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Conserved domains on  [gi|948284466|ref|NP_001303913|]
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ribosome biogenesis protein SLX9 homolog isoform 3 [Homo sapiens]

Protein Classification

FAM207/SLX9 family protein( domain architecture ID 10634010)

FAM207/SLX9 family protein similar to Saccharomyces cerevisiae ribosome biogenesis protein SLX9 that is involved in ribosome biogenesis, and is required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLX9 pfam15341
Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is ...
 84-206 9.19e-30

Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences.


:

Pssm-ID: 464660  Cd Length: 118  Bit Score: 106.59  E-value: 9.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284466   84 KTVLPKKEKMKLRREQWLQKIEAIKLAEQKHREERRRRATVVVGDLHPLRDALPELLGLEAGSRRQARSRESNKPRPSEL 163
Cdd:pfam15341   1 KFRLSKKDKRKIKREAFLSKIEKSKSALKRRKKKARRPSKKLVGDLDSLADALPELEEEETDKSTKPSKQKSLKSKPGAA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 948284466  164 SRmsaaqRQQLLEEERTRFQELLASPAYRASPLVAIGQTLARQ 206
Cdd:pfam15341  81 KR-----KKKLEKEERERFQKVLAHPSFKSNPFAALREHISNT 118
 
Name Accession Description Interval E-value
SLX9 pfam15341
Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is ...
 84-206 9.19e-30

Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences.


Pssm-ID: 464660  Cd Length: 118  Bit Score: 106.59  E-value: 9.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284466   84 KTVLPKKEKMKLRREQWLQKIEAIKLAEQKHREERRRRATVVVGDLHPLRDALPELLGLEAGSRRQARSRESNKPRPSEL 163
Cdd:pfam15341   1 KFRLSKKDKRKIKREAFLSKIEKSKSALKRRKKKARRPSKKLVGDLDSLADALPELEEEETDKSTKPSKQKSLKSKPGAA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 948284466  164 SRmsaaqRQQLLEEERTRFQELLASPAYRASPLVAIGQTLARQ 206
Cdd:pfam15341  81 KR-----KKKLEKEERERFQKVLAHPSFKSNPFAALREHISNT 118
PTZ00121 PTZ00121
MAEBL; Provisional
 70-185 9.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 9.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284466   70 DVRSVTSVRRGAEAKTVLPKKEKMKLRREQWLQKIEAIKLAEQKHREERRR----RATVVVGDLHPLRDALPELLGLEAG 145
Cdd:PTZ00121 1526 EAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKnmalRKAEEAKKAEEARIEEVMKLYEEEK 1605

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 948284466  146 SRR--QARSRESNKPRPSELS-----RMSAAQRQQLLEEERTRFQEL 185
Cdd:PTZ00121 1606 KMKaeEAKKAEEAKIKAEELKkaeeeKKKVEQLKKKEAEEKKKAEEL 1652
 
Name Accession Description Interval E-value
SLX9 pfam15341
Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is ...
 84-206 9.19e-30

Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences.


Pssm-ID: 464660  Cd Length: 118  Bit Score: 106.59  E-value: 9.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284466   84 KTVLPKKEKMKLRREQWLQKIEAIKLAEQKHREERRRRATVVVGDLHPLRDALPELLGLEAGSRRQARSRESNKPRPSEL 163
Cdd:pfam15341   1 KFRLSKKDKRKIKREAFLSKIEKSKSALKRRKKKARRPSKKLVGDLDSLADALPELEEEETDKSTKPSKQKSLKSKPGAA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 948284466  164 SRmsaaqRQQLLEEERTRFQELLASPAYRASPLVAIGQTLARQ 206
Cdd:pfam15341  81 KR-----KKKLEKEERERFQKVLAHPSFKSNPFAALREHISNT 118
PTZ00121 PTZ00121
MAEBL; Provisional
 70-185 9.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 9.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284466   70 DVRSVTSVRRGAEAKTVLPKKEKMKLRREQWLQKIEAIKLAEQKHREERRR----RATVVVGDLHPLRDALPELLGLEAG 145
Cdd:PTZ00121 1526 EAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKnmalRKAEEAKKAEEARIEEVMKLYEEEK 1605

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 948284466  146 SRR--QARSRESNKPRPSELS-----RMSAAQRQQLLEEERTRFQEL 185
Cdd:PTZ00121 1606 KMKaeEAKKAEEAKIKAEELKkaeeeKKKVEQLKKKEAEEKKKAEEL 1652
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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