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Conserved domains on  [gi|974141082|ref|NP_001305794|]
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glycine N-methyltransferase isoform 2 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 37-156 9.69e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 74.67  E-value: 9.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  37 DTRSRTAEYKAWLLGLLRQHGCQ--RVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPAFDKWVIe 114
Cdd:COG2227    2 SDPDARDFWDRRLAALLARLLPAggRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA------RERAAELNVDFV- 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 974141082 115 EANWMTLDKdvpqsAEGGFDAVICLgNSFAHLPD------------CKGGLLVI 156
Cdd:COG2227   75 QGDLEDLPL-----EDGSFDLVICS-EVLEHLPDpaallrelarllKPGGLLLL 122
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 37-156 9.69e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 74.67  E-value: 9.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  37 DTRSRTAEYKAWLLGLLRQHGCQ--RVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPAFDKWVIe 114
Cdd:COG2227    2 SDPDARDFWDRRLAALLARLLPAggRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA------RERAAELNVDFV- 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 974141082 115 EANWMTLDKdvpqsAEGGFDAVICLgNSFAHLPD------------CKGGLLVI 156
Cdd:COG2227   75 QGDLEDLPL-----EDGSFDLVICS-EVLEHLPDpaallrelarllKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 61-148 2.47e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 61.81  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082   61 VLDVACGTGVDSIMLVEE-GFSVTSVDASDKMLKYAlkerwNRRHEPAFDKWVIEEANWMTLDKdvpqsAEGGFDAVICL 139
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERA-----RERAAEAGLNVEFVQGDAEDLPF-----PDGSFDLVVSS 70


                  ....*....
gi 974141082  140 GnSFAHLPD 148
Cdd:pfam13649  71 G-VLHHLPD 78
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 22-147 1.10e-09

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 57.15  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  22 YADGEAARVwQLYIGDTRSRT-AEYKAWLLGLLRQHGCqRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlKERW 100
Cdd:PRK07580  29 YSDAPVSKV-RATVRAGHQRMrDTVLSWLPADGDLTGL-RILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEA-RERA 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974141082 101 NRRHEPafdkwviEEANWMTLDKDvpqSAEGGFDAVICLgNSFAHLP 147
Cdd:PRK07580 106 PEAGLA-------GNITFEVGDLE---SLLGRFDTVVCL-DVLIHYP 141
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 60-156 8.55e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.05  E-value: 8.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  60 RVLDVACGTGVDSIMLVE-EGFSVTSVDASDKMLKYALKERWNRRHepafDKWVIEEANWMTLDKDVPQSaeggFDAVIC 138
Cdd:cd02440    1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLA----DNVEVLKGDAEELPPEADES----FDVIIS 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 974141082 139 lGNSFAHLPD-------------CKGGLLVI 156
Cdd:cd02440   73 -DPPLHHLVEdlarfleearrllKPGGVLVL 102
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 59-97 1.90e-03

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 38.78  E-value: 1.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 974141082   59 QRVLDVACGTGVDSIML---VEEGFSVTSVDASDKMLKYALK 97
Cdd:TIGR01934  41 QKVLDVACGTGDLAIELaksAPDRGKVTGVDFSSEMLEVAKK 82
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 37-156 9.69e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 74.67  E-value: 9.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  37 DTRSRTAEYKAWLLGLLRQHGCQ--RVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPAFDKWVIe 114
Cdd:COG2227    2 SDPDARDFWDRRLAALLARLLPAggRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA------RERAAELNVDFV- 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 974141082 115 EANWMTLDKdvpqsAEGGFDAVICLgNSFAHLPD------------CKGGLLVI 156
Cdd:COG2227   75 QGDLEDLPL-----EDGSFDLVICS-EVLEHLPDpaallrelarllKPGGLLLL 122
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 37-156 3.04e-14

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 68.10  E-value: 3.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  37 DTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlKERWNRRHEPAfdKWVIEEA 116
Cdd:COG2226    2 DRVAARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELA-RERAAEAGLNV--EFVVGDA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 974141082 117 NWMTLdkdvpqsAEGGFDAVICLgNSFAHLPDC------------KGGLLVI 156
Cdd:COG2226   79 EDLPF-------PDGSFDLVISS-FVLHHLPDPeralaeiarvlkPGGRLVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 61-148 2.47e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 61.81  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082   61 VLDVACGTGVDSIMLVEE-GFSVTSVDASDKMLKYAlkerwNRRHEPAFDKWVIEEANWMTLDKdvpqsAEGGFDAVICL 139
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERA-----RERAAEAGLNVEFVQGDAEDLPF-----PDGSFDLVVSS 70


                  ....*....
gi 974141082  140 GnSFAHLPD 148
Cdd:pfam13649  71 G-VLHHLPD 78
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 47-148 2.97e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 57.63  E-value: 2.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  47 AWLLGLLRQHGCQRVLDVACGTGVDSIMLVEE-GFSVTSVDASDKMLKYAlkERWNRRHEPAfDKWVIEEANWMTLDkdv 125
Cdd:COG2230   41 DLILRKLGLKPGMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYA--RERAAEAGLA-DRVEVRLADYRDLP--- 114

                         90       100
                 ....*....|....*....|...
gi 974141082 126 pqsAEGGFDAVICLGnSFAHLPD 148
Cdd:COG2230  115 ---ADGQFDAIVSIG-MFEHVGP 133
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
20-162 3.26e-10

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 58.09  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  20 DQYADgeaarVWQLYIGDTR--SRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlK 97
Cdd:COG4976   12 DQYAD-----SYDAALVEDLgyEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKA-R 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 974141082  98 ERwnrrhePAFDKWVIEEANwmtldkDVPQSaEGGFDAVICLGnSFAHLPD------------CKGGLLVIDHRNYD 162
Cdd:COG4976   86 EK------GVYDRLLVADLA------DLAEP-DGRFDLIVAAD-VLTYLGDlaavfagvaralKPGGLFIFSVEDAD 148
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 22-147 1.10e-09

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 57.15  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  22 YADGEAARVwQLYIGDTRSRT-AEYKAWLLGLLRQHGCqRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlKERW 100
Cdd:PRK07580  29 YSDAPVSKV-RATVRAGHQRMrDTVLSWLPADGDLTGL-RILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEA-RERA 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974141082 101 NRRHEPafdkwviEEANWMTLDKDvpqSAEGGFDAVICLgNSFAHLP 147
Cdd:PRK07580 106 PEAGLA-------GNITFEVGDLE---SLLGRFDTVVCL-DVLIHYP 141
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 60-156 8.55e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.05  E-value: 8.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  60 RVLDVACGTGVDSIMLVE-EGFSVTSVDASDKMLKYALKERWNRRHepafDKWVIEEANWMTLDKDVPQSaeggFDAVIC 138
Cdd:cd02440    1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLA----DNVEVLKGDAEELPPEADES----FDVIIS 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 974141082 139 lGNSFAHLPD-------------CKGGLLVI 156
Cdd:cd02440   73 -DPPLHHLVEdlarfleearrllKPGGVLVL 102
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
60-158 2.11e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.98  E-value: 2.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  60 RVLDVACGTGVDSIMLVEE--GFSVTSVDASDKMLKYAlkerwnRRHEPAFDkwvIEEANWMTLDkdvpqsAEGGFDAVI 137
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARA------RARLPNVR---FVVADLRDLD------PPEPFDLVV 68

                         90       100       110
                 ....*....|....*....|....*....|...
gi 974141082 138 ClGNSFAHLPDCK------------GGLLVIDH 158
Cdd:COG4106   69 S-NAALHWLPDHAallarlaaalapGGVLAVQV 100
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 62-156 2.39e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 47.66  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082   62 LDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwNRRHEPAFDKWVIEEANWMTLdkdvpqsAEGGFDAVICLgN 141
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELA-----REKAPREGLTFVVGDAEDLPF-------PDNSFDLVLSS-E 67

                          90       100
                  ....*....|....*....|....*..
gi 974141082  142 SFAHLPD------------CKGGLLVI 156
Cdd:pfam08241  68 VLHHVEDperalreiarvlKPGGILII 94
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 60-156 2.79e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.26  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082   60 RVLDVACGTGVDSIMLVEEGFS---VTSVDASDKMLKYALKERwnRRHEpaFDKWVIEEANWMTLDKDVpqsAEGGFDAV 136
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELGPnaeVVGIDISEEAIEKARENA--QKLG--FDNVEFEQGDIEELPELL---EDDKFDVV 78

                          90       100
                  ....*....|....*....|
gi 974141082  137 ICLGnSFAHLPDCKGGLLVI 156
Cdd:pfam13847  79 ISNC-VLNHIPDPDKVLQEI 97
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 62-148 4.15e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.28  E-value: 4.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082   62 LDVACGTGVDSIMLVEE--GFSVTSVDASDKMLKYALKErwnrrhepaFDKWVIEEANWMTLDK-DVPQSAEGGFDAVIC 138
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARER---------LAALGLLNAVRVELFQlDLGELDPGSFDVVVA 71

                          90
                  ....*....|
gi 974141082  139 LgNSFAHLPD 148
Cdd:pfam08242  72 S-NVLHHLAD 80
PRK08317 PRK08317
hypothetical protein; Provisional
 43-148 7.16e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 46.08  E-value: 7.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  43 AEYKAWLLGLLRQHGCQRVLDVACGTGVDSIML---VEEGFSVTSVDASDKMLKYAlKERwnrrhepafdkwVIEEANWM 119
Cdd:PRK08317   5 RRYRARTFELLAVQPGDRVLDVGCGPGNDARELarrVGPEGRVVGIDRSEAMLALA-KER------------AAGLGPNV 71

                         90       100       110
                 ....*....|....*....|....*....|..
gi 974141082 120 TLDKDVPQS---AEGGFDAVICLgNSFAHLPD 148
Cdd:PRK08317  72 EFVRGDADGlpfPDGSFDAVRSD-RVLQHLED 102
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 34-180 9.29e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 44.73  E-value: 9.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082   34 YIGDTRSRTAEYKAWLLGLLRQHGcqRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMlkyalkerwnrrHEPAFDKWVI 113
Cdd:pfam13489   1 YAHQRERLLADLLLRLLPKLPSPG--RVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIA------------IERALLNVRF 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  114 EEAnwmtlDKDVPQSAEGGFDAVIC-------------LGNSFAHLPDckGGLLVI-DHRNYDHILS-----TGCAPPGK 174
Cdd:pfam13489  67 DQF-----DEQEAAVPAGKFDVIVArevlehvpdppalLRQIAALLKP--GGLLLLsTPLASDEADRlllewPYLRPRNG 139


                  ....*.
gi 974141082  175 NIYYKS 180
Cdd:pfam13489 140 HISLFS 145
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 44-166 2.90e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 43.75  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  44 EYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEE-GFSVTSVDASDKMLKYAlkerwNRRHEPAFdkwvIEEANWMTLD 122
Cdd:COG0500   13 GLAALLALLERLPKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALA-----RARAAKAG----LGNVEFLVAD 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 974141082 123 -KDVPQSAEGGFDAVICLGnSFAHLPDC--------------KGGLLVIDHRNYDHILS 166
Cdd:COG0500   84 lAELDPLPAESFDLVVAFG-VLHHLPPEereallrelaralkPGGVLLLSASDAAAALS 141
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 59-116 1.14e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.45  E-value: 1.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974141082  59 QRVLDVACGTGVDSIMLVEEG---FSVTSVDASDKMLKYAlKERWNRRHEPAFDKWVIEEA 116
Cdd:PRK00216  53 DKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAVG-REKLRDLGLSGNVEFVQGDA 112
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 49-107 7.83e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 40.13  E-value: 7.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 974141082  49 LLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPA 107
Cdd:PRK10258  34 LLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQA------RQKDAA 86
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 59-97 1.90e-03

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 38.78  E-value: 1.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 974141082   59 QRVLDVACGTGVDSIML---VEEGFSVTSVDASDKMLKYALK 97
Cdd:TIGR01934  41 QKVLDVACGTGDLAIELaksAPDRGKVTGVDFSSEMLEVAKK 82
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 39-138 6.37e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 37.44  E-value: 6.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  39 RSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEE--GFSVTSVDASDKMLKYAlkeRWNRRHEPAFDKWVIEEA 116
Cdd:COG2890   94 RPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKErpDARVTAVDISPDALAVA---RRNAERLGLEDRVRFLQG 170

                         90       100
                 ....*....|....*....|..
gi 974141082 117 NWMTldkdvPQSAEGGFDAVIC 138
Cdd:COG2890  171 DLFE-----PLPGDGRFDLIVS 187
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 48-163 9.40e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 36.68  E-value: 9.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141082  48 WLLGLLRQHGCQRVLDVACGTGVDSIMLVEE--GFSVTSVDASDKMLKYALKerwNRRHEPA------------------ 107
Cdd:PRK09328  99 WALEALLLKEPLRVLDLGTGSGAIALALAKErpDAEVTAVDISPEALAVARR---NAKHGLGarveflqgdwfeplpggr 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974141082 108 FDKWV-----IEEANWMTLDKDV----PQSA----EGGFDAV--IClGNSFAHLpdCKGGLLVIDHrNYDH 163
Cdd:PRK09328 176 FDLIVsnppyIPEADIHLLQPEVrdhePHLAlfggEDGLDFYrrII-EQAPRYL--KPGGWLLLEI-GYDQ 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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