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Conserved domains on  [gi|1018443258|ref|NP_001309852|]
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capZ-interacting protein isoform 2 [Homo sapiens]

Protein Classification

CAP-ZIP_m and RCSD domain-containing protein( domain architecture ID 11700656)

CAP-ZIP_m and RCSD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RCSD pfam05177
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
 199-299 2.64e-19

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


:

Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 82.40  E-value: 2.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258 199 RTLGPAEKPPLRRSPSRTEKQEED-RATEEAKNGEKARRSSEEVDGQHPAQEEVPEsPQTSGPEAENRCGSPREEKPAGE 277
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKgRAPEEAEHSPKAVGGSEEEKPKSPAKEEAVE-AQASSPEAANGCGSPTEEKKAGE 79

                          90       100
                  ....*....|....*....|..
gi 1018443258 278 EAEMEKATEVKGERVQNEEVGP 299
Cdd:pfam05177  80 KVEEKKSSEVKEERAENEEDSP 101
CAP-ZIP_m super family cl21113
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
 51-136 5.11e-09

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


The actual alignment was detected with superfamily member pfam15255:

Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 54.45  E-value: 5.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258  51 KSSPLIEKLQANLTFDPAALLPGASPKSPGLK-AMVSPFHSPPSTPSSPGVRSRPSE--AEEVPVSFDQPPEGSHLPCYN 127
Cdd:pfam15255   7 EPSSRIGKLQANLAINPAALLPGAAPQIPGAKsVLPGLAFPSSEPARSTSPESTPTAqgSGEAGVSFDLPAQADTLHSAN 86


                  ....*....
gi 1018443258 128 KVRTRGSIK 136
Cdd:pfam15255  87 KSRAKVTGK 95
 
Name Accession Description Interval E-value
RCSD pfam05177
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
 199-299 2.64e-19

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 82.40  E-value: 2.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258 199 RTLGPAEKPPLRRSPSRTEKQEED-RATEEAKNGEKARRSSEEVDGQHPAQEEVPEsPQTSGPEAENRCGSPREEKPAGE 277
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKgRAPEEAEHSPKAVGGSEEEKPKSPAKEEAVE-AQASSPEAANGCGSPTEEKKAGE 79

                          90       100
                  ....*....|....*....|..
gi 1018443258 278 EAEMEKATEVKGERVQNEEVGP 299
Cdd:pfam05177  80 KVEEKKSSEVKEERAENEEDSP 101
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
 51-136 5.11e-09

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 54.45  E-value: 5.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258  51 KSSPLIEKLQANLTFDPAALLPGASPKSPGLK-AMVSPFHSPPSTPSSPGVRSRPSE--AEEVPVSFDQPPEGSHLPCYN 127
Cdd:pfam15255   7 EPSSRIGKLQANLAINPAALLPGAAPQIPGAKsVLPGLAFPSSEPARSTSPESTPTAqgSGEAGVSFDLPAQADTLHSAN 86


                  ....*....
gi 1018443258 128 KVRTRGSIK 136
Cdd:pfam15255  87 KSRAKVTGK 95
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 193-383 2.66e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.98  E-value: 2.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258  193 AAGEGVRTLGPAEKPPLRRSP----SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGS 268
Cdd:TIGR00927  638 AEHTGERTGEEGERPTEAEGEngeeSGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEH 717

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258  269 PREEKPAGEEAEMEKATEVKGERVQNE---EVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGA 345
Cdd:TIGR00927  718 EGETEAEGTEDEGEIETGEEGEEVEDEgegEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGA 797

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1018443258  346 VLEPGCSPQTGP-AQLETSSEVQSEPAVPKPEDDTPVQD 383
Cdd:TIGR00927  798 EGKVEHEGETEAgEKDEHEGQSETQADDTEVKDETGEQE 836
 
Name Accession Description Interval E-value
RCSD pfam05177
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
 199-299 2.64e-19

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 82.40  E-value: 2.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258 199 RTLGPAEKPPLRRSPSRTEKQEED-RATEEAKNGEKARRSSEEVDGQHPAQEEVPEsPQTSGPEAENRCGSPREEKPAGE 277
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKgRAPEEAEHSPKAVGGSEEEKPKSPAKEEAVE-AQASSPEAANGCGSPTEEKKAGE 79

                          90       100
                  ....*....|....*....|..
gi 1018443258 278 EAEMEKATEVKGERVQNEEVGP 299
Cdd:pfam05177  80 KVEEKKSSEVKEERAENEEDSP 101
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
 51-136 5.11e-09

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 54.45  E-value: 5.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258  51 KSSPLIEKLQANLTFDPAALLPGASPKSPGLK-AMVSPFHSPPSTPSSPGVRSRPSE--AEEVPVSFDQPPEGSHLPCYN 127
Cdd:pfam15255   7 EPSSRIGKLQANLAINPAALLPGAAPQIPGAKsVLPGLAFPSSEPARSTSPESTPTAqgSGEAGVSFDLPAQADTLHSAN 86


                  ....*....
gi 1018443258 128 KVRTRGSIK 136
Cdd:pfam15255  87 KSRAKVTGK 95
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 193-383 2.66e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.98  E-value: 2.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258  193 AAGEGVRTLGPAEKPPLRRSP----SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGS 268
Cdd:TIGR00927  638 AEHTGERTGEEGERPTEAEGEngeeSGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEH 717

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443258  269 PREEKPAGEEAEMEKATEVKGERVQNE---EVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGA 345
Cdd:TIGR00927  718 EGETEAEGTEDEGEIETGEEGEEVEDEgegEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGA 797

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1018443258  346 VLEPGCSPQTGP-AQLETSSEVQSEPAVPKPEDDTPVQD 383
Cdd:TIGR00927  798 EGKVEHEGETEAgEKDEHEGQSETQADDTEVKDETGEQE 836
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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