PEST proteolytic signal-containing nuclear protein isoform f [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| PCNP super family | cl21289 | PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear ... |
22-93 | 4.63e-14 | ||
PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation. The actual alignment was detected with superfamily member pfam15473: Pssm-ID: 464736 Cd Length: 155 Bit Score: 63.72 E-value: 4.63e-14
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| Name | Accession | Description | Interval | E-value | ||
| PCNP | pfam15473 | PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear ... |
22-93 | 4.63e-14 | ||
PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation. Pssm-ID: 464736 Cd Length: 155 Bit Score: 63.72 E-value: 4.63e-14
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| Name | Accession | Description | Interval | E-value | ||
| PCNP | pfam15473 | PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear ... |
22-93 | 4.63e-14 | ||
PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation. Pssm-ID: 464736 Cd Length: 155 Bit Score: 63.72 E-value: 4.63e-14
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