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Conserved domains on  [gi|1059045646|ref|NP_001317247|]
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flavin-containing monooxygenase 1 isoform 2 [Mus musculus]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-161 8.27e-107

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 315.56  E-value: 8.27e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFV 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1059045646  83 PNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSFP 161
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-161 8.27e-107

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 315.56  E-value: 8.27e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFV 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1059045646  83 PNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSFP 161
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-160 2.49e-33

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 122.28  E-value: 2.49e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEhveegraslYKSVVSNSSREMSCYPDFPFPEDYPNFVP 83
Cdd:COG2072     8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNR---------YPGLRLDTPSHLYSLPFFPNWSDDPDFPT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  84 NSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDfavSGQWeVVTVTNGKQNSAifDAVMVCTGFLTNPHLP----LDS 159
Cdd:COG2072    79 GDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRW-TVTTDDGETLTA--RFVVVATGPLSRPKIPdipgLED 152


                  .
gi 1059045646 160 F 160
Cdd:COG2072   153 F 153
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-161 2.08e-22

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 93.00  E-value: 2.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEG-----------RASLYKSVVSNSSREMSCYPD 71
Cdd:PLN02172   11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  72 FPF----------PEDYPNfvpNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITkrpdfAVSGQWEVVTVTNGK-QNSAIF 140
Cdd:PLN02172   91 FPFvprfddesrdSRRYPS---HREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGGfSKDEIF 162

                         170       180
                  ....*....|....*....|....*
gi 1059045646 141 DAVMVCTGFLTNP---HLP-LDSFP 161
Cdd:PLN02172  163 DAVVVCNGHYTEPnvaHIPgIKSWP 187
beta-trefoil_MIR_POMT1 cd23281
MIR domain, beta-trefoil fold, found in protein O-mannosyl-transferase 1 (POMT1) and similar ...
 59-140 4.93e-03

MIR domain, beta-trefoil fold, found in protein O-mannosyl-transferase 1 (POMT1) and similar proteins; POMT1 (EC 2.4.1.109), also called dolichyl-phosphate-mannose--protein mannosyltransferase 1, belongs to the glycosyltransferase 39 family. It transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. It is essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins, but not of cadherins and protocaherins. POMT1 contains a MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467752 [Multi-domain]  Cd Length: 191  Bit Score: 36.13  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  59 VSNSSREMSCYPDFPFpedypNFVPNSLF-LEYLKLYS-----TQFNLQ-RCIYFNTKV---CSITKRPDFAVsGQWEVV 128
Cdd:cd23281    99 LSPTHQEVSCYIDYNI-----SMPAQNLWrIEIVNRDSegdtwKAIKSQfRLIHVNTSAalkLSGKQLPDWGF-GQLEVA 172

                          90
                  ....*....|..
gi 1059045646 129 TVTNGKQNSAIF 140
Cdd:cd23281   173 TDRAGNQSSTVW 184
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-161 8.27e-107

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 315.56  E-value: 8.27e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFV 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1059045646  83 PNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSFP 161
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-160 2.49e-33

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 122.28  E-value: 2.49e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEhveegraslYKSVVSNSSREMSCYPDFPFPEDYPNFVP 83
Cdd:COG2072     8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNR---------YPGLRLDTPSHLYSLPFFPNWSDDPDFPT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  84 NSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDfavSGQWeVVTVTNGKQNSAifDAVMVCTGFLTNPHLP----LDS 159
Cdd:COG2072    79 GDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRW-TVTTDDGETLTA--RFVVVATGPLSRPKIPdipgLED 152


                  .
gi 1059045646 160 F 160
Cdd:COG2072   153 F 153
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-161 2.08e-22

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 93.00  E-value: 2.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEG-----------RASLYKSVVSNSSREMSCYPD 71
Cdd:PLN02172   11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  72 FPF----------PEDYPNfvpNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITkrpdfAVSGQWEVVTVTNGK-QNSAIF 140
Cdd:PLN02172   91 FPFvprfddesrdSRRYPS---HREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGGfSKDEIF 162

                         170       180
                  ....*....|....*....|....*
gi 1059045646 141 DAVMVCTGFLTNP---HLP-LDSFP 161
Cdd:PLN02172  163 DAVVVCNGHYTEPnvaHIPgIKSWP 187
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-40 6.02e-06

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 45.21  E-value: 6.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGL 40
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
6-150 6.21e-06

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 44.19  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   6 AIVGAGVSGLAS----IKCCLEEGLEPTCFERSSD-LGGLWRfTEHVEEGRAslyksvvsNS-SREMSCYPDFPF----- 74
Cdd:pfam13454   1 AIVGGGPSGLALlerlLARAPKRPLEITLFDPSPPgAGGVYR-TDQSPEHLL--------NVpASRMSLFPDDPPhflew 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  75 ----------PEDYPN-FVPNSLFLEYLKLYSTQF-----NLQRCIYFNTKVCSITKRPDfavsGQWevVTVTNGkqNSA 138
Cdd:pfam13454  72 lrargaldeaPGLDPDdFPPRALYGRYLRDRFEEAlarapAGVTVRVHRARVTDLRPRGD----GYR--VLLADG--RTL 143

                         170
                  ....*....|..
gi 1059045646 139 IFDAVMVCTGFL 150
Cdd:pfam13454 144 AADAVVLATGHG 155
PRK07233 PRK07233
hypothetical protein; Provisional
 4-40 2.90e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 43.34  E-value: 2.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1059045646   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGL 40
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-39 3.22e-05

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 43.30  E-value: 3.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1059045646   1 MVKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGG 39
Cdd:COG3349     2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGG 40
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 3-43 3.43e-05

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 43.20  E-value: 3.43e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRF 43
Cdd:PRK12769  328 KRVAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 3-43 3.54e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 43.23  E-value: 3.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1059045646   3 KRVAIVGAGVSGLAsikcCLEE----GLEPTCFERSSDLGGLWRF 43
Cdd:PRK12810  144 KKVAVVGSGPAGLA----AADQlaraGHKVTVFERADRIGGLLRY 184
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
3-148 6.74e-05

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 42.25  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646   3 KRVAIVGAGVSG---LASIKCCLEEGLEPTCFERSSDLGglwrftehveEGRAslY----KSVVSN-SSREMSCYPDFP- 73
Cdd:COG4529     6 KRIAIIGGGASGtalAIHLLRRAPEPLRITLFEPRPELG----------RGVA--YstdsPEHLLNvPAGRMSAFPDDPd 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  74 --------------FPEDYPNFVPNSLFLEYLK-----LYSTQFNLQRCIYFNTKVCSITKRpdfavSGQWEVVTvTNGK 134
Cdd:COG4529    74 hflrwlrengaraaPAIDPDAFVPRRLFGEYLRerlaeALARAPAGVRLRHIRAEVVDLERD-----DGGYRVTL-ADGE 147

                         170
                  ....*....|....
gi 1059045646 135 qnSAIFDAVMVCTG 148
Cdd:COG4529   148 --TLRADAVVLATG 159
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-66 7.13e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 39.44  E-value: 7.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1059045646   7 IVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGL---WRFTEHVEEGRASLYKSVVSNSSREM 66
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNaysYRVPGYVFDYGAHIFHGSDEPNVRDL 63
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-43 3.27e-04

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 40.12  E-value: 3.27e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1059045646   3 KRVAIVGAGVSGLAsikcC----LEEGLEPTCFERSSDLGGLWRF 43
Cdd:COG0493   122 KKVAVVGSGPAGLA----AayqlARAGHEVTVFEALDKPGGLLRY 162
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-36 4.24e-04

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 40.06  E-value: 4.24e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSD 36
Cdd:COG0771     5 KKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPA 38
PRK07588 PRK07588
FAD-binding domain;
3-39 2.59e-03

FAD-binding domain;


Pssm-ID: 169028 [Multi-domain]  Cd Length: 391  Bit Score: 37.41  E-value: 2.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDL--GG 39
Cdd:PRK07588    1 MKVAISGAGIAGPTLAYWLRRYGHEPTLIERAPELrtGG 39
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
70-156 3.61e-03

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 36.82  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  70 PDFPFPEDYPNfvpNSLFLEYLKLYSTQFNLQrcIYFNTKVCSITKrpdfaVSGQWEVVTvtngkqNSAIFDA--VMVCT 147
Cdd:pfam13738  63 PAFTFNREHPS---GNEYAEYLRRVADHFELP--INLFEEVTSVKK-----EDDGFVVTT------SKGTYQAryVIIAT 126


                  ....*....
gi 1059045646 148 GFLTNPHLP 156
Cdd:pfam13738 127 GEFDFPNKL 135
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 3-43 3.72e-03

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 37.40  E-value: 3.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1059045646   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRF 43
Cdd:PRK12814  194 KKVAIIGAGPAGLTAAYYLLRKGHDVTIFDANEQAGGMMRY 234
beta-trefoil_MIR_POMT1 cd23281
MIR domain, beta-trefoil fold, found in protein O-mannosyl-transferase 1 (POMT1) and similar ...
 59-140 4.93e-03

MIR domain, beta-trefoil fold, found in protein O-mannosyl-transferase 1 (POMT1) and similar proteins; POMT1 (EC 2.4.1.109), also called dolichyl-phosphate-mannose--protein mannosyltransferase 1, belongs to the glycosyltransferase 39 family. It transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. It is essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins, but not of cadherins and protocaherins. POMT1 contains a MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467752 [Multi-domain]  Cd Length: 191  Bit Score: 36.13  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059045646  59 VSNSSREMSCYPDFPFpedypNFVPNSLF-LEYLKLYS-----TQFNLQ-RCIYFNTKV---CSITKRPDFAVsGQWEVV 128
Cdd:cd23281    99 LSPTHQEVSCYIDYNI-----SMPAQNLWrIEIVNRDSegdtwKAIKSQfRLIHVNTSAalkLSGKQLPDWGF-GQLEVA 172

                          90
                  ....*....|..
gi 1059045646 129 TVTNGKQNSAIF 140
Cdd:cd23281   173 TDRAGNQSSTVW 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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