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Conserved domains on  [gi|1042818151|ref|NP_001310225|]
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zinc finger protein 197 isoform 4 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 3.41e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.28  E-value: 3.41e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1042818151   3 LVMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSL 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-640 3.66e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 211 KPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKC--KECGKGFYRHSGLIIHLRRHSGERPYKCNecGKVFSQNAYLIDHQ 288
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 289 RLHKGEEPYKCNKCQK-----AFILKKSLILHQRIHSGEKPYK-CDECGKTFAQTTYLI-DHQRLHSAENPYKCkecgkv 361
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHpPLPANSLSKDPSSN------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 362 firsKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSREKPYKCTECGKAFTQSaylFDHQRLHNGEKPYECNE 441
Cdd:COG5048   184 ----LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 442 CGKVFILKKSLILHQRFHtgenlyeckdcgkvfGSNRNLIDHERLhngEKPYECRECGKTFIMSKSFMVHQ--KLHTQE- 518
Cdd:COG5048   257 ASESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 519 -KAYKC--EDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSNRNLIE-------HKRIHSGEKPYECDECGKC--- 585
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSNSCIrnf 398

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1042818151 586 ---FILKKSLIGHqrIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACSECGK 640
Cdd:COG5048   399 krdSNLSLHIITH--LSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
547-796 9.27e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 9.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 547 KPFECSECGRAFSSNRNLIEHKRIHSGEKPYEC--DECGKCFILKKSLIGHQRIHTREKSYKCND-CGKVFSYRSNLIAH 623
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 624 QRIHTGEKPYACSECGKGFTYNRNLIEHQRIHSgekTYECHVCRKVLTSSRNLMVHQRIHtgeKPYKCNECGKDFSQNKN 703
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 704 LVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCSKVFRQRKNLTVHQKIHTDEKPCECDVSEKEFS 783
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250
                  ....*....|...
gi 1042818151 784 QTSNLHLQQKIHT 796
Cdd:COG5048   266 PTASSQSSSPNES 278
zf-H2C2_2 pfam13465
Zinc-finger double domain;
171-196 1.85e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 171 HLINHRRIHTGEKPHKCKECGKGFIQ 196
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 3.41e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.28  E-value: 3.41e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1042818151   3 LVMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSL 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.27e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 1.27e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1042818151   4 VMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB smart00349
krueppel associated box;
4-44 4.45e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.01  E-value: 4.45e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1042818151    4 VMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSLE 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-640 3.66e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 211 KPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKC--KECGKGFYRHSGLIIHLRRHSGERPYKCNecGKVFSQNAYLIDHQ 288
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 289 RLHKGEEPYKCNKCQK-----AFILKKSLILHQRIHSGEKPYK-CDECGKTFAQTTYLI-DHQRLHSAENPYKCkecgkv 361
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHpPLPANSLSKDPSSN------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 362 firsKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSREKPYKCTECGKAFTQSaylFDHQRLHNGEKPYECNE 441
Cdd:COG5048   184 ----LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 442 CGKVFILKKSLILHQRFHtgenlyeckdcgkvfGSNRNLIDHERLhngEKPYECRECGKTFIMSKSFMVHQ--KLHTQE- 518
Cdd:COG5048   257 ASESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 519 -KAYKC--EDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSNRNLIE-------HKRIHSGEKPYECDECGKC--- 585
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSNSCIrnf 398

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1042818151 586 ---FILKKSLIGHqrIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACSECGK 640
Cdd:COG5048   399 krdSNLSLHIITH--LSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
547-796 9.27e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 9.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 547 KPFECSECGRAFSSNRNLIEHKRIHSGEKPYEC--DECGKCFILKKSLIGHQRIHTREKSYKCND-CGKVFSYRSNLIAH 623
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 624 QRIHTGEKPYACSECGKGFTYNRNLIEHQRIHSgekTYECHVCRKVLTSSRNLMVHQRIHtgeKPYKCNECGKDFSQNKN 703
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 704 LVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCSKVFRQRKNLTVHQKIHTDEKPCECDVSEKEFS 783
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250
                  ....*....|...
gi 1042818151 784 QTSNLHLQQKIHT 796
Cdd:COG5048   266 PTASSQSSSPNES 278
zf-H2C2_2 pfam13465
Zinc-finger double domain;
675-700 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 675 NLMVHQRIHTGEKPYKCNECGKDFSQ 700
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-224 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 199 SLLMHLRNHSGEKPYKCNECGKAFSQ 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 355-512 1.22e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 42.17  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 355 CKECgKVFIRSKSLLLHQrVHTEKKTFGCKK--CGkIFSSKSNFIDHkrMHsrekpykCTECGKAFtQSAYLFDHQRLHN 432
Cdd:PLN03086  410 CRNC-KHYIPSRSIALHE-AYCSRHNVVCPHdgCG-IVLRVEEAKNH--VH-------CEKCGQAF-QQGEMEKHMKVFH 476

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 433 geKPYECnECGkVFILKKSLILHQRFHTGENLYECKDCGKVF--GSN--------RNLIDHERLhNGEKPYECRECGKTf 502
Cdd:PLN03086  477 --EPLQC-PCG-VVLEKEQMVQHQASTCPLRLITCRFCGDMVqaGGSamdvrdrlRGMSEHESI-CGSRTAPCDSCGRS- 550

                         170
                  ....*....|
gi 1042818151 503 IMSKSFMVHQ 512
Cdd:PLN03086  551 VMLKEMDIHQ 560
zf-H2C2_2 pfam13465
Zinc-finger double domain;
171-196 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 171 HLINHRRIHTGEKPHKCKECGKGFIQ 196
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 631-683 2.68e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 2.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1042818151 631 KPYaCSECGKGFTYNRNLIEHQRihsgEKTYECHVCRKVLTSSRNLMVH-QRIH 683
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 323-378 3.11e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 3.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1042818151 323 KPYkCDECGKTFAQTTYLIDHQRLHSaenpYKCKECGKVFIRSKSLLLH-QRVHTEK 378
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHKET 52
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 3.41e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.28  E-value: 3.41e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1042818151   3 LVMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSL 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.27e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 1.27e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1042818151   4 VMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB smart00349
krueppel associated box;
4-44 4.45e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.01  E-value: 4.45e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1042818151    4 VMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSLE 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-640 3.66e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 211 KPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKC--KECGKGFYRHSGLIIHLRRHSGERPYKCNecGKVFSQNAYLIDHQ 288
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 289 RLHKGEEPYKCNKCQK-----AFILKKSLILHQRIHSGEKPYK-CDECGKTFAQTTYLI-DHQRLHSAENPYKCkecgkv 361
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHpPLPANSLSKDPSSN------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 362 firsKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSREKPYKCTECGKAFTQSaylFDHQRLHNGEKPYECNE 441
Cdd:COG5048   184 ----LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 442 CGKVFILKKSLILHQRFHtgenlyeckdcgkvfGSNRNLIDHERLhngEKPYECRECGKTFIMSKSFMVHQ--KLHTQE- 518
Cdd:COG5048   257 ASESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 519 -KAYKC--EDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSNRNLIE-------HKRIHSGEKPYECDECGKC--- 585
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSNSCIrnf 398

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1042818151 586 ---FILKKSLIGHqrIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACSECGK 640
Cdd:COG5048   399 krdSNLSLHIITH--LSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-561 9.78e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 9.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 157 YKCDMCCKHFNKISHLINHRRIHTGEKPHKC--KECGKGFIQRSSLLMHLRNHSGEKPYKCN-ECGKAFSQSAYLLNHQR 233
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 234 IHTGEKPYKCKECGKGFYRHSGLIIHLRRHS---GERPYKCNECGKVFSQNAYLI-DHQRLHKGEEPYKCNkcqkafilk 309
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHpPLPANSLSKDPSSNL--------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 310 kSLILHQRIHSGEKPYKCDECGKTFAQTTYLIDHQRLHSAENPYKCKECGkvFIRSKSLLLHQRVHTEKKTFG--CKKCG 387
Cdd:COG5048   185 -SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSDSSssASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 388 KIFSSKSNFID--HKRMHSRE-----KPYKCTECGKAFTQSAYLFDHQR--LHNGE--KPYECNE--CGKVFILKKSLIL 454
Cdd:COG5048   262 RSSLPTASSQSssPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 455 HQRFHTGENLYECKDC-------GKVFGSNRNLIDHERLHNGEKPYEC--RECGKTFIMSKSFMVHQKLHT--QEKAYKC 523
Cdd:COG5048   342 HILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKN 421

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1042818151 524 EDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSN 561
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-726 1.82e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 323 KPYKCDECGKTFAQTTYLIDHQRLHSAENPYKC--KECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNF--ID 398
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSssLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 399 HKRMHSReKPYKCTECGKAFTQSAYL--FDHQRLHNGEKPYE-CNECGKVFI--LKKSLILHQRFHTGENLyeckdcgkv 473
Cdd:COG5048   112 SSSSNSN-DNNLLSSHSLPPSSRDPQlpDLLSISNLRNNPLPgNNSSSVNTPqsNSLHPPLPANSLSKDPS--------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 474 fgSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLHTQEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECSE 553
Cdd:COG5048   182 --SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 554 CGRAFSSNRNLIEHKRIHSGE-------KPYECDECGKCFILKKSLIGHQR--IHTRE--KSYKC--NDCGKVFSYRSNL 620
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 621 IAHQRIHTGEKPYACSECGKGFTYNRNLIE-------HQRIHSGEKTYEC--HVCRKVLTSSRNLMVHQRIHTGEKP--Y 689
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynC 419

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1042818151 690 KCNECGKDFSQNKNLVVHQRMHTGEKPYECDKCRKSF 726
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
407-768 2.97e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 407 KPYKCTECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKKSLILHQRF---HTGENLYECKDCGKVFGSNRNLIDH 483
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrthHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 484 ERLHNGEKPYECRECGKTFIMSKSFMVHQKLHTQEKAYKCEDCGKAF----------------------SYNSSLLVHRR 541
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 542 IHTGEKPFECSECGRAFSSNRNLIEHKRIHSGEKPYECDECGkcFILKKSLIGHQRIHTREKSYKCNDC-------GKVF 614
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSDSSSSASesprsslPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 615 SYRSNLIAH-QRIHTG-EKPYACSECGKGFTYNRNLIEHQR--IHSGE--KTYECHV--CRKVLTSSRNLMVHQRIHTGE 686
Cdd:COG5048   270 SQSSSPNESdSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 687 KPYKC--NECGKDFSQNKNLVVHQRMH-----TGEKPYECD--KCRKSFTSKRNLVGHQRIHTGEKPYGCND--CSKVFR 755
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFN 429

                         410
                  ....*....|...
gi 1042818151 756 QRKNLTVHQKIHT 768
Cdd:COG5048   430 RHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
547-796 9.27e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 9.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 547 KPFECSECGRAFSSNRNLIEHKRIHSGEKPYEC--DECGKCFILKKSLIGHQRIHTREKSYKCND-CGKVFSYRSNLIAH 623
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 624 QRIHTGEKPYACSECGKGFTYNRNLIEHQRIHSgekTYECHVCRKVLTSSRNLMVHQRIHtgeKPYKCNECGKDFSQNKN 703
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 704 LVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCSKVFRQRKNLTVHQKIHTDEKPCECDVSEKEFS 783
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250
                  ....*....|...
gi 1042818151 784 QTSNLHLQQKIHT 796
Cdd:COG5048   266 PTASSQSSSPNES 278
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-394 1.83e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 192 KGFIQRSSLLMHLRNHSG-EKPYKCNECGKAFSQSAYLLNHQR--IHTGE--KPYKCKE--CGKGFYRHSGLIIHLRRHS 264
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 265 GERPYKC--NECGKVFSQNAylidhqrlhkgeepykcNKCQKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLID 342
Cdd:COG5048   348 SISPAKEklLNSSSKFSPLL-----------------NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIIT 410

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1042818151 343 HQRLHSAEnpYKCKECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFSSKS 394
Cdd:COG5048   411 HLSFRPYN--CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
675-700 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 675 NLMVHQRIHTGEKPYKCNECGKDFSQ 700
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
703-728 6.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 703 NLVVHQRMHTGEKPYECDKCRKSFTS 728
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-224 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 199 SLLMHLRNHSGEKPYKCNECGKAFSQ 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 355-512 1.22e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 42.17  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 355 CKECgKVFIRSKSLLLHQrVHTEKKTFGCKK--CGkIFSSKSNFIDHkrMHsrekpykCTECGKAFtQSAYLFDHQRLHN 432
Cdd:PLN03086  410 CRNC-KHYIPSRSIALHE-AYCSRHNVVCPHdgCG-IVLRVEEAKNH--VH-------CEKCGQAF-QQGEMEKHMKVFH 476

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 433 geKPYECnECGkVFILKKSLILHQRFHTGENLYECKDCGKVF--GSN--------RNLIDHERLhNGEKPYECRECGKTf 502
Cdd:PLN03086  477 --EPLQC-PCG-VVLEKEQMVQHQASTCPLRLITCRFCGDMVqaGGSamdvrdrlRGMSEHESI-CGSRTAPCDSCGRS- 550

                         170
                  ....*....|
gi 1042818151 503 IMSKSFMVHQ 512
Cdd:PLN03086  551 VMLKEMDIHQ 560
zf-H2C2_2 pfam13465
Zinc-finger double domain;
563-586 1.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|....
gi 1042818151 563 NLIEHKRIHSGEKPYECDECGKCF 586
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 605-627 1.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|...
gi 1042818151 605 YKCNDCGKVFSYRSNLIAHQRIH 627
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 1.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 311 SLILHQRIHSGEKPYKCDECGKTFAQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
227-252 1.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 227 YLLNHQRIHTGEKPYKCKECGKGFYR 252
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
171-196 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 171 HLINHRRIHTGEKPHKCKECGKGFIQ 196
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 631-683 2.68e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 2.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1042818151 631 KPYaCSECGKGFTYNRNLIEHQRihsgEKTYECHVCRKVLTSSRNLMVH-QRIH 683
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 629-712 3.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042818151 629 GEKPYACS--ECGKGFTyNRNLIEHQRIHSgektyecHvCRKVLTSSRNLMVHQRIHTGEKPYKCNECGKDFSQNKNLVV 706
Cdd:COG5189   346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHG-------H-QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1042818151 707 HqRMHT 712
Cdd:COG5189   417 H-RKHS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 323-378 3.11e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 3.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1042818151 323 KPYkCDECGKTFAQTTYLIDHQRLHSaenpYKCKECGKVFIRSKSLLLH-QRVHTEK 378
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHKET 52
zf-H2C2_2 pfam13465
Zinc-finger double domain;
619-644 3.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 619 NLIAHQRIHTGEKPYACSECGKGFTY 644
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 211-260 4.01e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 4.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1042818151 211 KPYkCNECGKAFSQSAYLLNHQRIHTgekpYKCKECGKGFYRHSGLIIHL 260
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
535-560 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 535 SLLVHRRIHTGEKPFECSECGRAFSS 560
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-420 6.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 1042818151 395 NFIDHKRMHSREKPYKCTECGKAFTQ 420
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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