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Conserved domains on  [gi|1070257837|ref|NP_001333056|]
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glutathione-specific gamma-glutamylcyclotransferase 2 isoform 2 [Homo sapiens]

Protein Classification

gamma-glutamylcyclotransferase family protein( domain architecture ID 366289)

gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl

CATH:  3.10.490.10
Gene Ontology:  GO:0016746
PubMed:  18515354|20110353
SCOP:  4002485

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GGCT_like super family cl22886
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 2-118 3.02e-57

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


The actual alignment was detected with superfamily member pfam04752:

Pssm-ID: 451440  Cd Length: 176  Bit Score: 175.27  E-value: 3.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070257837   2 GCVWGVAYRLPVGKEEEVKAYLDFREK-GGYRTTTVIFYPK-DPTTKPFSVLLYIGTCDNPDYLGPAPLEDIAEQIFNAA 79
Cdd:pfam04752  58 GRTWGVAYRIPAETAEEVLEYLDVREQiNGYTTHEVPFYPDqDTDGRPVNALVYVATPKNPQYLGDDPLEQIAKQIATAR 137

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1070257837  80 GPSGRNTEYLFELANSIRNLVPEEADEHLFALEKLVKER 118
Cdd:pfam04752 138 GPSGPNAEYLFELAQALRKLGPGVQDDHLFELEKLVKKL 176
 
Name Accession Description Interval E-value
ChaC pfam04752
ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases ...
 2-118 3.02e-57

ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.


Pssm-ID: 398428  Cd Length: 176  Bit Score: 175.27  E-value: 3.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070257837   2 GCVWGVAYRLPVGKEEEVKAYLDFREK-GGYRTTTVIFYPK-DPTTKPFSVLLYIGTCDNPDYLGPAPLEDIAEQIFNAA 79
Cdd:pfam04752  58 GRTWGVAYRIPAETAEEVLEYLDVREQiNGYTTHEVPFYPDqDTDGRPVNALVYVATPKNPQYLGDDPLEQIAKQIATAR 137

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1070257837  80 GPSGRNTEYLFELANSIRNLVPEEADEHLFALEKLVKER 118
Cdd:pfam04752 138 GPSGPNAEYLFELAQALRKLGPGVQDDHLFELEKLVKKL 176
ChaC2 COG3703
Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and ...
 2-121 1.63e-26

Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and metabolism];


Pssm-ID: 442917  Cd Length: 190  Bit Score: 97.58  E-value: 1.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070257837   2 GCVWGVAYRLPVGKEEEVKAYLDFREK--GGY--RTTTVIFypkdPTTKPFSVLLYIGTCDNPDYLGPAPLEDIAEQIFN 77
Cdd:COG3703    71 GSCRGVAFRVPPEDAEAVLAYLWRREMvtGVYlpRWLPVRL----ADGRRVEALAFVADRDHPQYAGGLSLEEQARIIAQ 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070257837  78 AAGPSGRNTEYLFELANSIRNLvpEEADEHLFALEKLVKERLEG 121
Cdd:COG3703   147 AVGPSGSNADYLLNTAEHLREL--GIRDPHLEALARLVRALLAA 188
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 2-55 1.69e-03

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 35.40  E-value: 1.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1070257837   2 GCVWGVAYRLPvgkeEEVKAYLDFREK--GGYRTTTVIFYPKDPTTKPfsVLLYIG 55
Cdd:cd06661    50 ARVWGELYEVD----PEDLARLDAFEGvpGGYRREEVEVELEDGEGVE--AWVYVA 99
 
Name Accession Description Interval E-value
ChaC pfam04752
ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases ...
 2-118 3.02e-57

ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.


Pssm-ID: 398428  Cd Length: 176  Bit Score: 175.27  E-value: 3.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070257837   2 GCVWGVAYRLPVGKEEEVKAYLDFREK-GGYRTTTVIFYPK-DPTTKPFSVLLYIGTCDNPDYLGPAPLEDIAEQIFNAA 79
Cdd:pfam04752  58 GRTWGVAYRIPAETAEEVLEYLDVREQiNGYTTHEVPFYPDqDTDGRPVNALVYVATPKNPQYLGDDPLEQIAKQIATAR 137

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1070257837  80 GPSGRNTEYLFELANSIRNLVPEEADEHLFALEKLVKER 118
Cdd:pfam04752 138 GPSGPNAEYLFELAQALRKLGPGVQDDHLFELEKLVKKL 176
ChaC2 COG3703
Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and ...
 2-121 1.63e-26

Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and metabolism];


Pssm-ID: 442917  Cd Length: 190  Bit Score: 97.58  E-value: 1.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070257837   2 GCVWGVAYRLPVGKEEEVKAYLDFREK--GGY--RTTTVIFypkdPTTKPFSVLLYIGTCDNPDYLGPAPLEDIAEQIFN 77
Cdd:COG3703    71 GSCRGVAFRVPPEDAEAVLAYLWRREMvtGVYlpRWLPVRL----ADGRRVEALAFVADRDHPQYAGGLSLEEQARIIAQ 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070257837  78 AAGPSGRNTEYLFELANSIRNLvpEEADEHLFALEKLVKERLEG 121
Cdd:COG3703   147 AVGPSGSNADYLLNTAEHLREL--GIRDPHLEALARLVRALLAA 188
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 2-55 1.69e-03

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 35.40  E-value: 1.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1070257837   2 GCVWGVAYRLPvgkeEEVKAYLDFREK--GGYRTTTVIFYPKDPTTKPfsVLLYIG 55
Cdd:cd06661    50 ARVWGELYEVD----PEDLARLDAFEGvpGGYRREEVEVELEDGEGVE--AWVYVA 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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