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Conserved domains on  [gi|808175984|ref|NP_001294915|]
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alpha-2,8-sialyltransferase 8E isoform 1 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467718  Cd Length: 273  Bit Score: 592.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 134 SEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSR 213
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 214 CGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 294 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 808175984 374 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 592.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 134 SEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSR 213
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 214 CGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 294 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 808175984 374 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 154-401 2.04e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 276.03  E-value: 2.04e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984  154 FTTQKNTPLGTKLKYEvDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIs 233
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984  234 EKYTMDVGVKTDVVTVNP-SIITERFHKL--EKWRRPFYRVLQVYE--NASVLLPAFYNTRNTDVSIRVKYVLDDFESPQ 308
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984  309 A---VYYFHPQYLVNVSRYWL-SLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPsglYITHHYYDNVKPRP--- 381
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSR---GNSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 808175984  382 -GFHAMPSEIFNFLHLHSRGI 401
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 592.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 134 SEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSR 213
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 214 CGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 294 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 808175984 374 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 134-406 7.20e-173

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 483.68  E-value: 7.20e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 134 SEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSR 213
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 214 CGREINSADFVFRCNLPPISekYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 294 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                        250       260       270
                 ....*....|....*....|....*....|...
gi 808175984 374 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23971  239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 135-404 3.25e-124

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 360.22  E-value: 3.25e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 135 EANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRC 214
Cdd:cd23991    2 EHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 215 GREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVS 294
Cdd:cd23991   82 GAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 295 IRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYY 374
Cdd:cd23991  162 FKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYY 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 808175984 375 DNVKPRPGFHAMPSEIFNFLHLHSRGILRV 404
Cdd:cd23991  242 DNQLPKPGFHSMPKEFYQLLQLHSKGILKL 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 139-405 3.50e-104

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 309.45  E-value: 3.50e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 139 FKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRsQFKKCAVVGNGGILKNSRCGREI 218
Cdd:cd23989    6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQL-PLKKCSVVGNGGILKNSGCGQQI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 219 NSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVK 298
Cdd:cd23989   85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 299 YVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVK 378
Cdd:cd23989  165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVL 244

                        250       260
                 ....*....|....*....|....*..
gi 808175984 379 PRPGFHAMPSEIFNFLHLHSRGILRVH 405
Cdd:cd23989  245 PDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 136-406 1.48e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 287.24  E-value: 1.48e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 136 ANQFKSTLSRCCNaPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCG 215
Cdd:cd23963    3 LDKFRKELERLLN-TRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 216 REINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23963   82 KEIDSHDFVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNSLkkNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 294 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRaKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23963  161 LLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHY 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 808175984 374 YDNVKPRP--GFHAMPSEiFNFLH-LHSRGILRVHT 406
Cdd:cd23963  240 YDDLSPSTknKVHNMPEE-FKLLReLHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 154-401 2.04e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 276.03  E-value: 2.04e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984  154 FTTQKNTPLGTKLKYEvDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIs 233
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984  234 EKYTMDVGVKTDVVTVNP-SIITERFHKL--EKWRRPFYRVLQVYE--NASVLLPAFYNTRNTDVSIRVKYVLDDFESPQ 308
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984  309 A---VYYFHPQYLVNVSRYWL-SLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPsglYITHHYYDNVKPRP--- 381
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSR---GNSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 808175984  382 -GFHAMPSEIFNFLHLHSRGI 401
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 163-406 9.30e-62

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 200.72  E-value: 9.30e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 163 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGV 242
Cdd:cd23969   30 GDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-EGYEKDVGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 243 KTDVVTVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDvsiRVKYVLD---DFESPQAVYYFHPQY 317
Cdd:cd23969  109 KSNLTTMNPSVIPHAYGDLvnATDKEKFVERLRQLGDSILWIPAFVSKGGEE---HVQWTNEiilKHKLNVKTAYPPLRL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 318 LVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPR--PGFHAMPSEIFNFLH 395
Cdd:cd23969  186 NHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRKYLttARPHKMPEEFRALRS 265

                        250
                 ....*....|.
gi 808175984 396 LHSRGILRVHT 406
Cdd:cd23969  266 LHQRGALRLHT 276
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 175-406 1.69e-61

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 200.31  E-value: 1.69e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 175 IYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSII 254
Cdd:cd23970   46 VFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLTTFNPSIL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 255 TERFHKL--EKWRRPFYRVLQVYENASVLLPAF-YNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVR 331
Cdd:cd23970  125 EKYYNNLltIQDRNNFFLSLKKLDGAILWIPAFfFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKTKHLS 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 332 AKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYD------NVKPRPgFHAMPSEIFNFLHLHSRGILRVH 405
Cdd:cd23970  205 PKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYDkkgtkfTTKWQE-SHQLPAEFVLLYKMHGAGVLKLT 283


                 .
gi 808175984 406 T 406
Cdd:cd23970  284 L 284
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 163-406 2.28e-56

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 186.68  E-value: 2.28e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 163 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTMDVGV 242
Cdd:cd23987   30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 243 KTDVVTVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDvsiRVKYVLD-DFESPQAVYYFHP--QY 317
Cdd:cd23987  109 KTDLVTMNPSVVQRAFEDLvnETWKEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVNDlILKHHINVRTAYPslRL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 318 LVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVK----PRPGFHAMPSEIFNF 393
Cdd:cd23987  186 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 265

                        250
                 ....*....|...
gi 808175984 394 LHLHSRGILRVHT 406
Cdd:cd23987  266 KNLHQQGALKLTV 278
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 163-406 1.54e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 174.37  E-value: 1.54e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 163 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTMDVGV 242
Cdd:cd23988   30 GDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-FAADVGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 243 KTDVVTVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFY-NTRNTDVSIRVKYVLDDFESPQAVYyfhPQY-L 318
Cdd:cd23988  109 KSDFITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFMvKGGEKHVEWVNALILKNKLKVRTAY---PSLrL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 319 VNVSR-YWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPR----PGFHAMPSEIFNF 393
Cdd:cd23988  186 IHAVRgYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRyfsnAGPHRMPLEFKTL 265

                        250
                 ....*....|...
gi 808175984 394 LHLHSRGILRVHT 406
Cdd:cd23988  266 NVLHNRGALKLTT 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 200-382 1.76e-29

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 113.23  E-value: 1.76e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 200 CAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSIiterFHKLEKWRRPFYRVLQVYENAS 279
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPT-KGFEKDVGSKTTFRVLNSKW----AGFYLRGPRCGCHPLPLEEEVV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 280 VLLPAFYNTRNTDVSIRVKYvlddfeSPQAVYYFH---PQYLVNVSRYWLSLGVRAKRI----STGLILVTAALELCEEV 352
Cdd:cd19952   76 LILSRAAAADFKRLKRRKKR------HDNAVLLLTdpaPDLLSYVRKRLEKLGLKSFFGgnapSSGLLAVLLALQLCDSV 149

                        170       180       190
                 ....*....|....*....|....*....|
gi 808175984 353 HLFGFWAFPMNPSGLYitHHYYDNVKPRPG 382
Cdd:cd19952  150 DLYGFGVDSGHAPKVP--YHYYDLVEAEEG 177
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 199-406 6.88e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 89.24  E-value: 6.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 199 KCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTmDVGVKTD--VVTVNPSIITERFHklekwrrpfyrVLQVYE 276
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEK-DVGTKTSfyTFFPESLHNSLLKH-----------VPQDKD 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 277 NASVLLP-----------AFYNTRNTDVSIRVKYVLDDFES---PQAVYYFHPQYLVNVSRYWLslgvRAKRI---STGL 339
Cdd:cd23964  152 TKYLFIPfkirdydyldaVLSGKPVPDGCDKGKRPPPLFGPklnATNVRLLHPDFIRYLFNRWL----NSSTSyrpTTGA 227

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 808175984 340 ILVTAALELCEEVHLFGF---WAFPMnpsglyithHYYDN----VKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23964  228 LMLLTALHTCDQVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 180-405 3.81e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 86.57  E-value: 3.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 180 QEIFRMFPKDMPYYR---SQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTdvvtvnpsiiTE 256
Cdd:cd23966   57 EKLFQVVPGENPYRTrdpNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT-KGFEKDVGSKT----------TH 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 257 RFhklekwrrpfyrvlqVY-ENAS--------VLLP-----------AFYNTRNTDVSIRVKYVLDdfESPQAVYYFHPQ 316
Cdd:cd23966  126 HF---------------MYpESAVdldpgvhlVLVPfkvldlqwlisALTTGEITRTYTPVKRFIK--ADKDKVLVINPA 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 317 YLVNVSRYWLSLgvRAKRISTGLILVTAALELCEEVHLFGFWAfpmNPSGLYitHHYYDNVKPRPGFHAMPSEIFNFLH- 395
Cdd:cd23966  189 FIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGNW--HHYWEKNRSAGAFRKTGVHDADFESd 261

                        250
                 ....*....|....
gi 808175984 396 ----LHSRGILRVH 405
Cdd:cd23966  262 iikkLAKEGKIRVY 275
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 184-406 5.45e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 86.73  E-value: 5.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 184 RMFPKDM-PYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNlPPISEKYTMDVGVKTDVVTVNPSIIterFHKLE 262
Cdd:cd23974   70 QMFDWWDrPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTL---MNSLR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 263 KWRRPFYRVL-QVYENASVLLP-----------AFYNT---RNTDVSIR-VKYVLDDFeSPQAVYYFHP---QYLVNvsR 323
Cdd:cd23974  146 AYAGVGFNGPpQSKETRYIFLPdhdrdyllvkaALTHTpidRGRDKSKRpSKYFGKDV-TAEKFKIYHPdfiRYLRN--R 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 324 YWLS--LGVRAKRI---STGLILVTAALELCEEVHLFGFwafpMNPSGLYITHHYYDNVKPRPGF---HAMPSEIFNFLH 395
Cdd:cd23974  223 FLWSpiLNTKQRDIyrpSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQK 298

                        250
                 ....*....|.
gi 808175984 396 LHSRGILRVHT 406
Cdd:cd23974  299 LHKAGLIKLYM 309
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 198-395 1.30e-17

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 80.80  E-value: 1.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTdvvtvnpsiiTERFhklekwrrpfyrvlqVYEN 277
Cdd:cd23967    3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPV-KGYEKDVGSKT----------TFRM---------------FYPE 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 278 ASVLLPAFYNtRNTDVSIrVKYVLDDFESPQAVYY---------------------------FHPQYLVNVSRYWLSL-- 328
Cdd:cd23967   57 SAFRDPEEYD-SDWLLVL-VPFKSMDLLWLQAVIKgkkpngkggfwkkiatsvpkppkkiriLNPYILQEAAFDLIGLpm 134

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808175984 329 --GVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSglyITHHYYDNVKprpgfhaMPSEIFNFLH 395
Cdd:cd23967  135 ngKQGKNVPTTGIIAIVMALHYCDEVDIAGFGYDPSDPN---APLHYYDSLT-------MKAIKRSWTH 193
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 151-378 4.12e-16

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 77.70  E-value: 4.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 151 AFLFTTQKNTPLGTKLKYevdtSGIYHINQEIFRMFPKdmpyyrsqFKKCAVVGNGGILKNSRCGREINSADFVFRCNLP 230
Cdd:cd23968   11 AAPFSTLRKTTSPFKDLL----SLRYPFPESSLENTKR--------YNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 231 PiSEKYTMDVGVKTDVVTVNPSIITERFHKLekWRRPFYRvlqvyeNASVLL--PAFYNTRNTDVSIRVKYvlDDFES-- 306
Cdd:cd23968   79 P-TKGFEKDVGSKTTLRLINSQILSKPEFNF--LTDPLYR------NVTLLVwdPSSYNVNLEKWYKKPDF--DFFPNyi 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 307 ------P-QAVYYFHPQYLVNVsryWLSLGVRAKRI------STGLILVTAALELCEEVHLFGFWafpmnPSgLYITH-- 371
Cdd:cd23968  148 kyrrrhPeEPFYLIDPRFLWRL---WDILQEYTPEKikpnppSSGFIGIVLMLHLCDWVDVYEYV-----PS-VRQTDrc 218


                 ....*..
gi 808175984 372 HYYDNVK 378
Cdd:cd23968  219 HYYDVEK 225
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 165-376 1.17e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 76.84  E-value: 1.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 165 KLKYEVDTSGIYHINQEIFRMFPKD---MPYYRS-QFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDV 240
Cdd:cd23980   45 RLQREKKPKNLNDTIRELFQVVPGNvdpLLEKRLvSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADV 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 241 GVKTDVVTVNPSIITERFHKLEKWRRPFyRVLQVYENASVLLPAFYNTRNTDVSIRVKYvlddfeSPQAVYYFHPQYLVN 320
Cdd:cd23980  124 GSKTTHHFVYPESFRELAQNVSMILVPF-KTLDLEWVISATTTGTISHTYVPVPRKIKV------KKEKILIYHPAFIKY 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 808175984 321 VSRYWLSLGVRAKriSTGLILVTAALELCEEVHLFGFWAfpmNPSGLYitHHYYDN 376
Cdd:cd23980  197 VFDRWLQGHGRYP--STGILSVIFSLHVCDEVDLYGFGA---DSKGNW--HHYWEN 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 199-405 1.57e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 76.79  E-value: 1.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 199 KCAVVGNGGILKNSRCGREINSADFVFRCNlPPISEKYTMDVGVKTDV--VTVNpsiiTERFHKLEKWRRPFYRVLQVYE 276
Cdd:cd23972   84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygFTVN----TMKNSLISYWNLGFTRTPQGQD 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 277 NASVLLPA----FYNTRNTDVSIRVKYVLDDFESPQAvyYF------------HPQYLvnvsRYWLSLGVRAKRI----- 335
Cdd:cd23972  159 LQYIFIPSdirdYVMLRSAILGVPVPEGLDKGDRPHK--YFgpeasakkfkllHPDFI----SYLTDRFLKSKLLnthyg 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 336 -----STGLILVTAALELCEEVHLFGF-----WAFpmnpsglyiTHHYYDNVKPRPGF---HAMPSEIFNFLHLHSRGIL 402
Cdd:cd23972  233 hlympSTGALMLLTALHTCDQVSAYGFitsnyWKF---------SDHYYERKKKPLVFyanHDMLLEAALWRRLHKAGIL 303


                 ...
gi 808175984 403 RVH 405
Cdd:cd23972  304 QLY 306
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 199-407 1.03e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 74.40  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 199 KCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSIITERFHKLEKwrRPFYRVLQVYENA 278
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVI-KGYEEDVGTRTSFYVHTAHSITSSLMILQK--RGFKNIPQDKDIK 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 279 SVLLPAF---YN-----TRNTDVSIRV-------KYVLDDFeSPQAVYYFHPQYLvnvsRYWLSLGVRAK---------- 333
Cdd:cd23973  162 YILFPEGprdYQwlealLKNKTIPSGAyygrrprSYFSGDF-TEDKYLVLHPDFL----RYVKNRFLRSKtlkgkywaiy 236

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 808175984 334 RISTGLILVTAALELCEEVHLFGFwafpMNPSGLYITHHYYDNVKPRPGF---HAMPSEIFNFLHLHSRGILRVHTG 407
Cdd:cd23973  237 RPTTGAFLLLTALHLCDTVSAYGF----ITEDYRKYPDHYYDKKKTKLVFyinHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 198-377 3.32e-13

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 68.23  E-value: 3.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISeKYTMDVGVKT-------DVVTVNPS---------IITERFHKL 261
Cdd:cd23984    3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTtfrlcypESIFSDPShydpnttvvLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 262 eKWrrpfyrVLQVYENASVLLPAFYNtrntdvsirvKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVR------AKRI 335
Cdd:cd23984   82 -RW------LLDLLMGKKVSAKGFWK----------KPALNLIYKPNQIRILNPFILRIAAYELLHFPKRfpkekkPKHP 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 808175984 336 STGLILVTAALELCEEVHLFGfwaFPMNPSGLYITHHYYDNV 377
Cdd:cd23984  145 TTGIIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGNE 183
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 198-395 9.26e-13

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 66.61  E-value: 9.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTMDVGVKTDVvtvnpsiiterfhklekwrRPFY----RVLQ 273
Cdd:cd23982    3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTI-------------------RLFYpesaQFDP 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 274 VYENAS----VLLP----AFY--------NTRNTDVSIRVKYVLDDFEsPQAVYYFHPQYLVNVSRYWLSLGVRAKRI-- 335
Cdd:cd23982   63 GIENDPdtllVLVPfkplDFYwlyeilsnEKRVRKGFWKQPPRIWDAN-PKQIRILNPYYTYVAATKLLQVPGQRKKKqk 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808175984 336 -STGLILVTAALELCEEVHLFGFwAFPMNPSGlYITHHYYDNVKPRpgfhAMPSEIFNFLH 395
Cdd:cd23982  142 pTTGLLAITLALHLCDEVHIAGF-GYPDNGNS-NQPIHYYNQITLK----SMANSGHNLNA 196
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 196-357 1.01e-12

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 67.81  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 196 QFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISeKYTMDVGVKTDVVTVNPSIITERFHKLEKwrRPFYR--VLQ 273
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA-GFQQDVGTKTTIRLINSQLVTTEKHKFLK--DSLYNegILI 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 274 VYEnasvllPAFYNT------RNTDVSIrvkyvlddFESPQAVYYFHPQ---YLVNVSRYW----LSLGVRAKRI----- 335
Cdd:cd23985  121 VWD------PAPYHSdipewyKNPDYNF--------FENYKTYRRLNPNqpfYILHPQMQWelwdIIQENSPEEIqpnpp 186

                        170       180
                 ....*....|....*....|..
gi 808175984 336 STGLILVTAALELCEEVHLFGF 357
Cdd:cd23985  187 SSGMLGIILMMTLCDQVDVYEF 208
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 193-357 3.27e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 66.40  E-value: 3.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 193 YRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDVGVKTDVVTVNPSIITERFHKLEkwRRPFYR-- 270
Cdd:cd23986   45 HLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNPNHHFI--DSSLYKdv 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 271 VLQVYENA--SVLLPAFYNtrNTDVSIRVKYVLDDFESP-QAVYYFHPQY---LVNVSRYWLSLGVRAKRISTGLILVTA 344
Cdd:cd23986  122 ILVAWDPApySANLHKWYK--KPDYNLFTPYVQYRKRNPnQPFYILHPKFiwqLWDIIQENTQEKIQPNPPSSGFIGILI 199

                        170
                 ....*....|...
gi 808175984 345 ALELCEEVHLFGF 357
Cdd:cd23986  200 MMSMCREVHVYEY 212
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 198-378 3.69e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 59.17  E-value: 3.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSIITERFHKLE----------KWRRP 267
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAIQKPEQYEkdslfvlagfKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 268 FYRVLQVYENASVLLPAFYNTrntdVSIRVKyvlddfESPQAVYYFHPQYLVNVSRYWLSLGV------RAKRISTGLIL 341
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKS----VATRVP------REPHEIRILNPYFIQEAAFSFIGLPFnnglmgRGNIPTLGSVA 151

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 808175984 342 VTAALELCEEVHLFGFwAFPMNPSglYITHHYYDNVK 378
Cdd:cd23981  152 ITMALHNCDEVAVAGF-GYDMNTP--NAPLHYYETIK 185
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 166-376 1.00e-09

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 59.11  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 166 LKYEVDTSGIYHINQEIFRMFPKDMPYY---RSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDVGV 242
Cdd:cd23979   46 LQPQFKPHNTKEVLSKLFQIIPGENPYRswdPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGS 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 243 KTDVVTVNPSIITERFHKLEKWRRPFyRVLQVYENASVLLPAFYNTRNTDVS--IRVKYVLDDFESPQAVYYFHPQYLVN 320
Cdd:cd23979  125 RTTHHFMYPESAKNLPANVSFVLVPF-KTLDLLWITSALSTGQIRFTYAPVKqfLRVDKDKVQIYNPAFFKYIHDRWTEH 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 808175984 321 VSRYwlslgvrakrISTGLILVTAALELCEEVHLFGFWAfpmNPSGLYitHHYYDN 376
Cdd:cd23979  204 HGRY----------PSTGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 198-375 2.34e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 57.25  E-value: 2.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDV-VTVNPSI--ITERFHKLEKWRRPFYRVLqv 274
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPT-RGYEKDVGRRTTIrVVSHSSLprLLRNAILLLAGTRAPTVVV-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 275 yenasVLLPafYNTRNTDVSIRVKYVLDDFES-PQAVYYFHPQYLVN-----------VSRY----WLslgvrakriSTG 338
Cdd:cd23965   79 -----FWGP--ETKMNKDGAGKYNLLRSLSKKyPDVEFYSLTPEKMDyadelfeketgKSRIksgtWL---------STG 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 808175984 339 LILVTAALELCEEVHLFG-----FWAFPMNPSGLYithHYYD 375
Cdd:cd23965  143 WFTMLLALDVCDEIKVYGmvpenYCREHPNSKVPY---HYYE 181
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 198-377 8.56e-08

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 52.43  E-value: 8.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNP-------------------------- 251
Cdd:cd23983    3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPegapkseqeydptslfvavlfksvdf 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 252 ----SIITERfhKLEKWRRPFYrvLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQavyyfhpqylvnvSRYWls 327
Cdd:cd23983   82 awlkAMVKKE--PLSFWSRLFF--WKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQ-------------SRLW-- 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 808175984 328 lgVRAKRIST-GLILVTAALELCEEVHLFGFwAFPMNPSGLYIthHYYDNV 377
Cdd:cd23983  143 --GWDKNVPTlGVTAVVLATHLCDEVSLAGF-GYDLSQPHAPL--HYYDSV 188
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 198-375 3.89e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 44.47  E-value: 3.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDVGVKTDVVTVN----PSIITERFHKLEKWRRPFYRVLQ 273
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRVVShtsvPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 274 VYENASVLLPAfyNTRNTDVSIRVKYvlddfesPQA-VYYFHPQYLVNVSRYWLSLGVRAKR-----ISTGLILVTAALE 347
Cdd:cd23977   81 PERNMDRDGGG--KTYRALLTLAKMY-------PHLqVYTLTEEKMAYCDGVFQNETGKNRMksgsfLSTGWFTMILALE 151

                        170       180       190
                 ....*....|....*....|....*....|
gi 808175984 348 LCEEVHLFGFW--AFPMNPSGLYITHHYYD 375
Cdd:cd23977  152 LCEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 200-375 1.83e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 42.61  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 200 CAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDVGVKTDVVTVNPSIITERFHKlekwrrPFYRVLQVYENAS 279
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTIRVVSHTSVPLLLKN------PDYFFKETNETIY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808175984 280 VLLPAFYNTRNTDVSIRVKYVLDDFES-PQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTA------ALELCEEV 352
Cdd:cd23975   77 VIWGPFRNMRKDGKGIVYNMLKKAVESyPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGwftlilAMDACYGI 156

                        170       180
                 ....*....|....*....|....*
gi 808175984 353 HLFGFWAFPMNPSGLY--ITHHYYD 375
Cdd:cd23975  157 HVYGMINDTYCKTEGYrkVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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