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Conserved domains on  [gi|1057503256|ref|NP_001317160|]
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nucleosome assembly protein 1-like 1 isoform 1 [Homo sapiens]

Protein Classification

NAP domain-containing protein( domain architecture ID 10469758)

NAP domain-containing protein similar to Saccharomyces cerevisiae nucleosome assembly protein (NAP) and Homo sapiens protein SET

CATH:  3.30.1120.90
Gene Ontology:  GO:0042393|GO:0003682|GO:0006334
SCOP:  4003454

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
76-343 5.79e-92

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


:

Pssm-ID: 460010  Cd Length: 203  Bit Score: 274.82  E-value: 5.79e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256  76 RRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFdkrfeiinaiyepteeecewkpdeedeiseelkekakiede 155
Cdd:pfam00956   1 RRVNALKKLQKEHEKLEAEFQEEVHELEKKYAALYQPLY----------------------------------------- 39
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 156 kkdeekedpkgipefwltvfKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAgqPMSFVLEFHFEPNEYFTNEVLTKTYRM 235
Cdd:pfam00956  40 --------------------KNLPLLSEMITERDEPALKHLKDIKIEYPLD--EPGFTLEFHFAPNPYFTNTVLTKTYYY 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 236 RSEPDdsdpfsfdGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPESGDL--- 312
Cdd:pfam00956  98 QDEPD--------GPEIIKAEGTEIDWKEGKNVTVKTVKKKQRNKGTGQTRTVTKTVPTESFFNFFSPPEVPEDEDEdde 169
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1057503256 313 -DDDAEAILAADFEIGHFLRERIIPRSVLYFT 343
Cdd:pfam00956 170 eDEELEERLELDYEIGEDIKDKIIPRAVLYFT 201
 
Name Accession Description Interval E-value
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
76-343 5.79e-92

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


Pssm-ID: 460010  Cd Length: 203  Bit Score: 274.82  E-value: 5.79e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256  76 RRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFdkrfeiinaiyepteeecewkpdeedeiseelkekakiede 155
Cdd:pfam00956   1 RRVNALKKLQKEHEKLEAEFQEEVHELEKKYAALYQPLY----------------------------------------- 39
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 156 kkdeekedpkgipefwltvfKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAgqPMSFVLEFHFEPNEYFTNEVLTKTYRM 235
Cdd:pfam00956  40 --------------------KNLPLLSEMITERDEPALKHLKDIKIEYPLD--EPGFTLEFHFAPNPYFTNTVLTKTYYY 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 236 RSEPDdsdpfsfdGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPESGDL--- 312
Cdd:pfam00956  98 QDEPD--------GPEIIKAEGTEIDWKEGKNVTVKTVKKKQRNKGTGQTRTVTKTVPTESFFNFFSPPEVPEDEDEdde 169
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1057503256 313 -DDDAEAILAADFEIGHFLRERIIPRSVLYFT 343
Cdd:pfam00956 170 eDEELEERLELDYEIGEDIKDKIIPRAVLYFT 201
PTZ00007 PTZ00007
(NAP-L) nucleosome assembly protein -L; Provisional
50-343 2.68e-50

(NAP-L) nucleosome assembly protein -L; Provisional


Pssm-ID: 240226 [Multi-domain]  Cd Length: 337  Bit Score: 172.29  E-value: 2.68e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256  50 AALQERLDGlVETPTGYIESLPRVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAiyePTE 129
Cdd:PTZ00007   16 SDIIEGLDS-IELDDEKLSHLTDEQRETLKKLQLLQKEFDDLEVEYNAELRKLRSKYEDLYNPIYDKRKEALVQ---NGG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 130 EEcewkpdeedeiseelkekakiedekkdeekEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQP 209
Cdd:PTZ00007   92 AE------------------------------IGTPGLPQFWLTAMKNNNTLGSAIEEHDEPILSYLSDISCEYTEPNKQ 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 210 MSFVLEFHFEPNEYFTNEVLTKTYRMRSEPDDsdpfsfDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVT 289
Cdd:PTZ00007  142 EGFILVFTFAPNPFFSNTVLTKTYHMKVLDGD------DEPLLSNTVATEIDWKQGKDVTKKVVTKKQRHKKTKETRTVT 215
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1057503256 290 KTVSNDSFFNFFAPPEVPESGDLDD-------DAEAILAADFEIGHFLRERIIPRSVLYFT 343
Cdd:PTZ00007  216 ETVDRESFFNFFTSHEVPSDEELEKmskheiaELEMIVETDYEIGITIRDKLIPYAVYWFL 276
 
Name Accession Description Interval E-value
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
76-343 5.79e-92

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


Pssm-ID: 460010  Cd Length: 203  Bit Score: 274.82  E-value: 5.79e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256  76 RRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFdkrfeiinaiyepteeecewkpdeedeiseelkekakiede 155
Cdd:pfam00956   1 RRVNALKKLQKEHEKLEAEFQEEVHELEKKYAALYQPLY----------------------------------------- 39
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 156 kkdeekedpkgipefwltvfKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAgqPMSFVLEFHFEPNEYFTNEVLTKTYRM 235
Cdd:pfam00956  40 --------------------KNLPLLSEMITERDEPALKHLKDIKIEYPLD--EPGFTLEFHFAPNPYFTNTVLTKTYYY 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 236 RSEPDdsdpfsfdGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPESGDL--- 312
Cdd:pfam00956  98 QDEPD--------GPEIIKAEGTEIDWKEGKNVTVKTVKKKQRNKGTGQTRTVTKTVPTESFFNFFSPPEVPEDEDEdde 169
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1057503256 313 -DDDAEAILAADFEIGHFLRERIIPRSVLYFT 343
Cdd:pfam00956 170 eDEELEERLELDYEIGEDIKDKIIPRAVLYFT 201
PTZ00007 PTZ00007
(NAP-L) nucleosome assembly protein -L; Provisional
50-343 2.68e-50

(NAP-L) nucleosome assembly protein -L; Provisional


Pssm-ID: 240226 [Multi-domain]  Cd Length: 337  Bit Score: 172.29  E-value: 2.68e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256  50 AALQERLDGlVETPTGYIESLPRVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAiyePTE 129
Cdd:PTZ00007   16 SDIIEGLDS-IELDDEKLSHLTDEQRETLKKLQLLQKEFDDLEVEYNAELRKLRSKYEDLYNPIYDKRKEALVQ---NGG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 130 EEcewkpdeedeiseelkekakiedekkdeekEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQP 209
Cdd:PTZ00007   92 AE------------------------------IGTPGLPQFWLTAMKNNNTLGSAIEEHDEPILSYLSDISCEYTEPNKQ 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 210 MSFVLEFHFEPNEYFTNEVLTKTYRMRSEPDDsdpfsfDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVT 289
Cdd:PTZ00007  142 EGFILVFTFAPNPFFSNTVLTKTYHMKVLDGD------DEPLLSNTVATEIDWKQGKDVTKKVVTKKQRHKKTKETRTVT 215
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1057503256 290 KTVSNDSFFNFFAPPEVPESGDLDD-------DAEAILAADFEIGHFLRERIIPRSVLYFT 343
Cdd:PTZ00007  216 ETVDRESFFNFFTSHEVPSDEELEKmskheiaELEMIVETDYEIGITIRDKLIPYAVYWFL 276
PTZ00008 PTZ00008
(NAP-S) nucleosome assembly protein-S; Provisional
83-267 9.70e-03

(NAP-S) nucleosome assembly protein-S; Provisional


Pssm-ID: 185394  Cd Length: 185  Bit Score: 36.71  E-value: 9.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256  83 NLQVKCAQieakfyeEVHDLERKYAVLYQPLFDKRFEIInaiyepteeecewkpdeedeiseelkEKakiedekkdeeke 162
Cdd:PTZ00008    2 ELDEECAK-------EQMNIQRQFDEKKKPLFEKRQEII--------------------------EK------------- 35
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503256 163 dpkgIPEFWLTVFKNVDLLSDMVQEhDEPILKHLKDIKVKFS-DAGQPMSFVLEFHFEPNEYFTNEVLTKTYRmrsepdd 241
Cdd:PTZ00008   36 ----IPGFWADTLRRHPALSYLVPE-DIDILEHLKKIDLEDNlDNNGSYKITLIFDEKAKEFMEPLVLVKHVI------- 103
                         170       180
                  ....*....|....*....|....*.
gi 1057503256 242 sdpFSFDGPEIMGCTgcQIDWKKGKN 267
Cdd:PTZ00008  104 ---FKNNQEKVVEVT--KIKWKEGKS 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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