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ADP-ribose glycohydrolase OARD1 isoform d [Homo sapiens]
macro domain-containing protein( domain architecture ID 1211)
macro domain-containing protein functions in the recognition, interpretation, and turnover of ADP-ribose (ADPr) signaling
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
Macro_SF super family | cl00019 | macrodomain superfamily; Macrodomains are found in a variety of proteins with diverse cellular ... |
13-61 | 2.22e-23 | ||
macrodomain superfamily; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Macrodomains include the yeast macrodomain Poa1 which is a phosphatase of ADP-ribose-1"-phosphate, a by-product of tRNA splicing. Some macrodomains have ADPr-unrelated binding partners such as the coronavirus SUD-N (N-terminal subdomain) and SUD-M (middle subdomain) of the SARS-unique domain (SUD) which bind G-quadruplexes (unusual nucleic-acid structures formed by consecutive guanosine nucleotides). Macrodomains regulate a wide variety of cellular and organismal processes, including DNA damage repair, signal transduction, and immune response. The actual alignment was detected with superfamily member cd02901: Pssm-ID: 469581 Cd Length: 135 Bit Score: 85.77 E-value: 2.22e-23
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Name | Accession | Description | Interval | E-value | ||
Macro_Poa1p-like | cd02901 | macrodomain, Poa1p-like family; Macrodomains are found in a variety of proteins with diverse ... |
13-61 | 2.22e-23 | ||
macrodomain, Poa1p-like family; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Members of this family show similarity to the yeast protein Poa1p, reported to be a phosphatase specific for Appr-1"-p, a tRNA splicing metabolite. Poa1p may play a role in tRNA splicing regulation. Pssm-ID: 394873 Cd Length: 135 Bit Score: 85.77 E-value: 2.22e-23
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Name | Accession | Description | Interval | E-value | ||
Macro_Poa1p-like | cd02901 | macrodomain, Poa1p-like family; Macrodomains are found in a variety of proteins with diverse ... |
13-61 | 2.22e-23 | ||
macrodomain, Poa1p-like family; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Members of this family show similarity to the yeast protein Poa1p, reported to be a phosphatase specific for Appr-1"-p, a tRNA splicing metabolite. Poa1p may play a role in tRNA splicing regulation. Pssm-ID: 394873 Cd Length: 135 Bit Score: 85.77 E-value: 2.22e-23
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Macro_SF | cd02749 | macrodomain superfamily; Macrodomains are found in a variety of proteins with diverse cellular ... |
28-57 | 3.75e-05 | ||
macrodomain superfamily; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Macrodomains include the yeast macrodomain Poa1 which is a phosphatase of ADP-ribose-1"-phosphate, a by-product of tRNA splicing. Some macrodomains have ADPr-unrelated binding partners such as the coronavirus SUD-N (N-terminal subdomain) and SUD-M (middle subdomain) of the SARS-unique domain (SUD) which bind G-quadruplexes (unusual nucleic-acid structures formed by consecutive guanosine nucleotides). Macrodomains regulate a wide variety of cellular and organismal processes, including DNA damage repair, signal transduction, and immune response. Pssm-ID: 394871 Cd Length: 121 Bit Score: 38.53 E-value: 3.75e-05
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Blast search parameters | ||||
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