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Conserved domains on  [gi|1016081731|ref|NP_001309131|]
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pro-neuregulin-1, membrane-bound isoform isoform a [Homo sapiens]

Protein Classification

Neuregulin domain-containing protein( domain architecture ID 10490017)

Neuregulin domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
9-364 1.20e-147

Neuregulin intracellular region;


:

Pssm-ID: 426627  Cd Length: 360  Bit Score: 421.94  E-value: 1.20e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731   9 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 88
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731  89 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 164
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731 165 RYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFM-EEERPLLLVTPPRLREKKFDHHPQ--QFS 241
Cdd:pfam02158 159 RYVSALTTPARLSPVDFHYPLPPQVPTFEITSPNSSHAVSLPPAAPSPYGlEEEQPLLYQTPPRLRQKSYDLYRQqnQRN 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731 242 SFHHNpahDSNSLPASPLRIVEDEEYETTQEYEPAQE-PVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETE 320
Cdd:pfam02158 239 SYHHN---STGSLPPSPLRIVEDDEYETTQEYESALEqPKRTLTNSRRWRRSKLNGHIAQRGEADRDSSSVSSSSESETE 315
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1016081731 321 DERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPA-GRFSTQE 364
Cdd:pfam02158 316 EERVGESTPFLSIQNPLAASLEPSPLYRPADSRTNPAsGRFSTQE 360
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
9-364 1.20e-147

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 421.94  E-value: 1.20e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731   9 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 88
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731  89 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 164
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731 165 RYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFM-EEERPLLLVTPPRLREKKFDHHPQ--QFS 241
Cdd:pfam02158 159 RYVSALTTPARLSPVDFHYPLPPQVPTFEITSPNSSHAVSLPPAAPSPYGlEEEQPLLYQTPPRLRQKSYDLYRQqnQRN 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731 242 SFHHNpahDSNSLPASPLRIVEDEEYETTQEYEPAQE-PVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETE 320
Cdd:pfam02158 239 SYHHN---STGSLPPSPLRIVEDDEYETTQEYESALEqPKRTLTNSRRWRRSKLNGHIAQRGEADRDSSSVSSSSESETE 315
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1016081731 321 DERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPA-GRFSTQE 364
Cdd:pfam02158 316 EERVGESTPFLSIQNPLAASLEPSPLYRPADSRTNPAsGRFSTQE 360
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
9-364 1.20e-147

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 421.94  E-value: 1.20e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731   9 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 88
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731  89 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 164
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731 165 RYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFM-EEERPLLLVTPPRLREKKFDHHPQ--QFS 241
Cdd:pfam02158 159 RYVSALTTPARLSPVDFHYPLPPQVPTFEITSPNSSHAVSLPPAAPSPYGlEEEQPLLYQTPPRLRQKSYDLYRQqnQRN 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081731 242 SFHHNpahDSNSLPASPLRIVEDEEYETTQEYEPAQE-PVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETE 320
Cdd:pfam02158 239 SYHHN---STGSLPPSPLRIVEDDEYETTQEYESALEqPKRTLTNSRRWRRSKLNGHIAQRGEADRDSSSVSSSSESETE 315
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1016081731 321 DERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPA-GRFSTQE 364
Cdd:pfam02158 316 EERVGESTPFLSIQNPLAASLEPSPLYRPADSRTNPAsGRFSTQE 360
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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