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Conserved domains on  [gi|972782074|ref|NP_001305459|]
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trafficking protein particle complex subunit 2-like protein isoform 8 [Homo sapiens]

Protein Classification

trafficking protein particle complex subunit 2-like protein( domain architecture ID 13000929)

trafficking protein particle complex subunit 2-like protein (TRAPPC2L) plays a role in vesicular transport from endoplasmic reticulum to Golgi

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 2-105 2.24e-57

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


:

Pssm-ID: 341444  Cd Length: 135  Bit Score: 173.16  E-value: 2.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074   2 VHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVM 81
Cdd:cd14854   32 AHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKFILVLEDTNTPLRDNDVRTLFRRLHNAYVDAV 110

                         90       100
                 ....*....|....*....|....
gi 972782074  82 CNPFYNPGDRIQSRAFDNMVTSMM 105
Cdd:cd14854  111 SNPFYPPGTPITSKKFDRRVDSLV 134
 
Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 2-105 2.24e-57

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 173.16  E-value: 2.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074   2 VHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVM 81
Cdd:cd14854   32 AHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKFILVLEDTNTPLRDNDVRTLFRRLHNAYVDAV 110

                         90       100
                 ....*....|....*....|....
gi 972782074  82 CNPFYNPGDRIQSRAFDNMVTSMM 105
Cdd:cd14854  111 SNPFYPPGTPITSKKFDRRVDSLV 134
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 1-107 3.40e-39

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 126.99  E-value: 3.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074    1 MVHTSLDVVDEKISAmgkalvdQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNtaLRDNEIRSMFRKLHNSYTDV 80
Cdd:pfam04628  32 IAHASLDIVDELQWK-------TNNMYLGTIDKFYKLSVSAYVTNSHIKFILVHESST--KSDENIKQFFQEVHELYVKT 102

                          90       100
                  ....*....|....*....|....*..
gi 972782074   81 MCNPFYNPGDRIQSRAFDNMVTSMMIQ 107
Cdd:pfam04628 103 LMNPFYKPNDPIRSPAFDKKVRKLAKK 129
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
1-104 3.78e-10

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 53.38  E-value: 3.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074   1 MVHTSLDVVDEKISAMGKAlvdqrelYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDV 80
Cdd:COG5603   39 IIHASLDIVVWLQWSVNTS-------YFDCLDSFGDLRISAYIMPSGMKFLFIHQNQS----RKNARSFLQEVHELYAKT 107

                         90       100
                 ....*....|....*....|....
gi 972782074  81 MCNPFYNPGDRIQSRAFDNMVTSM 104
Cdd:COG5603  108 LMSPFYEPDEPIRSQAFDDGVREA 131
 
Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 2-105 2.24e-57

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 173.16  E-value: 2.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074   2 VHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVM 81
Cdd:cd14854   32 AHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKFILVLEDTNTPLRDNDVRTLFRRLHNAYVDAV 110

                         90       100
                 ....*....|....*....|....
gi 972782074  82 CNPFYNPGDRIQSRAFDNMVTSMM 105
Cdd:cd14854  111 SNPFYPPGTPITSKKFDRRVDSLV 134
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 1-107 3.40e-39

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 126.99  E-value: 3.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074    1 MVHTSLDVVDEKISAmgkalvdQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNtaLRDNEIRSMFRKLHNSYTDV 80
Cdd:pfam04628  32 IAHASLDIVDELQWK-------TNNMYLGTIDKFYKLSVSAYVTNSHIKFILVHESST--KSDENIKQFFQEVHELYVKT 102

                          90       100
                  ....*....|....*....|....*..
gi 972782074   81 MCNPFYNPGDRIQSRAFDNMVTSMMIQ 107
Cdd:pfam04628 103 LMNPFYKPNDPIRSPAFDKKVRKLAKK 129
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 25-104 2.05e-17

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 71.75  E-value: 2.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074  25 ELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNeIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDNMVTSM 104
Cdd:cd14853   54 EKYLKLSDKTNEYKVHAYVTATGLKFVMLTDVLMDRIEDV-LKNFFSDLYVLYVKKNPNPFYEPNSPIRSRLFDSKVQSL 132
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 1-98 5.43e-15

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 65.63  E-value: 5.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074   1 MVHTSLDVVDEKISAMGKalvdqreLYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDV 80
Cdd:cd14825   38 IAHAALDLVDELQWTTNN-------MYLKSVDRFNEWSVSAFVTAGNIRFLLLHDNKN----DDGIKNFFQEVYELYVKI 106

                         90
                 ....*....|....*...
gi 972782074  81 MCNPFYNPGDRIQSRAFD 98
Cdd:cd14825  107 LMNPFYEPNTPIRSPAFD 124
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
1-104 3.78e-10

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 53.38  E-value: 3.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074   1 MVHTSLDVVDEKISAMGKAlvdqrelYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDV 80
Cdd:COG5603   39 IIHASLDIVVWLQWSVNTS-------YFDCLDSFGDLRISAYIMPSGMKFLFIHQNQS----RKNARSFLQEVHELYAKT 107

                         90       100
                 ....*....|....*....|....
gi 972782074  81 MCNPFYNPGDRIQSRAFDNMVTSM 104
Cdd:COG5603  108 LMSPFYEPDEPIRSQAFDDGVREA 131
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 30-99 1.23e-06

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 43.84  E-value: 1.23e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972782074   30 LLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDneirSMFRKLHNSYTD-VMCNPFYNPGDRIQSRAFDN 99
Cdd:pfam04099  59 ESLETDTFKLHCLETLTGIKFVLVTDPGTGINRD----SLLRKYYELYSDyVLKNPFYSLGMPIRCELFDE 125
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 34-104 2.97e-06

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 42.50  E-value: 2.97e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 972782074  34 TEDYKVYGYVTNSKVKFVMVVDSSNTALRdneirSMFRKLHNSYTD-VMCNPFYNPGDRIQSRAFDNMVTSM 104
Cdd:cd14856   61 TDTFRLHCFQTLTGIKFVLVADPKQPGLD-----ALLRRVYELYADyVLKNPFYELEMPIRCELFDENLQKL 127
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 32-101 1.15e-05

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 41.38  E-value: 1.15e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972782074  32 YPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDnEIRSMFRKLHNSYtdVMCNPFYNPGDRIQSRAFDNMV 101
Cdd:cd14855   63 YTTNKYKLHYYETPTGLKFVLLTDPNVGDLRD-VLQQIYSNIYVEY--VVKNPLYPPGEPITSELFRSKL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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