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Conserved domains on  [gi|953953841|ref|NP_001304124|]
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cadherin-3 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 8.70e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 8.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953953841 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 5.23e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 99.73  E-value: 5.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031    3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                         90
                 ....*....|....*....
gi 953953841 193 ASVEDPMNISIIVTDQNDH 211
Cdd:cd00031   80 NVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 8.23e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.23  E-value: 8.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304    2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 953953841 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304   76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 9.57e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 446 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953953841 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_pro super family cl07391
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-96 4.33e-03

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


The actual alignment was detected with superfamily member pfam08758:

Pssm-ID: 471661  Cd Length: 90  Bit Score: 36.92  E-value: 4.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 953953841   26 PCRAVFREAEVTLEAGgAEQEPGQALGKV-FMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIF 96
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVkFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSF 71
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 8.70e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 8.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953953841 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 5.23e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 99.73  E-value: 5.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031    3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                         90
                 ....*....|....*....
gi 953953841 193 ASVEDPMNISIIVTDQNDH 211
Cdd:cd00031   80 NVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 8.23e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.23  E-value: 8.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304    2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 953953841 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304   76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
220-319 1.33e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841  220 FRGSVLEGVLPGTSVMQVTATDEDDaiyTYNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQ 299
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGG----NFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 953953841  300 ATDMDGDGSTTTAVAVVEIL 319
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 238-326 3.11e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 3.11e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841   238 TATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQATDMDGDGSTTTAVAVVE 317
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDDG----LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 953953841   318 ILDANDNAP 326
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
333-432 9.13e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 9.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841  333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTITTHPesnqGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 953953841  412 NEAPFVLklpTSTATIVVHVE 432
Cdd:pfam00028  75 DSGGPPL---SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 9.57e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 446 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953953841 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
113-206 9.59e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 9.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841  113 PISVPENGK-GPFPQRLNQLKSNKDRDTKIFYSITGPGadspPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN 191
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 953953841  192 GASVEDPMNISIIVT 206
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-438 1.18e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.18e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841   350 TVTDLDAPNSpaWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLklpTSTATIVV 429
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL---SSTATVTI 71


                   ....*....
gi 953953841   430 HVEDVNEAP 438
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
446-527 2.59e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841  446 VVEVQEGIPTGEPVCVYTAEDPDKE-NQKISYRILRD-PAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76


                  ....
gi 953953841  524 GSPP 527
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 463-546 1.67e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841   463 TAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREDEQfvrnnIYEVMVLAMDNGSPPTTGTGTLLLTLID 540
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-----EYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 953953841   541 VNDHGP 546
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 136-213 2.30e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 2.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841   136 DRDT----KIFYSITGPGADsppeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDH 211
Cdd:smart00112   4 DADSgengKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 953953841   212 KP 213
Cdd:smart00112  80 AP 81
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-96 4.33e-03

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 36.92  E-value: 4.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 953953841   26 PCRAVFREAEVTLEAGgAEQEPGQALGKV-FMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIF 96
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVkFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSF 71
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 8.70e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 8.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953953841 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 5.23e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 99.73  E-value: 5.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031    3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                         90
                 ....*....|....*....
gi 953953841 193 ASVEDPMNISIIVTDQNDH 211
Cdd:cd00031   80 NVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 8.23e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.23  E-value: 8.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304    2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 953953841 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304   76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
220-319 1.33e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841  220 FRGSVLEGVLPGTSVMQVTATDEDDaiyTYNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQ 299
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGG----NFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 953953841  300 ATDMDGDGSTTTAVAVVEIL 319
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 238-326 3.11e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 3.11e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841   238 TATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQATDMDGDGSTTTAVAVVE 317
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDDG----LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 953953841   318 ILDANDNAP 326
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
333-432 9.13e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 9.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841  333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTITTHPesnqGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 953953841  412 NEAPFVLklpTSTATIVVHVE 432
Cdd:pfam00028  75 DSGGPPL---SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 9.57e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 446 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953953841 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
113-206 9.59e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 9.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841  113 PISVPENGK-GPFPQRLNQLKSNKDRDTKIFYSITGPGadspPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN 191
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 953953841  192 GASVEDPMNISIIVT 206
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-438 1.18e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.18e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841   350 TVTDLDAPNSpaWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLklpTSTATIVV 429
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL---SSTATVTI 71


                   ....*....
gi 953953841   430 HVEDVNEAP 438
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
446-527 2.59e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841  446 VVEVQEGIPTGEPVCVYTAEDPDKE-NQKISYRILRD-PAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76


                  ....
gi 953953841  524 GSPP 527
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 463-546 1.67e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841   463 TAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREDEQfvrnnIYEVMVLAMDNGSPPTTGTGTLLLTLID 540
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-----EYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 953953841   541 VNDHGP 546
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 136-213 2.30e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 2.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841   136 DRDT----KIFYSITGPGADsppeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDH 211
Cdd:smart00112   4 DADSgengKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 953953841   212 KP 213
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 114-211 3.71e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 3.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953841 114 ISVPENGkgPFPQRLNQLKSnKDRDT----KIFYSITGPgadsPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVS 189
Cdd:cd11304    4 VSVPENA--PPGTVVLTVSA-TDPDSgengEVTYSIVSG----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 953953841 190 ENGASVEDPMNISIIVTDQNDH 211
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-96 4.33e-03

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 36.92  E-value: 4.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 953953841   26 PCRAVFREAEVTLEAGgAEQEPGQALGKV-FMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIF 96
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVkFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSF 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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