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Conserved domains on  [gi|1015123180|ref|NP_001309006|]
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zinc finger and SCAN domain-containing protein 5A isoform d [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 1.34e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.34e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015123180 337 SLKEHQRIHSGEKPYKCSKCPRAFSR 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 2.46e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.46e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015123180 281 SLQFHQRTHTGERPYTCDVCQKQFTQ 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-334 2.13e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.13e-04
                          10        20
                  ....*....|....*....|..
gi 1015123180 313 HKRSHTGEKPFECKDCKKVFTY 334
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-375 3.48e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 222 ASPVSHPDGQEAKALPPFACDVCEKRFTCNSKLVIHKRS--HTGERL--FQC--NLCGKRFMQLISLQFHQRTHTGERPY 295
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 296 TC--DVCQKQFTQKSYLK-----CHKRSHTGEKPFEC--KDCKKVFTYRGSLKEH--QRIHSGEKPYKCSKCPRAFSRLK 364
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHY 432

                         170
                  ....*....|.
gi 1015123180 365 LLRRHQKTHPE 375
Cdd:COG5048   433 NLIPHKKIHTN 443
Treacle super family cl25490
Treacher Collins syndrome protein Treacle;
39-238 2.52e-03

Treacher Collins syndrome protein Treacle;


The actual alignment was detected with superfamily member pfam03546:

Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 39.67  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180  39 DDLKDVSSQRASSVNQMRPGEGQAHRELQILPRVPALSRRQGEDFLL-HKSIDVTGDPKSLRPKQTLE--KDLKENREEN 115
Cdd:pfam03546 166 EEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGAAPAPpQKAGPVATQVKAERSKEDSEssEESSDSEEEA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 116 PGLTSP---EPQLPKSPTDLVRAKEGKDPPKIASVENVDADTPSACVVEREASTHSgnrgdalnLSSP------KRSKPD 186
Cdd:pfam03546 246 PAAATPaqaKPALKTPQTKASPRKGTPITPTSAKVPPVRVGTPAPWKAGTVTSPAC--------ASSPavargaQRPEED 317

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1015123180 187 ASSISQEEPQGEATPVGNReSPGQAGMNSIHSPGPASPVSHPDGQEAKALPP 238
Cdd:pfam03546 318 SSSSEESESEEETAPAAAV-GQAKSVGKGLQGKAASAPTKGPSGQGTAPVPP 368
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 1.34e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.34e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015123180 337 SLKEHQRIHSGEKPYKCSKCPRAFSR 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 2.46e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.46e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015123180 281 SLQFHQRTHTGERPYTCDVCQKQFTQ 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-334 2.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.13e-04
                          10        20
                  ....*....|....*....|..
gi 1015123180 313 HKRSHTGEKPFECKDCKKVFTY 334
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-375 3.48e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 222 ASPVSHPDGQEAKALPPFACDVCEKRFTCNSKLVIHKRS--HTGERL--FQC--NLCGKRFMQLISLQFHQRTHTGERPY 295
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 296 TC--DVCQKQFTQKSYLK-----CHKRSHTGEKPFEC--KDCKKVFTYRGSLKEH--QRIHSGEKPYKCSKCPRAFSRLK 364
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHY 432

                         170
                  ....*....|.
gi 1015123180 365 LLRRHQKTHPE 375
Cdd:COG5048   433 NLIPHKKIHTN 443
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
39-238 2.52e-03

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 39.67  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180  39 DDLKDVSSQRASSVNQMRPGEGQAHRELQILPRVPALSRRQGEDFLL-HKSIDVTGDPKSLRPKQTLE--KDLKENREEN 115
Cdd:pfam03546 166 EEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGAAPAPpQKAGPVATQVKAERSKEDSEssEESSDSEEEA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 116 PGLTSP---EPQLPKSPTDLVRAKEGKDPPKIASVENVDADTPSACVVEREASTHSgnrgdalnLSSP------KRSKPD 186
Cdd:pfam03546 246 PAAATPaqaKPALKTPQTKASPRKGTPITPTSAKVPPVRVGTPAPWKAGTVTSPAC--------ASSPavargaQRPEED 317

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1015123180 187 ASSISQEEPQGEATPVGNReSPGQAGMNSIHSPGPASPVSHPDGQEAKALPP 238
Cdd:pfam03546 318 SSSSEESESEEETAPAAAV-GQAKSVGKGLQGKAASAPTKGPSGQGTAPVPP 368
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-276 3.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.70e-03
                          10        20
                  ....*....|....*....|...
gi 1015123180 254 LVIHKRSHTGERLFQCNLCGKRF 276
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 1.34e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.34e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015123180 337 SLKEHQRIHSGEKPYKCSKCPRAFSR 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 2.46e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.46e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015123180 281 SLQFHQRTHTGERPYTCDVCQKQFTQ 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 351-373 1.44e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.44e-04
                          10        20
                  ....*....|....*....|...
gi 1015123180 351 YKCSKCPRAFSRLKLLRRHQKTH 373
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-334 2.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.13e-04
                          10        20
                  ....*....|....*....|..
gi 1015123180 313 HKRSHTGEKPFECKDCKKVFTY 334
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 323-345 2.64e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 2.64e-04
                          10        20
                  ....*....|....*....|...
gi 1015123180 323 FECKDCKKVFTYRGSLKEHQRIH 345
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-375 3.48e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 222 ASPVSHPDGQEAKALPPFACDVCEKRFTCNSKLVIHKRS--HTGERL--FQC--NLCGKRFMQLISLQFHQRTHTGERPY 295
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 296 TC--DVCQKQFTQKSYLK-----CHKRSHTGEKPFEC--KDCKKVFTYRGSLKEH--QRIHSGEKPYKCSKCPRAFSRLK 364
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHY 432

                         170
                  ....*....|.
gi 1015123180 365 LLRRHQKTHPE 375
Cdd:COG5048   433 NLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-356 7.32e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 7.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015123180 293 RPYTCDVCQKQFTQKSYLKCHKRSHTGEKPFECKD--CKKVFTYRGSLKEHQRIHSGEKPYKCSKC 356
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 207-371 2.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 207 SPGQAGMNSIH--SPGPASPVSHPDGQEAKALPPFACDVCEK--RFTCNSKLVIHKRSHTGERlfqcNLCGKRFMQLIsl 282
Cdd:COG5189   271 SPSQGSAELFEesSLGFDYEFIHKSVGNKEIRGGISTGEMIDvrKLPCTNSSSNGKLAHGGER----NIDTPSRMLKV-- 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 283 qfhqrthTGERPYTCDV--CQKQFTQKSYLKCHKR-SHTGEKPFECKDCKKvftyrgslkeHQRIHSGEKPYKCSKCPRA 359
Cdd:COG5189   345 -------KDGKPYKCPVegCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKR 407

                         170
                  ....*....|..
gi 1015123180 360 FSRLKLLRRHQK 371
Cdd:COG5189   408 YKNLNGLKYHRK 419
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
39-238 2.52e-03

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 39.67  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180  39 DDLKDVSSQRASSVNQMRPGEGQAHRELQILPRVPALSRRQGEDFLL-HKSIDVTGDPKSLRPKQTLE--KDLKENREEN 115
Cdd:pfam03546 166 EEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGAAPAPpQKAGPVATQVKAERSKEDSEssEESSDSEEEA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015123180 116 PGLTSP---EPQLPKSPTDLVRAKEGKDPPKIASVENVDADTPSACVVEREASTHSgnrgdalnLSSP------KRSKPD 186
Cdd:pfam03546 246 PAAATPaqaKPALKTPQTKASPRKGTPITPTSAKVPPVRVGTPAPWKAGTVTSPAC--------ASSPavargaQRPEED 317

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1015123180 187 ASSISQEEPQGEATPVGNReSPGQAGMNSIHSPGPASPVSHPDGQEAKALPP 238
Cdd:pfam03546 318 SSSSEESESEEETAPAAAV-GQAKSVGKGLQGKAASAPTKGPSGQGTAPVPP 368
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-276 3.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.70e-03
                          10        20
                  ....*....|....*....|...
gi 1015123180 254 LVIHKRSHTGERLFQCNLCGKRF 276
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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