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Conserved domains on  [gi|1015809732|ref|NP_001309107|]
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contactin-associated protein-like 4 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 5.11e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.08  E-value: 5.11e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   54 HGPGFARLNRrdgAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWG 131
Cdd:cd00057     24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1015809732  132 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 176
Cdd:cd00057    101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 771-889 6.38e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 6.38e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  771 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 849
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809732  850 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 889
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 5.39e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.39e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  212 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 291
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809732  292 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 996-1126 1.13e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  996 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 1075
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809732 1076 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1126
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 543-584 3.84e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 50.64  E-value: 3.84e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809732  543 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 584
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 503-534 8.88e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 8.88e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809732  503 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 534
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-429 3.35e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member cd00110:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 3.35e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  371 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLK 429
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLV 59
COLFI super family cl02436
Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 554-637 4.69e-04

Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


The actual alignment was detected with superfamily member smart00038:

Pssm-ID: 470578  Cd Length: 232  Bit Score: 43.23  E-value: 4.69e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   554 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 620
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809732   621 NR--AEHCEQEFTYYCKKS 637
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-946 1.74e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809732  912 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 946
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 5.11e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.08  E-value: 5.11e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   54 HGPGFARLNRrdgAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWG 131
Cdd:cd00057     24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1015809732  132 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 176
Cdd:cd00057    101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 771-889 6.38e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 6.38e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  771 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 849
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809732  850 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 889
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 744-888 7.35e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 7.35e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  744 SASFDTEaSYLHFPTFHGEL-SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtfsFDVGNGPFEISVQSPTH 820
Cdd:cd00110      1 GVSFSGS-SYVRLPTLPAPRtRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGRLV---LRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809732  821 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPaDGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLN 888
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSP-GGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 5.39e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.39e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  212 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 291
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809732  292 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-174 5.72e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 112.54  E-value: 5.72e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   54 HGPGFARLNRrDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSNWVTSYLLMFSDSGWNWKQYRQEdsiwGF 132
Cdd:pfam00754   11 EGPAAAALDG-DPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDE----KI 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1015809732  133 SGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEV 174
Cdd:pfam00754   86 PGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
LamG smart00282
Laminin G domain;
766-890 1.70e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 111.66  E-value: 1.70e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   766 DVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtFSFDVGNGPFEISVQsPTHFNDNQWHHVRVERNMKEASLQVD 843
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGRLV-LRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809732   844 QLTPKTQPAPAdGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLNGM 890
Cdd:smart00282   79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-177 6.55e-26

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 104.51  E-value: 6.55e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732    55 GPGFARLNRrDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYlLMFSDSGWNWKQYRQEDSIwGFSG 134
Cdd:smart00231   22 AAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPG 98

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 1015809732   135 NANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFGC 177
Cdd:smart00231   99 NSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 194-339 3.10e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.10  E-value: 3.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  194 YRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQLRRARLFLLINSGEAKLPststlvnLTLGSLLDDQHW 272
Cdd:cd00110     10 VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGSGSLV-------LSSKTPLNDGQW 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809732  273 HSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRN-FHGCLENLYYN 339
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
208-341 1.97e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 94.33  E-value: 1.97e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   208 ISLKFKTMQSDGILLHREGPNG-DHITLQLRRARLFLLIN--SGEAKLPSTSTLVNltlgslldDQHWHSVLIQRLGKQV 284
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDlgSGPARLTSDPTPLN--------DGQWHRVAVERNGRSV 73

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809732   285 NFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:smart00282   74 TLSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 996-1126 1.13e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  996 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 1075
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809732 1076 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1126
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 992-1123 5.23e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 67.83  E-value: 5.23e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  992 IKFSFRTTRTPSLLLFVSSF-YKEYLSVIIaKNGSLQIRYKLNKyqEPDVVNFDfKNMADGQLHHIMINREEGVVFIEID 1070
Cdd:cd00110     24 ISFSFRTTSPNGLLLYAGSQnGGDFLALEL-EDGRLVLRYDLGS--GSLVLSSK-TPLNDGQWHSVSVERNGRSVTLSVD 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1015809732 1071 DNRRRQVHLSSGTEF-SAVKSLVLGRILEHSDVdqdTALAGAQGFTGCLSAVQL 1123
Cdd:cd00110    100 GERVVESGSPGGSALlNLDGPLYLGGLPEDLKS---PGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
992-1126 1.32e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 1.32e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   992 IKFSFRTTRTPSLLLFVSSFYK-EYLSVIIaKNGSLQIRYKLNkyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 1070
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809732  1071 DNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDTAlagAQGFTGCLSAVQLSHV 1126
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGpLYLGGLPEDLKLPPLPV---TPGFRGCIRNLKVNGK 132
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 543-584 3.84e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 50.64  E-value: 3.84e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809732  543 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 584
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 503-534 8.88e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 8.88e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809732  503 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 534
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 542-589 2.57e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.77  E-value: 2.57e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1015809732  542 QSC-EAYKHRGNTSGFYYIDSDGSgpLEPFLLYCNMTET--AWTIIQH--NGS 589
Cdd:cd00087      4 RDCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDTDggGWTVIQRrgDGS 54
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-429 3.35e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 3.35e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  371 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLK 429
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLV 59
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 545-593 4.10e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 43.03  E-value: 4.10e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1015809732   545 EAYKHRGNTSGFYYIDSDGSGplEPFLLYCNMTETA--WTIIQH--NGS-DLTR 593
Cdd:smart00186    7 DVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGggWTVIQRrmDGSvDFYR 58
COLFI smart00038
Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 554-637 4.69e-04

Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 197483  Cd Length: 232  Bit Score: 43.23  E-value: 4.69e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   554 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 620
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809732   621 NR--AEHCEQEFTYYCKKS 637
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-946 1.74e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809732  912 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 946
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 501-535 2.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.29e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1015809732  501 DRCL-PNYCEHGGECSQSWSTFHCNCTNtGYRGATC 535
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 5.11e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.08  E-value: 5.11e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   54 HGPGFARLNRrdgAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWG 131
Cdd:cd00057     24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1015809732  132 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 176
Cdd:cd00057    101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 771-889 6.38e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 6.38e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  771 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 849
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809732  850 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 889
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 744-888 7.35e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 7.35e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  744 SASFDTEaSYLHFPTFHGEL-SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtfsFDVGNGPFEISVQSPTH 820
Cdd:cd00110      1 GVSFSGS-SYVRLPTLPAPRtRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGRLV---LRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809732  821 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPaDGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLN 888
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSP-GGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 5.39e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.39e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  212 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 291
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809732  292 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-174 5.72e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 112.54  E-value: 5.72e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   54 HGPGFARLNRrDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSNWVTSYLLMFSDSGWNWKQYRQEdsiwGF 132
Cdd:pfam00754   11 EGPAAAALDG-DPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDE----KI 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1015809732  133 SGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEV 174
Cdd:pfam00754   86 PGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
LamG smart00282
Laminin G domain;
766-890 1.70e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 111.66  E-value: 1.70e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   766 DVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtFSFDVGNGPFEISVQsPTHFNDNQWHHVRVERNMKEASLQVD 843
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGRLV-LRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809732   844 QLTPKTQPAPAdGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLNGM 890
Cdd:smart00282   79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-177 6.55e-26

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 104.51  E-value: 6.55e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732    55 GPGFARLNRrDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYlLMFSDSGWNWKQYRQEDSIwGFSG 134
Cdd:smart00231   22 AAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPG 98

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 1015809732   135 NANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFGC 177
Cdd:smart00231   99 NSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 194-339 3.10e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.10  E-value: 3.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  194 YRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQLRRARLFLLINSGEAKLPststlvnLTLGSLLDDQHW 272
Cdd:cd00110     10 VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGSGSLV-------LSSKTPLNDGQW 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809732  273 HSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRN-FHGCLENLYYN 339
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
208-341 1.97e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 94.33  E-value: 1.97e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   208 ISLKFKTMQSDGILLHREGPNG-DHITLQLRRARLFLLIN--SGEAKLPSTSTLVNltlgslldDQHWHSVLIQRLGKQV 284
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDlgSGPARLTSDPTPLN--------DGQWHRVAVERNGRSV 73

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809732   285 NFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:smart00282   74 TLSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
771-893 1.00e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 89.30  E-value: 1.00e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  771 FKTTASSGVFLENLGIA--DFIRIELRSPTVvTFSFDVGNGPfeISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPK 848
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRL-EVSYDLGSGA--AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809732  849 T--QPAPADGHvlLQLNSQLFVGGT---------ATRQRGFLGCIRSLQLNGMTLD 893
Cdd:pfam00054   78 TgeSPLGATTD--LDVDGPLYVGGLpslgvkkrrLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 996-1126 1.13e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  996 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 1075
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809732 1076 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1126
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 992-1123 5.23e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 67.83  E-value: 5.23e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  992 IKFSFRTTRTPSLLLFVSSF-YKEYLSVIIaKNGSLQIRYKLNKyqEPDVVNFDfKNMADGQLHHIMINREEGVVFIEID 1070
Cdd:cd00110     24 ISFSFRTTSPNGLLLYAGSQnGGDFLALEL-EDGRLVLRYDLGS--GSLVLSSK-TPLNDGQWHSVSVERNGRSVTLSVD 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1015809732 1071 DNRRRQVHLSSGTEF-SAVKSLVLGRILEHSDVdqdTALAGAQGFTGCLSAVQL 1123
Cdd:cd00110    100 GERVVESGSPGGSALlNLDGPLYLGGLPEDLKS---PGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
992-1126 1.32e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 1.32e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   992 IKFSFRTTRTPSLLLFVSSFYK-EYLSVIIaKNGSLQIRYKLNkyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 1070
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809732  1071 DNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDTAlagAQGFTGCLSAVQLSHV 1126
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGpLYLGGLPEDLKLPPLPV---TPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
212-341 1.89e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 1.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  212 FKTMQSDGILLHREGPN-GDHITLQLRRARLFLLINSGeaklpstSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVD- 289
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELRDGRLEVSYDLG-------SGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDg 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809732  290 EHRHHfharGEFNL-----MNLDYEISFGGIPAPGKSVS-FPHR-NFHGCLENLYYNGV 341
Cdd:pfam00054   74 EARPT----GESPLgattdLDVDGPLYVGGLPSLGVKKRrLAISpSFDGCIRDVIVNGK 128
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 543-584 3.84e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 50.64  E-value: 3.84e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809732  543 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 584
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 503-534 8.88e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 8.88e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809732  503 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 534
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 957-1079 1.81e-04

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 43.89  E-value: 1.81e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   957 GSSVIYNFQENyllsKNSSSHAASFHgDMKLSREM-IKFSFRTTRTPSLLLF--VSSFYKEYLSVIIakNGSLQI---RY 1030
Cdd:smart00210   25 PGSPAYRLGDP----ALVPQPTRDLF-PSGLPEDFsLLTTFRQTPKSRGVLFaiYDAQNVRQFGLEV--DGRANTlllRY 97

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 1015809732  1031 KLNKyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDDNRRRQVHL 1079
Cdd:smart00210   98 QGVD-GKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPL 145
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 542-589 2.57e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.77  E-value: 2.57e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1015809732  542 QSC-EAYKHRGNTSGFYYIDSDGSgpLEPFLLYCNMTET--AWTIIQH--NGS 589
Cdd:cd00087      4 RDCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDTDggGWTVIQRrgDGS 54
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-429 3.35e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 3.35e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732  371 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLK 429
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLV 59
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 545-593 4.10e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 43.03  E-value: 4.10e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1015809732   545 EAYKHRGNTSGFYYIDSDGSGplEPFLLYCNMTETA--WTIIQH--NGS-DLTR 593
Cdd:smart00186    7 DVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGggWTVIQRrmDGSvDFYR 58
COLFI smart00038
Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 554-637 4.69e-04

Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 197483  Cd Length: 232  Bit Score: 43.23  E-value: 4.69e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809732   554 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 620
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809732   621 NR--AEHCEQEFTYYCKKS 637
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-946 1.74e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809732  912 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 946
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 501-535 2.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.29e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1015809732  501 DRCL-PNYCEHGGECSQSWSTFHCNCTNtGYRGATC 535
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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