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Conserved domains on  [gi|816197584|ref|NP_001295277|]
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zinc finger protein 433 isoform 3 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.49e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 93.30  E-value: 1.49e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 816197584    3 SVAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-600 3.23e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 194 PYKCKFCGKALMFLSLYLIHKRTHTGEKPYQC--KQCGKAFSHSSSLRIHERTHTGEKPYKCNECGKAFHSSTCLHAHKR 271
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 272 THTGE-KPYECKQCGKAFSSSHSFQIHERTHTGEKPYECKEC-GKAFKCPSSVRRHERTHSRkkpyeckHCGKVLSYLTS 349
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPAN-------SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 350 FQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEKTHTGEKPYKCNQCGKAFNSSSSFRYHERTHTGEKPYECKQCGKAFR 429
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 430 SASLLQTHGRTHTGE-------KPYACKECGKPFSNFSFFQIHERMHREE----KPYEC--KGYGKTFSLPSLFHRHERT 496
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 497 HTGGKTYECKQCGRSF-------NCSSSFRYHGRTHTGEKPYEC--KQCGKAFRSASQLQIHGRTHTGEKPYECK--QCG 565
Cdd:COG5048  346 HTSISPAKEKLLNSSSkfspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 816197584 566 KAFGSASHLQMHGRTHTGEKPYECKQCGKSFGCAS 600
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
629-654 1.78e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197584  629 NLRRHGRTHTGEKPYKCNQCGKVFRC 654
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
601-624 9.85e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.85e-03
                          10        20
                  ....*....|....*....|....
gi 816197584  601 RLQMHGRTHTGEKPYKCKQCGKAF 624
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.49e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 93.30  E-value: 1.49e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 816197584    3 SVAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 2.86e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 2.86e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 816197584     4 VAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASIGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.55e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 1.55e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 816197584   4 VAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASI 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-600 3.23e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 194 PYKCKFCGKALMFLSLYLIHKRTHTGEKPYQC--KQCGKAFSHSSSLRIHERTHTGEKPYKCNECGKAFHSSTCLHAHKR 271
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 272 THTGE-KPYECKQCGKAFSSSHSFQIHERTHTGEKPYECKEC-GKAFKCPSSVRRHERTHSRkkpyeckHCGKVLSYLTS 349
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPAN-------SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 350 FQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEKTHTGEKPYKCNQCGKAFNSSSSFRYHERTHTGEKPYECKQCGKAFR 429
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 430 SASLLQTHGRTHTGE-------KPYACKECGKPFSNFSFFQIHERMHREE----KPYEC--KGYGKTFSLPSLFHRHERT 496
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 497 HTGGKTYECKQCGRSF-------NCSSSFRYHGRTHTGEKPYEC--KQCGKAFRSASQLQIHGRTHTGEKPYECK--QCG 565
Cdd:COG5048  346 HTSISPAKEKLLNSSSkfspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 816197584 566 KAFGSASHLQMHGRTHTGEKPYECKQCGKSFGCAS 600
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-402 5.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 816197584  377 SLQTHEKTHTGEKPYKCNQCGKAFNS 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
629-654 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197584  629 NLRRHGRTHTGEKPYKCNQCGKVFRC 654
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
601-624 9.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.85e-03
                          10        20
                  ....*....|....*....|....
gi 816197584  601 RLQMHGRTHTGEKPYKCKQCGKAF 624
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.49e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 93.30  E-value: 1.49e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 816197584    3 SVAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 2.86e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 2.86e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 816197584     4 VAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASIGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.55e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 1.55e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 816197584   4 VAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASI 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-600 3.23e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 194 PYKCKFCGKALMFLSLYLIHKRTHTGEKPYQC--KQCGKAFSHSSSLRIHERTHTGEKPYKCNECGKAFHSSTCLHAHKR 271
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 272 THTGE-KPYECKQCGKAFSSSHSFQIHERTHTGEKPYECKEC-GKAFKCPSSVRRHERTHSRkkpyeckHCGKVLSYLTS 349
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPAN-------SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 350 FQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEKTHTGEKPYKCNQCGKAFNSSSSFRYHERTHTGEKPYECKQCGKAFR 429
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 430 SASLLQTHGRTHTGE-------KPYACKECGKPFSNFSFFQIHERMHREE----KPYEC--KGYGKTFSLPSLFHRHERT 496
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 497 HTGGKTYECKQCGRSF-------NCSSSFRYHGRTHTGEKPYEC--KQCGKAFRSASQLQIHGRTHTGEKPYECK--QCG 565
Cdd:COG5048  346 HTSISPAKEKLLNSSSkfspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 816197584 566 KAFGSASHLQMHGRTHTGEKPYECKQCGKSFGCAS 600
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-656 1.43e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 1.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 249 KPYKCNECGKAFHSSTCLHAHKRTHTGEKPYEC--KQCGKAFSSSHSFQIHERTHTGEKPYEC--KECGKAFKCPSSVRR 324
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 325 HERTHSRKKPYECKHcGKVLSYLTSFQNHLGMHTGEISHKCKICGKAFY----SPSSLQTHEKTHTGEKPYKCNqcgkaf 400
Cdd:COG5048  112 SSSSNSNDNNLLSSH-SLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNL------ 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 401 nsssSFRYHERTHTGEKPYECKQCGKAFRSASLLQTHGRTHTGEKPYACKECGKPF-------SNFSFFQIHERMHREEK 473
Cdd:COG5048  185 ----SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 474 PYECKGYgKTFSLPSLFHRHERTHTGGKT-YECKQCGRSFNCSSSFRYHGRT--HTGE--KPYEC--KQCGKAFRSASQL 546
Cdd:COG5048  261 PRSSLPT-ASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 547 QIHGRTHTGEKPYECK--QCGKAFGSAS------HLQMHGRTHTgEKPYEC--KQCGKSFGCASRLQMHGRTHTGEKP-- 614
Cdd:COG5048  340 KRHILLHTSISPAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPyn 418

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 816197584 615 YKCKQCGKAFGCPSNLRRHGRTHTGEKPYKCNQCGKVFRCSS 656
Cdd:COG5048  419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-572 9.22e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 148 FNCLSSVQTHERAHSGRKLYVC--EECGKTFISHSNLQRHRIMHRGDGPYKC-KFCGKALMFLSLYLIHKRTHTGEKPYQ 224
Cdd:COG5048   43 FSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 225 CKQCGKAFSHSSSLRIHERTHTGEKPYKCNEC-GKAFHSSTCLHAHKRTHTGEKPyeckqcgKAFSSSHSFQIHERTHTG 303
Cdd:COG5048  123 LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 304 EK-PYECKECGKAFKCPSSVRRHERTHSRKK-PYECKHCGKVLSYLTSFQNHLGMHTgeISHKCKICGKAFYSPSSLQTH 381
Cdd:COG5048  196 IPsSSENSPLSSSYSIPSSSSDQNLENSSSSlPLTTNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 382 EKTHTGE-------KPYKCNQCGKAFNSSSSFRYHERT--HTGE--KPYEC--KQCGKAFRSASLLQTHGRTHTGEKPYA 448
Cdd:COG5048  274 SPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 449 CKECGKPFSNfsffqihermhreekpyeckgYGKTFSLPSLFHRHERTHTGGKTYEC--KQCGRSFNCSSSFRYHGRTHT 526
Cdd:COG5048  354 EKLLNSSSKF---------------------SPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 816197584 527 GEKPYECK--QCGKAFRSASQLQIHGRTHTGEKPYECKQCGKAFGSAS 572
Cdd:COG5048  413 SFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-494 4.01e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 4.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 211 LIHKRTHTGEKPYQCKQCGKAFSHSSSLRIHERTHTGEKPYKCNECGKAFH--------SSTCLHAHKrTHTGEKPYECK 282
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqspSSLSSSDSS-SSASESPRSSL 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 283 QcGKAFSSSHSFQIHERTHTG-EKPYECKECGKAFKCPSSVRRHERthsrkkpyeckhcgkvlSYLTSFQNHLGMHTGEI 361
Cdd:COG5048  266 P-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYS 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 362 shkckICGKAFYSPSSLQTHEKTHTGEKPYKC--NQCGKAFNSSS-----SFRYHERTHTGEKPYEC--KQCGKAFRSAS 432
Cdd:COG5048  328 -----LCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDS 402

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 816197584 433 LLQTHGRTHTGEKPYACK--ECGKPFSNFSFFQIHERMHREEKPYECKGYGKTFSLPSLFHRHE 494
Cdd:COG5048  403 NLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-402 5.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 816197584  377 SLQTHEKTHTGEKPYKCNQCGKAFNS 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-260 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 816197584  237 SLRIHERTHTGEKPYKCNECGKAF 260
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 220-330 1.38e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197584 220 EKPYQCKQCGKAFSHSSSLRIHERTH----TGEKPYKCN--ECGKAFHSSTCL-----HAHKRTHTGEKPYEckqcgkaf 288
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIDTPSRmlkvKDGKPYKCPveGCNKKYKNQNGLkyhmlHGHQNQKLHENPSP-------- 386

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 816197584 289 SSSHSFQIHErthtgeKPYECKECGKAFKCPSSVRRHeRTHS 330
Cdd:COG5189  387 EKMNIFSAKD------KPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-318 1.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197584  293 SFQIHERTHTGEKPYECKECGKAFKC 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-430 1.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197584  405 SFRYHERTHTGEKPYECKQCGKAFRS 430
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
629-654 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197584  629 NLRRHGRTHTGEKPYKCNQCGKVFRC 654
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
213-234 2.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.69e-03
                          10        20
                  ....*....|....*....|..
gi 816197584  213 HKRTHTGEKPYQCKQCGKAFSH 234
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-290 3.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.12e-03
                          10        20
                  ....*....|....*....|..
gi 816197584  269 HKRTHTGEKPYECKQCGKAFSS 290
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
573-596 6.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.27e-03
                          10        20
                  ....*....|....*....|....
gi 816197584  573 HLQMHGRTHTGEKPYECKQCGKSF 596
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
601-624 9.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.85e-03
                          10        20
                  ....*....|....*....|....
gi 816197584  601 RLQMHGRTHTGEKPYKCKQCGKAF 624
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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