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Conserved domains on  [gi|1057867021|ref|NP_001317259|]
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luc7-like protein 3 isoform 2 [Homo sapiens]

Protein Classification

LUC7 domain-containing protein( domain architecture ID 12042729)

LUC7 domain-containing protein similar to Homo sapiens Luc7-like protein 3 that may play a role in RNA splicing

Gene Ontology:  GO:0003729|GO:0006376|GO:0005685

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LUC7 pfam03194
LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs ...
4-246 3.14e-109

LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).


:

Pssm-ID: 460842 [Multi-domain]  Cd Length: 246  Bit Score: 323.78  E-value: 3.14e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021   4 AAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSS-RFMKVGYE 82
Cdd:pfam03194   3 QRALLDELMGRNRNLAPSEKKKKKHFDDPEVCKSYLVGFCPHDLFTNTKADLGPCPKIHDEALKADYEKASkRKKKYGYE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021  83 RDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSgaagPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLV 162
Cdd:pfam03194  83 REFLRFLQKLIDDVDRKIRKGKQRLELTQEEIEQ----TDELKQEQISVLEEKIKKLLEEAEELGEEGNVDEAQKLMKKV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021 163 EQLKEERELL--RSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE 240
Cdd:pfam03194 159 EELKEEKEELeqQYESLTKESAASQEKKMEVCEVCGAFLIVNDADRRLADHLTGKQHLGYAKIRDTLEELKEKIEERREE 238

                  ....*.
gi 1057867021 241 PDRDER 246
Cdd:pfam03194 239 REERRE 244
 
Name Accession Description Interval E-value
LUC7 pfam03194
LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs ...
4-246 3.14e-109

LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).


Pssm-ID: 460842 [Multi-domain]  Cd Length: 246  Bit Score: 323.78  E-value: 3.14e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021   4 AAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSS-RFMKVGYE 82
Cdd:pfam03194   3 QRALLDELMGRNRNLAPSEKKKKKHFDDPEVCKSYLVGFCPHDLFTNTKADLGPCPKIHDEALKADYEKASkRKKKYGYE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021  83 RDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSgaagPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLV 162
Cdd:pfam03194  83 REFLRFLQKLIDDVDRKIRKGKQRLELTQEEIEQ----TDELKQEQISVLEEKIKKLLEEAEELGEEGNVDEAQKLMKKV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021 163 EQLKEERELL--RSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE 240
Cdd:pfam03194 159 EELKEEKEELeqQYESLTKESAASQEKKMEVCEVCGAFLIVNDADRRLADHLTGKQHLGYAKIRDTLEELKEKIEERREE 238

                  ....*.
gi 1057867021 241 PDRDER 246
Cdd:pfam03194 239 REERRE 244
LUC7 COG5200
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and ...
4-244 1.17e-37

U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification];


Pssm-ID: 227527 [Multi-domain]  Cd Length: 258  Bit Score: 138.56  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021   4 AAQLLDELMGRDRNLApdEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYER 83
Cdd:COG5200     5 QRKVLEQLMGPERSTF--DPCRPTHFTDKKVCISMLVGFCPFDLFRNTKRSLGKCPTSHEEKYKAEYERNGRERAEEYEW 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021  84 DFLRYLQSLLAEVERRIRRGHARLAlsqnqqssgaagPTGKNEEKIQVLTDKIDVLLQQIEELGSEG-------KVEEAQ 156
Cdd:COG5200    83 EYLRLLVRIVLSCNDGIRAAGLEDR------------TTPEEFGKIKEKEELFNRVDESIGELGMEGdalakrkLVERAC 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021 157 GMMKLVEQLKEERELLRSTTSTIESF--AAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKL 234
Cdd:COG5200   151 SAFNELERLREERKEIKEAVYSMVENngQGTHQKLQVCGICGAYLSRLDTDRRLADHFNGKLHLGYLLVRSDLADLLKKF 230
                         250
                  ....*....|...
gi 1057867021 235 ---RKRTEEPDRD 244
Cdd:COG5200   231 gisRVAEIFKEGF 243
 
Name Accession Description Interval E-value
LUC7 pfam03194
LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs ...
4-246 3.14e-109

LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).


Pssm-ID: 460842 [Multi-domain]  Cd Length: 246  Bit Score: 323.78  E-value: 3.14e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021   4 AAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSS-RFMKVGYE 82
Cdd:pfam03194   3 QRALLDELMGRNRNLAPSEKKKKKHFDDPEVCKSYLVGFCPHDLFTNTKADLGPCPKIHDEALKADYEKASkRKKKYGYE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021  83 RDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSgaagPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLV 162
Cdd:pfam03194  83 REFLRFLQKLIDDVDRKIRKGKQRLELTQEEIEQ----TDELKQEQISVLEEKIKKLLEEAEELGEEGNVDEAQKLMKKV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021 163 EQLKEERELL--RSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE 240
Cdd:pfam03194 159 EELKEEKEELeqQYESLTKESAASQEKKMEVCEVCGAFLIVNDADRRLADHLTGKQHLGYAKIRDTLEELKEKIEERREE 238

                  ....*.
gi 1057867021 241 PDRDER 246
Cdd:pfam03194 239 REERRE 244
LUC7 COG5200
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and ...
4-244 1.17e-37

U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification];


Pssm-ID: 227527 [Multi-domain]  Cd Length: 258  Bit Score: 138.56  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021   4 AAQLLDELMGRDRNLApdEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYER 83
Cdd:COG5200     5 QRKVLEQLMGPERSTF--DPCRPTHFTDKKVCISMLVGFCPFDLFRNTKRSLGKCPTSHEEKYKAEYERNGRERAEEYEW 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021  84 DFLRYLQSLLAEVERRIRRGHARLAlsqnqqssgaagPTGKNEEKIQVLTDKIDVLLQQIEELGSEG-------KVEEAQ 156
Cdd:COG5200    83 EYLRLLVRIVLSCNDGIRAAGLEDR------------TTPEEFGKIKEKEELFNRVDESIGELGMEGdalakrkLVERAC 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867021 157 GMMKLVEQLKEERELLRSTTSTIESF--AAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKL 234
Cdd:COG5200   151 SAFNELERLREERKEIKEAVYSMVENngQGTHQKLQVCGICGAYLSRLDTDRRLADHFNGKLHLGYLLVRSDLADLLKKF 230
                         250
                  ....*....|...
gi 1057867021 235 ---RKRTEEPDRD 244
Cdd:COG5200   231 gisRVAEIFKEGF 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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