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Conserved domains on  [gi|1015809678|ref|NP_001309072|]
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transport and Golgi organization protein 2 homolog isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
60-300 4.73e-109

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


:

Pssm-ID: 461729  Cd Length: 255  Bit Score: 317.28  E-value: 4.73e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEeGKEGGTWLGISTRGKLAALTNYLQPQLD----WQARGRGELVTH 135
Cdd:pfam05742  15 PLILAANRDEFLNRPTAPAHWWEENPNILGGRDLE-GREGGTWLGITKQGRIAALTNYREPSSGppdaVGARSRGLLVND 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 136 FLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLF 215
Cdd:pfam05742  94 FLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVERGKRLF 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 216 LEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQGGEYVQPMlskyAAVCVRCPG----YGTRTNTIILVDADGHV 291
Cdd:pfam05742 172 EELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTGPEWERLL----SSIFIPPIPpggrYGTRSQTVILVDKDGKV 246

                  ....*....
gi 1015809678 292 TFTERSMMD 300
Cdd:pfam05742 247 TFIERTLYD 255
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
60-300 4.73e-109

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 317.28  E-value: 4.73e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEeGKEGGTWLGISTRGKLAALTNYLQPQLD----WQARGRGELVTH 135
Cdd:pfam05742  15 PLILAANRDEFLNRPTAPAHWWEENPNILGGRDLE-GREGGTWLGITKQGRIAALTNYREPSSGppdaVGARSRGLLVND 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 136 FLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLF 215
Cdd:pfam05742  94 FLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVERGKRLF 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 216 LEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQGGEYVQPMlskyAAVCVRCPG----YGTRTNTIILVDADGHV 291
Cdd:pfam05742 172 EELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTGPEWERLL----SSIFIPPIPpggrYGTRSQTVILVDKDGKV 246

                  ....*....
gi 1015809678 292 TFTERSMMD 300
Cdd:pfam05742 247 TFIERTLYD 255
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
60-317 3.95e-73

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 225.91  E-value: 3.95e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEEGkegGTWLGISTRGKLAALTNYLQPQL-DWQARGRGELVTHFLT 138
Cdd:COG3332    15 PLVLAANRDEFYARPTAPPARWPDAPGVLAGRDLEAG---GTWLGVNRHGRFAALTNRRDPSGpPAGARSRGELVLDFLA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 139 TDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAkgdviCYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEA 218
Cdd:COG3332    92 GESAPAAYLALLALDAAAYNGFNLLVGDADRL-----FYLSNRGDALVRRLAPGVHGLSNALLDTPWPKVARLKAALAAA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 219 VErsqalPKDVLIASLLDVLNNEE----AQLPDPAIedqgGEYVQPMLSkyaAVCVRCPGYGTRTNTIILVDADGHVTFT 294
Cdd:COG3332   167 LA-----PDDPDPDALFALLADRTpapdAELPDTGV----GLEWERLLS---SIFIHGPGYGTRSSTLLALDADGRVEFA 234
                         250       260
                  ....*....|....*....|...
gi 1015809678 295 ERSmMDKDLSHWETRTYEFTLQS 317
Cdd:COG3332   235 ERR-FDADGPPCGTRRFRFTLLS 256
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
60-300 4.73e-109

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 317.28  E-value: 4.73e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEeGKEGGTWLGISTRGKLAALTNYLQPQLD----WQARGRGELVTH 135
Cdd:pfam05742  15 PLILAANRDEFLNRPTAPAHWWEENPNILGGRDLE-GREGGTWLGITKQGRIAALTNYREPSSGppdaVGARSRGLLVND 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 136 FLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLF 215
Cdd:pfam05742  94 FLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVERGKRLF 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 216 LEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQGGEYVQPMlskyAAVCVRCPG----YGTRTNTIILVDADGHV 291
Cdd:pfam05742 172 EELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTGPEWERLL----SSIFIPPIPpggrYGTRSQTVILVDKDGKV 246

                  ....*....
gi 1015809678 292 TFTERSMMD 300
Cdd:pfam05742 247 TFIERTLYD 255
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
60-317 3.95e-73

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 225.91  E-value: 3.95e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEEGkegGTWLGISTRGKLAALTNYLQPQL-DWQARGRGELVTHFLT 138
Cdd:COG3332    15 PLVLAANRDEFYARPTAPPARWPDAPGVLAGRDLEAG---GTWLGVNRHGRFAALTNRRDPSGpPAGARSRGELVLDFLA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 139 TDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAkgdviCYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEA 218
Cdd:COG3332    92 GESAPAAYLALLALDAAAYNGFNLLVGDADRL-----FYLSNRGDALVRRLAPGVHGLSNALLDTPWPKVARLKAALAAA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809678 219 VErsqalPKDVLIASLLDVLNNEE----AQLPDPAIedqgGEYVQPMLSkyaAVCVRCPGYGTRTNTIILVDADGHVTFT 294
Cdd:COG3332   167 LA-----PDDPDPDALFALLADRTpapdAELPDTGV----GLEWERLLS---SIFIHGPGYGTRSSTLLALDADGRVEFA 234
                         250       260
                  ....*....|....*....|...
gi 1015809678 295 ERSmMDKDLSHWETRTYEFTLQS 317
Cdd:COG3332   235 ERR-FDADGPPCGTRRFRFTLLS 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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