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Conserved domains on  [gi|960513866|ref|NP_001304720|]
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THAP domain-containing protein 6 isoform 2 [Homo sapiens]

Protein Classification

THAP domain-containing protein( domain architecture ID 10659521)

THAP domain-containing protein may act as a DNA-binding transcription regulator

CATH:  3.30.40.180|2.40.128.20
Gene Ontology:  GO:0003700|GO:0046872|GO:0043565
PubMed:  20144952|12575992
SCOP:  4002822

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-90 7.86e-18

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 214951  Cd Length: 80  Bit Score: 73.62  E-value: 7.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960513866     4 CCSAIGCASRclpNSKLKGLTFHVFPT-DENIKRKWVLAMKRLDVNAagiWEPKKGDVLCSRHFKKTDFDRSapNIKLKP 82
Cdd:smart00980   1 KCCVPGCGNR---SKKNPGLSFFRFPKeDPELRKKWLENLGLPDDPN---RKPKKRSRICSRHFEPDDFDNS--GRRLKP 72


                   ....*...
gi 960513866    83 GVIPSIFD 90
Cdd:smart00980  73 GAVPTLFL 80
SCP-1 super family cl30946
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 90-164 1.46e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


The actual alignment was detected with superfamily member pfam05483:

Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 38.55  E-value: 1.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 960513866   90 DSPYHLQEHSYSVMDSPKKLKHKLDHVIGELEDTKESLRNVLDREKRFQKSLR---KTIRELKDECLISQETANRLDT 164
Cdd:pfam05483 268 DKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQiatKTICQLTEEKEAQMEELNKAKA 345
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-90 7.86e-18

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 73.62  E-value: 7.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960513866     4 CCSAIGCASRclpNSKLKGLTFHVFPT-DENIKRKWVLAMKRLDVNAagiWEPKKGDVLCSRHFKKTDFDRSapNIKLKP 82
Cdd:smart00980   1 KCCVPGCGNR---SKKNPGLSFFRFPKeDPELRKKWLENLGLPDDPN---RKPKKRSRICSRHFEPDDFDNS--GRRLKP 72


                   ....*...
gi 960513866    83 GVIPSIFD 90
Cdd:smart00980  73 GAVPTLFL 80
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-89 5.53e-17

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 71.41  E-value: 5.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960513866    5 CSAIGCASRclpNSKLKGLTFHVFPTDENIKRKWVLAMKRLDvnaagiWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGV 84
Cdd:pfam05485   1 CSVPGCTNR---KKKNPRTSFHKFPKDPERRKKWLNACKRKD------LPPPSNSYVCSLHFEENDFEKSGGKRKLKPGA 71


                  ....*
gi 960513866   85 IPSIF 89
Cdd:pfam05485  72 IPTLF 76
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 90-164 1.46e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 38.55  E-value: 1.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 960513866   90 DSPYHLQEHSYSVMDSPKKLKHKLDHVIGELEDTKESLRNVLDREKRFQKSLR---KTIRELKDECLISQETANRLDT 164
Cdd:pfam05483 268 DKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQiatKTICQLTEEKEAQMEELNKAKA 345
PLN02939 PLN02939
transferase, transferring glycosyl groups
 95-175 7.40e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 36.42  E-value: 7.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960513866  95 LQEHSYSVMDSPKKLKHKLDHVigelEDTKESLRnVLDREKRFQKSlrkTIRELKDECLISQETANRLDTFCWDCCQESI 174
Cdd:PLN02939 231 LKEENMLLKDDIQFLKAELIEV----AETEERVF-KLEKERSLLDA---SLRELESKFIVAQEDVSKLSPLQYDCWWEKV 302


                 .
gi 960513866 175 E 175
Cdd:PLN02939 303 E 303
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-90 7.86e-18

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 73.62  E-value: 7.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960513866     4 CCSAIGCASRclpNSKLKGLTFHVFPT-DENIKRKWVLAMKRLDVNAagiWEPKKGDVLCSRHFKKTDFDRSapNIKLKP 82
Cdd:smart00980   1 KCCVPGCGNR---SKKNPGLSFFRFPKeDPELRKKWLENLGLPDDPN---RKPKKRSRICSRHFEPDDFDNS--GRRLKP 72


                   ....*...
gi 960513866    83 GVIPSIFD 90
Cdd:smart00980  73 GAVPTLFL 80
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-89 5.53e-17

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 71.41  E-value: 5.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960513866    5 CSAIGCASRclpNSKLKGLTFHVFPTDENIKRKWVLAMKRLDvnaagiWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGV 84
Cdd:pfam05485   1 CSVPGCTNR---KKKNPRTSFHKFPKDPERRKKWLNACKRKD------LPPPSNSYVCSLHFEENDFEKSGGKRKLKPGA 71


                  ....*
gi 960513866   85 IPSIF 89
Cdd:pfam05485  72 IPTLF 76
DM3 smart00692
Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;
25-89 4.91e-05

Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;


Pssm-ID: 128933  Cd Length: 59  Bit Score: 39.60  E-value: 4.91e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 960513866    25 FHVFPTDENIKRKWVLAMkRLDVNAAGIWEPKkgdvLCSRHFKKTDFDRSApniKLKPGVIPSIF 89
Cdd:smart00692   1 LFRFPKDPELLKKWEHNL-RLSPDEKKLKNSR----ICSRHFEPECFGKRR---RLKPGAVPTLE 57
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 90-164 1.46e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 38.55  E-value: 1.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 960513866   90 DSPYHLQEHSYSVMDSPKKLKHKLDHVIGELEDTKESLRNVLDREKRFQKSLR---KTIRELKDECLISQETANRLDT 164
Cdd:pfam05483 268 DKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQiatKTICQLTEEKEAQMEELNKAKA 345
PLN02939 PLN02939
transferase, transferring glycosyl groups
 95-175 7.40e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 36.42  E-value: 7.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960513866  95 LQEHSYSVMDSPKKLKHKLDHVigelEDTKESLRnVLDREKRFQKSlrkTIRELKDECLISQETANRLDTFCWDCCQESI 174
Cdd:PLN02939 231 LKEENMLLKDDIQFLKAELIEV----AETEERVF-KLEKERSLLDA---SLRELESKFIVAQEDVSKLSPLQYDCWWEKV 302


                 .
gi 960513866 175 E 175
Cdd:PLN02939 303 E 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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