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Conserved domains on  [gi|998429253|ref|NP_001307236|]
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U3 small nucleolar ribonucleoprotein protein IMP4 isoform d [Homo sapiens]

Protein Classification

Brix domain-containing protein( domain architecture ID 10657983)

Brix domain-containing protein similar to Homo sapiens ribosome production factor 1 and U3 small nucleolar ribonucleoprotein protein IMP4

CATH:  3.40.50.10480
Gene Ontology:  GO:0019843|GO:0006364
PubMed:  11406393
SCOP:  4004748

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Brix smart00879
The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from ...
31-198 5.52e-57

The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from yeast and humans, Arabidopsis thaliana Peter Pan-like protein and several hypothetical proteins.


:

Pssm-ID: 214879 [Multi-domain]  Cd Length: 180  Bit Score: 179.08  E-value: 5.52e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253    31 MITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEH--RGTPVGLIVSHLPFGPTAYFT 108
Cdd:smart00879   1 LITTSRKPSKRTRQLAKDLRRLFPPSTKINRGKNKLNELLEFASEKGNTDLLVVFESssKGRPLNLTIYRLPNGPTLDFK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253   109 LCNVVMRHDIPD---LGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDD------SHRVITFANQDDYISFRHHVY 179
Cdd:smart00879  81 ILNVSLRKELKGfktGNCLTGSRPLLIFNNFFTELGKLIKELFQDLFPGPPEHkkslpgLRRVVTFSNQDDYIFFRHYRI 160
                          170       180
                   ....*....|....*....|
gi 998429253   180 K-KTDHRNVELTEVGPRFEL 198
Cdd:smart00879 161 KfGKKKPRVELQEIGPRFTL 180
 
Name Accession Description Interval E-value
Brix smart00879
The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from ...
31-198 5.52e-57

The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from yeast and humans, Arabidopsis thaliana Peter Pan-like protein and several hypothetical proteins.


Pssm-ID: 214879 [Multi-domain]  Cd Length: 180  Bit Score: 179.08  E-value: 5.52e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253    31 MITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEH--RGTPVGLIVSHLPFGPTAYFT 108
Cdd:smart00879   1 LITTSRKPSKRTRQLAKDLRRLFPPSTKINRGKNKLNELLEFASEKGNTDLLVVFESssKGRPLNLTIYRLPNGPTLDFK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253   109 LCNVVMRHDIPD---LGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDD------SHRVITFANQDDYISFRHHVY 179
Cdd:smart00879  81 ILNVSLRKELKGfktGNCLTGSRPLLIFNNFFTELGKLIKELFQDLFPGPPEHkkslpgLRRVVTFSNQDDYIFFRHYRI 160
                          170       180
                   ....*....|....*....|
gi 998429253   180 K-KTDHRNVELTEVGPRFEL 198
Cdd:smart00879 161 KfGKKKPRVELQEIGPRFTL 180
Brix pfam04427
Brix domain;
35-201 5.94e-26

Brix domain;


Pssm-ID: 461304 [Multi-domain]  Cd Length: 180  Bit Score: 99.58  E-value: 5.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253   35 SRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVgalvracKANGVTDLLVVHEHRgtPVGLIVSHL-----PFGPTAYFTL 109
Cdd:pfam04427   1 GRKTSSRLRQLLKDLRSLMKPHTASFLKRNSN-------PLEDVTHLEFLSEKN--DCSLFVFGShskkrPNGPTLEFGV 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253  110 CNVVMRHDIPD-LGTMSEAKPHLITHG--FSSRLGKRVSDILRYLFPVPKDDSH---RVITFA---NQDDYISFRHHVYK 180
Cdd:pfam04427  72 ENYSLMKDLKGtGNCLKGSRPLLVFNGsfFSDPNFKLLKSLFQDLFRVPPINLKgidRVILFSaydNQPDKIWFRHYQIR 151
                         170       180
                  ....*....|....*....|....*...
gi 998429253  181 KTDHRN-------VELTEVGPRFELKLY 201
Cdd:pfam04427 152 LKEKKKsgtklprVELVEIGPRFDLKLR 179
IMP4 COG2136
rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain [Translation, ...
32-199 1.85e-11

rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain [Translation, ribosomal structure and biogenesis]; rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 441739  Cd Length: 173  Bit Score: 60.78  E-value: 1.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253  32 ITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPvGLIVSHLPFG---PTAYFT 108
Cdd:COG2136    2 ITTSRKPSQRTRSFCKDLSRVLPNSVYVNRGKKSLRDLLEEALELGADRLVIIGERKGNP-GRLRFYDVEGnelLSIGLI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253 109 LCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLG-KRVSDILRYLFPVPKD-DSHRVITFANQDD----YISFrhhvYKKT 182
Cdd:COG2136   81 LIGVKLSREIPGNVRIYNASSLVVKASEPVVSGaGELADLLSELLGFEAIeSSYDVIVLIRGDEkgifEIEF----LKSD 156
                        170
                 ....*....|....*..
gi 998429253 183 DHRnvelteVGPRFELK 199
Cdd:COG2136  157 GGP------VGPLLRIK 167
PRK03972 PRK03972
ribosomal biogenesis protein; Validated
31-133 3.20e-05

ribosomal biogenesis protein; Validated


Pssm-ID: 179689  Cd Length: 208  Bit Score: 43.36  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253  31 MITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLI---VSHLPFGPTAYF 107
Cdd:PRK03972   3 LITTSHRPTRRTRSFGHDLERVFPNSLYLTRGKKTIQDLLMEAYDRGYERLLIINVWKGNPLKMTfikVGPEDWGYLGYL 82
                         90       100
                 ....*....|....*....|....*...
gi 998429253 108 TLCNVVMRHDIP--DLGTMSEAKPHLIT 133
Cdd:PRK03972  83 YLHGIKLQREMGfrNLRPIREDMPLVIT 110
 
Name Accession Description Interval E-value
Brix smart00879
The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from ...
31-198 5.52e-57

The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from yeast and humans, Arabidopsis thaliana Peter Pan-like protein and several hypothetical proteins.


Pssm-ID: 214879 [Multi-domain]  Cd Length: 180  Bit Score: 179.08  E-value: 5.52e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253    31 MITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEH--RGTPVGLIVSHLPFGPTAYFT 108
Cdd:smart00879   1 LITTSRKPSKRTRQLAKDLRRLFPPSTKINRGKNKLNELLEFASEKGNTDLLVVFESssKGRPLNLTIYRLPNGPTLDFK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253   109 LCNVVMRHDIPD---LGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDD------SHRVITFANQDDYISFRHHVY 179
Cdd:smart00879  81 ILNVSLRKELKGfktGNCLTGSRPLLIFNNFFTELGKLIKELFQDLFPGPPEHkkslpgLRRVVTFSNQDDYIFFRHYRI 160
                          170       180
                   ....*....|....*....|
gi 998429253   180 K-KTDHRNVELTEVGPRFEL 198
Cdd:smart00879 161 KfGKKKPRVELQEIGPRFTL 180
Brix pfam04427
Brix domain;
35-201 5.94e-26

Brix domain;


Pssm-ID: 461304 [Multi-domain]  Cd Length: 180  Bit Score: 99.58  E-value: 5.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253   35 SRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVgalvracKANGVTDLLVVHEHRgtPVGLIVSHL-----PFGPTAYFTL 109
Cdd:pfam04427   1 GRKTSSRLRQLLKDLRSLMKPHTASFLKRNSN-------PLEDVTHLEFLSEKN--DCSLFVFGShskkrPNGPTLEFGV 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253  110 CNVVMRHDIPD-LGTMSEAKPHLITHG--FSSRLGKRVSDILRYLFPVPKDDSH---RVITFA---NQDDYISFRHHVYK 180
Cdd:pfam04427  72 ENYSLMKDLKGtGNCLKGSRPLLVFNGsfFSDPNFKLLKSLFQDLFRVPPINLKgidRVILFSaydNQPDKIWFRHYQIR 151
                         170       180
                  ....*....|....*....|....*...
gi 998429253  181 KTDHRN-------VELTEVGPRFELKLY 201
Cdd:pfam04427 152 LKEKKKsgtklprVELVEIGPRFDLKLR 179
IMP4 COG2136
rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain [Translation, ...
32-199 1.85e-11

rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain [Translation, ribosomal structure and biogenesis]; rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 441739  Cd Length: 173  Bit Score: 60.78  E-value: 1.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253  32 ITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPvGLIVSHLPFG---PTAYFT 108
Cdd:COG2136    2 ITTSRKPSQRTRSFCKDLSRVLPNSVYVNRGKKSLRDLLEEALELGADRLVIIGERKGNP-GRLRFYDVEGnelLSIGLI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253 109 LCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLG-KRVSDILRYLFPVPKD-DSHRVITFANQDD----YISFrhhvYKKT 182
Cdd:COG2136   81 LIGVKLSREIPGNVRIYNASSLVVKASEPVVSGaGELADLLSELLGFEAIeSSYDVIVLIRGDEkgifEIEF----LKSD 156
                        170
                 ....*....|....*..
gi 998429253 183 DHRnvelteVGPRFELK 199
Cdd:COG2136  157 GGP------VGPLLRIK 167
PRK03972 PRK03972
ribosomal biogenesis protein; Validated
31-133 3.20e-05

ribosomal biogenesis protein; Validated


Pssm-ID: 179689  Cd Length: 208  Bit Score: 43.36  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253  31 MITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLI---VSHLPFGPTAYF 107
Cdd:PRK03972   3 LITTSHRPTRRTRSFGHDLERVFPNSLYLTRGKKTIQDLLMEAYDRGYERLLIINVWKGNPLKMTfikVGPEDWGYLGYL 82
                         90       100
                 ....*....|....*....|....*...
gi 998429253 108 TLCNVVMRHDIP--DLGTMSEAKPHLIT 133
Cdd:PRK03972  83 YLHGIKLQREMGfrNLRPIREDMPLVIT 110
PRK00933 PRK00933
ribosomal biogenesis protein; Validated
30-91 5.04e-05

ribosomal biogenesis protein; Validated


Pssm-ID: 234867  Cd Length: 165  Bit Score: 42.35  E-value: 5.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 998429253  30 VMITTSRDPSSRLKMFAKELKLVFpGAQRMNRGRHEVGALVRACKANgvtDLLVVHEHRGTP 91
Cdd:PRK00933   1 MIITTSRKPSQRTRSLVKDLARFL-NCKYVNRGKMSLQELLEECEAR---YLLIIGEYKGNP 58
BRX1 COG5154
RNA-binding protein required for 60S ribosomal subunit biogenesis [Translation, ribosomal ...
29-209 2.43e-03

RNA-binding protein required for 60S ribosomal subunit biogenesis [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227483  Cd Length: 283  Bit Score: 38.45  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253  29 KVMITTSRDPSSRLKMFAKELKLVFPGA---QRMNRGRhEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTA 105
Cdd:COG5154   32 TSLILSSRGVSYRIRHLMKDLSRLVPHSkkeQKLDMKK-NLGQLNELAELYNCNNMLFFESRKRSDLYLMGARIPNGPTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998429253 106 YFTLCNVvmrHDIPDLG----TMSEAKPHLIthgFSSRLG-----KRVSDILRYLFPVPKDDSH------RVITFANQDD 170
Cdd:COG5154  111 KFRMHNL---HTMDELNftgnSLKGSRPVLS---FDKEFEdiphlKYAKELLEHIFGIPKGARRskpfidKVLCFFILDG 184
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 998429253 171 YISFRHHVYKKTDH---RNVELTEVGPRFELKLYMIRLGTLE 209
Cdd:COG5154  185 KIWVRCYEIGRENEdksKDVKLEEIGPRFVMTVIKILEGSFG 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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