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Conserved domains on  [gi|891713352|ref|NP_001297602|]
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DISP complex protein LRCH3 isoform 3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 564-672 2.12e-73

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409121  Cd Length: 109  Bit Score: 232.19  E-value: 2.12e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 564 KLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQ 643
Cdd:cd21272    1 ELIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQ 80

                         90       100
                 ....*....|....*....|....*....
gi 891713352 644 EQLCLPLHILEEKGLGQVAVTVQALLELA 672
Cdd:cd21272   81 EQLCLPLHILEEKGLSQVAVTVQALLELA 109
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 1.37e-40

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 153.94  E-value: 1.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  80 DLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIAS 158
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 159 NNKLVSLPEEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEeLAEVP-LIRLDFSCNKITVIPVCY 237
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTnLEELDLSNNQLTDLPPLA 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 891713352 238 rNLRHLQVITLDNNPLQSPPAQICIKGKIHIFKYLNIQACKIAPDLPDY 286
Cdd:COG4886  270 -NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
 
Name Accession Description Interval E-value
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 564-672 2.12e-73

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 232.19  E-value: 2.12e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 564 KLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQ 643
Cdd:cd21272    1 ELIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQ 80

                         90       100
                 ....*....|....*....|....*....
gi 891713352 644 EQLCLPLHILEEKGLGQVAVTVQALLELA 672
Cdd:cd21272   81 EQLCLPLHILEEKGLSQVAVTVQALLELA 109
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 1.37e-40

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 153.94  E-value: 1.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  80 DLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIAS 158
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 159 NNKLVSLPEEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEeLAEVP-LIRLDFSCNKITVIPVCY 237
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTnLEELDLSNNQLTDLPPLA 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 891713352 238 rNLRHLQVITLDNNPLQSPPAQICIKGKIHIFKYLNIQACKIAPDLPDY 286
Cdd:COG4886  270 -NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-234 1.82e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  81 LTDTTR-ADLSRNRLSEIPMeacHFVS-LESLNLYQNCIRYIPEavlNL-QALTFLNISRNQLSTLPVHL---------- 147
Cdd:PRK15370 239 LPDTIQeMELSINRITELPE---RLPSaLQSLDLFHNKISCLPE---NLpEELRYLSVYDNSIRTLPAHLpsgithlnvq 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 148 --------CNLP--LKVLIASNNKLVSLPEEIGhlRHLTELDVSCNEIQTVPSQIGnlEALRDFNVRRNHLLRLPEELAe 217
Cdd:PRK15370 313 snsltalpETLPpgLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP- 387

                        170
                 ....*....|....*..
gi 891713352 218 VPLIRLDFSCNKITVIP 234
Cdd:PRK15370 388 AALQIMQASRNNLVRLP 404
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 567-641 1.08e-11

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 61.56  E-value: 1.08e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 891713352   567 DQLRKHIEYRLKVSLPC---DLGAALTDGVVLCHLANHVRPRSVPSIHVPspavPKLTMAKCRRNVENFLDACRKIGV 641
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPpvtNFSSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLGG 74
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-212 2.42e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  89 LSRNRLSEIPMEAcHFVSLESLNLYQNCIRYIpEAVLNLQALTFLNISRNQLStLPVHLCNLP---------LKVLIASN 159
Cdd:cd21340   53 LQNNQIEKIENLE-NLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP-PGEKLTFDPrslaalsnsLRVLNISG 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 891713352 160 NKLVSLpEEIGHLRHLTELDVSCNEIQTVPSQ---IGNLEALRDFNVRRNHLLRLP 212
Cdd:cd21340  130 NNIDSL-EPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRELDLTGNPVCKKP 184
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 567-643 4.61e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 48.82  E-value: 4.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  567 DQLRKHIEYRLKVSLPC----DLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVpkltmaKCRRNVENFLD-ACRKIGV 641
Cdd:pfam00307   5 KELLRWINSHLAEYGPGvrvtNFTTDLRDGLALCALLNKLAPGLVDKKKLNKSEF------DKLENINLALDvAEKKLGV 78


                  ..
gi 891713352  642 PQ 643
Cdd:pfam00307  79 PK 80
LRR_8 pfam13855
Leucine rich repeat;
152-208 2.18e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 891713352  152 LKVLIASNNKLVSLPEEI-GHLRHLTELDVSCNEIQTV-PSQIGNLEALRDFNVRRNHL 208
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
SCP1 COG5199
Calponin [Cytoskeleton];
564-668 1.19e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 43.37  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 564 KLIDQLRKHIEYRL--KVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPkltmakcRRNVENFLDACRKIGV 641
Cdd:COG5199   13 KQQKEVTLWIETVLgeKFEPPGDLLSLLKDGVRLCRILNEASPLDIKYKESKMPFVQ-------MENISSFINGLKKLRV 85

                         90       100
                 ....*....|....*....|....*..
gi 891713352 642 PQEQLCLPLHILEEKGLGQVAVTVQAL 668
Cdd:COG5199   86 PEYELFQTNDLFEAKDLRQVVICLYSL 112
 
Name Accession Description Interval E-value
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 564-672 2.12e-73

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 232.19  E-value: 2.12e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 564 KLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQ 643
Cdd:cd21272    1 ELIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQ 80

                         90       100
                 ....*....|....*....|....*....
gi 891713352 644 EQLCLPLHILEEKGLGQVAVTVQALLELA 672
Cdd:cd21272   81 EQLCLPLHILEEKGLSQVAVTVQALLELA 109
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 564-670 1.47e-63

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 206.00  E-value: 1.47e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 564 KLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQ 643
Cdd:cd21205    1 EQIEQLRKSIESRLKVTLPDDLGEALMDGVVLCHLANHVRPRSVPSIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 80

                         90       100
                 ....*....|....*....|....*..
gi 891713352 644 EQLCLPLHILEEKGLGQVAVTVQALLE 670
Cdd:cd21205   81 ERLCSPGDILEEKGLVRVAVTVQALLQ 107
CH_LRCH2 cd21271
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 561-670 2.28e-60

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409120  Cd Length: 111  Bit Score: 197.84  E-value: 2.28e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 561 EELKLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIG 640
Cdd:cd21271    2 EELELIEQLRENIESRLKVILPEDLGAALMDGVVLCHLANHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKLG 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 891713352 641 VPQEQLCLPLHILEEKGLGQVAVTVQALLE 670
Cdd:cd21271   82 VPEDKLCLPHHILEEKGLVKVSVTVQALLD 111
CH_LRCH1 cd21270
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 561-671 4.07e-52

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409119  Cd Length: 112  Bit Score: 175.81  E-value: 4.07e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 561 EELKLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIG 640
Cdd:cd21270    1 EERELTEQLRENIETRLKVSLPEDLGAALMDGVVLCHLVNHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKIG 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 891713352 641 VPQEQLCLPLHILEEKGLGqVAVTVQALLEL 671
Cdd:cd21270   81 VPEADLCSPYDILQLNLRG-IRKTVETLLAL 110
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 1.37e-40

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 153.94  E-value: 1.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  80 DLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIAS 158
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 159 NNKLVSLPEEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEeLAEVP-LIRLDFSCNKITVIPVCY 237
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTnLEELDLSNNQLTDLPPLA 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 891713352 238 rNLRHLQVITLDNNPLQSPPAQICIKGKIHIFKYLNIQACKIAPDLPDY 286
Cdd:COG4886  270 -NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 561-669 4.59e-39

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 139.65  E-value: 4.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 561 EELKLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIG 640
Cdd:cd21273    1 DEKELRAQLRKTLESRLKVTLPEDLAEALSNGAVLCQLANQLRPRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMG 80

                         90       100
                 ....*....|....*....|....*....
gi 891713352 641 VPQEQLCLPLHILEEKGLGQVAVTVQALL 669
Cdd:cd21273   81 VPEVDLCSPSDVLLQGPAAVLRTVLALLA 109
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-254 8.94e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.07  E-value: 8.94e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  61 VLSLSGRKLREFPRGAANhdLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQL 140
Cdd:COG4886  117 SLDLSGNQLTDLPEELAN--LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 141 STLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTVPSqIGNLEALRDFNVRRNHLLRLPEELAEVP 219
Cdd:COG4886  195 TDLPEPLGNLTnLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANLTN 273

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 891713352 220 LIRLDFSCNKITVIpvcyrNLRHLQVITLDNNPLQ 254
Cdd:COG4886  274 LKTLDLSNNQLTDL-----KLKELELLLGLNSLLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-285 2.32e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.05  E-value: 2.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  80 DLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNciryipEAVLNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIAS 158
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTnLKELDLS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 159 NNKLVSLPEEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEELAEVP-LIRLDFSCNKITVIPVCY 237
Cdd:COG4886  145 NNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTnLEELDLSGNQLTDLPEPL 224

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 891713352 238 RNLRHLQVITLDNNPLQSPPAqicIKGKIHIfKYLNIQACKIApDLPD 285
Cdd:COG4886  225 ANLTNLETLDLSNNQLTDLPE---LGNLTNL-EELDLSNNQLT-DLPP 267
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 566-668 2.23e-21

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 89.32  E-value: 2.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 566 IDQLRKHIEYRLKVSLP---CDLGAALTDGVVLCHLANHVRPRSVPSIHVPSpavpkLTMAKCRRNVENFLDACRKIGVP 642
Cdd:cd00014    1 EEELLKWINEVLGEELPvsiTDLFESLRDGVLLCKLINKLSPGSIPKINKKP-----KSPFKKRENINLFLNACKKLGLP 75

                         90       100
                 ....*....|....*....|....*.
gi 891713352 643 QEQLCLPLHILEEKGLGQVAVTVQAL 668
Cdd:cd00014   76 ELDLFEPEDLYEKGNLKKVLGTLWAL 101
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-234 1.82e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  81 LTDTTR-ADLSRNRLSEIPMeacHFVS-LESLNLYQNCIRYIPEavlNL-QALTFLNISRNQLSTLPVHL---------- 147
Cdd:PRK15370 239 LPDTIQeMELSINRITELPE---RLPSaLQSLDLFHNKISCLPE---NLpEELRYLSVYDNSIRTLPAHLpsgithlnvq 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 148 --------CNLP--LKVLIASNNKLVSLPEEIGhlRHLTELDVSCNEIQTVPSQIGnlEALRDFNVRRNHLLRLPEELAe 217
Cdd:PRK15370 313 snsltalpETLPpgLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP- 387

                        170
                 ....*....|....*..
gi 891713352 218 VPLIRLDFSCNKITVIP 234
Cdd:PRK15370 388 AALQIMQASRNNLVRLP 404
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-206 7.67e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 7.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  61 VLSLSGRKLREFPRGAANhdLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNCIRYIPEaVLNLQALTFLNISRNQL 140
Cdd:COG4886  186 ELDLSNNQITDLPEPLGN--LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL 262

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 891713352 141 STLPvHLCNLP-LKVLIASNNKLVSLP----EEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRN 206
Cdd:COG4886  263 TDLP-PLANLTnLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 567-641 1.08e-11

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 61.56  E-value: 1.08e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 891713352   567 DQLRKHIEYRLKVSLPC---DLGAALTDGVVLCHLANHVRPRSVPSIHVPspavPKLTMAKCRRNVENFLDACRKIGV 641
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPpvtNFSSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLGG 74
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-212 2.42e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  89 LSRNRLSEIPMEAcHFVSLESLNLYQNCIRYIpEAVLNLQALTFLNISRNQLStLPVHLCNLP---------LKVLIASN 159
Cdd:cd21340   53 LQNNQIEKIENLE-NLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP-PGEKLTFDPrslaalsnsLRVLNISG 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 891713352 160 NKLVSLpEEIGHLRHLTELDVSCNEIQTVPSQ---IGNLEALRDFNVRRNHLLRLP 212
Cdd:cd21340  130 NNIDSL-EPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRELDLTGNPVCKKP 184
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 584-668 5.26e-11

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 60.02  E-value: 5.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 584 DLGAALTDGVVLCHLANHVRPRSVPSIHvpspavpklTMA---KCRRNVENFLDACRKIGVPQEQLCLPLHILEEKGLGQ 660
Cdd:cd21207   27 DYEDVLKDGVILCKLINILKPGSVKKIN---------TSKmafKLMENIENFLTACKGYGVPKTDLFQTVDLYEKKNIPQ 97


                 ....*...
gi 891713352 661 VAVTVQAL 668
Cdd:cd21207   98 VTNCLFAL 105
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-253 2.26e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  88 DLSRNRLS-EIPMEACHFVSLESLNLYQNCIR-YIPEAVLNLQALTFLNISRNQLS-TLPVHLCNL-PLK-VLIASNNKL 162
Cdd:PLN00113 146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMkSLKwIYLGYNNLS 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 163 VSLPEEIGHLRHLTELD-VSCNEIQTVPSQIGNLEALRDFNVRRNHLL-RLPEELAEVP-LIRLDFSCNKIT-VIPVCYR 238
Cdd:PLN00113 226 GEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQkLISLDLSDNSLSgEIPELVI 305

                        170
                 ....*....|....*
gi 891713352 239 NLRHLQVITLDNNPL 253
Cdd:PLN00113 306 QLQNLEILHLFSNNF 320
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 582-661 3.40e-10

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 58.04  E-value: 3.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 582 PCDLGAALTDGVVLCHLANHVRPRSVPSIHVpspaVPKLTMAK--CRRNVENFLDACR-KIGVPQEQLCLPLHILEEKGL 658
Cdd:cd21201   29 VFDLAQALRDGVLLCQLLNRLSPGSVDDREI----NLRPQMSQflCLKNIRTFLQACRtVFGLRSADLFEPEDLYDVTNF 104


                 ...
gi 891713352 659 GQV 661
Cdd:cd21201  105 GKV 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 582-668 1.28e-09

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 55.84  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 582 PCDLGAALTDGVVLCHLANHVRPRSVPSIHvpSPAVPKLTMakcrRNVENFLDACRKIGVPQEQLCLPLHILEEKGLGQV 661
Cdd:cd21210   19 QGDLLDALKDGVVLCKLANRILPADIRKYK--ESKMPFVQM----ENISAFLNAARKLGVPENDLFQTVDLFERKNPAQV 92


                 ....*..
gi 891713352 662 AVTVQAL 668
Cdd:cd21210   93 LQCLHAL 99
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 567-646 1.89e-09

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 55.81  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 567 DQLRKHIEYRLKVSLPCDL-GAALTDGVVLCHLANHVRPRSVPSI-HVPSPAVpkltmakCRRNVENFLDACRKIGVPQE 644
Cdd:cd21208    3 KEARTWIEAVTGKKFPSDDfRESLEDGILLCELINAIKPGSIKKInRLPTPIA-------GLDNLNLFLKACEDLGLKDS 75


                 ..
gi 891713352 645 QL 646
Cdd:cd21208   76 QL 77
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-257 2.53e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 2.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  89 LSRNRLSEIP-MEACHfvSLESLNLYQNCIRYIpEAVLNLQALTFLNISRNQLSTLPvHLCNLP-LKVLIASNNKLVSLp 166
Cdd:cd21340    9 LNDKNITKIDnLSLCK--NLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIE-NLENLVnLKKLYLGGNRISVV- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 167 EEIGHLRHLTELDVSCneiQTVP----------SQIGNLEALRDFNVRRNHlLRLPEELAEVP-LIRLDFSCNKITVI-P 234
Cdd:cd21340   84 EGLENLTNLEELHIEN---QRLPpgekltfdprSLAALSNSLRVLNISGNN-IDSLEPLAPLRnLEQLDASNNQISDLeE 159

                        170       180
                 ....*....|....*....|....*
gi 891713352 235 VC--YRNLRHLQVITLDNNPLQSPP 257
Cdd:cd21340  160 LLdlLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
131-273 5.58e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 5.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 131 TFLNISRNQLSTLPvHLCNLPLKVLIASNNKLVSLPEEIGhlRHLTELDVSCNEIQTVPSQIGnlEALRDFNVRRNHLLR 210
Cdd:PRK15370 181 TELRLKILGLTTIP-ACIPEQITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITE 255

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 891713352 211 LPEELAEVpLIRLDFSCNKITVIPvcyRNL-RHLQVITLDNNPLQSPPAQIcIKGKIHIFKYLN 273
Cdd:PRK15370 256 LPERLPSA-LQSLDLFHNKISCLP---ENLpEELRYLSVYDNSIRTLPAHL-PSGITHLNVQSN 314
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-231 1.02e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.71  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  80 DLTDTTRADLSRNRLS-EIPMEACHFVSLESLNLYQNCIR-YIPEAVLNLQALTFLNISRNQLS-TLPVHLCNLP-LKVL 155
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPrLQVL 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 156 IASNNKLV-SLPEEIGHLRHLTELDVSCNEIQ-------------------------TVPSQIGNLEALRDFNVRRNHLL 209
Cdd:PLN00113 338 QLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFS 417

                        170       180
                 ....*....|....*....|....
gi 891713352 210 -RLPEELAEVPLIR-LDFSCNKIT 231
Cdd:PLN00113 418 gELPSEFTKLPLVYfLDISNNNLQ 441
CH_CNN cd21211
calponin homology (CH) domain found in the calponin family; Calponin is an actin ...
 558-672 4.28e-08

calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409060 [Multi-domain]  Cd Length: 108  Bit Score: 51.54  E-value: 4.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 558 QREEELklidqlRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLtmakcrRNVENFLDACR 637
Cdd:cd21211    3 QKEAEL------RTWIEGVTGLSIGPNFQKGLKDGIILCELINKLQPGSVKKINESMQNWHQL------ENIGNFIKAIV 70

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 891713352 638 KIGVPQEQLCLPLHILEEKGLGQVAVTVQALLELA 672
Cdd:cd21211   71 SYGMKPHDIFEANDLFENGNMTQVQVTLLALAGKA 105
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 584-671 2.39e-07

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 49.72  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 584 DLGAALTDGVVLCHLANHVRPRSVPSI--HVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQeqlcLPLHILEEKGLGQV 661
Cdd:cd21203   25 EFRLCLRDGVVLCKLLNKLQPGAVPKVveSPDDPDGAAGSAFQYFENVRNFLVAIEEMGLPT----FEASDLEQGGGGSR 100

                         90
                 ....*....|
gi 891713352 662 AVTVQALLEL 671
Cdd:cd21203  101 PRVVDCILAL 110
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-208 3.46e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 3.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  80 DLTDTTRADLSRNRLS-EIPmEACHFVSLESLNLYQNCIR-YIPEAVLNLQALTFLNISRNQLS-TLPVHLCNLP-LKVL 155
Cdd:PLN00113 450 DMPSLQMLSLARNKFFgGLP-DSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKkLVSL 528

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 891713352 156 IASNNKLV-SLPEEIGHLRHLTELDVSCNEIQ-TVPSQIGNLEALRDFNVRRNHL 208
Cdd:PLN00113 529 DLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 567-643 4.61e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 48.82  E-value: 4.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  567 DQLRKHIEYRLKVSLPC----DLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVpkltmaKCRRNVENFLD-ACRKIGV 641
Cdd:pfam00307   5 KELLRWINSHLAEYGPGvrvtNFTTDLRDGLALCALLNKLAPGLVDKKKLNKSEF------DKLENINLALDvAEKKLGV 78


                  ..
gi 891713352  642 PQ 643
Cdd:pfam00307  79 PK 80
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
 558-672 5.34e-07

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 48.77  E-value: 5.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 558 QREEELKLidqlrkHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLtmakcrRNVENFLDACR 637
Cdd:cd21283    3 QKEAELRT------WIEGLTGRSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQL------ENLSNFIKAMV 70

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 891713352 638 KIGVPQEQLCLPLHILEEKGLGQVAVTVQALLELA 672
Cdd:cd21283   71 SYGMKPVDLFEANDLFESGNMTQVQVSLLALAGMA 105
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-285 6.67e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 6.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  78 NHDLTDTTRADLSRNRLSEIPMEACHFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLPLKVLIA 157
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 158 SNNKLVSLPEEIGHLRHLTELDVSCNEiqtvpsQIGNLEALRdfnvrrnhllrlpeelaevpliRLDFSCNKITVIPVCY 237
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLE----------------------SLDLSGNQLTDLPEEL 132

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 891713352 238 RNLRHLQVITLDNNPLQSPPAQIcikGKIHIFKYLNIQACKIApDLPD 285
Cdd:COG4886  133 ANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLT-DLPE 176
CH_VAV1 cd21262
calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the ...
 583-668 7.28e-07

calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV1 protein.


Pssm-ID: 409111  Cd Length: 120  Bit Score: 48.40  E-value: 7.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 583 CDLGAALTDGVVLCHLANHVRPRSVPSIHVpsPAVPKLTMAKCRRNVENFLDAC-RKIGVPQEQLCLPLHILEEKGLGQV 661
Cdd:cd21262   30 CDLAQALRDGVLLCQLLNNLLPHAVNLREI--NLRPQMSQFLCLKNIRTFLSTCcEKFGLRKSELFEAFDLFDVRDFGKV 107


                 ....*..
gi 891713352 662 AVTVQAL 668
Cdd:cd21262  108 IDTLSIL 114
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
129-257 3.13e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.55  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 129 ALTFLNISRNQLSTLPVhlcnLPLKV--LIASNNKLVSLPEEIGHLRhltELDVSCNEIQTVPSQIGNLEALRDFNVRRN 206
Cdd:PRK15387 303 GLQELSVSDNQLASLPA----LPSELckLWAYNNQLTSLPTLPSGLQ---ELSVSDNQLASLPTLPSELYKLWAYNNRLT 375

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 891713352 207 HLLRLPEELAEvplirLDFSCNKITVIPVCYRNLRHLQVitlDNNPLQSPP 257
Cdd:PRK15387 376 SLPALPSGLKE-----LIVSGNRLTSLPVLPSELKELMV---SGNRLTSLP 418
CH_PIX cd21202
calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak ...
 585-668 6.06e-06

calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409051 [Multi-domain]  Cd Length: 114  Bit Score: 45.60  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 585 LGAALTDGVVLCHLANHVRPRSVPSIHvPSPavpkLTMAKCRRNVENFLDACRKIGVPQEQLCLPLHILEEKGLGQVAVT 664
Cdd:cd21202   30 LSESLKNGVVLCRLVNRLKPGTVEKIY-DEP----TTEEECLYNFESFLKACQELGILAEEIFDPNDLYSGGNFQKVLST 104


                 ....
gi 891713352 665 VQAL 668
Cdd:cd21202  105 LERL 108
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
89-215 6.20e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.78  E-value: 6.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  89 LSRNRLSEIPMEACHFVSLESlnlYQNCIRYIPEAVLNLQALTflnISRNQLSTLPV-------------HLCNLP---- 151
Cdd:PRK15387 309 VSDNQLASLPALPSELCKLWA---YNNQLTSLPTLPSGLQELS---VSDNQLASLPTlpselyklwaynnRLTSLPalps 382

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 891713352 152 -LKVLIASNNKLVSLPEEIGHLRhltELDVSCNEIQTVPSQIGNLEALrdfNVRRNHLLRLPEEL 215
Cdd:PRK15387 383 gLKELIVSGNRLTSLPVLPSELK---ELMVSGNRLTSLPMLPSGLLSL---SVYRNQLTRLPESL 441
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 588-672 8.34e-06

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 45.72  E-value: 8.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 588 ALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTM-AKC-----------RRNVENFLDACRKIGVPQEQLCLPLHILEE 655
Cdd:cd21204   31 ELRNGVVLCQLAQKIQEAAEKAREAGKKNGPPPSYkLKCnenakpgsffaRDNVANFLRWCRKLGVDEVLLFESEDLVLH 110

                         90
                 ....*....|....*..
gi 891713352 656 KGLGQVAVTvqaLLELA 672
Cdd:cd21204  111 KNPRQVLLC---LLELA 124
CH_CNN3 cd21284
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ...
 558-672 8.47e-06

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409133 [Multi-domain]  Cd Length: 111  Bit Score: 45.28  E-value: 8.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 558 QREEELklidqlRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLtmakcrRNVENFLDACR 637
Cdd:cd21284    5 QKEEEL------RNWIEEVTGMSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQL------ENIGNFIKAIQ 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 891713352 638 KIGVPQEQLCLPLHILEEKGLGQVAVTVQALLELA 672
Cdd:cd21284   73 AYGMKPHDIFEANDLFENGNMTQVQTTLLALAGLA 107
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 558-672 2.13e-05

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 44.10  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 558 QREEELklidqlRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLtmakcrRNVENFLDACR 637
Cdd:cd21282    3 QTEEEL------RVWIEGVTGRRIGDNFMDGLKDGVILCELINKLQPGSVRKINESTQNWHKL------ENIGNFIKAIM 70

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 891713352 638 KIGVPQEQLCLPLHILEEKGLGQVAVTVQALLELA 672
Cdd:cd21282   71 HYGVKPHDIFEANDLFENTNHTQVQSTLIALASMA 105
LRR_8 pfam13855
Leucine rich repeat;
152-208 2.18e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 891713352  152 LKVLIASNNKLVSLPEEI-GHLRHLTELDVSCNEIQTV-PSQIGNLEALRDFNVRRNHL 208
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
106-173 2.68e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 2.68e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 106 SLESLNLYQNCIRYIPEAVLnlQALTFLNISRNQLSTLPVhlcNLP--LKVLIASNNKLVSLPEEIGHLR 173
Cdd:PRK15370 347 ELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPE---NLPaaLQIMQASRNNLVRLPESLPHFR 411
LRR_8 pfam13855
Leucine rich repeat;
173-253 4.25e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  173 RHLTELDVSCNEIQTV-PSQIGNLEALRdfnvrrnhllrlpeelaevpliRLDFSCNKITVI-PVCYRNLRHLQVITLDN 250
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLK----------------------VLDLSNNLLTTLsPGAFSGLPSLRYLDLSG 58


                  ...
gi 891713352  251 NPL 253
Cdd:pfam13855  59 NRL 61
CH_VAV3 cd21264
calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously ...
 584-668 7.88e-05

calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1. Its function has been implicated in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV3 protein.


Pssm-ID: 409113  Cd Length: 117  Bit Score: 42.64  E-value: 7.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 584 DLGAALTDGVVLCHLANHVRPRSV--PSIHVPspavPKLTMAKCRRNVENFLDA-CRKIGVPQEQLCLPLHILEEKGLGQ 660
Cdd:cd21264   31 DLAQTLRDGVLLCQLLNNLRPHSInlKEINLR----PQMSQFLCLKNIRTFLSAcCETFGMRKSELFEAFDLFDVRDFGK 106


                 ....*...
gi 891713352 661 VAVTVQAL 668
Cdd:cd21264  107 VIETLSKL 114
SCP1 COG5199
Calponin [Cytoskeleton];
564-668 1.19e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 43.37  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 564 KLIDQLRKHIEYRL--KVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPkltmakcRRNVENFLDACRKIGV 641
Cdd:COG5199   13 KQQKEVTLWIETVLgeKFEPPGDLLSLLKDGVRLCRILNEASPLDIKYKESKMPFVQ-------MENISSFINGLKKLRV 85

                         90       100
                 ....*....|....*....|....*..
gi 891713352 642 PQEQLCLPLHILEEKGLGQVAVTVQAL 668
Cdd:COG5199   86 PEYELFQTNDLFEAKDLRQVVICLYSL 112
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 589-672 1.81e-04

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 42.17  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 589 LTDGVVLCHLANHVRPRSvpsiHVPSPAVPKLTMA-KCRRNVENFLDACRKIGVPQEQLCLPLHILEEKGLGQVAVTVQA 667
Cdd:cd21280   39 LKDGTVLCHLINSLYPKG----QAPVKKIQASTMAfKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMASVQRTLMN 114


                 ....*
gi 891713352 668 LLELA 672
Cdd:cd21280  115 LGGLA 119
CH_PLS_FIM_rpt1 cd21217
first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
 577-641 2.31e-04

first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409066 [Multi-domain]  Cd Length: 114  Bit Score: 41.02  E-value: 2.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 891713352 577 LKVSLPCDLGA-----ALTDGVVLCHLANHVRPRSVP--SIHVPSPavpkLTMAKCRRNVENFLDACRKIGV 641
Cdd:cd21217   20 LKHLLPIDPDGddlfeALRDGVLLCKLINKIVPGTIDerKLNKKKP----KNIFEATENLNLALNAAKKIGC 87
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 566-642 3.81e-04

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 40.67  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 566 IDQLRKHIEYRLKVSLPC--DLGAALTDGVVLCHLANHVRPRSVPSIHVPSpavPKLTMakcrRNVEN---FLDACRKIG 640
Cdd:cd21206   10 LEEAKQWIEACLNEELPPttEFEEELRNGVVLAKLANKFAPKLVPLKKIYD---VGLQF----RHTDNinhFLRALKKIG 82


                 ..
gi 891713352 641 VP 642
Cdd:cd21206   83 LP 84
CH_VAV2 cd21263
calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely ...
 584-668 5.92e-04

calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV2 protein.


Pssm-ID: 409112  Cd Length: 119  Bit Score: 40.33  E-value: 5.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 584 DLGAALTDGVVLCHLANHVRPRSVPSIHVPSPavPKLTMAKCRRNVENFLDACR-KIGVPQEQLCLPLHILEEKGLGQVA 662
Cdd:cd21263   31 DLAQALRDGVLLCQLLHNLSPGSIDLKDINFR--PQMSQFLCLKNIRTFLKVCHdKFGLRNSELFDPFDLFDVRDFGKVI 108


                 ....*.
gi 891713352 663 VTVQAL 668
Cdd:cd21263  109 SALSRL 114
CH_LMO7 cd21277
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ...
 584-649 6.07e-04

calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409126 [Multi-domain]  Cd Length: 116  Bit Score: 40.20  E-value: 6.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 891713352 584 DLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTmakcrrNVENFLDACRKIGVPQEQLCLP 649
Cdd:cd21277   21 DFRSALENGVLLCDLINKIKPGIIKKINRLSTPIAGLD------NINVFLKACEKLGLKEAQLFHP 80
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-234 1.12e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  62 LSLSGRKLREFPRGAanhDLTDTTRADLSRNRLSEIPMEAcHFVSLESLNLYQNCIRYIPEAVL-NLQALTFLNISRNQL 140
Cdd:COG4886  233 LDLSNNQLTDLPELG---NLTNLEELDLSNNQLTDLPPLA-NLTNLKTLDLSNNQLTDLKLKELeLLLGLNSLLLLLLLL 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 141 STLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEELAEVPL 220
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                        170
                 ....*....|....
gi 891713352 221 IRLDFSCNKITVIP 234
Cdd:COG4886  389 LLLLLLTTTAGVLL 402
CH_betaPIX cd21266
calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak ...
 585-636 1.17e-03

calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak Interactive eXchange factor (beta-PIX), also called PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor 7 (ARHGEF7), p85, or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Beta-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409115  Cd Length: 112  Bit Score: 39.13  E-value: 1.17e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 891713352 585 LGAALTDGVVLCHLANHVRPRSVPSIHvPSPAvpklTMAKCRRNVENFLDAC 636
Cdd:cd21266   29 LQASLKDGVVLCRLLERLLPGSIDKVY-PEPR----TESECLSNIREFLRGC 75
CH_TAGLN3 cd21281
calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal ...
 589-672 1.49e-03

calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409130 [Multi-domain]  Cd Length: 119  Bit Score: 39.17  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 589 LTDGVVLCHLANHVRPRSvpsiHVPSPAVPKLTMA-KCRRNVENFLDACRKIGVPQEQLCLPLHILEEKGLGQVAVTVQA 667
Cdd:cd21281   34 LMDGTILCRLINSLYPPG----KEPIKKISETKMAfKQMEKISQFLQAAEAYGVITTDIFQTVDLWEGKDMAAVQRTLMA 109


                 ....*
gi 891713352 668 LLELA 672
Cdd:cd21281  110 LGSVA 114
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
133-261 3.15e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352 133 LNISRNQLSTLPVhlCnLP--LKVLIASNNKLVSLPEEIGHLRhltELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLR 210
Cdd:PRK15387 206 LNVGESGLTTLPD--C-LPahITTLVIPDNNLTSLPALPPELR---TLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPA 279

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 891713352 211 LPEELAEVPLIRldfscNKITVIPVCYRNLRHLQVITLDNNPLQSPPAQIC 261
Cdd:PRK15387 280 LPSGLCKLWIFG-----NQLTSLPVLPPGLQELSVSDNQLASLPALPSELC 325
CH_alphaPIX cd21265
calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak ...
 585-641 4.62e-03

calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak Interactive eXchange factor (alpha-PIX), also called PAK-interacting exchange factor alpha, Rho guanine nucleotide exchange factor 6 (ARHGEF6), Rac/Cdc42 guanine nucleotide exchange factor 6, or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Alpha-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409114  Cd Length: 117  Bit Score: 37.49  E-value: 4.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 891713352 585 LGAALTDGVVLCHLANHVRPRSVPSiHVPSPAvpklTMAKCRRNVENFLDACRKIGV 641
Cdd:cd21265   31 LKSSLKDGVVLCKLIERLLPGSVEK-YCLEPK----TEADCIGNIKEFLKGCAALKV 82
LRR_8 pfam13855
Leucine rich repeat;
106-162 6.61e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 6.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 891713352  106 SLESLNLYQNCIRYI-PEAVLNLQALTFLNISRNQLSTL-PVHLCNLP-LKVLIASNNKL 162
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPsLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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