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Conserved domains on  [gi|822606534|ref|NP_001296162|]
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leucine-rich repeat-containing protein 31 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-356 9.03e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 87.03  E-value: 9.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  86 TQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELSLSWNsQVGGKLP---RVLHTFQQGSKIRTLELVDCALt 162
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLN-ETGRIPRglqSLLQGLTKGCGLQELDLSDNAL- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 163 SQDGVFVGHLLPKLQSLQVFDLSNNRNIGSCLEVIAQGLRS-ASGLKELKLRSCGLSQKSIRLLDGVFASLDVLRILDLS 241
Cdd:cd00116   94 GPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDlPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 242 CNKELGGGFEDVPAQLASLKHLEVLDLHQCSLTAGDVTSLTQIIPLLSNLEELDLSSNR-DVGGSSENLLCRLRFLPALK 320
Cdd:cd00116  174 NNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNlTDAGAAALASALLSPNISLL 253

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 822606534 321 SLLINSCALQSEAFAALADASVYLPALEILNLSWNK 356
Cdd:cd00116  254 TLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNK 289
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-356 9.03e-19

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 87.03  E-value: 9.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  86 TQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELSLSWNsQVGGKLP---RVLHTFQQGSKIRTLELVDCALt 162
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLN-ETGRIPRglqSLLQGLTKGCGLQELDLSDNAL- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 163 SQDGVFVGHLLPKLQSLQVFDLSNNRNIGSCLEVIAQGLRS-ASGLKELKLRSCGLSQKSIRLLDGVFASLDVLRILDLS 241
Cdd:cd00116   94 GPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDlPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 242 CNKELGGGFEDVPAQLASLKHLEVLDLHQCSLTAGDVTSLTQIIPLLSNLEELDLSSNR-DVGGSSENLLCRLRFLPALK 320
Cdd:cd00116  174 NNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNlTDAGAAALASALLSPNISLL 253

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 822606534 321 SLLINSCALQSEAFAALADASVYLPALEILNLSWNK 356
Cdd:cd00116  254 TLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNK 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-463 5.19e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 5.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  48 TGLDLNSYGLTAVDVKETDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELS 127
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 128 LSWNSqvggklprvlhTFQQGSKIRTLELVDCALTSqdgvfVGHLLPKLQSLQVFDLSNNRnigscLEVIAQGLRSASGL 207
Cdd:COG4886  103 LSGNE-----------ELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQ-----LTDLPEPLGNLTNL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 208 KELKLRSCGLSQksirlLDGVFASLDVLRILDLSCNKelgggFEDVPAQLASLKHLEVLDLHQCSLTagdvtSLTQIIPL 287
Cdd:COG4886  162 KSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQ-----ITDLPEPLGNLTNLEELDLSGNQLT-----DLPEPLAN 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 288 LSNLEELDLSSNRDVGgssenlLCRLRFLPALKSLLINSCALQSeafaalADASVYLPALEILNLSWNKCVGGNLELLQQ 367
Cdd:COG4886  227 LTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 368 TLHLSRLLRVLRLSSCSLVTEDVVLLASVIQSGHLATLQKLDLSYNDGICDAGWAILCQNLCFLKELTELDISLRPSSSQ 447
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        410
                 ....*....|....*.
gi 822606534 448 DCGQWFSHLLCAVTQL 463
Cdd:COG4886  375 LEATLLTLALLLLTLL 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-309 1.07e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  93 NKLKVLRLSSCRLTTEDVQTLGGALEMTpeleELSLSWNSqVGGKLPRVLHTFQQGSKIRTlelvdcaltsQDGVFVGHL 172
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLF----KLILFSNS-LEGEIPKSLGACRSLRRVRL----------QDNSFSGEL 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 173 ---LPKLQSLQVFDLSNNR---NIGS------CLEVIAQGLRSASG-----LKELKLRSCGLSQKSIR-LLDGVFASLDV 234
Cdd:PLN00113 421 pseFTKLPLVYFLDISNNNlqgRINSrkwdmpSLQMLSLARNKFFGglpdsFGSKRLENLDLSRNQFSgAVPRKLGSLSE 500

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 822606534 235 LRILDLSCNKELGggfeDVPAQLASLKHLEVLDLHQCSLTaGDVTSLTQIIPLLSnleELDLSSNRDVGGSSENL 309
Cdd:PLN00113 501 LMQLKLSENKLSG----EIPDELSSCKKLVSLDLSHNQLS-GQIPASFSEMPVLS---QLDLSQNQLSGEIPKNL 567
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-356 9.03e-19

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 87.03  E-value: 9.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  86 TQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELSLSWNsQVGGKLP---RVLHTFQQGSKIRTLELVDCALt 162
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLN-ETGRIPRglqSLLQGLTKGCGLQELDLSDNAL- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 163 SQDGVFVGHLLPKLQSLQVFDLSNNRNIGSCLEVIAQGLRS-ASGLKELKLRSCGLSQKSIRLLDGVFASLDVLRILDLS 241
Cdd:cd00116   94 GPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDlPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 242 CNKELGGGFEDVPAQLASLKHLEVLDLHQCSLTAGDVTSLTQIIPLLSNLEELDLSSNR-DVGGSSENLLCRLRFLPALK 320
Cdd:cd00116  174 NNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNlTDAGAAALASALLSPNISLL 253

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 822606534 321 SLLINSCALQSEAFAALADASVYLPALEILNLSWNK 356
Cdd:cd00116  254 TLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNK 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-463 5.19e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 5.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  48 TGLDLNSYGLTAVDVKETDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELS 127
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 128 LSWNSqvggklprvlhTFQQGSKIRTLELVDCALTSqdgvfVGHLLPKLQSLQVFDLSNNRnigscLEVIAQGLRSASGL 207
Cdd:COG4886  103 LSGNE-----------ELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQ-----LTDLPEPLGNLTNL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 208 KELKLRSCGLSQksirlLDGVFASLDVLRILDLSCNKelgggFEDVPAQLASLKHLEVLDLHQCSLTagdvtSLTQIIPL 287
Cdd:COG4886  162 KSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQ-----ITDLPEPLGNLTNLEELDLSGNQLT-----DLPEPLAN 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 288 LSNLEELDLSSNRDVGgssenlLCRLRFLPALKSLLINSCALQSeafaalADASVYLPALEILNLSWNKCVGGNLELLQQ 367
Cdd:COG4886  227 LTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 368 TLHLSRLLRVLRLSSCSLVTEDVVLLASVIQSGHLATLQKLDLSYNDGICDAGWAILCQNLCFLKELTELDISLRPSSSQ 447
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        410
                 ....*....|....*.
gi 822606534 448 DCGQWFSHLLCAVTQL 463
Cdd:COG4886  375 LEATLLTLALLLLTLL 390
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 136-463 5.85e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 75.85  E-value: 5.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 136 GKLPRVLHTFQQGSKIRTLELVD---CALTSQDGVFVGHLLPKLQSLQVFDLSNN--RNIGSCLEVIAQGLRSASGLKEL 210
Cdd:cd00116    7 GELLKTERATELLPKLLCLQVLRlegNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGLTKGCGLQEL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 211 KLRSCGLSQKSIRLLDGvFASLDVLRILDLSCNKELGGGFEDVPAQLASLKH-LEVLDLHQCSLTAGDVTSLTQIIPLLS 289
Cdd:cd00116   87 DLSDNALGPDGCGVLES-LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 290 NLEELDLSSNrDVGGSSENLLCR-LRFLPALKSLLINSCALQSEAFAALADASVYLPALEILNLswnkcvggnlellqqt 368
Cdd:cd00116  166 DLKELNLANN-GIGDAGIRALAEgLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL---------------- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 369 lhlsrllrvlrlSSCSLVTEDVVLLASVIQSGhLATLQKLDLSYNDgICDAGWAILCQNLCFLKELTELDISLRPSSSQD 448
Cdd:cd00116  229 ------------GDNNLTDAGAAALASALLSP-NISLLTLSLSCND-ITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG 294

                        330
                 ....*....|....*
gi 822606534 449 CGQWFSHLLCAVTQL 463
Cdd:cd00116  295 AQLLAESLLEPGNEL 309
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-273 1.25e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 71.62  E-value: 1.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  67 LEELDVSWNDFARGALHMLTQQM-HPVNKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELSLSWNSQVGGKLPRVLHTF 145
Cdd:cd00116  110 LQELKLNNNGLGDRGLRLLAKGLkDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 146 QQGSKIRTLELVDCALTSQDGVFVGHLLPKLQSLQVFDLSNNrNIGS-CLEVIAQGLRS-ASGLKELKLRSCGLSQKSIR 223
Cdd:cd00116  190 KANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDN-NLTDaGAAALASALLSpNISLLTLSLSCNDITDDGAK 268

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 822606534 224 LLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKH-LEVLDLHQCSL 273
Cdd:cd00116  269 DLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 63-356 6.00e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.80  E-value: 6.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  63 KETDLEELDVSWNDFArgALHMLTQQMHPVNKLKVLRLS--SCRLTTEDV--QTLGGALEMTPELEELSLSWNSQVGGK- 137
Cdd:COG5238   65 FEGQGDPGLNPVALEK--AAEAFPTQLLVVDWEGAEEVSpvALAETATAVatPPPDLRRIMAKTLEDSLILYLALPRRIn 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 138 LPRVLHTFQQGSKIrTLELVDCALTSQDGVFVGHLLpKLQSLQVFDLSNNRNIGSCLEVIAQGLRSASGLKELKLRSCGL 217
Cdd:COG5238  143 LIQVLKDPLGGNAV-HLLGLAARLGLLAAISMAKAL-QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 218 SQKSIRLLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKHLEVLDLHQCSLTAGDVTSLTQIIPLLSNLEELDLS 297
Cdd:COG5238  221 GDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS 300

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 822606534 298 SNRDVGGSSENLLCRLRFLPALKSLLINSCALQSEAFAALADASVYLPALEILNLSWNK 356
Cdd:COG5238  301 VNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQ 359
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 93-299 2.85e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 2.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  93 NKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELSLsWNSQVGGK-LPRVLHTFQQGSKIRTLELVDCALTSQDGVFVGH 171
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWL-KRNPIGDEgAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 172 LLPKLQSLQVFDLSNNRNIGSCLEVIAQGLRSASGLKELKLRSCGLSQKSIRLLDGVFASLDVLRILDLSCNKELGGGFE 251
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAI 338

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 822606534 252 DVPAQLASLKHLEVLDLHQCSLTAGDVTSLTQIIPLLSNLEELDLSSN 299
Cdd:COG5238  339 ALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKN 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 176-299 2.91e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 2.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 176 LQSLQVFDLSNNRnIgSCLEviaqGLRSASGLKELKLrscgLSQksiRLLDG---------VFASLDVLRILDLSCNKEl 246
Cdd:cd21340   67 LVNLKKLYLGGNR-I-SVVE----GLENLTNLEELHI----ENQ---RLPPGekltfdprsLAALSNSLRVLNISGNNI- 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 822606534 247 gggfeDVPAQLASLKHLEVLDLHQCSLTagDVTSLTQIIPLLSNLEELDLSSN 299
Cdd:cd21340  133 -----DSLEPLAPLRNLEQLDASNNQIS--DLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-309 1.07e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  93 NKLKVLRLSSCRLTTEDVQTLGGALEMTpeleELSLSWNSqVGGKLPRVLHTFQQGSKIRTlelvdcaltsQDGVFVGHL 172
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLF----KLILFSNS-LEGEIPKSLGACRSLRRVRL----------QDNSFSGEL 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 173 ---LPKLQSLQVFDLSNNR---NIGS------CLEVIAQGLRSASG-----LKELKLRSCGLSQKSIR-LLDGVFASLDV 234
Cdd:PLN00113 421 pseFTKLPLVYFLDISNNNlqgRINSrkwdmpSLQMLSLARNKFFGglpdsFGSKRLENLDLSRNQFSgAVPRKLGSLSE 500

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 822606534 235 LRILDLSCNKELGggfeDVPAQLASLKHLEVLDLHQCSLTaGDVTSLTQIIPLLSnleELDLSSNRDVGGSSENL 309
Cdd:PLN00113 501 LMQLKLSENKLSG----EIPDELSSCKKLVSLDLSHNQLS-GQIPASFSEMPVLS---QLDLSQNQLSGEIPKNL 567
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 65-188 1.78e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  65 TDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELSLSWNSqVGGKLPRVLHT 144
Cdd:cd00116  165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNN-LTDAGAAALAS 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 822606534 145 --FQQGSKIRTLELVDCALTSQDGVFVGHLLPKLQSLQVFDLSNNR 188
Cdd:cd00116  244 alLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNK 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-325 1.02e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  65 TDLEELDVSWNDFARgalhmLTQQMHPVNKLKVLRLSSCRLTTedvqtLGGALEMTPELEELSLSwNSQVGgKLPRVLHT 144
Cdd:COG4886  159 TNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLS-GNQLT-DLPEPLAN 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 145 FqqgSKIRTLELVDCALTSQDGvfvghlLPKLQSLQVFDLSNNR--NIGSCLEViaqglrsaSGLKELKLRSCGLSQKSI 222
Cdd:COG4886  227 L---TNLETLDLSNNQLTDLPE------LGNLTNLEELDLSNNQltDLPPLANL--------TNLKTLDLSNNQLTDLKL 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 223 RLLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKHLEVLDLHQCSLTAGDVTSLTQIIPLLSNLEELDLSSNRDV 302
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369

                        250       260
                 ....*....|....*....|...
gi 822606534 303 GGSSENLLCRLRFLPALKSLLIN 325
Cdd:COG4886  370 GLLGLLEATLLTLALLLLTLLLL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-360 2.16e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534  92 VNKLKVLRLSSCRLTTEDVQTLGgalEMTpELEELSLSWNSqVGGKLPRVLhtfQQGSKIRTLELVDCALTSQDGVFVGH 171
Cdd:PLN00113 187 LTSLEFLTLASNQLVGQIPRELG---QMK-SLKWIYLGYNN-LSGEIPYEI---GGLTSLNHLDLVYNNLTGPIPSSLGN 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 172 L----------------LPK----LQSLQVFDLSNNRNIGSCLEVIAQglrsASGLKELKLRSCGLSQKsirlLDGVFAS 231
Cdd:PLN00113 259 LknlqylflyqnklsgpIPPsifsLQKLISLDLSDNSLSGEIPELVIQ----LQNLEILHLFSNNFTGK----IPVALTS 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822606534 232 LDVLRILDLSCNKELGGgfedVPAQLASLKHLEVLDLHQCSLT---------AGDVTSLT--------QIIPLLS---NL 291
Cdd:PLN00113 331 LPRLQVLQLWSNKFSGE----IPKNLGKHNNLTVLDLSTNNLTgeipeglcsSGNLFKLIlfsnslegEIPKSLGacrSL 406

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 822606534 292 EELDLSSNrdvgGSSENLLCRLRFLPALKSLLINSCALQSEafaaLADASVYLPALEILNLSWNKCVGG 360
Cdd:PLN00113 407 RRVRLQDN----SFSGELPSEFTKLPLVYFLDISNNNLQGR----INSRKWDMPSLQMLSLARNKFFGG 467
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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