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Conserved domains on  [gi|948284470|ref|NP_001303904|]
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protein LZIC isoform c [Homo sapiens]

Protein Classification

ICAT domain-containing protein( domain architecture ID 10533939)

ICAT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICAT pfam06384
Beta-catenin-interacting protein ICAT; This family consists of several eukaryotic ...
 113-172 1.15e-26

Beta-catenin-interacting protein ICAT; This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions.


:

Pssm-ID: 399405  Cd Length: 76  Bit Score: 97.03  E-value: 1.15e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284470  113 MDRDLMVGKLERDLYTQQKVEILTALRKLGEKLTADDEAFLSANAGAILSQFEKVSTDLG 172
Cdd:pfam06384   1 IQRDVKLGKLSKDSYIQQKVEILTALKKLGEKLTPEEEAFLEQHSSASLSQFEKVSGDLG 60
 
Name Accession Description Interval E-value
ICAT pfam06384
Beta-catenin-interacting protein ICAT; This family consists of several eukaryotic ...
 113-172 1.15e-26

Beta-catenin-interacting protein ICAT; This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions.


Pssm-ID: 399405  Cd Length: 76  Bit Score: 97.03  E-value: 1.15e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284470  113 MDRDLMVGKLERDLYTQQKVEILTALRKLGEKLTADDEAFLSANAGAILSQFEKVSTDLG 172
Cdd:pfam06384   1 IQRDVKLGKLSKDSYIQQKVEILTALKKLGEKLTPEEEAFLEQHSSASLSQFEKVSGDLG 60
 
Name Accession Description Interval E-value
ICAT pfam06384
Beta-catenin-interacting protein ICAT; This family consists of several eukaryotic ...
 113-172 1.15e-26

Beta-catenin-interacting protein ICAT; This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions.


Pssm-ID: 399405  Cd Length: 76  Bit Score: 97.03  E-value: 1.15e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284470  113 MDRDLMVGKLERDLYTQQKVEILTALRKLGEKLTADDEAFLSANAGAILSQFEKVSTDLG 172
Cdd:pfam06384   1 IQRDVKLGKLSKDSYIQQKVEILTALKKLGEKLTPEEEAFLEQHSSASLSQFEKVSGDLG 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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