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Conserved domains on  [gi|1011750764|ref|NP_001308546|]
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neuron-specific vesicular protein calcyon isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Calcyon super family cl05734
D1 dopamine receptor-interacting protein (calcyon); This family consists of several D1 ...
 38-96 7.86e-28

D1 dopamine receptor-interacting protein (calcyon); This family consists of several D1 dopamine receptor-interacting (calcyon) proteins. D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) and schizophrenia.


The actual alignment was detected with superfamily member pfam06387:

Pssm-ID: 461892  Cd Length: 177  Bit Score: 100.62  E-value: 7.86e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1011750764  38 QHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTETPAAWGDGYRAAKEERKG 96
Cdd:pfam06387 119 KHKRCTPATLEMYYTEQDPERRGRFYTAISHYNLAKKTGTESVSPWLSVISAEKEVEQA 177
 
Name Accession Description Interval E-value
Calcyon pfam06387
D1 dopamine receptor-interacting protein (calcyon); This family consists of several D1 ...
 38-96 7.86e-28

D1 dopamine receptor-interacting protein (calcyon); This family consists of several D1 dopamine receptor-interacting (calcyon) proteins. D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) and schizophrenia.


Pssm-ID: 461892  Cd Length: 177  Bit Score: 100.62  E-value: 7.86e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1011750764  38 QHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTETPAAWGDGYRAAKEERKG 96
Cdd:pfam06387 119 KHKRCTPATLEMYYTEQDPERRGRFYTAISHYNLAKKTGTESVSPWLSVISAEKEVEQA 177
 
Name Accession Description Interval E-value
Calcyon pfam06387
D1 dopamine receptor-interacting protein (calcyon); This family consists of several D1 ...
 38-96 7.86e-28

D1 dopamine receptor-interacting protein (calcyon); This family consists of several D1 dopamine receptor-interacting (calcyon) proteins. D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) and schizophrenia.


Pssm-ID: 461892  Cd Length: 177  Bit Score: 100.62  E-value: 7.86e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1011750764  38 QHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTETPAAWGDGYRAAKEERKG 96
Cdd:pfam06387 119 KHKRCTPATLEMYYTEQDPERRGRFYTAISHYNLAKKTGTESVSPWLSVISAEKEVEQA 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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