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Conserved domains on  [gi|970598256|ref|NP_001305123|]
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endonuclease III-like protein 1 isoform 3 [Homo sapiens]

Protein Classification

endonuclease III domain-containing protein( domain architecture ID 11415064)

endonuclease III domain-containing protein such as endonuclease III, a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

CATH:  1.10.1670.10
Gene Ontology:  GO:0016798|GO:0006284|GO:0051539
PubMed:  10908318|1411536
SCOP:  4001141

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-192 1.85e-66

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 202.25  E-value: 1.85e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  12 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 91
Cdd:COG0177   21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  92 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 171
Cdd:COG0177  101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                        170       180
                 ....*....|....*....|.
gi 970598256 172 CLPVHPRCHACLNQALCPAAQ 192
Cdd:COG0177  178 CKARKPKCEECPLADLCPYYG 198
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-192 1.85e-66

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 202.25  E-value: 1.85e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  12 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 91
Cdd:COG0177   21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  92 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 171
Cdd:COG0177  101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                        170       180
                 ....*....|....*....|.
gi 970598256 172 CLPVHPRCHACLNQALCPAAQ 192
Cdd:COG0177  178 CKARKPKCEECPLADLCPYYG 198
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 20-169 5.70e-52

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 163.59  E-value: 5.70e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256    20 LSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGV 99
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   100 GPKMAHLAMAVAWGTVsGIAVDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPRELWHEINGLLVGFGQ 169
Cdd:smart00478  81 GRKTANAVLSFALGKP-FIPVDTHVLRIAKRLGLVDK-KSTPEEVEKLLEKLLPEEDWRELNLLLIDFGR 148
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 12-168 8.09e-48

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 153.55  E-value: 8.09e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  12 YQVLLSLMLSSQTKDQVTAGAMQRLRAR-GLTVDSILQTDDATLGKLIYPVGFwRSKVKYIKQTSAILQQHYGGDI---P 87
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERyGPTPEALAAADEEELRELIRSLGY-RRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  88 ASVAELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPRELWHEINGLLVGF 167
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALG-PDAFPVDTHVRRVLKRLGLIPK-KKTPEELEELLEELLPKPYWGEANQALMDL 157


                 .
gi 970598256 168 G 168
Cdd:cd00056  158 G 158
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 12-179 2.09e-45

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 148.30  E-value: 2.09e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   12 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 91
Cdd:TIGR01083  28 FELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNKAKNIIELCRKLVERYGGEVPEDRE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   92 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 171
Cdd:TIGR01083 108 ELVKLPGVGRKTANVVLNVAFG-IPAIAVDTHVFRVSNRLGLSK--GKDPIKVEEDLMKLVPREFWVKLHHWLILHGRYT 184


                  ....*...
gi 970598256  172 CLPVHPRC 179
Cdd:TIGR01083 185 CKARKPLC 192
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 16-154 1.73e-43

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 142.04  E-value: 1.73e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   16 LSLMLSSQTKDQVTAGAMQRLRAR-GLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELV 94
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 970598256   95 A-LPGVGPKMAHLAMAVAWG-TVSGIAVDTHVHRIANRLRWTkKATKSPEETRAALEEWLPR 154
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrPDPLPVVDTHVRRVLKRLGLI-KEKPTPKEVERELEELWPP 141
PRK10702 PRK10702
endonuclease III; Provisional
 12-188 4.96e-25

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 96.62  E-value: 4.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  12 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 91
Cdd:PRK10702  30 FELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENVIKTCRILLEQHNGEVPEDRA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  92 ELVALPGVGPKMAHLAMAVAWGTVSgIAVDTHVHRIANRLRWTkkATKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 171
Cdd:PRK10702 110 ALEALPGVGRKTANVVLNTAFGWPT-IAVDTHIFRVCNRTQFA--PGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYT 186

                        170
                 ....*....|....*..
gi 970598256 172 CLPVHPRCHACLNQALC 188
Cdd:PRK10702 187 CIARKPRCGSCIIEDLC 203
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-192 1.85e-66

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 202.25  E-value: 1.85e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  12 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 91
Cdd:COG0177   21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  92 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 171
Cdd:COG0177  101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                        170       180
                 ....*....|....*....|.
gi 970598256 172 CLPVHPRCHACLNQALCPAAQ 192
Cdd:COG0177  178 CKARKPKCEECPLADLCPYYG 198
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 20-169 5.70e-52

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 163.59  E-value: 5.70e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256    20 LSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGV 99
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   100 GPKMAHLAMAVAWGTVsGIAVDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPRELWHEINGLLVGFGQ 169
Cdd:smart00478  81 GRKTANAVLSFALGKP-FIPVDTHVLRIAKRLGLVDK-KSTPEEVEKLLEKLLPEEDWRELNLLLIDFGR 148
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 12-168 8.09e-48

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 153.55  E-value: 8.09e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  12 YQVLLSLMLSSQTKDQVTAGAMQRLRAR-GLTVDSILQTDDATLGKLIYPVGFwRSKVKYIKQTSAILQQHYGGDI---P 87
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERyGPTPEALAAADEEELRELIRSLGY-RRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  88 ASVAELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPRELWHEINGLLVGF 167
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALG-PDAFPVDTHVRRVLKRLGLIPK-KKTPEELEELLEELLPKPYWGEANQALMDL 157


                 .
gi 970598256 168 G 168
Cdd:cd00056  158 G 158
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 12-179 2.09e-45

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 148.30  E-value: 2.09e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   12 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 91
Cdd:TIGR01083  28 FELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNKAKNIIELCRKLVERYGGEVPEDRE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   92 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 171
Cdd:TIGR01083 108 ELVKLPGVGRKTANVVLNVAFG-IPAIAVDTHVFRVSNRLGLSK--GKDPIKVEEDLMKLVPREFWVKLHHWLILHGRYT 184


                  ....*...
gi 970598256  172 CLPVHPRC 179
Cdd:TIGR01083 185 CKARKPLC 192
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 16-154 1.73e-43

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 142.04  E-value: 1.73e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   16 LSLMLSSQTKDQVTAGAMQRLRAR-GLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELV 94
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 970598256   95 A-LPGVGPKMAHLAMAVAWG-TVSGIAVDTHVHRIANRLRWTkKATKSPEETRAALEEWLPR 154
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrPDPLPVVDTHVRRVLKRLGLI-KEKPTPKEVERELEELWPP 141
PRK10702 PRK10702
endonuclease III; Provisional
 12-188 4.96e-25

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 96.62  E-value: 4.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  12 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 91
Cdd:PRK10702  30 FELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENVIKTCRILLEQHNGEVPEDRA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  92 ELVALPGVGPKMAHLAMAVAWGTVSgIAVDTHVHRIANRLRWTkkATKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 171
Cdd:PRK10702 110 ALEALPGVGRKTANVVLNTAFGWPT-IAVDTHIFRVCNRTQFA--PGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYT 186

                        170
                 ....*....|....*..
gi 970598256 172 CLPVHPRCHACLNQALC 188
Cdd:PRK10702 187 CIARKPRCGSCIIEDLC 203
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 32-192 2.66e-21

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 86.82  E-value: 2.66e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  32 AMQRLRARG-LTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDI------PASV--AELVALPGVGPK 102
Cdd:COG2231   50 AIANLKEAGlLDPEALAALDPEELAELIRPSGFYNQKAKRLKNLARWLVERYGGGLeklkalPTEElrEELLSLKGIGPE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256 103 mahlamavawgTVSGIA----------VDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPR--ELWHEINGLLVGFGQQ 170
Cdd:COG2231  130 -----------TADSILlyafnrpvfvVDAYTRRIFSRLGLIEE-DASYDELQRLFEENLPPdvALYNEFHALIVEHGKE 197

                        170       180
                 ....*....|....*....|..
gi 970598256 171 TCLPVhPRCHACLNQALCPAAQ 192
Cdd:COG2231  198 YCKKK-PKCEECPLRDLCPYGG 218
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 81-105 1.57e-07

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 45.87  E-value: 1.57e-07
                          10        20
                  ....*....|....*....|....*
gi 970598256   81 HYGGDIPASVAELVALPGVGPKMAH 105
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAE 25
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 171-191 1.91e-04

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 37.14  E-value: 1.91e-04
                           10        20
                   ....*....|....*....|.
gi 970598256   171 TCLPVHPRCHACLNQALCPAA 191
Cdd:smart00525   1 ICTARKPRCDECPLKDLCPAY 21
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 67-162 2.71e-04

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 40.66  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256   67 KVKYIKQTS----------AILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANR---LRW 133
Cdd:TIGR00588 186 RARYIRETAralleeqggrAWLQQIRGASYEDAREALCELPGVGPKVADCICLMGLDKPQAVPVDVHVWRIANRdypWHP 265

                          90       100
                  ....*....|....*....|....*....
gi 970598256  134 TKKATKSPEETRAALEEWLPRELWHEING 162
Cdd:TIGR00588 266 KTSRAKGPSPFARKELGNFFRSLWGPYAG 294
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 42-151 3.59e-04

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 39.87  E-value: 3.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  42 TVDSILQTDDATLGKLiypvGFWRSKVKYIKQTSAILQQH-------YGGDIPASVAELVALPGVGPKMAHLAMAVAWG- 113
Cdd:COG0122  129 TPEALAAASEEELRAC----GLSRRKARYLRALARAVADGeldlealAGLDDEEAIARLTALPGIGPWTAEMVLLFALGr 204

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 970598256 114 --TVSgiAVDTHVHRIANRLRWTKKATkSPEETRAALEEW 151
Cdd:COG0122  205 pdAFP--AGDLGLRRALGRLYGLGERP-TPKELRELAEPW 241
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 77-182 2.55e-03

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 37.81  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598256  77 ILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRwtkkatkspeetraALEEWLP--- 153
Cdd:COG1194   94 QVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFG-EPAPIVDGNVKRVLSRLF--------------AIEGPIGspa 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 970598256 154 --RELWHEINGLL----VG--------FGQQTCLPVHPRCHAC 182
Cdd:COG1194  159 akKELWALAEELLpperPGdfnqalmdLGATVCTPKKPKCLLC 201
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 88-104 9.36e-03

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 33.68  E-value: 9.36e-03
                         10
                 ....*....|....*..
gi 970598256  88 ASVAELVALPGVGPKMA 104
Cdd:COG1555   18 ATAEELQTLPGIGPKLA 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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