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Conserved domains on  [gi|953768348|ref|NP_001304113|]
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cadherin-1 isoform 2 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10555552)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-116 7.18e-41

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 462590  Cd Length: 90  Bit Score: 144.78  E-value: 7.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348   27 PCHPGFDAESYTFTVPRRhLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDST 106
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 953768348  107 YRK-FSTKVTL 116
Cdd:pfam08758  80 GEKmASVKVTV 90
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-258 9.32e-37

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


:

Pssm-ID: 206635  Cd Length: 98  Bit Score: 133.24  E-value: 9.32e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 158 IPPISCPENEKGPfpKNLVQIKSNKDKEGKVFYSITGQGADTPPvGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSS 237
Cdd:cd00031    1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 953768348 238 NGNAVEDPMEILITVTDQNDN 258
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 757-816 1.29e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.30  E-value: 1.29e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  757 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 816
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 431-530 1.13e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 431 RVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDN 509
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953768348 510 GSPVATGTGTLLLILSDVNDN 530
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-371 3.04e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 3.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 266 VFKGSVMEGALPGTSVMEVTATDADDDVNtynAAIAYTILSQDPElpdkNMFTINRNTGVISVvTTGLDRESFPTYTLVV 345
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953768348 346 QAADLQGEGLSTTATAVITVTDTNDN 371
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
537-625 5.24e-09

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 5.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  537 RTIFFCE---RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTqesiiLKPKMAL---EVGDYKINLKLMD 610
Cdd:pfam00028   1 YSASVPEnapVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 953768348  611 N--QNKDQVTTLEVSVC 625
Cdd:pfam00028  76 SggPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-116 7.18e-41

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 144.78  E-value: 7.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348   27 PCHPGFDAESYTFTVPRRhLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDST 106
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 953768348  107 YRK-FSTKVTL 116
Cdd:pfam08758  80 GEKmASVKVTV 90
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-258 9.32e-37

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 133.24  E-value: 9.32e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 158 IPPISCPENEKGPfpKNLVQIKSNKDKEGKVFYSITGQGADTPPvGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSS 237
Cdd:cd00031    1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 953768348 238 NGNAVEDPMEILITVTDQNDN 258
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 28-114 2.77e-35

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 128.55  E-value: 2.77e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348    28 CHPGFDAESYTFTVPRrHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTY 107
Cdd:smart01055   1 CKPGFSEEKYTFHVPS-HLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 953768348   108 -RKFSTKV 114
Cdd:smart01055  80 qEKKEIKV 87
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 757-816 1.29e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.30  E-value: 1.29e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  757 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 816
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 431-530 1.13e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 431 RVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDN 509
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953768348 510 GSPVATGTGTLLLILSDVNDN 530
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-371 3.04e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 3.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 266 VFKGSVMEGALPGTSVMEVTATDADDDVNtynAAIAYTILSQDPElpdkNMFTINRNTGVISVvTTGLDRESFPTYTLVV 345
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953768348 346 QAADLQGEGLSTTATAVITVTDTNDN 371
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
269-356 6.22e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 6.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  269 GSVMEGALPGTSVMEVTATDADDDVNTYnaaIAYTILSQDPElpdkNMFTINRNTGVISVVTTgLDRESFPTYTLVVQAA 348
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGR---IFYSILGGGPG----GNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ....*...
gi 953768348  349 DLQGEGLS 356
Cdd:pfam00028  75 DSGGPPLS 82
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 448-532 1.62e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.62e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348   448 TAQEPDTFMEQKITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTLLLILSD 526
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 953768348   527 VNDNAP 532
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
159-253 5.81e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  159 PPISCPENEK-GPFPKNLVQIKSNKDKEGKVFYSITGQGADtppvGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSS 237
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 953768348  238 NGNAVEDPMEILITVT 253
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 186-260 6.86e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 6.86e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 953768348   186 GKVFYSITGQGADtppvGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKP 260
Cdd:smart00112  11 GKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-373 7.72e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.72e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348   285 TATDADDDVNtynAAIAYTILSQDpelpDKNMFTINRNTGVIsVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVIT 364
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGN----DDGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 953768348   365 VTDTNDNPP 373
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
432-520 1.96e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  432 VEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRD-TANWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNG 510
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSG 77

                          90
                  ....*....|
gi 953768348  511 SPVATGTGTL 520
Cdd:pfam00028  78 GPPLSSTATV 87
Cadherin pfam00028
Cadherin domain;
537-625 5.24e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 5.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  537 RTIFFCE---RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTqesiiLKPKMAL---EVGDYKINLKLMD 610
Cdd:pfam00028   1 YSASVPEnapVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 953768348  611 N--QNKDQVTTLEVSVC 625
Cdd:pfam00028  76 SggPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-116 7.18e-41

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 144.78  E-value: 7.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348   27 PCHPGFDAESYTFTVPRRhLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDST 106
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 953768348  107 YRK-FSTKVTL 116
Cdd:pfam08758  80 GEKmASVKVTV 90
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-258 9.32e-37

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 133.24  E-value: 9.32e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 158 IPPISCPENEKGPfpKNLVQIKSNKDKEGKVFYSITGQGADTPPvGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSS 237
Cdd:cd00031    1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 953768348 238 NGNAVEDPMEILITVTDQNDN 258
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 28-114 2.77e-35

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 128.55  E-value: 2.77e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348    28 CHPGFDAESYTFTVPRrHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTY 107
Cdd:smart01055   1 CKPGFSEEKYTFHVPS-HLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 953768348   108 -RKFSTKV 114
Cdd:smart01055  80 qEKKEIKV 87
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 757-816 1.29e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.30  E-value: 1.29e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  757 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 816
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 431-530 1.13e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 431 RVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDN 509
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953768348 510 GSPVATGTGTLLLILSDVNDN 530
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-371 3.04e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 3.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 266 VFKGSVMEGALPGTSVMEVTATDADDDVNtynAAIAYTILSQDPElpdkNMFTINRNTGVISVvTTGLDRESFPTYTLVV 345
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953768348 346 QAADLQGEGLSTTATAVITVTDTNDN 371
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
269-356 6.22e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 6.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  269 GSVMEGALPGTSVMEVTATDADDDVNTYnaaIAYTILSQDPElpdkNMFTINRNTGVISVVTTgLDRESFPTYTLVVQAA 348
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGR---IFYSILGGGPG----GNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ....*...
gi 953768348  349 DLQGEGLS 356
Cdd:pfam00028  75 DSGGPPLS 82
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 448-532 1.62e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.62e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348   448 TAQEPDTFMEQKITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTLLLILSD 526
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 953768348   527 VNDNAP 532
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
159-253 5.81e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  159 PPISCPENEK-GPFPKNLVQIKSNKDKEGKVFYSITGQGADtppvGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSS 237
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 953768348  238 NGNAVEDPMEILITVT 253
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 186-260 6.86e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 6.86e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 953768348   186 GKVFYSITGQGADtppvGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKP 260
Cdd:smart00112  11 GKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-373 7.72e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.72e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348   285 TATDADDDVNtynAAIAYTILSQDpelpDKNMFTINRNTGVIsVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVIT 364
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGN----DDGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 953768348   365 VTDTNDNPP 373
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-258 1.08e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348 161 ISCPENEKGPFPknLVQIK-SNKDKE--GKVFYSITGQGADtppvGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSS 237
Cdd:cd11304    4 VSVPENAPPGTV--VLTVSaTDPDSGenGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953768348 238 NGNAVEDPMEILITVTDQNDN 258
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
432-520 1.96e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  432 VEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRD-TANWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNG 510
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSG 77

                          90
                  ....*....|
gi 953768348  511 SPVATGTGTL 520
Cdd:pfam00028  78 GPPLSSTATV 87
Cadherin pfam00028
Cadherin domain;
537-625 5.24e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 5.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768348  537 RTIFFCE---RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTqesiiLKPKMAL---EVGDYKINLKLMD 610
Cdd:pfam00028   1 YSASVPEnapVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 953768348  611 N--QNKDQVTTLEVSVC 625
Cdd:pfam00028  76 SggPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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