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Conserved domains on  [gi|1047225413|ref|NP_001316675|]
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protein DPCD isoform 6 [Homo sapiens]

Protein Classification

DPCD superfamily-containing protein( domain architecture ID 141607)

DPCD superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPCD super family cl20800
DPCD protein family; This protein is a found in eukaryotes and a mutation in this protein is ...
 6-50 3.67e-25

DPCD protein family; This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD). This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants.


The actual alignment was detected with superfamily member pfam14913:

Pssm-ID: 464369  Cd Length: 190  Bit Score: 91.16  E-value: 3.67e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1047225413   6 WLESLRTAQKTALLQDGRRKVHYLFPDGKEMAEEYDEKTSELLER 50
Cdd:pfam14913   1 WLETLKSAKKTSLIQDGRRKVHYTFPDGKEMVEEYDLKTDELLVR 45
 
Name Accession Description Interval E-value
DPCD pfam14913
DPCD protein family; This protein is a found in eukaryotes and a mutation in this protein is ...
 6-50 3.67e-25

DPCD protein family; This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD). This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants.


Pssm-ID: 464369  Cd Length: 190  Bit Score: 91.16  E-value: 3.67e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1047225413   6 WLESLRTAQKTALLQDGRRKVHYLFPDGKEMAEEYDEKTSELLER 50
Cdd:pfam14913   1 WLETLKSAKKTSLIQDGRRKVHYTFPDGKEMVEEYDLKTDELLVR 45
 
Name Accession Description Interval E-value
DPCD pfam14913
DPCD protein family; This protein is a found in eukaryotes and a mutation in this protein is ...
 6-50 3.67e-25

DPCD protein family; This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD). This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants.


Pssm-ID: 464369  Cd Length: 190  Bit Score: 91.16  E-value: 3.67e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1047225413   6 WLESLRTAQKTALLQDGRRKVHYLFPDGKEMAEEYDEKTSELLER 50
Cdd:pfam14913   1 WLETLKSAKKTSLIQDGRRKVHYTFPDGKEMVEEYDLKTDELLVR 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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