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Conserved domains on  [gi|994317251|ref|NP_001307128|]
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histidine protein methyltransferase 1 homolog [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1904217)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnt1 super family cl43977
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 186-322 3.65e-09

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3897:

Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 56.43  E-value: 3.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 994317251 186 FAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLpNVVANS-TLEDEENDVNEPDVKRcrkpkvtqlykcr 264
Cdd:COG3897   69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRL-NAALNGvAITTRLGDWRDPPAAG------------- 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 994317251 265 ffsgewsefcklvlsseklfvKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLA 322
Cdd:COG3897  135 ---------------------GFDLILGGDVLYERDLAEPLLPFLDRLAAPGGEVLIG 171
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 186-322 3.65e-09

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 56.43  E-value: 3.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 994317251 186 FAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLpNVVANS-TLEDEENDVNEPDVKRcrkpkvtqlykcr 264
Cdd:COG3897   69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRL-NAALNGvAITTRLGDWRDPPAAG------------- 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 994317251 265 ffsgewsefcklvlsseklfvKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLA 322
Cdd:COG3897  135 ---------------------GFDLILGGDVLYERDLAEPLLPFLDRLAAPGGEVLIG 171
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 165-324 2.84e-07

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 50.02  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 994317251  165 GLKIWECTFDLLAYFTKA------KVKFAGKKVLDLGCGSGLLGITAfkggskEIHFQDYNSMVID-EVTLPNVVANSTL 237
Cdd:pfam10294  18 GGHVWDAAVVLSKYLEMKifkelgANNLSGLNVLELGSGTGLVGIAV------ALLLPGASVTITDlEEALELLKKNIEL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 994317251  238 EDEENDVnepdvkrcrkpKVTQLykcrffsgEWSEfcKLvlsSEKLFVK--YDLILTSETIYNPDYYSNLHQTFLRLLSK 315
Cdd:pfam10294  92 NALSSKV-----------VVKVL--------DWGE--NL---PPDLFDGhpVDLILAADCVYNEDSFPLLEKTLKDLLGK 147


                  ....*....
gi 994317251  316 NGRVLLASK 324
Cdd:pfam10294 148 ESVILVAYK 156
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
182-246 2.32e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 45.14  E-value: 2.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 994317251 182 AKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDynsmvIDEVTLPNVVANStledEENDVNE 246
Cdd:PRK00517 114 EKLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD-----IDPQAVEAARENA----ELNGVEL 169
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 188-244 8.79e-05

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 43.67  E-value: 8.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 994317251  188 GKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDE---------VTLPNVVANSTLED---EENDV 244
Cdd:TIGR00406 160 DKNVIDVGCGSGILSIAALKLGAAKVVGIDIDPLAVESarknaelnqVSDRLQVKLIYLEQpieGKADV 228
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 186-322 3.65e-09

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 56.43  E-value: 3.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 994317251 186 FAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLpNVVANS-TLEDEENDVNEPDVKRcrkpkvtqlykcr 264
Cdd:COG3897   69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRL-NAALNGvAITTRLGDWRDPPAAG------------- 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 994317251 265 ffsgewsefcklvlsseklfvKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLA 322
Cdd:COG3897  135 ---------------------GFDLILGGDVLYERDLAEPLLPFLDRLAAPGGEVLIG 171
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 165-324 2.84e-07

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 50.02  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 994317251  165 GLKIWECTFDLLAYFTKA------KVKFAGKKVLDLGCGSGLLGITAfkggskEIHFQDYNSMVID-EVTLPNVVANSTL 237
Cdd:pfam10294  18 GGHVWDAAVVLSKYLEMKifkelgANNLSGLNVLELGSGTGLVGIAV------ALLLPGASVTITDlEEALELLKKNIEL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 994317251  238 EDEENDVnepdvkrcrkpKVTQLykcrffsgEWSEfcKLvlsSEKLFVK--YDLILTSETIYNPDYYSNLHQTFLRLLSK 315
Cdd:pfam10294  92 NALSSKV-----------VVKVL--------DWGE--NL---PPDLFDGhpVDLILAADCVYNEDSFPLLEKTLKDLLGK 147


                  ....*....
gi 994317251  316 NGRVLLASK 324
Cdd:pfam10294 148 ESVILVAYK 156
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
182-246 1.40e-05

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 46.32  E-value: 1.40e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 994317251 182 AKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDynsmvIDEVTLPNVVANSTLedeeNDVNE 246
Cdd:COG2264  143 EKLLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVD-----IDPVAVEAARENAEL----NGVED 198
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
182-246 2.32e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 45.14  E-value: 2.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 994317251 182 AKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDynsmvIDEVTLPNVVANStledEENDVNE 246
Cdd:PRK00517 114 EKLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD-----IDPQAVEAARENA----ELNGVEL 169
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 187-246 7.12e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 44.18  E-value: 7.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 994317251  187 AGKKVLDLGCGSGLLGITAFKGGSKEIHFQDynsmvIDEVTLpnvvaNSTLED-EENDVNE 246
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVD-----IDPVAV-----RAAKENaELNGVEA 211
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 188-244 8.79e-05

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 43.67  E-value: 8.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 994317251  188 GKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDE---------VTLPNVVANSTLED---EENDV 244
Cdd:TIGR00406 160 DKNVIDVGCGSGILSIAALKLGAAKVVGIDIDPLAVESarknaelnqVSDRLQVKLIYLEQpieGKADV 228
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 175-203 6.49e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.90  E-value: 6.49e-04
                         10        20
                 ....*....|....*....|....*....
gi 994317251 175 LLAYFTKAKvkfAGKKVLDLGCGSGLLGI 203
Cdd:COG4123   28 LLAAFAPVK---KGGRVLDLGTGTGVIAL 53
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
186-245 2.55e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 38.73  E-value: 2.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 994317251 186 FAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDynsmvIDEVTLpnVVANSTLEDEENDVN 245
Cdd:COG2263   44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVD-----IDPEAL--EIARENAERLGVRVD 96
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 187-224 5.26e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 37.48  E-value: 5.26e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 994317251 187 AGKKVLDLGCGSGLLGIT-AFKGGSKEIHFQDYNSMVID 224
Cdd:COG2813   49 LGGRVLDLGCGYGVIGLAlAKRNPEARVTLVDVNARAVE 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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