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Conserved domains on  [gi|961658099|ref|NP_001304853|]
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WD repeat-containing protein 19 isoform 2 [Homo sapiens]

Protein Classification

ATP-binding protein; NACHT and WD repeat domain-containing protein; WD40 and Coatomer_WDAD domain-containing protein; WD40 and RING_Ubox domain-containing protein; WD40 repeat domain-containing protein; protein kinase family protein; WD40 and WD40_3 domain-containing protein; WD40 repeat domain-containing protein; WD40 repeat domain-containing protein( domain architecture ID 11239800)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to Saccharomyces cerevisiae checkpoint protein RAD24 and Arabidopsis thaliana disease resistance protein RPS5; NACHT and WD repeat domain-containing protein; WD40 and Coatomer_WDAD domain-containing protein; WD40 and RING_Ubox domain-containing protein; WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; protein kinase family protein containing WD40 repeat(s), may catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine and/or tyrosine residues on protein substrates; WD40 and WD40_3 domain-containing protein; WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
348-404 4.59e-30

WD domain, G-beta repeat;


:

Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 4.59e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 961658099   348 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 404
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 622-840 1.23e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  622 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 696
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  697 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQ 763
Cdd:COG2956    93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  764 --------WQSVIRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 830
Cdd:COG2956   173 ldpdcaraLLLLAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                         250
                  ....*....|
gi 961658099  831 NKMEIYADII 840
Cdd:COG2956   246 DLLLALADLL 255
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-186 6.42e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 6.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961658099  114 HKDNLTSIAVSQTLNKVATCG-DNCIKIQDLVDLKDMYVilnLDEENKGLGTLSWTDDGQLLALSTQRGSLHVF 186
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSsDGTIKLWDLSTGKCLGT---LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
348-404 4.59e-30

WD domain, G-beta repeat;


Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 4.59e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 961658099   348 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 404
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 622-840 1.23e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  622 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 696
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  697 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQ 763
Cdd:COG2956    93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  764 --------WQSVIRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 830
Cdd:COG2956   173 ldpdcaraLLLLAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                         250
                  ....*....|
gi 961658099  831 NKMEIYADII 840
Cdd:COG2956   246 DLLLALADLL 255
CLH smart00299
Clathrin heavy chain repeat homology;
691-804 1.68e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 39.95  E-value: 1.68e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099    691 ENMKQFSEAAQLYekgLYYDKAASV-YIRSKNwakvgdllPHVSSPKIhlqYAKAKEADGrYKEAVVAYENAKQWQSVIR 769
Cdd:smart00299   39 ENPALQTKLIELY---AKYDPQKEIeRLDNKS--------NHYDIEKV---GKLCEKAKL-YEEAVELYKKDGNFKDAIV 103

                            90       100       110
                    ....*....|....*....|....*....|....*
gi 961658099    770 IYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQL 804
Cdd:smart00299  104 TLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-186 6.42e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 6.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961658099  114 HKDNLTSIAVSQTLNKVATCG-DNCIKIQDLVDLKDMYVilnLDEENKGLGTLSWTDDGQLLALSTQRGSLHVF 186
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSsDGTIKLWDLSTGKCLGT---LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
348-404 4.59e-30

WD domain, G-beta repeat;


Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 4.59e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 961658099   348 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 404
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 622-840 1.23e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  622 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 696
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  697 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQ 763
Cdd:COG2956    93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  764 --------WQSVIRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 830
Cdd:COG2956   173 ldpdcaraLLLLAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                         250
                  ....*....|
gi 961658099  831 NKMEIYADII 840
Cdd:COG2956   246 DLLLALADLL 255
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 550-763 8.36e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 8.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  550 LEQIKGIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIP-----FISKEYAIQ 624
Cdd:COG3914     8 ALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAAllllaALLELAALL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  625 LEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMsiRMGDIrrgvNQALKHPSRVLKRD---------CGAILENMKQ 695
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLL--ALGRL----EEALAALRRALALNpdfaeaylnLGEALRRLGR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961658099  696 FSEAAQLYEKGLyydkaasvyirsknwakvgDLLPHvsSPKIHLQYAKAKEADGRYKEAVVAYENAKQ 763
Cdd:COG3914   162 LEEAIAALRRAL-------------------ELDPD--NAEALNNLGNALQDLGRLEEAIAAYRRALE 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 513-761 1.81e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  513 NDEAAWNELARACLHHMEVEFAIRVYRRIgnvgivmsLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLY--LASSCP--IA 588
Cdd:COG2956    40 ETVEAHLALGNLYRRRGEYDRAIRIHQKL--------LERDPDRAEALLELAQDYLKAGLLDRAEELLekLLELDPddAE 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  589 ALEMRRDL----QHWDSALQLAKHLAP--DQIPFISKEYAIQLEFAGDYVNALAHYEKGITgDNKEHDEACLAgVAQMSI 662
Cdd:COG2956   112 ALRLLAEIyeqeGDWEKAIEVLERLLKlgPENAHAYCELAELYLEQGDYDEAIEALEKALK-LDPDCARALLL-LAELYL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  663 RMGDirrgVNQALKHPSRVLKRDcgaiLENMKQFSEAAQLYEKGLYYDKAASVYIRsknwakvgdLLPHVSSPKIHLQYA 742
Cdd:COG2956   190 EQGD----YEEAIAALERALEQD----PDYLPALPRLAELYEKLGDPEEALELLRK---------ALELDPSDDLLLALA 252

                         250
                  ....*....|....*....
gi 961658099  743 KAKEADGRYKEAVVAYENA 761
Cdd:COG2956   253 DLLERKEGLEAALALLERQ 271
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
687-761 2.93e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 43.72  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  687 GAILENMKQFSEAAQLYEK---GLYYD------KAASVYIRSKNWAKVGDLL-------PHVSSPKIHLQYAKAKEADGR 750
Cdd:COG4700    96 ADALLELGRYDEAIELYEEaltGIFADdphillGLAQALFELGRYAEALETLekliaknPDFKSSDAHLLYARALEALGD 175

                          90
                  ....*....|.
gi 961658099  751 YKEAVVAYENA 761
Cdd:COG4700   176 LEAAEAELEAL 186
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 620-763 3.43e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  620 EYAIQLEFAGDYVNALAHYEKGITgDNKEHDEAcLAGVAQMSIRMGDIRRGV---NQALK-HP-SRVLKRDCGAILENMK 694
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALE-LDPDNPEA-FALLGEILLQLGDLDEAIvllHEALElDPdEPEARLNLGLALLKAG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961658099  695 QFSEAAQLYEKGLYYDKaasvyirsknwakvgdllphvSSPKIHLQYAKAKEADGRYKEAVVAYENAKQ 763
Cdd:COG4783    87 DYDEALALLEKALKLDP---------------------EHPEAYLRLARAYRALGRPDEAIAALEKALE 134
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
672-770 4.14e-04

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 44.61  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  672 NQALKHpsrvLKRDCGAILENMKqFSEAAQLYEKGLYYDKaasvYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRY 751
Cdd:COG5290   881 ESALGH----LNEDLNVIREVMK-YICRHDLYDFLLLLYR----YDGELQKFKINIFAGNLVDNLYHISAAKAYEVEGKY 951

                          90
                  ....*....|....*....
gi 961658099  752 KEAVVAYENAKQWQSVIRI 770
Cdd:COG5290   952 IEAHGAYDSALMWRECGSI 970
CLH smart00299
Clathrin heavy chain repeat homology;
691-804 1.68e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 39.95  E-value: 1.68e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099    691 ENMKQFSEAAQLYekgLYYDKAASV-YIRSKNwakvgdllPHVSSPKIhlqYAKAKEADGrYKEAVVAYENAKQWQSVIR 769
Cdd:smart00299   39 ENPALQTKLIELY---AKYDPQKEIeRLDNKS--------NHYDIEKV---GKLCEKAKL-YEEAVELYKKDGNFKDAIV 103

                            90       100       110
                    ....*....|....*....|....*....|....*
gi 961658099    770 IYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQL 804
Cdd:smart00299  104 TLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
629-761 6.09e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 6.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658099  629 GDYVNALAHYEKGITGDNKEHDEACLAGVAQMsiRMGDIRrgvnQALKHPSRVLKRD---------CGAILENMKQFSEA 699
Cdd:COG0457    22 GRYEEAIEDYEKALELDPDDAEALYNLGLAYL--RLGRYE----EALADYEQALELDpddaealnnLGLALQALGRYEEA 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961658099  700 AQLYEKGLyydkaasvyirsknwakvgDLLPhvSSPKIHLQYAKAKEADGRYKEAVVAYENA 761
Cdd:COG0457    96 LEDYDKAL-------------------ELDP--DDAEALYNLGLALLELGRYDEAIEAYERA 136
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-186 6.42e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 6.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961658099  114 HKDNLTSIAVSQTLNKVATCG-DNCIKIQDLVDLKDMYVilnLDEENKGLGTLSWTDDGQLLALSTQRGSLHVF 186
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSsDGTIKLWDLSTGKCLGT---LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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