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Conserved domains on  [gi|1062594046|ref|NP_001318013|]
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alpha-adducin isoform 7 [Mus musculus]

Protein Classification

class II aldolase/adducin head domain-containing protein( domain architecture ID 842)

class II aldolase/adducin head domain-containing protein involved in catalyzing central steps of carbohydrate metabolism; it promotes carbon-carbon bond cleavage and stabilizes enolate intermediates using divalent cations

Gene Symbol:  ADD3
PubMed:  10581174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Aldolase_II super family cl00214
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 145-391 6.85e-98

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


The actual alignment was detected with superfamily member PRK07044:

Pssm-ID: 469663  Cd Length: 252  Bit Score: 303.31  E-value: 6.85e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044   17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVAYHDYHGILVDEEEKILIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044   95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLDPGKYKAKSRSPGTPAGEGSgsppkwqiGEQEFEALMRM 383
Cdd:PRK07044  174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAGA--------GELAWPALLRK 242

                         250
                  ....*....|
gi 1062594046 384 LD--NLGYRT 391
Cdd:PRK07044  243 LDriDPGYRD 252
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 614-735 6.04e-06

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 6.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  614 GSEENLDETREQKEKSPPDQSAVP-NTPPSTPVKLEEDLPQE----PTSRDDSDATTFKPTPPDLSPDEPSE-ALAFPAV 687
Cdd:PHA03307   100 PAREGSPTPPGPSSPDPPPPTPPPaSPPPSPAPDLSEMLRPVgspgPPPAASPPAAGASPAAVASDAASSRQaALPLSSP 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1062594046  688 EEEAHASPDP-TQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 735
Cdd:PHA03307   180 EETARAPSSPpAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 145-391 6.85e-98

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 303.31  E-value: 6.85e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044   17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVAYHDYHGILVDEEEKILIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044   95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLDPGKYKAKSRSPGTPAGEGSgsppkwqiGEQEFEALMRM 383
Cdd:PRK07044  174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAGA--------GELAWPALLRK 242

                         250
                  ....*....|
gi 1062594046 384 LD--NLGYRT 391
Cdd:PRK07044  243 LDriDPGYRD 252
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 142-352 1.18e-68

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 224.94  E-value: 1.18e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 142 EKLLRcKLAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIV--DRGSTNLGvnqa 219
Cdd:cd00398     1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSAR-DRDRGYFLITPSGVDYEEMTASDLVVVDAQGKVVegKKPSSETP---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 220 gftLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL---GDVAYHDYHGILvDEEEKILIQKNLG-PKSK 295
Cdd:cd00398    75 ---LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGfPNSK 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1062594046 296 VLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGG--PDNLVLLDPGKYKAK 352
Cdd:cd00398   151 AVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQlpPISLELLNKEYLRKH 209
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 145-341 9.41e-57

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 192.74  E-value: 9.41e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGstnlGVNQAGFTLH 224
Cdd:COG0235     6 LREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGD----LKPSSETPLH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPIS-PEAL-SLGDVAYHDYHGIlVDEEEKILIQKNLGpKSKVLILRNH 302
Cdd:COG0235    80 LAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEqTEAAaFLGDVPVVPYAGP-GTEELAEAIAEALG-DRPAVLLRNH 157

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1062594046 303 GLVSVGESVEEAFYYIHNLVVACEIQVRTLAsAGGPDNL 341
Cdd:COG0235   158 GVVVWGKDLAEAFDRAEVLEEAARIQLLALA-LGGPLVL 195
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 147-329 5.46e-55

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 186.60  E-value: 5.46e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 147 CKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGstnLGVNqAGFTLHSA 226
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG---LKPS-SETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 227 VYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL--GDVAYHDYHGiLVDEEEKILIQKNLGPKSKVLILRNHGL 304
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYT-PGTEELGERIAEALGGDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 1062594046 305 VSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 149-329 2.73e-53

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 182.45  E-value: 2.73e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  149 LAAFYRLADLFGWSQLIYNHITTRVNsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTnlGVNQAGFTLHSAVY 228
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARVG-EEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  229 AARPDAKCIVHIHTPAGAAVSAM--KCGLLPIS-PEALSLGDVAYHDYHGILVDEEEKI-LIQKNLGPK---SKVLILRN 301
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEqAAAFLGGEIPYAPYAGPGTELAEEGaELAEALAEAlpdRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 1062594046  302 HGLVSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 614-735 6.04e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 6.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  614 GSEENLDETREQKEKSPPDQSAVP-NTPPSTPVKLEEDLPQE----PTSRDDSDATTFKPTPPDLSPDEPSE-ALAFPAV 687
Cdd:PHA03307   100 PAREGSPTPPGPSSPDPPPPTPPPaSPPPSPAPDLSEMLRPVgspgPPPAASPPAAGASPAAVASDAASSRQaALPLSSP 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1062594046  688 EEEAHASPDP-TQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 735
Cdd:PHA03307   180 EETARAPSSPpAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
Androgen_recep pfam02166
Androgen receptor;
604-735 1.07e-03

Androgen receptor;


Pssm-ID: 426632 [Multi-domain]  Cd Length: 501  Bit Score: 42.22  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 604 YRREVERKQKGSEENLDETREQKEKSPP---DQSAVPNTPPSTPVKLEEDLP---------QEPTSRDDSDATTFKPTPP 671
Cdd:pfam02166   6 YPRPPAKTFRGAFQNLFQSVREVIQNPGprhPEAAGGAAPPGARLQHQQQQQqqvpqqpqqQESSPRQPQASVQPQQAGD 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1062594046 672 DLSPDEPSEALA-FPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGS--PMDPGSD 735
Cdd:pfam02166  86 DGSPPAHNRGPAgYLALEDDEQPQPSQAQPAAECCPENGCVPEPGAAAAAGKGLPQQAvaPAAPDDD 152
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 592-710 1.15e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 42.36  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 592 PFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEEDLP--QEPTSRDDSDATTFKPT 669
Cdd:COG5180   188 PRDALKDSPEKLDRPKVEVKDEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATvdAQPEMRPPADAKERRRA 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1062594046 670 PpdlspdepsealafpavEEEAHASPDPTQPPAEADPEPAS 710
Cdd:COG5180   268 A-----------------IGDTPAAEPPGLPVLEAGSEPQS 291
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 145-391 6.85e-98

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 303.31  E-value: 6.85e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044   17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVAYHDYHGILVDEEEKILIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044   95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLDPGKYKAKSRSPGTPAGEGSgsppkwqiGEQEFEALMRM 383
Cdd:PRK07044  174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAGA--------GELAWPALLRK 242

                         250
                  ....*....|
gi 1062594046 384 LD--NLGYRT 391
Cdd:PRK07044  243 LDriDPGYRD 252
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 142-352 1.18e-68

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 224.94  E-value: 1.18e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 142 EKLLRcKLAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIV--DRGSTNLGvnqa 219
Cdd:cd00398     1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSAR-DRDRGYFLITPSGVDYEEMTASDLVVVDAQGKVVegKKPSSETP---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 220 gftLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL---GDVAYHDYHGILvDEEEKILIQKNLG-PKSK 295
Cdd:cd00398    75 ---LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGfPNSK 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1062594046 296 VLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGG--PDNLVLLDPGKYKAK 352
Cdd:cd00398   151 AVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQlpPISLELLNKEYLRKH 209
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 145-341 9.41e-57

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 192.74  E-value: 9.41e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGstnlGVNQAGFTLH 224
Cdd:COG0235     6 LREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGD----LKPSSETPLH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPIS-PEAL-SLGDVAYHDYHGIlVDEEEKILIQKNLGpKSKVLILRNH 302
Cdd:COG0235    80 LAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEqTEAAaFLGDVPVVPYAGP-GTEELAEAIAEALG-DRPAVLLRNH 157

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1062594046 303 GLVSVGESVEEAFYYIHNLVVACEIQVRTLAsAGGPDNL 341
Cdd:COG0235   158 GVVVWGKDLAEAFDRAEVLEEAARIQLLALA-LGGPLVL 195
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 147-329 5.46e-55

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 186.60  E-value: 5.46e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 147 CKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGstnLGVNqAGFTLHSA 226
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG---LKPS-SETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 227 VYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL--GDVAYHDYHGiLVDEEEKILIQKNLGPKSKVLILRNHGL 304
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYT-PGTEELGERIAEALGGDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 1062594046 305 VSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 149-329 2.73e-53

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 182.45  E-value: 2.73e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  149 LAAFYRLADLFGWSQLIYNHITTRVNsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTnlGVNQAGFTLHSAVY 228
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARVG-EEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  229 AARPDAKCIVHIHTPAGAAVSAM--KCGLLPIS-PEALSLGDVAYHDYHGILVDEEEKI-LIQKNLGPK---SKVLILRN 301
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEqAAAFLGGEIPYAPYAGPGTELAEEGaELAEALAEAlpdRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 1062594046  302 HGLVSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
PRK06661 PRK06661
hypothetical protein; Provisional
 149-334 4.69e-43

hypothetical protein; Provisional


Pssm-ID: 168637  Cd Length: 231  Bit Score: 155.76  E-value: 4.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 149 LAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgSTNLGVNQAGFTLHSAVY 228
Cdd:PRK06661    7 LAAAYRIMAYLSLDDHTYTHLSAR-PKNADFYYIYPFGLRFEEVTTENLLKVSLDGQILE--GEEYQYNKTGYFIHGSIY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 229 AARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGD-VAYHDYHGILVDE--EEKILIQkNLGpKSKVLILRNHGLV 305
Cdd:PRK06661   84 KTRPDISAIFHYHTPASIAVSALKCGLLPISQWALHFYDrISYHNYNSLALDAdkQSSRLVN-DLK-QNYVMLLRNHGAI 161

                         170       180
                  ....*....|....*....|....*....
gi 1062594046 306 SVGESVEEAFYYIHNLVVACEIQVRTLAS 334
Cdd:PRK06661  162 TCGKTIHEAMFYTYHLEQACKTQCLLNST 190
PRK06208 PRK06208
class II aldolase/adducin family protein;
148-371 1.10e-39

class II aldolase/adducin family protein;


Pssm-ID: 235743  Cd Length: 274  Bit Score: 147.83  E-value: 1.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 148 KLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgsTNLGVNQAGFTLHSAV 227
Cdd:PRK06208   46 RLAAAFRLFARFGFDEGLAGHITARDPELPDHFWVNPLGVHFSQIKVSDLLLVDHDGEVVE---GDRPLNRAAFAIHSAI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 228 YAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVA-YHDYHGILVDEEEKILIQKNLGPKsKVLILRNHGLV 305
Cdd:PRK06208  123 HEARPDVVAAAHTHSTYGKAWSTLGRPLDPITQDACAFyEDHAlFDDFTGVVVDTSEGRRIAAALGTH-KAVILQNHGLL 201

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1062594046 306 SVGESVEEA-FYYIhNLVVACEIQVrtLASAGGPdnLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQ 371
Cdd:PRK06208  202 TVGPSVDAAaWWFI-ALERACQTQL--LAEAAGP--PQPIDHETARHTRSQVGSEYGGWFNFQPLYQ 263
PRK06486 PRK06486
aldolase;
114-385 1.11e-25

aldolase;


Pssm-ID: 235814  Cd Length: 262  Bit Score: 107.10  E-value: 1.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 114 MA-ALNMSLGMVTPVNDLRGSDSIAYdkgeklLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEV 192
Cdd:PRK06486    1 MAhSLTTDSAPPAGNRPLLDSDAVAQ------ARVDLAACFRAAARHGLEEGICNHFSAVLPGHDDLFLVNPYGYAFSEI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 193 TASSLVKVNLQGDIVD-RGStnlgVNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMK-CGLLPISPEALSL-GDVA 269
Cdd:PRK06486   75 TASDLLICDFDGNVLAgRGE----PEATAFFIHARIHRAIPRAKAAFHTHMPYATALSLTEgRPLTTLGQTALKFyGRTA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 270 Y-HDYHGILVDEEEKILIQKNLGPKSkVLILRNHGLVSVGESVEEAF---YYihnLVVACEIQVRTLaSAGGPdnLVLLD 345
Cdd:PRK06486  151 VdEDYNGLALDAAEGDRIARAMGDAD-IVFLKNHGVMVCGPRIAEAWddlYY---LERACEVQVLAM-STGRP--LVPVD 223

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1062594046 346 PGKYKAKSRspgtpagegsgsppKWQIGEQE-----FEALMRMLD 385
Cdd:PRK06486  224 PAIAAAVAR--------------QMREGDREsarlhLEALRRTLD 254
PRK07090 PRK07090
class II aldolase/adducin domain protein; Provisional
 145-338 7.22e-20

class II aldolase/adducin domain protein; Provisional


Pssm-ID: 180832  Cd Length: 260  Bit Score: 90.08  E-value: 7.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 145 LRCKLAAFYRLADLFGWSQLIYNHITTRvnSEQEH-FLIVPFGLLYSEVTASSLVKVNLQGDIVD-RGSTNlGVNQagft 222
Cdd:PRK07090   31 LRQKLALTCRILFDAGHDSGLAGQITAR--AEAPGtYYTQRLGLGFDEITASNLLLVDEDLNVLDgEGMPN-PANR---- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 223 LHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVAY-HDYHGILVDEEEKILIQKNLGPKSKVLiLR 300
Cdd:PRK07090  104 FHSWIYRARPDVNCIIHTHPPHVAALSMLEVPLVVSHMDTCPLyDDCAFlKDWPGVPVGNEEGEIISAALGDKRAIL-LS 182

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1062594046 301 NHGLVSVGESVEEAFYYIHNLVVACEIQVrtLASAGGP 338
Cdd:PRK07090  183 HHGQLVAGKSIEEACVLALLIERAARLQL--LAMAAGP 218
PRK07490 PRK07490
hypothetical protein; Provisional
 135-334 1.54e-18

hypothetical protein; Provisional


Pssm-ID: 236031 [Multi-domain]  Cd Length: 245  Bit Score: 85.54  E-value: 1.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 135 SIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNlqGDIVDRGSTNL 214
Cdd:PRK07490    1 MTMALSDEEQIRVDLAAAFRWIARLGMHEAVANHFSAAVSADGKQFLLNPKWKHFSRIRASDLLLLD--ADDPSTAERPD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 215 GVNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCG-LLPISPE-ALSLGDVAYHDYHGILVDEEEKILIQKNLGP 292
Cdd:PRK07490   79 VPDATAWAIHGQIHRRLPHARCVMHVHSVYATALACLADPtLPPIDQNtARFFNRVAVDTLYGGMALEEEGERLAGLLGD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1062594046 293 KSkVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLAS 334
Cdd:PRK07490  159 KR-RLLMGNHGVLVTGDTVAEAFDDLYYFERACQTYITALST 199
PRK08333 PRK08333
aldolase;
143-316 1.85e-12

aldolase;


Pssm-ID: 181393 [Multi-domain]  Cd Length: 184  Bit Score: 66.38  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 143 KLLRCKLAAFYRLADLFGWSQLIYNHITTRVNseqEHFLIVPFGLLYSEVTASSLVKVNLQGDIVD--RGSTNlgvnqag 220
Cdd:PRK08333    2 RNVKAQLVKYSKLAHERGLTAAFGGNLSIRVG---NLVFIKATGSVMDELTREQVAVIDLNGNQLSsvRPSSE------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 221 FTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLP-ISPEA-LSLGDVAYHDYHGI----LVDEEEKILIQKNlgpks 294
Cdd:PRK08333   72 YRLHLAVYRNRPDVRAIAHLHPPYSIVASTLLEEELPiITPEAeLYLKKIPILPFRPAgsveLAEQVAEAMKEYD----- 146

                         170       180
                  ....*....|....*....|..
gi 1062594046 295 kVLILRNHGLVSVGESVEEAFY 316
Cdd:PRK08333  147 -AVIMERHGIVTVGRSLREAFY 167
PRK06557 PRK06557
L-ribulose-5-phosphate 4-epimerase; Validated
 176-314 1.14e-11

L-ribulose-5-phosphate 4-epimerase; Validated


Pssm-ID: 235829 [Multi-domain]  Cd Length: 221  Bit Score: 65.03  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 176 EQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrGSTNLGVNQAGftlHSAVYAARPDAKCIVHIHTPAGAAVSA----M 251
Cdd:PRK06557   41 GTDLVVIKPSGVSYDDLTPEDMVVVDLDGNVVE-GDLKPSSDTAS---HLYVYRHMPDVGGVVHTHSTYATAWAArgepI 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1062594046 252 KCGLLPISPEAlsLGDVAYHDYHGILVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEA 314
Cdd:PRK06557  117 PCVLTAMADEF--GGPIPVGPFALIGDEAIGKGIVETLKGGRSPAVLMQNHGVFTIGKDAEDA 177
PRK08130 PRK08130
putative aldolase; Validated
 179-316 2.13e-08

putative aldolase; Validated


Pssm-ID: 181241 [Multi-domain]  Cd Length: 213  Bit Score: 55.27  E-value: 2.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 179 HFLIVPFGLLYSEVTASSLVKVNLQGDIV--DRGSTNLgvnqagfTLHSAVYAARPDAKCIVHIHTPAGAAVS------- 249
Cdd:PRK08130   38 GWLVTPTGSCLGRLDPARLSKVDADGNWLsgDKPSKEV-------PLHRAIYRNNPECGAVVHLHSTHLTALSclggldp 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1062594046 250 -----------AMKCGLLPISPeALSLGDVAyhdyhgiLVDEEEKiliqknLGPKSKVLILRNHGLVSVGESVEEAFY 316
Cdd:PRK08130  111 tnvlppftpyyVMRVGHVPLIP-YYRPGDPA-------IAEALAG------LAARYRAVLLANHGPVVWGSSLEAAVN 174
PRK08087 PRK08087
L-fuculose-phosphate aldolase;
177-333 5.70e-07

L-fuculose-phosphate aldolase;


Pssm-ID: 181226 [Multi-domain]  Cd Length: 215  Bit Score: 50.89  E-value: 5.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 177 QEHFLIVPFGLLYSEVTASSLVKVNlqgdivDRGSTNLG-VNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGL 255
Cdd:PRK08087   35 QDGMLITPTGIPYEKLTESHIVFVD------GNGKHEEGkLPSSEWRFHMAAYQTRPDANAVVHNHAVHCTAVSILNRPI 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 256 LPISPE-ALSLGD----VAYHDYHGILVDEEEKILIQknlgpKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVR 330
Cdd:PRK08087  109 PAIHYMiAAAGGNsipcAPYATFGTRELSEHVALALK-----NRKATLLQHHGLIACEVNLEKALWLAHEVEVLAQLYLK 183


                  ...
gi 1062594046 331 TLA 333
Cdd:PRK08087  184 TLA 186
PRK06833 PRK06833
L-fuculose-phosphate aldolase;
174-338 8.83e-07

L-fuculose-phosphate aldolase;


Pssm-ID: 180717 [Multi-domain]  Cd Length: 214  Bit Score: 50.52  E-value: 8.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 174 NSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrGSTnlgVNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKC 253
Cdd:PRK06833   34 NREQGLMAITPSGIDYFEIKPEDIVIMDLDGKVVE-GER---KPSSELDMHLIFYRNREDINAIVHTHSPYATTLACLGW 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 254 GLLPISPE-ALSLGDVAYHDYHGI----LVDEEEKILIQKnlgpksKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQ 328
Cdd:PRK06833  110 ELPAVHYLiAVAGPNVRCAEYATFgtkeLAENAFEAMEDR------RAVLLANHGLLAGANNLKNAFNIAEEIEFCAEIY 183

                         170
                  ....*....|
gi 1062594046 329 VRTlASAGGP 338
Cdd:PRK06833  184 YQT-KSIGEP 192
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 614-735 6.04e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 6.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  614 GSEENLDETREQKEKSPPDQSAVP-NTPPSTPVKLEEDLPQE----PTSRDDSDATTFKPTPPDLSPDEPSE-ALAFPAV 687
Cdd:PHA03307   100 PAREGSPTPPGPSSPDPPPPTPPPaSPPPSPAPDLSEMLRPVgspgPPPAASPPAAGASPAAVASDAASSRQaALPLSSP 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1062594046  688 EEEAHASPDP-TQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 735
Cdd:PHA03307   180 EETARAPSSPpAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
PHA03169 PHA03169
hypothetical protein; Provisional
 597-735 2.05e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 44.58  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 597 TDRELEEYRREVERKQKGSEENlDETREQKEKSPPDQSAVP---------NTPPSTPVKLEEDLPQEPTSRDDSDATTFK 667
Cdd:PHA03169   73 TETAEESRHGEKEERGQGGPSG-SGSESVGSPTPSPSGSAEelasglspeNTSGSSPESPASHSPPPSPPSHPGPHEPAP 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1062594046 668 PTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEADPEPASAPTPG-AEEVASPATEEGSPMDPGSD 735
Cdd:PHA03169  152 PESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTsSPPPQSPPDEPGEPQSPTPQ 220
PHA03247 PHA03247
large tegument protein UL36; Provisional
 630-732 2.90e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  630 PPDQSAVPNTPPSTPVKleeDLPQEPTSRDDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEAD-PEP 708
Cdd:PHA03247  2734 ALPAAPAPPAVPAGPAT---PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADpPAA 2810

                           90       100
                   ....*....|....*....|....
gi 1062594046  709 ASAPTPGAEEVASPATEEGSPMDP 732
Cdd:PHA03247  2811 VLAPAAALPPAASPAGPLPPPTSA 2834
PHA03247 PHA03247
large tegument protein UL36; Provisional
 630-753 2.90e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  630 PPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPdlspdEPSEALAFPAVEEEAHASPDPTQPPAEADPE-- 707
Cdd:PHA03247  2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPP-----AVPAGPATPGGPARPARPPTTAGPPAPAPPAap 2775

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1062594046  708 ----PASAPTPGAEEVASPATEEGSPMDPGSDGSPGKSPSKKKKKFRTPS 753
Cdd:PHA03247  2776 aagpPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
620-729 3.54e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 620 DETREQKEKSPPDQSAVPNtpPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDL-SPDEPSEALAFPAVEEEAHASPDPT 698
Cdd:PRK07003  437 DRGDDAADGDAPVPAKANA--RASADSRCDERDAQPPADSGSASAPASDAPPDAaFEPAPRAAAPSAATPAAVPDARAPA 514

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1062594046 699 QPPAEADPEPASAPTPgaeEVASPATEEGSP 729
Cdd:PRK07003  515 AASREDAPAAAAPPAP---EARPPTPAAAAP 542
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 629-733 4.12e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 629 SPPDQSAVPNTPPSTPvkleedlPQEPTSRDDSDATTFKPTPPDLSPD--EPSEALAFPAVEEEAHASPDPTQPPAEADP 706
Cdd:PRK07764  698 PAQPAPAPAATPPAGQ-------ADDPAAQPPQAAQGASAPSPAADDPvpLPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770

                          90       100
                  ....*....|....*....|....*..
gi 1062594046 707 EPASAPTPGAEEVASPATEEGSPMDPG 733
Cdd:PRK07764  771 AAAPPPSPPSEEEEMAEDDAPSMDDED 797
PHA03247 PHA03247
large tegument protein UL36; Provisional
 628-729 5.38e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 5.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  628 KSPPDQS--AVPNTPPSTPVKleeDLPQEPTSRddsdATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEAD 705
Cdd:PHA03247  2864 RRPPSRSpaAKPAAPARPPVR---RLARPAVSR----STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                           90       100
                   ....*....|....*....|....
gi 1062594046  706 PEPASAPTPGAEEVASPATEEGSP 729
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGAGEPSGAVP 2960
PRK08660 PRK08660
aldolase;
180-327 6.89e-04

aldolase;


Pssm-ID: 181527 [Multi-domain]  Cd Length: 181  Bit Score: 41.48  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 180 FLIVPFGLLYSEVTASSLVKVNLQG-DIVDRG-STNLGVnqagftlHSAVYAaRPDAKCIVHIHTPAGAAVSAMKCGLLP 257
Cdd:PRK08660   33 LLITRTGSMLDEITEGDVIEVGIDDdGSVDPLaSSETPV-------HRAIYR-RTSAKAIVHAHPPYAVALSLLEDEIVP 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1062594046 258 ISPEALS-LGD--VAYHDYHGILVDEEEKILIQKNlgpksKVLILRNHGLVSVGESVEEAFYYIHNLVVACEI 327
Cdd:PRK08660  105 LDSEGLYfLGTipVVGGDIGSGELAENVARALSEH-----KGVVVRGHGTFAIGKTLEEAYIYTSQLEHSCKV 172
PHA03419 PHA03419
E4 protein; Provisional
 630-715 7.10e-04

E4 protein; Provisional


Pssm-ID: 223079 [Multi-domain]  Cd Length: 200  Bit Score: 41.47  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 630 PPDQSAVPNTPPSTPVKLEEDLPQEPTSR----DDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEAD 705
Cdd:PHA03419   63 PPPCPPSPGHPPQTNDTHEKDLALQPPPGgkkkEKKKKETEKPAQGGEKPDQGPEAKGEGEGHEPEDPPPEDTPPPPGGE 142

                          90
                  ....*....|
gi 1062594046 706 PEPASAPTPG 715
Cdd:PHA03419  143 GEVEGGPSPG 152
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 625-732 8.82e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 8.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  625 QKEKSPPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPdlSPDEPSEALAFPAVEEEAHASPDPTQPPAEA 704
Cdd:PRK10263   390 AVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAP--APEQPVAGNAWQAEEQQSTFAPQSTYQTEQT 467

                           90       100
                   ....*....|....*....|....*...
gi 1062594046  705 DPEPASAPTPgaeEVASPATEEGSPMDP 732
Cdd:PRK10263   468 YQQPAAQEPL---YQQPQPVEQQPVVEP 492
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 625-723 9.68e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 42.41  E-value: 9.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 625 QKEKSPPDqsavPNTPPSTPVKLEEDLPQEPTSrddsdATTFKPTPPdLSPDEPSEALAFPAVEEEAHAS--PDPTQPP- 701
Cdd:PHA03269   48 QAASRAPD----PAVAPTSAASRKPDLAQAPTP-----AASEKFDPA-PAPHQAASRAPDPAVAPQLAAApkPDAAEAFt 117

                          90       100
                  ....*....|....*....|....
gi 1062594046 702 --AEADPEPASAPTPGAEEVASPA 723
Cdd:PHA03269  118 saAQAHEAPADAGTSAASKKPDPA 141
Androgen_recep pfam02166
Androgen receptor;
604-735 1.07e-03

Androgen receptor;


Pssm-ID: 426632 [Multi-domain]  Cd Length: 501  Bit Score: 42.22  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 604 YRREVERKQKGSEENLDETREQKEKSPP---DQSAVPNTPPSTPVKLEEDLP---------QEPTSRDDSDATTFKPTPP 671
Cdd:pfam02166   6 YPRPPAKTFRGAFQNLFQSVREVIQNPGprhPEAAGGAAPPGARLQHQQQQQqqvpqqpqqQESSPRQPQASVQPQQAGD 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1062594046 672 DLSPDEPSEALA-FPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGS--PMDPGSD 735
Cdd:pfam02166  86 DGSPPAHNRGPAgYLALEDDEQPQPSQAQPAAECCPENGCVPEPGAAAAAGKGLPQQAvaPAAPDDD 152
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 592-710 1.15e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 42.36  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 592 PFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEEDLP--QEPTSRDDSDATTFKPT 669
Cdd:COG5180   188 PRDALKDSPEKLDRPKVEVKDEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATvdAQPEMRPPADAKERRRA 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1062594046 670 PpdlspdepsealafpavEEEAHASPDPTQPPAEADPEPAS 710
Cdd:COG5180   268 A-----------------IGDTPAAEPPGLPVLEAGSEPQS 291
sgaE PRK12348
L-ribulose-5-phosphate 4-epimerase; Reviewed
 173-327 1.70e-03

L-ribulose-5-phosphate 4-epimerase; Reviewed


Pssm-ID: 183460  Cd Length: 228  Bit Score: 40.55  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 173 VNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVD---RGSTNLGVnqagftlHSAVYAARPDAKCIVHIHTP------ 243
Cdd:PRK12348   31 IDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVEgeyRPSSDTAT-------HLELYRRYPSLGGIVHTHSThatawa 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 244 -AGAAVSAMKC-------GLLPISpEALSLGDVAyHDYhgilvDEEEKILIQKNLGPKSKV----LILRNHGLVSVGESV 311
Cdd:PRK12348  104 qAGLAIPALGTthadyffGDIPCT-RGLSEEEVQ-GEY-----ELNTGKVIIETLGNAEPLhtpgIVVYQHGPFAWGKDA 176

                         170
                  ....*....|....*.
gi 1062594046 312 EEAfyyIHNLVVACEI 327
Cdd:PRK12348  177 HDA---VHNAVVMEEV 189
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 629-735 1.83e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 629 SPPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPT-QPPAEADPE 707
Cdd:PRK07764  400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPApAAAPEPTAA 479

                          90       100
                  ....*....|....*....|....*...
gi 1062594046 708 PASAPTPGAEEVASPATEEGSPMDPGSD 735
Cdd:PRK07764  480 PAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
PHA03247 PHA03247
large tegument protein UL36; Provisional
 615-735 2.37e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  615 SEENLDETREQKEKSPPDQSAVPNTP-PSTPVKLEEDLPQEPTSRDDSDATTFKPTPPD-LSPDEPSEALAFPAVEEEAH 692
Cdd:PHA03247   364 SLEDLSAGRHHPKRASLPTRKRRSARhAATPFARGPGGDDQTRPAAPVPASVPTPAPTPvPASAPPPPATPLPSAEPGSD 443

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1062594046  693 ASPDPT---QPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 735
Cdd:PHA03247   444 DGPAPPperQPPAPATEPAPDDPDDATRKALDALRERRPPEPPGAD 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 629-735 2.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  629 SPPDQSAVPN-TPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDlsPDEPSEALAFPAVEEEAHASPDPTQPPAEAdPE 707
Cdd:PHA03247  2759 RPPTTAGPPApAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD--PADPPAAVLAPAAALPPAASPAGPLPPPTS-AQ 2835

                           90       100
                   ....*....|....*....|....*...
gi 1062594046  708 PASAPTPgAEEVASPATEEGSpMDPGSD 735
Cdd:PHA03247  2836 PTAPPPP-PGPPPPSLPLGGS-VAPGGD 2861
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 630-726 3.09e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 40.71  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 630 PPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTF-KPTPPDLSPDEPSEAlAFPAVEEEAHASPDPTQPPAEADPEP 708
Cdd:PHA03291  181 SADGSCDPALPLSAPRLGPADVFVPATPRPTPRTTASpETTPTPSTTTSPPST-TIPAPSTTIAAPQAGTTPEAEGTPAP 259

                          90       100
                  ....*....|....*....|..
gi 1062594046 709 asaPTPGAEEV----ASPATEE 726
Cdd:PHA03291  260 ---PTPGGGEAppanATPAPEA 278
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
640-729 3.49e-03

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 40.56  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 640 PPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSeaLAFPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEV 719
Cdd:PRK12373  190 PAGGLTSLTEEAGKARYNASKALAEDIGDTVKRIDGTEVP--LLAPWQGDAAPVPPSEAARPKSADAETNAALKTPATAP 267

                          90
                  ....*....|
gi 1062594046 720 ASPATEEGSP 729
Cdd:PRK12373  268 KAAAKNAKAP 277
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 631-724 3.95e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 631 PDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSEALAFPAVEEEahASPDPT-QPPAEADPEPA 709
Cdd:COG3266   258 PSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVALPAAPAAAAAAAAPAEA--AAPQPTaAKPVVTETAAP 335

                          90
                  ....*....|....*.
gi 1062594046 710 SAPTPGAEEVAS-PAT 724
Cdd:COG3266   336 AAPAPEAAAAAAaPAA 351
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 659-735 5.32e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.26  E-value: 5.32e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1062594046  659 DDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 735
Cdd:PRK12270    39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 630-729 6.84e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 6.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  630 PPDQSAVPNTPPSTPVKLEEDLPQEPTSRD-DSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEADP-- 706
Cdd:PHA03307    81 ANESRSTPTWSLSTLAPASPAREGSPTPPGpSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASpa 160

                           90       100
                   ....*....|....*....|....
gi 1062594046  707 -EPASAPTPGAEEVASPATEEGSP 729
Cdd:PHA03307   161 aVASDAASSRQAALPLSSPEETAR 184
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 594-729 7.20e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 7.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046  594 NTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEEDLPQEptsrDDSDATTfkptppdl 673
Cdd:PHA03307   263 ITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE----SSSSSTS-------- 330

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1062594046  674 SPDEPSEALAFPAVEEEaHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGSP 729
Cdd:PHA03307   331 SSSESSRGAAVSPGPSP-SRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRP 385
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 620-732 8.37e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 39.71  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594046 620 DETREQKEKSPPDQSAvPNTPPSTPVKLEEdlPQEPTSRDDSDATTFKPTPPDLSP-DEPSEALAFPAVEEEAHASPDPT 698
Cdd:PRK14949  629 LSPKEGDGKKSSADRK-PKTPPSRAPPASL--SKPASSPDASQTSASFDLDPDFELaTHQSVPEAALASGSAPAPPPVPD 705

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1062594046 699 ---QPPAEADPEPASAPTPGA--------EEVASPATEEGSPMDP 732
Cdd:PRK14949  706 pydRPPWEEAPEVASANDGPNnaaegnlsESVEDASNSELQAVEQ 750
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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