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Conserved domains on  [gi|1017029517|ref|NP_001309408|]
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BLOC-3 complex member HPS1 isoform f [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 2-159 1.46e-26

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465953  Cd Length: 125  Bit Score: 104.98  E-value: 1.46e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517   2 KCVLVATEGAEVLFYWTDQEfeeslrlkfgqseneeeelpaLEDQLSTLLAPVIISSMTMLEKLsDTYTCFSTENgnFLY 81
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDE---------------------DESLLFSLFGPLNGSISFMQTQD-DTLTSITCEN--TKV 56

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029517  82 VLHLFGECLFIAINGDHtESEGDLRRKLYVLKYLFEVHFGLVTVDGHLIRKElrppdlaqRVQLWEHFQSLLWTYSRL 159
Cdd:pfam19036  57 VFLEKGPLLLVAISRSG-ESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRP--------NEDLRRLLSGLEDLLDSL 125
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 507-662 1.40e-18

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465955  Cd Length: 103  Bit Score: 81.15  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 507 GLVHFIYVDRTTGQMVAPSLncsqktssELGKGPLAAFVKTKVWSLIQLARRYLQ--KGYTTLLFQEGDfYCSYFLWFEN 584
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSL--------PTDPPYTTEQRRRRLRSFYQLLHSTLHspSGPLKLLYKVSD-YESLLAWFTD 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029517 585 dmgyklqmievpvlsddsvpigmlggdyyrkllryysknrpteavrCYELLALHLSVIPTDLLVQQAGQLARRLWEAS 662
Cdd:pfam19038  72 ----------------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 204-372 3.19e-11

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465954  Cd Length: 98  Bit Score: 60.32  E-value: 3.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 204 EEALHAFLLVHSKLLAFYSSHSAsSLRPADLLALILLVQDLYPSEstaeddiqetdsfslpeeyftpapspgdqssgsti 283
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWA-SLHPSDLLLLFLLVQSSSPFK----------------------------------- 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 284 wleggtppmdalqiaedtlqtlvphcpvpsgprriFLDANVKESYCPLVPHTMYCLPLWQG-INLVLLTRSPSAPlALVL 362
Cdd:pfam19037  45 -----------------------------------SLELWIPICLPKFNPGVLHRYISFLGdINLCLLLLSGDKP-AFFE 88

                         170
                  ....*....|
gi 1017029517 363 SQLMDGFSML 372
Cdd:pfam19037  89 LSLLDDRFWL 98
 
Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 2-159 1.46e-26

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 104.98  E-value: 1.46e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517   2 KCVLVATEGAEVLFYWTDQEfeeslrlkfgqseneeeelpaLEDQLSTLLAPVIISSMTMLEKLsDTYTCFSTENgnFLY 81
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDE---------------------DESLLFSLFGPLNGSISFMQTQD-DTLTSITCEN--TKV 56

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029517  82 VLHLFGECLFIAINGDHtESEGDLRRKLYVLKYLFEVHFGLVTVDGHLIRKElrppdlaqRVQLWEHFQSLLWTYSRL 159
Cdd:pfam19036  57 VFLEKGPLLLVAISRSG-ESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRP--------NEDLRRLLSGLEDLLDSL 125
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 507-662 1.40e-18

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 81.15  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 507 GLVHFIYVDRTTGQMVAPSLncsqktssELGKGPLAAFVKTKVWSLIQLARRYLQ--KGYTTLLFQEGDfYCSYFLWFEN 584
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSL--------PTDPPYTTEQRRRRLRSFYQLLHSTLHspSGPLKLLYKVSD-YESLLAWFTD 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029517 585 dmgyklqmievpvlsddsvpigmlggdyyrkllryysknrpteavrCYELLALHLSVIPTDLLVQQAGQLARRLWEAS 662
Cdd:pfam19038  72 ----------------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 204-372 3.19e-11

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 60.32  E-value: 3.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 204 EEALHAFLLVHSKLLAFYSSHSAsSLRPADLLALILLVQDLYPSEstaeddiqetdsfslpeeyftpapspgdqssgsti 283
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWA-SLHPSDLLLLFLLVQSSSPFK----------------------------------- 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 284 wleggtppmdalqiaedtlqtlvphcpvpsgprriFLDANVKESYCPLVPHTMYCLPLWQG-INLVLLTRSPSAPlALVL 362
Cdd:pfam19037  45 -----------------------------------SLELWIPICLPKFNPGVLHRYISFLGdINLCLLLLSGDKP-AFFE 88

                         170
                  ....*....|
gi 1017029517 363 SQLMDGFSML 372
Cdd:pfam19037  89 LSLLDDRFWL 98
 
Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 2-159 1.46e-26

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 104.98  E-value: 1.46e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517   2 KCVLVATEGAEVLFYWTDQEfeeslrlkfgqseneeeelpaLEDQLSTLLAPVIISSMTMLEKLsDTYTCFSTENgnFLY 81
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDE---------------------DESLLFSLFGPLNGSISFMQTQD-DTLTSITCEN--TKV 56

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029517  82 VLHLFGECLFIAINGDHtESEGDLRRKLYVLKYLFEVHFGLVTVDGHLIRKElrppdlaqRVQLWEHFQSLLWTYSRL 159
Cdd:pfam19036  57 VFLEKGPLLLVAISRSG-ESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRP--------NEDLRRLLSGLEDLLDSL 125
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 507-662 1.40e-18

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 81.15  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 507 GLVHFIYVDRTTGQMVAPSLncsqktssELGKGPLAAFVKTKVWSLIQLARRYLQ--KGYTTLLFQEGDfYCSYFLWFEN 584
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSL--------PTDPPYTTEQRRRRLRSFYQLLHSTLHspSGPLKLLYKVSD-YESLLAWFTD 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029517 585 dmgyklqmievpvlsddsvpigmlggdyyrkllryysknrpteavrCYELLALHLSVIPTDLLVQQAGQLARRLWEAS 662
Cdd:pfam19038  72 ----------------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 204-372 3.19e-11

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 60.32  E-value: 3.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 204 EEALHAFLLVHSKLLAFYSSHSAsSLRPADLLALILLVQDLYPSEstaeddiqetdsfslpeeyftpapspgdqssgsti 283
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWA-SLHPSDLLLLFLLVQSSSPFK----------------------------------- 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029517 284 wleggtppmdalqiaedtlqtlvphcpvpsgprriFLDANVKESYCPLVPHTMYCLPLWQG-INLVLLTRSPSAPlALVL 362
Cdd:pfam19037  45 -----------------------------------SLELWIPICLPKFNPGVLHRYISFLGdINLCLLLLSGDKP-AFFE 88

                         170
                  ....*....|
gi 1017029517 363 SQLMDGFSML 372
Cdd:pfam19037  89 LSLLDDRFWL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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