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Conserved domains on  [gi|970919379|ref|NP_001305181|]
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uncharacterized protein C7orf50 isoform a [Homo sapiens]

Protein Classification

WKF domain-containing protein( domain architecture ID 10562794)

WKF domain-containing protein similar to Homo sapiens protein C7orf50, a hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels

Gene Ontology:  GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WKF pfam10180
WKF domain; This is the C-terminal conserved region of a family of proteins found from fungi ...
 104-165 1.19e-26

WKF domain; This is the C-terminal conserved region of a family of proteins found from fungi to humans. The domain is named WKF after a conserved sequence motif. This domain has been shown to bind RNA. This domain was previously known as DUF2373.


:

Pssm-ID: 462982  Cd Length: 62  Bit Score: 96.43  E-value: 1.19e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 970919379  104 DYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEA 165
Cdd:pfam10180   1 EYLRQWYNDRSNWKFNKNKQNWLLKNAFDEEKIPEEYFDALLEYLAGLKGGARERLREEAKE 62
 
Name Accession Description Interval E-value
WKF pfam10180
WKF domain; This is the C-terminal conserved region of a family of proteins found from fungi ...
 104-165 1.19e-26

WKF domain; This is the C-terminal conserved region of a family of proteins found from fungi to humans. The domain is named WKF after a conserved sequence motif. This domain has been shown to bind RNA. This domain was previously known as DUF2373.


Pssm-ID: 462982  Cd Length: 62  Bit Score: 96.43  E-value: 1.19e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 970919379  104 DYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEA 165
Cdd:pfam10180   1 EYLRQWYNDRSNWKFNKNKQNWLLKNAFDEEKIPEEYFDALLEYLAGLKGGARERLREEAKE 62
 
Name Accession Description Interval E-value
WKF pfam10180
WKF domain; This is the C-terminal conserved region of a family of proteins found from fungi ...
 104-165 1.19e-26

WKF domain; This is the C-terminal conserved region of a family of proteins found from fungi to humans. The domain is named WKF after a conserved sequence motif. This domain has been shown to bind RNA. This domain was previously known as DUF2373.


Pssm-ID: 462982  Cd Length: 62  Bit Score: 96.43  E-value: 1.19e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 970919379  104 DYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEA 165
Cdd:pfam10180   1 EYLRQWYNDRSNWKFNKNKQNWLLKNAFDEEKIPEEYFDALLEYLAGLKGGARERLREEAKE 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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