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trafficking protein particle complex subunit 2-like protein isoform 4 [Homo sapiens]
longin-like domain-containing protein( domain architecture ID 1000061)
longin-like domain-containing protein; longin-like domains are small protein domains present in a variety of proteins and members of protein complexes involved in or required for different steps during the transport of proteins from the ribosome to the ER to the plasma membrane, via the Golgi apparatus
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
longin-like super family | cl38905 | Longin-like domains; Longin-like domains are small protein domains present in a variety of ... |
60-125 | 5.01e-37 | ||
Longin-like domains; Longin-like domains are small protein domains present in a variety of proteins and members of protein complexes involved in or required for different steps during the transport of proteins from the ribosome to the ER to the plasma membrane, via the Golgi apparatus. Examples are mu and sigma subunits of the heterotetrameric adaptor protein (AP) complex, zeta and delta subunits of the heterotetrameric F-COPI complex, a subgroup of R-SNARE proteins, a subfamily of the transport protein particle (TRAPP), and the signal recognition particle receptor subunit alpha (SR-alpha). The actual alignment was detected with superfamily member cd14854: Pssm-ID: 365781 Cd Length: 135 Bit Score: 122.70 E-value: 5.01e-37
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Name | Accession | Description | Interval | E-value | ||
TRAPPC2L | cd14854 | Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ... |
60-125 | 5.01e-37 | ||
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. Pssm-ID: 341444 Cd Length: 135 Bit Score: 122.70 E-value: 5.01e-37
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Sedlin_N | pfam04628 | Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ... |
54-127 | 8.50e-28 | ||
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region. Pssm-ID: 335859 Cd Length: 129 Bit Score: 98.87 E-value: 8.50e-28
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TRS20 | COG5603 | Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion]; |
62-124 | 1.61e-07 | ||
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion]; Pssm-ID: 227890 Cd Length: 136 Bit Score: 46.83 E-value: 1.61e-07
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Name | Accession | Description | Interval | E-value | ||
TRAPPC2L | cd14854 | Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ... |
60-125 | 5.01e-37 | ||
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. Pssm-ID: 341444 Cd Length: 135 Bit Score: 122.70 E-value: 5.01e-37
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Sedlin_N | pfam04628 | Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ... |
54-127 | 8.50e-28 | ||
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region. Pssm-ID: 335859 Cd Length: 129 Bit Score: 98.87 E-value: 8.50e-28
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TRAPPC_longin-like | cd14853 | Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ... |
60-124 | 2.02e-13 | ||
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. Pssm-ID: 341443 Cd Length: 132 Bit Score: 62.12 E-value: 2.02e-13
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TRAPPC2_sedlin | cd14825 | Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ... |
60-118 | 1.61e-10 | ||
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder. Pssm-ID: 341429 Cd Length: 135 Bit Score: 54.84 E-value: 1.61e-10
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TRS20 | COG5603 | Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion]; |
62-124 | 1.61e-07 | ||
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion]; Pssm-ID: 227890 Cd Length: 136 Bit Score: 46.83 E-value: 1.61e-07
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TRAPPC4_synbindin | cd14856 | Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ... |
68-124 | 2.73e-05 | ||
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. Pssm-ID: 341446 Cd Length: 127 Bit Score: 40.58 E-value: 2.73e-05
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Sybindin | pfam04099 | Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ... |
62-119 | 4.97e-05 | ||
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses. Pssm-ID: 282019 Cd Length: 134 Bit Score: 39.99 E-value: 4.97e-05
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TRAPPC1_MUM2 | cd14855 | Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ... |
62-121 | 1.27e-03 | ||
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. Pssm-ID: 341445 Cd Length: 132 Bit Score: 36.37 E-value: 1.27e-03
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