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Conserved domains on  [gi|1022433619|ref|NP_001310944|]
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coronin-2B isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-455 3.28e-97

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 301.43  E-value: 3.28e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  10 SKFRNVYGKVANRE-HCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSflVIPLEQTGRIEPNYPKVCGHQGNVLDI 88
Cdd:PTZ00421    4 SRFRHTQGVPARPDrHFLNVTPSTALWDCSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  89 KWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPV 168
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 169 KMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANC-KNHRVNRVVFLGNMKRLLTTGVSRWNTRQIAL 247
Cdd:PTZ00421  162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAhASAKSQRCLWAKRKDLIITLGCSKSQQRQIML 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 248 WDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYlmEFRSPAPQKGLGVMPKHGLDV 327
Cdd:PTZ00421  242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 328 SACEVFRFYKLvTLKGLIePISMIVPRR-SDS-YQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFK 405
Cdd:PTZ00421  320 RKCEIARFYAL-TYHSLY-TIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTSPELMG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 406 AP------IKEKKSVVVNGID-----------------LLENVPPRTEN----------ELLRMFFRQQDEIRRLKEELA 452
Cdd:PTZ00421  398 ASalspsgKPRHSGVSVPASTsamthsfddntskhadpCAMGVKRMDEGilderlgrlqALSEKLRTQHEEIKRCREALQ 477


                  ...
gi 1022433619 453 QKD 455
Cdd:PTZ00421  478 KKE 480
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-455 3.28e-97

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 301.43  E-value: 3.28e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  10 SKFRNVYGKVANRE-HCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSflVIPLEQTGRIEPNYPKVCGHQGNVLDI 88
Cdd:PTZ00421    4 SRFRHTQGVPARPDrHFLNVTPSTALWDCSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  89 KWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPV 168
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 169 KMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANC-KNHRVNRVVFLGNMKRLLTTGVSRWNTRQIAL 247
Cdd:PTZ00421  162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAhASAKSQRCLWAKRKDLIITLGCSKSQQRQIML 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 248 WDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYlmEFRSPAPQKGLGVMPKHGLDV 327
Cdd:PTZ00421  242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 328 SACEVFRFYKLvTLKGLIePISMIVPRR-SDS-YQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFK 405
Cdd:PTZ00421  320 RKCEIARFYAL-TYHSLY-TIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTSPELMG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 406 AP------IKEKKSVVVNGID-----------------LLENVPPRTEN----------ELLRMFFRQQDEIRRLKEELA 452
Cdd:PTZ00421  398 ASalspsgKPRHSGVSVPASTsamthsfddntskhadpCAMGVKRMDEGilderlgrlqALSEKLRTQHEEIKRCREALQ 477


                  ...
gi 1022433619 453 QKD 455
Cdd:PTZ00421  478 KKE 480
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 7-70 1.25e-33

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 121.07  E-value: 1.25e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1022433619   7 YRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPLEQTGR 70
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-300 1.72e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 1.72e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  79 CGHQGNVLDIKWNPFiDNIIASCSEDTSVRIWEIPEGGLKRnmteallELHGHSRRVGLVEWHPTtNNILFSAGYDYKVL 158
Cdd:cd00200    48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVR-------TLTGHTSYVSSVAFSPD-GRILSSSSRDKTIK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 159 IWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGvs 238
Cdd:cd00200   119 VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS-- 196

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1022433619 239 rwNTRQIALWDQ--EDLSMPLIEEEiDGLSGLLFpfydADTHMLYLAGKGDGNIRYYEISTEKP 300
Cdd:cd00200   197 --SDGTIKLWDLstGKCLGTLRGHE-NGVNSVAF----SPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
80-300 5.33e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 5.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  80 GHQGNVLDIKWNPfiD-NIIASCSEDTSVRIWEIPEGGLkrnmteaLLELHGHSRRVGLVEWHPTtNNILFSAGYDYKVL 158
Cdd:COG2319   160 GHSGAVTSVAFSP--DgKLLASGSDDGTVRLWDLATGKL-------LRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 159 IWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGvs 238
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS-- 307

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1022433619 239 rwNTRQIALWDQEDlsmpliEEEIDGLSGLLFPFYDA----DTHMLYLAGkGDGNIRYYEISTEKP 300
Cdd:COG2319   308 --DDGTVRLWDLAT------GKLLRTLTGHTGAVRSVafspDGKTLASGS-DDGTVRLWDLATGEL 364
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-111 5.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.72e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1022433619   80 GHQGNVLDIKWNPFiDNIIASCSEDTSVRIWE 111
Cdd:smart00320  10 GHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-455 3.28e-97

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 301.43  E-value: 3.28e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  10 SKFRNVYGKVANRE-HCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSflVIPLEQTGRIEPNYPKVCGHQGNVLDI 88
Cdd:PTZ00421    4 SRFRHTQGVPARPDrHFLNVTPSTALWDCSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  89 KWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPV 168
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 169 KMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANC-KNHRVNRVVFLGNMKRLLTTGVSRWNTRQIAL 247
Cdd:PTZ00421  162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAhASAKSQRCLWAKRKDLIITLGCSKSQQRQIML 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 248 WDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYlmEFRSPAPQKGLGVMPKHGLDV 327
Cdd:PTZ00421  242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 328 SACEVFRFYKLvTLKGLIePISMIVPRR-SDS-YQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFK 405
Cdd:PTZ00421  320 RKCEIARFYAL-TYHSLY-TIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTSPELMG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 406 AP------IKEKKSVVVNGID-----------------LLENVPPRTEN----------ELLRMFFRQQDEIRRLKEELA 452
Cdd:PTZ00421  398 ASalspsgKPRHSGVSVPASTsamthsfddntskhadpCAMGVKRMDEGilderlgrlqALSEKLRTQHEEIKRCREALQ 477


                  ...
gi 1022433619 453 QKD 455
Cdd:PTZ00421  478 KKE 480
PTZ00420 PTZ00420
coronin; Provisional
 13-440 1.20e-63

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 215.97  E-value: 1.20e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  13 RNVYGKVANRehCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPLEQTGRiEPNYPKVCGHQGNVLDIKWNP 92
Cdd:PTZ00420    8 KNLYPDPSNN--LFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR-KPPVIKLKGHTSSILDLQFNP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  93 FIDNIIASCSEDTSVRIWEIPEGGLKRN-MTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLD-------V 164
Cdd:PTZ00420   85 CFSEILASGSEDLTIRVWEIPHNDESVKeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEnekrafqI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 165 GEPVKMIDchtdvilcMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE-------ANCKNHRVNRvvFLGNMKRLLTTGV 237
Cdd:PTZ00420  165 NMPKKLSS--------LKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSfhihdggKNTKNIWIDG--LGGDDNYILSTGF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 238 SRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKpyLSYLMEFRSPAPQKGL 317
Cdd:PTZ00420  235 SKNNMREMKLWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSF 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 318 GVMPKHGLDVSACEVFRFYKLVTlKGLIEPISMIVPRRSDS-YQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGY 396
Cdd:PTZ00420  313 GFLPKQICDVYKCEIGRVYKNEN-NSSIRPISFYVPRKNPTkFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKDLT 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1022433619 397 KKSSKMV--FKAPIKEKKSVVVNGidllENVPPRTenELLRMFFRQ 440
Cdd:PTZ00420  392 EDDLRITkkYKFVPQSFNSIIIGE----NYTSKRT--SIIRQFTKK 431
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 7-70 1.25e-33

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 121.07  E-value: 1.25e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1022433619   7 YRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPLEQTGR 70
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-300 1.72e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 1.72e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  79 CGHQGNVLDIKWNPFiDNIIASCSEDTSVRIWEIPEGGLKRnmteallELHGHSRRVGLVEWHPTtNNILFSAGYDYKVL 158
Cdd:cd00200    48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVR-------TLTGHTSYVSSVAFSPD-GRILSSSSRDKTIK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 159 IWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGvs 238
Cdd:cd00200   119 VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS-- 196

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1022433619 239 rwNTRQIALWDQ--EDLSMPLIEEEiDGLSGLLFpfydADTHMLYLAGKGDGNIRYYEISTEKP 300
Cdd:cd00200   197 --SDGTIKLWDLstGKCLGTLRGHE-NGVNSVAF----SPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
80-300 5.33e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 5.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  80 GHQGNVLDIKWNPfiD-NIIASCSEDTSVRIWEIPEGGLkrnmteaLLELHGHSRRVGLVEWHPTtNNILFSAGYDYKVL 158
Cdd:COG2319   160 GHSGAVTSVAFSP--DgKLLASGSDDGTVRLWDLATGKL-------LRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 159 IWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGvs 238
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS-- 307

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1022433619 239 rwNTRQIALWDQEDlsmpliEEEIDGLSGLLFPFYDA----DTHMLYLAGkGDGNIRYYEISTEKP 300
Cdd:COG2319   308 --DDGTVRLWDLAT------GKLLRTLTGHTGAVRSVafspDGKTLASGS-DDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-299 1.39e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  80 GHQGNVLDIKWNPfIDNIIASCSEDTSVRIWEIPEGGLKRnmteallELHGHSRRVGLVEWHPTTNNiLFSAGYDYKVLI 159
Cdd:cd00200     7 GHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR-------TLKGHTGPVRDVAASADGTY-LASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 160 WNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNmKRLLTTGvsr 239
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASS--- 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1022433619 240 WNTRQIALWDQEDLS-MPLIEEEIDGLSGLLFpfyDADTHMLYLAGkGDGNIRYYEISTEK 299
Cdd:cd00200   154 SQDGTIKLWDLRTGKcVATLTGHTGEVNSVAF---SPDGEKLLSSS-SDGTIKLWDLSTGK 210
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-249 1.59e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 1.59e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  80 GHQGNVLDIKWNPFiDNIIASCSEDTSVRIWEIPEGGLKRNmtealleLHGHSRRVGLVEWHPTTNNILFSAGyDYKVLI 159
Cdd:cd00200   133 GHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVAT-------LTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 160 WNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGVSR 239
Cdd:cd00200   204 WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADG 283

                         170
                  ....*....|
gi 1022433619 240 WntrqIALWD 249
Cdd:cd00200   284 T----IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
80-249 1.86e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 1.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  80 GHQGNVLDIKWNPfiDN-IIASCSEDTSVRIWEIPEGglkrnmtEALLELHGHSRRVGLVEWHPTtNNILFSAGYDYKVL 158
Cdd:COG2319   244 GHSGSVRSVAFSP--DGrLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVR 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 159 IWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEAncKNH--RVNRVVFLGNMKRLLTTG 236
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL--TGHtgAVTSVAFSPDGRTLASGS 391

                         170
                  ....*....|...
gi 1022433619 237 vsrwNTRQIALWD 249
Cdd:COG2319   392 ----ADGTVRLWD 400
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 345-387 3.03e-19

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 80.63  E-value: 3.03e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1022433619 345 IEPISMIVPRRS-DSYQEDIYPMTPGTEPALTPDEWLGGINRDP 387
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
80-249 4.74e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 4.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  80 GHQGNVLDIKWNPfIDNIIASCSEDTSVRIWEIPEGGLKRnmteallELHGHSRRVGLVEWHPTtNNILFSAGYDYKVLI 159
Cdd:COG2319    76 GHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLR-------TLTGHTGAVRSVAFSPD-GKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 160 WNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGvsr 239
Cdd:COG2319   147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS--- 223

                         170
                  ....*....|
gi 1022433619 240 wNTRQIALWD 249
Cdd:COG2319   224 -ADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
80-163 5.55e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 5.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  80 GHQGNVLDIKWNPFiDNIIASCSEDTSVRIWEIPEGGLkrnmteaLLELHGHSRRVGLVEWHPTtNNILFSAGYDYKVLI 159
Cdd:COG2319   328 GHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGEL-------LRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRL 398


                  ....
gi 1022433619 160 WNLD 163
Cdd:COG2319   399 WDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 167-300 6.96e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 6.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 167 PVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEanCKNHR--VNRVVFLGNMKRLLTTGvsrwNTRQ 244
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT--LKGHTgpVRDVAASADGTYLASGS----SDKT 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1022433619 245 IALWDQEDLSMP--LIEEEiDGLSGLLFpfyDADTHMLyLAGKGDGNIRYYEISTEKP 300
Cdd:cd00200    75 IRLWDLETGECVrtLTGHT-SYVSSVAF---SPDGRIL-SSSSRDKTIKVWDVETGKC 127
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-111 5.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.72e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1022433619   80 GHQGNVLDIKWNPFiDNIIASCSEDTSVRIWE 111
Cdd:smart00320  10 GHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 165-201 1.79e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1022433619  165 GEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRV 201
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 74-255 1.81e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619  74 NYPKV-CGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEallelhgHSRRVGLVEWHPTTNNILFSAG 152
Cdd:PLN00181  523 HYPVVeLASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKE-------HEKRVWSIDYSSADPTLLASGS 595

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 153 YDYKVLIWNLDVGEPVKMIDCHTDvILCMSFNTD-GSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHR-VNRVVFLGNmk 230
Cdd:PLN00181  596 DDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKtVSYVRFVDS-- 672

                         170       180
                  ....*....|....*....|....*
gi 1022433619 231 rllTTGVSRWNTRQIALWdqeDLSM 255
Cdd:PLN00181  673 ---STLVSSSTDNTLKLW---DLSM 691
WD40 pfam00400
WD domain, G-beta repeat;
165-201 3.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1022433619 165 GEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRV 201
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 pfam00400
WD domain, G-beta repeat;
80-111 5.34e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.34e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1022433619  80 GHQGNVLDIKWNPFiDNIIASCSEDTSVRIWE 111
Cdd:pfam00400   9 GHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
124-300 7.04e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 7.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 124 ALLELHGHSRRVGLVEWHPTTNNILfSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIE 203
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLA-AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022433619 204 PRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGvsrwNTRQIALWDQEDLS-MPLIEEEIDGLSGLLFpfyDADTHMLYL 282
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS----ADGTVRLWDLATGKlLRTLTGHSGAVTSVAF---SPDGKLLAS 179

                         170
                  ....*....|....*...
gi 1022433619 283 AGkGDGNIRYYEISTEKP 300
Cdd:COG2319   180 GS-DDGTVRLWDLATGKL 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-161 1.52e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1022433619  125 LLELHGHSRRVGLVEWHPTtNNILFSAGYDYKVLIWN 161
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
DivIC pfam04977
Septum formation initiator; DivIC from B. subtilis is necessary for both vegetative and ...
 434-472 3.44e-03

Septum formation initiator; DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.


Pssm-ID: 428231 [Multi-domain]  Cd Length: 69  Bit Score: 36.04  E-value: 3.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1022433619 434 LRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNSP 472
Cdd:pfam04977   5 LLTYYQLKQEIAQLQAEIAKLKQENEELEAEIKDLKSDP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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