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Conserved domains on  [gi|953953837|ref|NP_001304122|]
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vacuolar-sorting protein SNF8 isoform 3 [Homo sapiens]

Protein Classification

EAP30/Vps36 family vacuolar-sorting protein( domain architecture ID 10514443)

EAP30/Vps36 family vacuolar-sorting protein similar to EAP30, a subunit of the ELL complex, and Vps36 involved in Golgi to endosome trafficking

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EAP30 pfam04157
EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved ...
 10-208 1.30e-67

EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.


:

Pssm-ID: 461201  Cd Length: 210  Bit Score: 207.46  E-value: 1.30e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953837   10 AIAKKKLAEMSKQLDMFKTnLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLasgKGFWSEMLGVGDFYYELGVQIIE 89
Cdd:pfam04157  19 ELLSSAFEDLEALMEKFKE-LVEFAEKHKKKIKKNPEFRAQFQSMCASLGVDPL---TFWWMSLLGVGDFYYELAVQIVE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953837   90 VCLALKHRNGGLITLEELHQQVLKGRGkfAQDVSQDDLIRAIKKL-KALGTGFGIIPVGgtYLIqsVPAELNMDHTVVLQ 168
Cdd:pfam04157  95 VCLATRDENGGLISLDDLYARVNRARG--VELISPDDLLRAIKLLeLVLGSRLRKFKSG--LLV--VQLELNTDQTEVAS 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 953953837  169 -LAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLD 208
Cdd:pfam04157 169 rLGGLGGYVTASELADNLGWSVARAKEVLEDLEREGLLWRD 209
 
Name Accession Description Interval E-value
EAP30 pfam04157
EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved ...
 10-208 1.30e-67

EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.


Pssm-ID: 461201  Cd Length: 210  Bit Score: 207.46  E-value: 1.30e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953837   10 AIAKKKLAEMSKQLDMFKTnLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLasgKGFWSEMLGVGDFYYELGVQIIE 89
Cdd:pfam04157  19 ELLSSAFEDLEALMEKFKE-LVEFAEKHKKKIKKNPEFRAQFQSMCASLGVDPL---TFWWMSLLGVGDFYYELAVQIVE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953837   90 VCLALKHRNGGLITLEELHQQVLKGRGkfAQDVSQDDLIRAIKKL-KALGTGFGIIPVGgtYLIqsVPAELNMDHTVVLQ 168
Cdd:pfam04157  95 VCLATRDENGGLISLDDLYARVNRARG--VELISPDDLLRAIKLLeLVLGSRLRKFKSG--LLV--VQLELNTDQTEVAS 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 953953837  169 -LAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLD 208
Cdd:pfam04157 169 rLGGLGGYVTASELADNLGWSVARAKEVLEDLEREGLLWRD 209
 
Name Accession Description Interval E-value
EAP30 pfam04157
EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved ...
 10-208 1.30e-67

EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.


Pssm-ID: 461201  Cd Length: 210  Bit Score: 207.46  E-value: 1.30e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953837   10 AIAKKKLAEMSKQLDMFKTnLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLasgKGFWSEMLGVGDFYYELGVQIIE 89
Cdd:pfam04157  19 ELLSSAFEDLEALMEKFKE-LVEFAEKHKKKIKKNPEFRAQFQSMCASLGVDPL---TFWWMSLLGVGDFYYELAVQIVE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953837   90 VCLALKHRNGGLITLEELHQQVLKGRGkfAQDVSQDDLIRAIKKL-KALGTGFGIIPVGgtYLIqsVPAELNMDHTVVLQ 168
Cdd:pfam04157  95 VCLATRDENGGLISLDDLYARVNRARG--VELISPDDLLRAIKLLeLVLGSRLRKFKSG--LLV--VQLELNTDQTEVAS 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 953953837  169 -LAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLD 208
Cdd:pfam04157 169 rLGGLGGYVTASELADNLGWSVARAKEVLEDLEREGLLWRD 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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