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Conserved domains on  [gi|1017029493|ref|NP_001309423|]
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glutathione synthetase [Homo sapiens]

Protein Classification

eu-GS domain-containing protein( domain architecture ID 10083120)

eu-GS domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
eu-GS cd00228
Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from ...
6-474 0e+00

Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.


:

Pssm-ID: 238140  Cd Length: 471  Bit Score: 814.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493   6 GSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAF 85
Cdd:cd00228     1 PPIPDDKDQLEELAKDANDWAVANGLVMRDKSVQESSVVASHAPFTLLPSPFPEALFEQAVEVQPDFNELVDRISQDGKF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  86 LEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSaDGSPALKQIEINTISASFGGLASRTPAVHRH 165
Cdd:cd00228    81 LQQSLSSTKKVDEFTSRLLDIHKKVLEENKKQPVRLGIFRSDYMFDEK-DGTKGLKQIEINTISSSFGGLSSRVTELHRY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 166 VLSVL--SKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARN-IHVIRRTFEDI 242
Cdd:cd00228   160 VLSALgySKGLDSNRIPSNNAVKGIAEALAKAWEEYGDPRAVVLFVVQNEERNIYDQRFLEAELLERHqIHVIRKTLADV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 243 SEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQY-SLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLL 321
Cdd:cd00228   240 DEEGSLDDDGTLFVDGQEVAVVYFRAGYTPDDYpSESEWEARLLMERSSAIKCPSISTQLAGTKKIQQELAEPGVLERFL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 322 PgQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKI 401
Cdd:cd00228   320 P-NPEEVAKLRATFAGLYSLDDTEEGDEIVRKALEKPELFVLKPQREGGGNNIYGEEMREALLKLQGSEERAAYILMEKI 398
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017029493 402 EPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV 474
Cdd:cd00228   399 FPEPSENYLLRAGGPSHKEQAISELGIYGTYLRNKDEVVMNKQSGHLLRTKPISSAEGGVAAGFAVLDSIYLV 471
 
Name Accession Description Interval E-value
eu-GS cd00228
Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from ...
6-474 0e+00

Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.


Pssm-ID: 238140  Cd Length: 471  Bit Score: 814.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493   6 GSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAF 85
Cdd:cd00228     1 PPIPDDKDQLEELAKDANDWAVANGLVMRDKSVQESSVVASHAPFTLLPSPFPEALFEQAVEVQPDFNELVDRISQDGKF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  86 LEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSaDGSPALKQIEINTISASFGGLASRTPAVHRH 165
Cdd:cd00228    81 LQQSLSSTKKVDEFTSRLLDIHKKVLEENKKQPVRLGIFRSDYMFDEK-DGTKGLKQIEINTISSSFGGLSSRVTELHRY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 166 VLSVL--SKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARN-IHVIRRTFEDI 242
Cdd:cd00228   160 VLSALgySKGLDSNRIPSNNAVKGIAEALAKAWEEYGDPRAVVLFVVQNEERNIYDQRFLEAELLERHqIHVIRKTLADV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 243 SEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQY-SLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLL 321
Cdd:cd00228   240 DEEGSLDDDGTLFVDGQEVAVVYFRAGYTPDDYpSESEWEARLLMERSSAIKCPSISTQLAGTKKIQQELAEPGVLERFL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 322 PgQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKI 401
Cdd:cd00228   320 P-NPEEVAKLRATFAGLYSLDDTEEGDEIVRKALEKPELFVLKPQREGGGNNIYGEEMREALLKLQGSEERAAYILMEKI 398
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017029493 402 EPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV 474
Cdd:cd00228   399 FPEPSENYLLRAGGPSHKEQAISELGIYGTYLRNKDEVVMNKQSGHLLRTKPISSAEGGVAAGFAVLDSIYLV 471
glut_syn_euk TIGR01986
glutathione synthetase, eukaryotic; This model represents the eukaryotic glutathione ...
15-473 0e+00

glutathione synthetase, eukaryotic; This model represents the eukaryotic glutathione synthetase, which shows little resemblance to the analogous enzyme of Gram-negative bacteria (TIGR01380). In the Kinetoplastida, trypanothione replaces glutathione, but can be made from glutathione; a sequence from Leishmania is not included in the seed, is highly divergent, and therefore scores between the trusted and noise cutoffs.


Pssm-ID: 273912  Cd Length: 472  Bit Score: 731.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  15 LEELARQAVDRALAEGVLLRTSQEPTSSEV-VSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSST 93
Cdd:TIGR01986   1 LEELIQEANDWAIAHGVVMYPPSFEKEGPVnASVAPITLFPSPIPRACFDEAVQVQPVFNELYARISQDMAFLHKTLSST 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  94 IKQDDFTARLFDIHKQVLK--EGIAQTVFLGLNRSDYMFQRSaDGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLS 171
Cdd:TIGR01986  81 AKSDEFTGKLWDLYLKTLKsaQYKKQNFRLGLFRSDYMIDKK-DGTEQLKQVEFNTISVSFGGLSEKVSRLHSYLLRSNK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 172 KTKEAGK--ILSNNPSKGLALGIAKAWELYGSPN-------ALVLLIAQEKERNIFDQRAIENELLAR-NIHVIRRTFED 241
Cdd:TIGR01986 160 YDPKGPIynMVINTSGYGLAKGIAKAVESYKSPQsssttsdPIVLFIVQRNERNIFDQRVLELELLERfNIKSIRLTFAD 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 242 ISEKGSLDQDR-RLFVD--GQEIAVVYFRDGYMPRQYSLQ-NWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGML 317
Cdd:TIGR01986 240 VNDKLSIDDDTgKLFVRdtGQEIAVVYYRTGYTPTDYPSQkDWEARLLLEKSFAIKCPDIATQLAGSKKIQQELADPGVL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 318 EMLLPgQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDsEERASYIL 397
Cdd:TIGR01986 320 ERFLS-DAEKKASLRKTFAGLYPLDDTKLGREGIKLALEKPSKFVLKPQREGGGNNVYGEDIPNFLKGLEE-EEWDSYIL 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1017029493 398 MEKIEPEPFENCLLRPGsPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYP 473
Cdd:TIGR01986 398 MELIEPEPSENIILRDG-KSYKEQIISELGIYGCYVRNDKTVVSNEQSGSLLRTKFNTSNEGGVAAGFAVLDSIYL 472
GSH_synth_ATP pfam03917
Eukaryotic glutathione synthase, ATP binding domain;
12-472 0e+00

Eukaryotic glutathione synthase, ATP binding domain;


Pssm-ID: 461091  Cd Length: 465  Bit Score: 690.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  12 KQQLEELARQAVDRALAEGVLLRTSQEPtSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLS 91
Cdd:pfam03917   1 EEQLEELVENAKDWALAHGLLMRPKEDP-SGVLATHAPFTLFPSPFPRKLFEQAVAVQPAYNELYARVAQDEEFLEEILE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  92 STIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVL- 170
Cdd:pfam03917  80 EVIKVDDFTAKLWEIYEKVKEEGIVQPISLGLFRSDYMLHQDEGSSPSLKQVEFNTISSSFGGLSSKVSELHRYLLSRLg 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 171 ---SKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLAR-NIHVIRRTFEDISEKG 246
Cdd:pfam03917 160 aypDSLLDDENLPENNSLSGLAEGLAKAWKAYGSPKAVVLFVVQPGERNIFDQRHLEYELWENhGIRVIRRTLTEILEET 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 247 SLDQ-DRRLFVDGQEIAVVYFRDGYMPRQY-SLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLLPGQ 324
Cdd:pfam03917 240 KLDDpDRTLFVDGQEVSVVYFRAGYAPSDYpSEKEWDARLLLERSRAIKCPSILTQLAGTKKVQQVLATPGVLERFLPDE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 325 PEAvARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDsEERASYILMEKIEPE 404
Cdd:pfam03917 320 EEA-ARLRETFAGLYPLDDSEEGLEAVKLALENPEKYVLKPQREGGGNNIYGEDIPEFLKSLPE-EEWSAYILMELIEPP 397
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029493 405 PFENCLLRpGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPY 472
Cdd:pfam03917 398 PVKNYLVR-NGEVVKGEVISELGIYGTILWGGDEILENEQAGHLLRTKGSSSNEGGVAAGFGVLDSPY 464
PLN02977 PLN02977
glutathione synthetase
10-472 7.47e-169

glutathione synthetase


Pssm-ID: 215528  Cd Length: 478  Bit Score: 484.17  E-value: 7.47e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  10 QDKQQLEELARQAVDRALAEG--VLLRTSQEPTSSEVVSY--APFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAF 85
Cdd:PLN02977   10 LTKELLQDLVEEALVWSSLHGlvVGDRSDQRSGTVPGVGLvhAPISLLPTPFPRAAFKQACELAPLFNELVDRVSRDGEF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  86 LEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQrsaDGSPALKQIEINTISASFGGLASRTPAVHRH 165
Cdd:PLN02977   90 LQETLARTRKVDEFTSRLLDIHEKMGERNKREDIRLGLHRSDYMLD---EPTGLLLQVELNTISSSFPGLSSLVSQLHRS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 166 VLSVLSKT--KEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLAR-NIHVIRRTFEDI 242
Cdd:PLN02977  167 LLSRYGRVlgLDPERVPENPALEQFADALAAAWKEFGNPSAVVLMVVQPEERNMYDQRWLSFALWERhGIRTIRKTLAEI 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 243 SEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQY-SLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLL 321
Cdd:PLN02977  247 AAEGSLDEDGTLTVDGQPVAVVYFRAGYAPTDYpSEAEWRARLLLERSSAVKCPSIAYHLAGTKKVQQELAKPGVLERFL 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 322 PgQPEAVARLRATFAGLYSLDvGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLK--DSEERASYILME 399
Cdd:PLN02977  327 D-DKEDIAKLRKCFAGLWSLD-DEAAAEIVKLAIEKPELFVLKPQREGGGNNIYGDDLRETLERLQkeGGEDLAAYILMQ 404
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017029493 400 KIEPEPFENCLLRPGSPARvVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPY 472
Cdd:PLN02977  405 RIFPPVSRTYLVRNGVCEE-GETISELGIYGAYLRNGDKVIINEQSGYLLRTKAASSDEGGVAAGFAVLDSPY 476
 
Name Accession Description Interval E-value
eu-GS cd00228
Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from ...
6-474 0e+00

Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.


Pssm-ID: 238140  Cd Length: 471  Bit Score: 814.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493   6 GSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAF 85
Cdd:cd00228     1 PPIPDDKDQLEELAKDANDWAVANGLVMRDKSVQESSVVASHAPFTLLPSPFPEALFEQAVEVQPDFNELVDRISQDGKF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  86 LEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSaDGSPALKQIEINTISASFGGLASRTPAVHRH 165
Cdd:cd00228    81 LQQSLSSTKKVDEFTSRLLDIHKKVLEENKKQPVRLGIFRSDYMFDEK-DGTKGLKQIEINTISSSFGGLSSRVTELHRY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 166 VLSVL--SKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARN-IHVIRRTFEDI 242
Cdd:cd00228   160 VLSALgySKGLDSNRIPSNNAVKGIAEALAKAWEEYGDPRAVVLFVVQNEERNIYDQRFLEAELLERHqIHVIRKTLADV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 243 SEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQY-SLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLL 321
Cdd:cd00228   240 DEEGSLDDDGTLFVDGQEVAVVYFRAGYTPDDYpSESEWEARLLMERSSAIKCPSISTQLAGTKKIQQELAEPGVLERFL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 322 PgQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKI 401
Cdd:cd00228   320 P-NPEEVAKLRATFAGLYSLDDTEEGDEIVRKALEKPELFVLKPQREGGGNNIYGEEMREALLKLQGSEERAAYILMEKI 398
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017029493 402 EPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV 474
Cdd:cd00228   399 FPEPSENYLLRAGGPSHKEQAISELGIYGTYLRNKDEVVMNKQSGHLLRTKPISSAEGGVAAGFAVLDSIYLV 471
glut_syn_euk TIGR01986
glutathione synthetase, eukaryotic; This model represents the eukaryotic glutathione ...
15-473 0e+00

glutathione synthetase, eukaryotic; This model represents the eukaryotic glutathione synthetase, which shows little resemblance to the analogous enzyme of Gram-negative bacteria (TIGR01380). In the Kinetoplastida, trypanothione replaces glutathione, but can be made from glutathione; a sequence from Leishmania is not included in the seed, is highly divergent, and therefore scores between the trusted and noise cutoffs.


Pssm-ID: 273912  Cd Length: 472  Bit Score: 731.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  15 LEELARQAVDRALAEGVLLRTSQEPTSSEV-VSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSST 93
Cdd:TIGR01986   1 LEELIQEANDWAIAHGVVMYPPSFEKEGPVnASVAPITLFPSPIPRACFDEAVQVQPVFNELYARISQDMAFLHKTLSST 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  94 IKQDDFTARLFDIHKQVLK--EGIAQTVFLGLNRSDYMFQRSaDGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLS 171
Cdd:TIGR01986  81 AKSDEFTGKLWDLYLKTLKsaQYKKQNFRLGLFRSDYMIDKK-DGTEQLKQVEFNTISVSFGGLSEKVSRLHSYLLRSNK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 172 KTKEAGK--ILSNNPSKGLALGIAKAWELYGSPN-------ALVLLIAQEKERNIFDQRAIENELLAR-NIHVIRRTFED 241
Cdd:TIGR01986 160 YDPKGPIynMVINTSGYGLAKGIAKAVESYKSPQsssttsdPIVLFIVQRNERNIFDQRVLELELLERfNIKSIRLTFAD 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 242 ISEKGSLDQDR-RLFVD--GQEIAVVYFRDGYMPRQYSLQ-NWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGML 317
Cdd:TIGR01986 240 VNDKLSIDDDTgKLFVRdtGQEIAVVYYRTGYTPTDYPSQkDWEARLLLEKSFAIKCPDIATQLAGSKKIQQELADPGVL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 318 EMLLPgQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDsEERASYIL 397
Cdd:TIGR01986 320 ERFLS-DAEKKASLRKTFAGLYPLDDTKLGREGIKLALEKPSKFVLKPQREGGGNNVYGEDIPNFLKGLEE-EEWDSYIL 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1017029493 398 MEKIEPEPFENCLLRPGsPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYP 473
Cdd:TIGR01986 398 MELIEPEPSENIILRDG-KSYKEQIISELGIYGCYVRNDKTVVSNEQSGSLLRTKFNTSNEGGVAAGFAVLDSIYL 472
GSH_synth_ATP pfam03917
Eukaryotic glutathione synthase, ATP binding domain;
12-472 0e+00

Eukaryotic glutathione synthase, ATP binding domain;


Pssm-ID: 461091  Cd Length: 465  Bit Score: 690.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  12 KQQLEELARQAVDRALAEGVLLRTSQEPtSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLS 91
Cdd:pfam03917   1 EEQLEELVENAKDWALAHGLLMRPKEDP-SGVLATHAPFTLFPSPFPRKLFEQAVAVQPAYNELYARVAQDEEFLEEILE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  92 STIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVL- 170
Cdd:pfam03917  80 EVIKVDDFTAKLWEIYEKVKEEGIVQPISLGLFRSDYMLHQDEGSSPSLKQVEFNTISSSFGGLSSKVSELHRYLLSRLg 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 171 ---SKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLAR-NIHVIRRTFEDISEKG 246
Cdd:pfam03917 160 aypDSLLDDENLPENNSLSGLAEGLAKAWKAYGSPKAVVLFVVQPGERNIFDQRHLEYELWENhGIRVIRRTLTEILEET 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 247 SLDQ-DRRLFVDGQEIAVVYFRDGYMPRQY-SLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLLPGQ 324
Cdd:pfam03917 240 KLDDpDRTLFVDGQEVSVVYFRAGYAPSDYpSEKEWDARLLLERSRAIKCPSILTQLAGTKKVQQVLATPGVLERFLPDE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 325 PEAvARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDsEERASYILMEKIEPE 404
Cdd:pfam03917 320 EEA-ARLRETFAGLYPLDDSEEGLEAVKLALENPEKYVLKPQREGGGNNIYGEDIPEFLKSLPE-EEWSAYILMELIEPP 397
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029493 405 PFENCLLRpGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPY 472
Cdd:pfam03917 398 PVKNYLVR-NGEVVKGEVISELGIYGTILWGGDEILENEQAGHLLRTKGSSSNEGGVAAGFGVLDSPY 464
PLN02977 PLN02977
glutathione synthetase
10-472 7.47e-169

glutathione synthetase


Pssm-ID: 215528  Cd Length: 478  Bit Score: 484.17  E-value: 7.47e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  10 QDKQQLEELARQAVDRALAEG--VLLRTSQEPTSSEVVSY--APFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAF 85
Cdd:PLN02977   10 LTKELLQDLVEEALVWSSLHGlvVGDRSDQRSGTVPGVGLvhAPISLLPTPFPRAAFKQACELAPLFNELVDRVSRDGEF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  86 LEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQrsaDGSPALKQIEINTISASFGGLASRTPAVHRH 165
Cdd:PLN02977   90 LQETLARTRKVDEFTSRLLDIHEKMGERNKREDIRLGLHRSDYMLD---EPTGLLLQVELNTISSSFPGLSSLVSQLHRS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 166 VLSVLSKT--KEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLAR-NIHVIRRTFEDI 242
Cdd:PLN02977  167 LLSRYGRVlgLDPERVPENPALEQFADALAAAWKEFGNPSAVVLMVVQPEERNMYDQRWLSFALWERhGIRTIRKTLAEI 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 243 SEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQY-SLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLL 321
Cdd:PLN02977  247 AAEGSLDEDGTLTVDGQPVAVVYFRAGYAPTDYpSEAEWRARLLLERSSAVKCPSIAYHLAGTKKVQQELAKPGVLERFL 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 322 PgQPEAVARLRATFAGLYSLDvGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLK--DSEERASYILME 399
Cdd:PLN02977  327 D-DKEDIAKLRKCFAGLWSLD-DEAAAEIVKLAIEKPELFVLKPQREGGGNNIYGDDLRETLERLQkeGGEDLAAYILMQ 404
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017029493 400 KIEPEPFENCLLRPGSPARvVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPY 472
Cdd:PLN02977  405 RIFPPVSRTYLVRNGVCEE-GETISELGIYGAYLRNGDKVIINEQSGYLLRTKAASSDEGGVAAGFAVLDSPY 476
GSH_synthase pfam03199
Eukaryotic glutathione synthase;
204-302 1.88e-49

Eukaryotic glutathione synthase;


Pssm-ID: 460845 [Multi-domain]  Cd Length: 102  Bit Score: 164.19  E-value: 1.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 204 ALVLLIAQEKERNIFDQRAIENELLAR-NIHVIRRTFEDISEKGSLDQDRRLFVDG-QEIAVVYFRDGYMPRQY-SLQNW 280
Cdd:pfam03199   1 AVVLFVVQPNERNVFDQRLLEYELLERhGIRVIRRTLTELLEQTTLGPDRRLLYDGpFEVAVVYFRAGYSPDDYpSEKEW 80
                          90       100
                  ....*....|....*....|..
gi 1017029493 281 EARLLLERSHAAKCPDIATQLA 302
Cdd:pfam03199  81 EARLLLERSRAIKCPSILTQLA 102
PTZ00055 PTZ00055
glutathione synthetase; Provisional
49-469 2.50e-49

glutathione synthetase; Provisional


Pssm-ID: 240247  Cd Length: 619  Bit Score: 178.05  E-value: 2.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493  49 PFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEG---IAQTVFLGLNR 125
Cdd:PTZ00055   79 SFVLFPLPFPRKLLEDCCLCTLLLVELFDNMSCDLELLLDVFEQLKKYDKFVRDLLEICNEVYGSGernIKDDIRCYIGR 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 126 SDYMFQR----------------------------SADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVL------- 170
Cdd:PTZ00055  159 SDYFIHIdnltknktqgenefcktcyydhclcnisANNQSLEFKLVEYNTISVAFGNLSGLLFRAHKKLLRTVyrecfdl 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 171 ----SKTKEAGKIL----SNNPSKGLALGIAKAWELY--------GSPNALVLLIAQEKERNIFDQRAIENELLAR-NIH 233
Cdd:PTZ00055  239 egkgAERPMVGSILlekfKNHFYNGIVTCFKKCHRMYldeykplfGKNKVCVMSIVHEDLFNFFDKYKTANELFDKyGIH 318
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 234 VI------------RRTFEDISEKGSLD---------QDR-------RLFVD--GQ-------------EIAVVYFRDGY 270
Cdd:PTZ00055  319 VKtltinelillyeKKKLFLNYPWETLEdglvrvkkyQDDlhklhpgRLLIDlnSQenglnrlykrdcfEVSVVYFRSLY 398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 271 MPRQYSLQN--WEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLLP----------GQPEAVARLRATFAgl 338
Cdd:PTZ00055  399 SPDHMESDEriWLVREFLEFSDAVKIPSLPAQLVGSKRIQMYLLDPSILKRLVSlynkrkksdkQINHDMKLLKKTFA-- 476
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029493 339 YSLDVGEEGDQAI-AEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQ-LKDS-EERASYILMEKIEPEPFE--NCLLRP 413
Cdd:PTZ00055  477 LQVDPSLESNEHIvQDAIQNPSNYLLKPQREGGKNNLHGNEISEKLRLgYKNNkEKLSQYVLMQKIFPPSQPavFVRNLK 556
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029493 414 GSPARVV--QCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLD 469
Cdd:PTZ00055  557 SGSFEFSpeNSLTELGLYHNFIFDGNECILNEQKGYLARTKNEFETGGGAISGISSVN 614
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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