIhkIRIKWTKLTSDSGylKEVDVLVAMGNVVYHKKTYGGRVSVplKPGSDSDASL 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 808154260 194 EIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVF 230
Cdd:cd05714   87 VITDLTASDYGLYRCEVIEGIEDDQDVVALDVQGVVF 123
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 339-419 2.38e-21

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 87.85  E-value: 2.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 339 LTLTEAREACQEDDATIAKVGQLFAAWkFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPE---PGVRSFGFPDPQSrLYG 415
Cdd:cd03517   14 LTFPRAQRACLDISAQIATPEQLLAAY-EDGFEQCDAGWLADQTVRYPIQTPREGCYGDMdgfPGVRNYGVRDPDE-LYD 91


                 ....
gi 808154260 416 VYCY 419
Cdd:cd03517   92 VYCY 95
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 229-322 2.78e-21

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 87.52  E-value: 2.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 229 VFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLapGVRSYG 308
Cdd:cd03515    2 VFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHV--GIVDYG 79

                         90
                 ....*....|....
gi 808154260 309 PRHRRLHRYDVFCF 322
Cdd:cd03515   80 PRLNLSERWDAYCY 93
Ig_Aggrecan_like cd05878
Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core ...
 125-230 1.91e-20

Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG); The members here are composed of the immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core proteins (CSPGs). Included in this group are the Ig domains of other CSPGs: versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409462  Cd Length: 125  Bit Score: 86.52  E-value: 1.91e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 125 GASVILPCRYRYEPALVSPRRV----RVKWWKLSENGAPEKD--VLVAIGLRHRSFGDYQGRVHLRQDKEH--DVSLEIQ 196
Cdd:cd05878   12 GTSVTLPCYFIDPPHPVTPSTAplapRIKWSKVSVDGKKEKEvvLLVATEGRVRVNSAYQGRVSLPNYPAIpsDATLEVQ 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 808154260 197 DLRLEDYGRYRCEVIDGLEDESGLVELELRGVVF 230
Cdd:cd05878   92 SLRASDSGLYRCEVMHGIEDSQDTVELVVKGVVF 125
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 229-322 2.00e-19

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 82.75  E-value: 2.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 229 VFPYQSPNgryQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPglAPGVRS-Y 307
Cdd:cd03520    2 VFYATAPE---KFTFQEARAECRSLGAVLATTGQLYAAWRQGLDQCDPGWLADGSVRYPISTPRPQCGGG--LPGVRTlY 76

                         90       100
                 ....*....|....*....|..
gi 808154260 308 gpRHRR-------LHRYDVFCF 322
Cdd:cd03520   77 --RFPNqtgfpdpHSRFDAYCF 96
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 330-419 7.28e-18

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 78.27  E-value: 7.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 330 VYYLEHPE---KLTLTEAREACQEDDATIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGF 406
Cdd:cd03515    2 VFHLRSRSgkyKLTYTEAKAACEAEGAHLATYSQLSAAQQL-GFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                         90
                 ....*....|...
gi 808154260 407 PDPQSRLYGVYCY 419
Cdd:cd03515   81 RLNLSERWDAYCY 93
Ig_Neurocan cd05902
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 127-230 3.39e-15

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409483  Cd Length: 121  Bit Score: 71.79  E-value: 3.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 127 SVILPCRYRYEPALVSPRRV-RVKWWKLSEN-GAPEKDVLVAIGLRHRSFGDYQGRVHL--RQDKEHDVSLEIQDLRLED 202
Cdd:cd05902   14 SVLLPCVFTLPPSASSPPEGpRIKWTKLSTSgGQQQRPVLVARDNVVRVAKAFQGRVSLpgYPKNRYNASLVLSRLRYSD 93

                         90       100
                 ....*....|....*....|....*...
gi 808154260 203 YGRYRCEVIDGLEDESGLVELELRGVVF 230
Cdd:cd05902   94 SGTYRCEVVLGINDEQDTVPLEVTGVVF 121
Ig_Versican cd05901
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 127-230 1.14e-14

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409482  Cd Length: 128  Bit Score: 70.37  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 127 SVILPCRYRYEPAL-----VSPRRVRVKWWKL--SENGAPEKD--VLVAIGLRHRSFGDYQGRVHL--RQDKEHDVSLEI 195
Cdd:cd05901   14 SVVLPCRFSTLPTLppsynITSEFLRIKWTKIqvDKNGKDHKEttVLVAQNGIIKIGQEYMGRVSVpsHPEDQGDASLTI 93

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 808154260 196 QDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVF 230
Cdd:cd05901   94 VKLRASDAGVYRCEVMHGIEDTQDTVSLDVSGVVF 128
Ig_Aggrecan cd05900
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 116-230 1.96e-14

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggrecan has a wide distribution in connective tissue and extracellular matrices. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409481  Cd Length: 123  Bit Score: 69.58  E-value: 1.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 116 PEET-LFTYQGASVILPCrYRYEP----------ALVSPRrvrVKWWKLSENgaPEKDVLVAIGLRHRSFGDYQGRVHLR 184
Cdd:cd05900    2 PLESpLRVVLGSSLLIPC-YFQDPiakdpgaptvAPLSPR---IKWSFISKE--KESVLLVATEGKVRVNTEYLDRVSLP 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 808154260 185 QDK--EHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVF 230
Cdd:cd05900   76 NYPaiPSDATLEITELRSNDSGTYRCEVMHGIEDNYDTVEVQVKGIVF 123
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 115-212 1.17e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 58.24  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260  115 TPEETLFTYQGASVILPCRYryePALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFgdYQGRVHLRQDKE-HDVSL 193
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTY---SSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGV--KKGRFSGRGDPSnGDGSL 75

                          90
                  ....*....|....*....
gi 808154260  194 EIQDLRLEDYGRYRCEVID 212
Cdd:pfam07686  76 TIQNLTLSDSGTYTCAVIP 94
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 112-210 1.08e-08

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 52.91  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 112 VVETPEETLFTYQGaSVILPCRYRYEPALVsprRVRVKWWKLSENGApekdvlVAIGLRHRSfGD------YQGRVHLRQ 185
Cdd:cd16089    2 ILEGPESITGPWKG-SVNLPCTYVPEEGYT---QVLVKWLVQRDSDP------VTIFLRDSS-GDhiqqakYRGRLEVSK 70

                         90       100
                 ....*....|....*....|....*
gi 808154260 186 DKEHDVSLEIQDLRLEDYGRYRCEV 210
Cdd:cd16089   71 DTPGDVSLQLDTLEMDDRGHYTCQV 95
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 339-419 3.36e-08

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 52.08  E-value: 3.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 339 LTLTEAREACQEDDATIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVrsFGFPDPQSRLYGVYC 418
Cdd:cd03516   19 LNFTEAKEACRALGLTLASKAQVETALKF-GFETCRYGWVEDGFVVIPRIDPNPLCGKNGTGV--YILNSNLSSRYDAYC 95


                 .
gi 808154260 419 Y 419
Cdd:cd03516   96 Y 96
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 125-224 2.13e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 48.27  E-value: 2.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260   125 GASVILPCRYRYEPAlvsprrVRVKWWKlsengapEKDVLVAiglrhrsfgdYQGRVHLRQDKeHDVSLEIQDLRLEDYG 204
Cdd:smart00410   9 GESVTLSCEASGSPP------PEVTWYK-------QGGKLLA----------ESGRFSVSRSG-STSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|
gi 808154260   205 RYRCEVIDGLEDESGLVELE 224
Cdd:smart00410  65 TYTCAATNSSGSASSGTTLT 84
IGv smart00406
Immunoglobulin V-Type;
127-210 2.29e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 48.15  E-value: 2.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260   127 SVILPCRYRYepalVSPRRVRVKWWKLSENGAPEkdVLVAIGLRHRSFGD--YQGRVHLRQDK-EHDVSLEIQDLRLEDY 203
Cdd:smart00406   1 SVTLSCKFSG----STFSSYYVSWVRQPPGKGLE--WLGYIGSNGSSYYQesYKGRFTISKDTsKNDVSLTISNLRVEDT 74


                   ....*..
gi 808154260   204 GRYRCEV 210
Cdd:smart00406  75 GTYYCAV 81
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 111-210 3.88e-07

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 48.60  E-value: 3.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 111 LVVETPEETLFTYQGASVILPCRYRYEPALVSPRRVRvkwWKLSENGAPEKDVLVAIGlrHRSFGDY----QGRVHL-RQ 185
Cdd:cd20960    1 LLITSAQTEIKKVAGENVTLPCHHQLGLEDQGTLDIE---WLLLPSDKVEKVVITYSG--DRVYNHYypalKGRVAFtSN 75

                         90       100
                 ....*....|....*....|....*
gi 808154260 186 DKEHDVSLEIQDLRLEDYGRYRCEV 210
Cdd:cd20960   76 DLSGDASLNISNLKLSDTGTYQCKV 100
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 236-322 1.93e-05

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 44.37  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 236 NGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGgpglAPGVRSYGPRHRRLH 315
Cdd:cd03516   14 NGRYSLNFTEAKEACRALGLTLASKAQVETALKFGFETCRYGWVEDGFVVIPRIDPNPLCG----KNGTGVYILNSNLSS 89


                 ....*..
gi 808154260 316 RYDVFCF 322
Cdd:cd03516   90 RYDAYCY 96
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 125-213 5.94e-05

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 42.38  E-value: 5.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 125 GASVILPCRYRYEPALVSPRRVRVKWWKLSENgaPEKDVLVAIGLRHRSFGD-YQGRVHLRQDKEH-DVSLEIQDLRLED 202
Cdd:cd05712   14 GLCVLIPCSFSYPADYWVSNPVHGYWYRGGPY--PKYRPPVATNNRTREVHEsTQGRFRLLGDPGKkNCSLSISDARPED 91

                         90
                 ....*....|.
gi 808154260 203 YGRYRCEVIDG 213
Cdd:cd05712   92 SGKYFFRVERG 102
IgV_VCBP cd20963
Immunoglobulin Variable region-containing chitin-binding proteins; an immunoglobulin V-set ...
 125-210 4.53e-04

Immunoglobulin Variable region-containing chitin-binding proteins; an immunoglobulin V-set domain; The members here are composed of the immunoglobulin variable (IgV) region-containing chitin-binding proteins (VCBPs). VCBPs are secreted, immune-type molecules that have been identified in both amphioxus and sea squirt (Ciona intestinalis). VCBPs, which consist of a leader peptide, two tandem N-terminal immunoglobulin V-type domains and a single C-terminal chitin-binding domain, belong to a multigene family encoding secreted proteins. The VCBPs were identified first in the cephalochordate Branchiostoma floridae and show structural similarities with V-type domains of immunoglobulins and T cell receptors, suggesting that VCBPs represent a unique gut-associated form of innate immune proteins. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other.


Pssm-ID: 409555  Cd Length: 123  Bit Score: 39.91  E-value: 4.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 125 GASVILPCRYRYEPALVSPRrvrVKWWKLSengAPEKDVLVAIGLRH---------RSFGDYQGRVHLrQDKEHDvSLEI 195
Cdd:cd20963   17 GNRVELPCSYTISPAAQPPT---ITWLKGI---SVDRAEVVFKGFKYwnetsssgeVYFGDYAGRASV-ASLTQP-TLVL 88

                         90
                 ....*....|....*
gi 808154260 196 QDLRLEDYGRYRCEV 210
Cdd:cd20963   89 TDLKFDDWGRYWCRV 103
IgV_B7-H6 cd20981
Immunoglobulin variable (IgV) domain of B7-H6; The members here are composed of the ...
 111-225 6.48e-04

Immunoglobulin variable (IgV) domain of B7-H6; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H6 (also known as NCR3LG1). B7-H6 contains one IgV domain and one IgC domain (IgV-IgC) and belongs to the B7-family, which consists of structurally related cell-surface protein ligands which bind to receptors on lymphocytes that regulate immune responses. B7-H6 is a ligand of NKp30, which is a member of CD28 family and an activating receptor of natural killer (NK) cells. The expression of NKp30 has been found in most of NK cells, which is involved in the process of tumor cell killing and interaction with antigen presenting cells (APCs) such as dendritic cells. Studies showed that NK cells eliminate B7-H6-expressing tumor cells either directly via cytotoxicity or indirectly by cytokine secretion. For instance, chimeric NKp30-expressing T cells responded to B7-H6(+) tumor cells and those T cells produced IFN-gamma and killed B7-H6-expressing tumor cells in vivo. B7-H6 mRNA is not found in normal cells, while high expression of B7-H6 is found in certain type tumor cells, such as lymphoma, leukemia, ovarian cancer, brain tumors, breast cancers, and various sarcomas. Since B7-H6 can bind NKp30 to exert anti-tumor effects by NK cells, which are able to recognize the difference between cancer cells and normal cells, B7-H6 may serve as a promising target for cancer immunotherapy.


Pssm-ID: 409573  Cd Length: 114  Bit Score: 39.13  E-value: 6.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 111 LVVETP-EETLFTYQGASVILPCRYRYEPALvSPRRVRVKWWKLSENGAPEKDVLvaiglrhRSFGDYQ------GRVHL 183
Cdd:cd20981    1 LKVEMMaGGTQITPLNDNVTIFCNIFYSQPL-NITSMGITWFRKSLTFDKEVKVF-------EFFGDHQkafrpgAIVSP 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 808154260 184 RQDKEHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELEL 225
Cdd:cd20981   73 WRLKSGDASLQLPGVQLEEAGEYRCEVVVTPLKAQGTVQLEV 114
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 111-209 9.46e-04

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 38.48  E-value: 9.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 111 LVVETPEETLFtyqGASVILPCRYRyepalvSPRRVR-VKWWKLSEnGAPEkdvlvAIGLRHRSFGD-----YQGRVHLR 184
Cdd:cd05846    2 VVHTGDTRAVL---GGNATLSCNLT------LPEEVLqVTWQKIKA-SSPE-----NIVTYSKKYGVkiqpsYVRRISFT 66

                         90       100
                 ....*....|....*....|....*
gi 808154260 185 QDKEHDVSLEIQDLRLEDYGRYRCE 209
Cdd:cd05846   67 SSGLNSTSITIWNVTLEDEGCYKCL 91
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 128-210 1.14e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 37.31  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 128 VILPCRYRYEPAlvsprrVRVKWWKlseNGAPEKdvlvaiglrhrsfgdyQGRVHLRQDKEHDVSLEIQDLRLEDYGRYR 207
Cdd:cd00096    1 VTLTCSASGNPP------PTITWYK---NGKPLP----------------PSSRDSRRSELGNGTLTISNVTLEDSGTYT 55


                 ...
gi 808154260 208 CEV 210
Cdd:cd00096   56 CVA 58
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 113-225 1.16e-03

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 38.29  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 113 VETPEETLFTYQGASVILPCRYRYEPalVSPRrvrVKWWKLsengapEKDVLVAIGLRHRSFGDYQGRVHLRqdkehDVS 192
Cdd:cd20946    2 VPSSQQVVTVVENQEVILSCKTPKKT--SSPR---VEWKKL------QRDVTFVVFQNNKIQGDYKGRAEIL-----GTN 65

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 808154260 193 LEIQDLRLEDYGRYRCEVI---DGLEDESGLVELEL 225
Cdd:cd20946   66 ITIKNVTRSDSGKYRCEVSarsDGQNLGEVTVTLEV 101
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 123-210 1.89e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 37.81  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 123 YQGASVILPCRYryePALVSPRRVRVKWWKLsenGAPEKDVlVAIglRHRSFG-----DYQGRVHLR--QDKEHDVSLEI 195
Cdd:cd05718   12 FLGGSVTLPCSL---TSPGTTKITQVTWMKI---GAGSSQN-VAV--FHPQYGpsvpnPYAERVEFLaaRLGLRNATLRI 82

                         90
                 ....*....|....*
gi 808154260 196 QDLRLEDYGRYRCEV 210
Cdd:cd05718   83 RNLRVEDEGNYICEF 97
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 124-213 2.77e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 37.31  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 124 QGASVILPCRYRyepalVSPRRVRVKWWKLSENGAPEkdVLVAIGLRHRSF-GDYQGRVHLRQDKEHDVSLEIQDLRLED 202
Cdd:cd00099   12 EGESVTLSCEVS-----SSFSSTYIYWYRQKPGQGPE--FLIYLSSSKGKTkGGVPGRFSGSRDGTSSFSLTISNLQPED 84

                         90
                 ....*....|.
gi 808154260 203 YGRYRCEVIDG 213
Cdd:cd00099   85 SGTYYCAVSES 95
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 110-210 4.11e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260  110 KLVVETPEETLFTYQGASVILPCRYRYEPalvsprRVRVKWWKlseNGAPEKDVLVaiglRHRSFGDYQGrvhlrqdkeh 189
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSP------PPTITWYK---NGEPISSGST----RSRSLSGSNS---------- 57

                          90       100
                  ....*....|....*....|.
gi 808154260  190 dvSLEIQDLRLEDYGRYRCEV 210
Cdd:pfam13927  58 --TLTISNVTRSDAGTYTCVA 76
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 176-223 5.24e-03

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 36.40  E-value: 5.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 808154260 176 DYQGRVHLRQD--KEHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVEL 223
Cdd:cd05713   62 EYRGRTELLKDaiAEGSVALRIHNVRPSDEGQYTCFFRSGSFYEEATLEL 111
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
 125-211 5.35e-03

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 36.45  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154260 125 GASVILPCRYRYEPALVsprrvRVKWWKLSENGApekdvlVAIGLRHRSFG-----DYQGRVHLRQDKEHDVSLEIQDLR 199
Cdd:cd05887   14 GKNVSLKCLIEVNETIT-----QISWEKIHGKSS------QTVAVHHPQYGisiqgEYQGRVSFKNYSLNDATITLHNVG 82

                         90
                 ....*....|..
gi 808154260 200 LEDYGRYRCEVI 211
Cdd:cd05887   83 FSDSGKYICKAV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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