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Conserved domains on  [gi|916404479|ref|NP_001299601|]
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complement factor H-related protein 2 isoform 2 precursor [Homo sapiens]

Protein Classification

CCP domain-containing protein( domain architecture ID 13332024)

CCP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 25-79 2.01e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 2.01e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 916404479  25 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 79
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 24-141 1.42e-10

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 57.36  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916404479  24 KCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKYniklk 98
Cdd:PHA02927 147 KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF----- 220

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 916404479  99 wtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 141
Cdd:PHA02927 221 ----KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
 
Name Accession Description Interval E-value
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 25-79 2.01e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 2.01e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 916404479  25 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 79
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 25-79 9.53e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 9.53e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 916404479    25 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 79
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 24-141 1.42e-10

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 57.36  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916404479  24 KCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKYniklk 98
Cdd:PHA02927 147 KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF----- 220

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 916404479  99 wtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 141
Cdd:PHA02927 221 ----KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
Sushi pfam00084
Sushi repeat (SCR repeat);
25-79 1.61e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.27  E-value: 1.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 916404479   25 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 79
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 24-79 1.10e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 40.31  E-value: 1.10e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 916404479  24 KCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQN-----LYQLEGNNQITC-RNGQWS-EPPKC 79
Cdd:PHA02817  23 KCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNkEFPVC 84
 
Name Accession Description Interval E-value
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 25-79 2.01e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 2.01e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 916404479  25 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 79
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 25-79 9.53e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 9.53e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 916404479    25 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 79
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 24-141 1.42e-10

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 57.36  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916404479  24 KCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKYniklk 98
Cdd:PHA02927 147 KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF----- 220

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 916404479  99 wtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 141
Cdd:PHA02927 221 ----KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
Sushi pfam00084
Sushi repeat (SCR repeat);
25-79 1.61e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.27  E-value: 1.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 916404479   25 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 79
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 24-79 1.10e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 40.31  E-value: 1.10e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 916404479  24 KCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQN-----LYQLEGNNQITC-RNGQWS-EPPKC 79
Cdd:PHA02817  23 KCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNkEFPVC 84
PHA02831 PHA02831
EEV host range protein; Provisional
 25-121 5.47e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 38.43  E-value: 5.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916404479  25 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQ----NLYQLEGNNQITCRNGQW-SEPPKC-LDPC---VISQEIMEKYni 95
Cdd:PHA02831  78 CKDPVTILNGYIKN-KKDQYSFGDSVTYACKvnklEKYSIVGNETVKCINKQWvPKYPVCkLIRCkypALQNGFLNVF-- 154

                         90       100
                 ....*....|....*....|....*.
gi 916404479  96 klkwtnQQKLYsrTGDIVEFVCKSGY 121
Cdd:PHA02831 155 ------EKKFY--YGDIVNFKCKKGF 172
PHA02639 PHA02639
EEV host range protein; Provisional
 20-117 4.14e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 36.18  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916404479  20 VSAEKCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITC----RNGQWS-EPPKCL-----DPCVIsqei 89
Cdd:PHA02639  17 VKSIYCDKPDDISNGFITE-LMEKYEIGKLIEYTCNTDYALIGDRFRTCikdkNNAIWSnKAPFCMlkecnDPPSI---- 91

                         90       100
                 ....*....|....*....|....*...
gi 916404479  90 mekynIKLKWTNQQKLYsRTGDIVEFVC 117
Cdd:PHA02639  92 -----INGKIYNKREMY-KVGDEIYYVC 113
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 24-121 4.70e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 35.78  E-value: 4.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916404479  24 KCGPPPPIDNGDITsflLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQ-----WS------EPPKCLDPCVISQEIMEK 92
Cdd:PHA02927  85 RCPSPRDIDNGQLD---IGGVDFGSSITYSCNSGYQLIGESKSYCELGStgsmvWNpeapicESVKCQSPPSISNGRHNG 161

                         90       100
                 ....*....|....*....|....*....
gi 916404479  93 YNiklkwtnqqKLYSrTGDIVEFVCKSGY 121
Cdd:PHA02927 162 YE---------DFYT-DGSVVTYSCNSGY 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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