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large neutral amino acids transporter small subunit 4 isoform 1 [Homo sapiens]
FucP superfamily protein( domain architecture ID 1905563)
FucP superfamily protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
FucP super family | cl43255 | Fucose permease [Carbohydrate transport and metabolism]; |
87-239 | 3.87e-05 | |||
Fucose permease [Carbohydrate transport and metabolism]; The actual alignment was detected with superfamily member COG0738: Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 3.87e-05
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Name | Accession | Description | Interval | E-value | |||
FucP | COG0738 | Fucose permease [Carbohydrate transport and metabolism]; |
87-239 | 3.87e-05 | |||
Fucose permease [Carbohydrate transport and metabolism]; Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 3.87e-05
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MFS | cd06174 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
87-239 | 4.48e-05 | |||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 4.48e-05
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MFS_1 | pfam07690 | Major Facilitator Superfamily; |
87-227 | 1.74e-04 | |||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.74e-04
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Name | Accession | Description | Interval | E-value | |||
FucP | COG0738 | Fucose permease [Carbohydrate transport and metabolism]; |
87-239 | 3.87e-05 | |||
Fucose permease [Carbohydrate transport and metabolism]; Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 3.87e-05
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MFS | cd06174 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
87-239 | 4.48e-05 | |||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 4.48e-05
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NarK | COG2223 | Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
90-227 | 8.58e-05 | |||
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 8.58e-05
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MFS_1 | pfam07690 | Major Facilitator Superfamily; |
87-227 | 1.74e-04 | |||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.74e-04
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MFS_YcxA_like | cd17355 | MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
90-195 | 3.86e-04 | |||
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.03 E-value: 3.86e-04
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MFS_LmrB_MDR_like | cd17503 | Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
98-167 | 1.03e-03 | |||
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.79 E-value: 1.03e-03
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MFS_OFA_like | cd17353 | Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
90-160 | 1.30e-03 | |||
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.44 E-value: 1.30e-03
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UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
85-231 | 2.56e-03 | |||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.24 E-value: 2.56e-03
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MFS_Mch1p_like | cd17354 | Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
92-194 | 3.20e-03 | |||
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 39.93 E-value: 3.20e-03
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MFS_1 | pfam07690 | Major Facilitator Superfamily; |
90-195 | 3.41e-03 | |||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 3.41e-03
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MFS_PcaK_like | cd17365 | 4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
87-185 | 5.00e-03 | |||
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.49 E-value: 5.00e-03
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AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
90-187 | 6.11e-03 | |||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 6.11e-03
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AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
87-230 | 7.74e-03 | |||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 7.74e-03
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Blast search parameters | ||||
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