Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
1-525
0e+00
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.
The actual alignment was detected with superfamily member pfam19627:
Pssm-ID: 466132 [Multi-domain] Cd Length: 744 Bit Score: 977.02 E-value: 0e+00
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
1-525
0e+00
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.
Pssm-ID: 466132 [Multi-domain] Cd Length: 744 Bit Score: 977.02 E-value: 0e+00
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
539-584
2.99e-10
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 56.48 E-value: 2.99e-10
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
1-525
0e+00
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.
Pssm-ID: 466132 [Multi-domain] Cd Length: 744 Bit Score: 977.02 E-value: 0e+00
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
539-584
2.99e-10
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 56.48 E-value: 2.99e-10
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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specific hits meet or exceed a domain-specific e-value threshold
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the domain superfamily to which the specific and non-specific hits belong
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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