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Conserved domains on  [gi|1079280806|ref|NP_001333374|]
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neuroblast differentiation-associated protein AHNAK isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TamB super family cl34519
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
5109-5658 5.08e-09

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG2911:

Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 63.14  E-value: 5.08e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5109 PSPKLEGELQAPDLELSL----PAIHVEGLDIKAKAPKV----KMPDVDISVPKIEGDLKG-PKVQANLGAPDINIEG-L 5178
Cdd:COG2911     27 PLALLRGRLCIDELALSAsldgDRLRLDNLDLDAPEGALsgllDLVQATLDAEGLDLASSAlDDLDLRSGGNRLTLSGnL 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5179 DAKVKTPSFGISAPQVS-IPDVNVNLKGpKIKGDvpsvGLEGPDVDLQGPEAKIKFpkfsmpkigipgvKMEGGGAEVHA 5257
Cdd:COG2911    107 SAASLDGDLDLDAPDLAdLAALLPGLAG-SLSGD----GLDSLSLDADGTLAQHRL-------------DLDAKGEPASL 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5258 QLpSLEGDLRGPDVK-------LEGPDVSLKGPGvdlpSVNLSMPKVSGPDLDLNLKGP-SLKGDLDASVpSMKVHAPGL 5329
Cdd:COG2911    169 SL-ALSGGLDRDDGGtlsrldfLNTGRWGLAAPA----TLSYDDGRVTLGPLCLAGGGSlCLSGTLGGTL-DLQLRLKNL 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5330 NLSGVGgkmQVGGDGVKVPG-IDATTKL--NVGAPDVTLRgPSLQGDLAVSGDIKCPKVSVGAPDLSLEASEGSIKLpkm 5406
Cdd:COG2911    243 PLALLN---PFLPDDLGLSGtLNGDADLsgGLANPQGDAS-LSLSGDLTLNDGLGGLPLGLGDLTLNARLANGRLTL--- 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5407 klpQFGISTPGSD-LHVNAKGPQVSGELKGPGVDVNLKGPRISA-------PNVDFNLEGpKVKGSLGATGEIKGPTVGG 5478
Cdd:COG2911    316 ---DLTLDGGGLGtLSLSGSVPLADGLPPSAPLDGNLRLDNLDLallnpllPGVLERLSG-QLNGDLRLSGTLAAPQLNG 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5479 GL---------PGIGVQGLEGNLQmpgIKSSGCDVNLPGVNVKLPTGQISgpeikggLKGSeVGFHGAAP--DISVKGPA 5547
Cdd:COG2911    392 QLtlddgrlklPALGVRLTDINLR---LRFDGDRLTLDGLTADSGGGTLT-------LSGT-VDLDGLSWpaDLTLKGDN 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5548 FN---------MASPESDFGINLKGPKIKGGADVSGG-VSAPDISLGEGHLS----VKGSGGEWKGPQVSSALNLDTS-- 5611
Cdd:COG2911    461 LRvlnppdytaTVSGDLTLTGTPDGPTLSGNVTVPRArITLPELPPSAVSLSddvvVVNRPPEPVPEEEAAGLPLDLDln 540
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1079280806 5612 -KFAGGLHFSGPKVEGGVkGGQIGLQAPGLSVSGPQGHLESGSGKVTF 5658
Cdd:COG2911    541 vNLGDDVRVRGFGLDARL-GGDLRLTGTPGGAPRLTGEINLVRGRYNA 587
AsmA super family cl34531
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3050-3469 3.32e-07

Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG2982:

Pssm-ID: 442221 [Multi-domain]  Cd Length: 491  Bit Score: 56.97  E-value: 3.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3050 DLDVS-GPKVDIDVPDVNIEGPEGKLKGPKFKMPEMnikapkismpDIDLNLkgpkvkgdmdvsLPKVEGDMKVPDVDIK 3128
Cdd:COG2982     55 DLSLSlFPWPGVTLGDVTLSNPDGFGGPPLASAERL----------ELDLAL------------LPLLSGELEVDEITLD 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3129 GPKVDInapDVDVQG-PDWHLKMPKIKMPKismpgfKGEGPEVDVNLPKADLD---------VSGPKVDVDVPDVNIEGP 3198
Cdd:COG2982    113 GPVINL---ERDADGrANWDFLLAAAAAAA------DAEASAWSLDIGRLEITdgrlvyddaASGADLTLDDLNLTLSGP 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3199 D----------AKLKGPKFKMpEMNIKAPKISMP-DLDLNLKGPKMKGEVD--VSLANVEGDLKGPALDIK--GPKIDVD 3263
Cdd:COG2982    184 SldgpfrlsgsGRLNGQPLTL-DGKIGGLLALGPyPLKLDLRSGDLRLSLDgtVDLAGLDGQLALSGPSLRdlLALLGVT 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3264 APDidihGPDAKLKGpklkmpDMHVNMPKISMPEIDLNLKGSKLKGDVDVSG---PKLEGDIKAPSLDIK--GPEVDVSG 3338
Cdd:COG2982    263 LPE----PGPFSLSG------RLTADGDRLRLEDLKGTLGDSDLTGDLSVTGgdrPALTGDLASDRLDLDdlLPAAPAAA 332
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3339 PKLNIEGKSKKSRFKLP---------KFNFSGSKVQTPEVDVKGKKPDIDITGPKVDINAPDVEV-QGKVKGSkfkmpfL 3408
Cdd:COG2982    333 AAGAPAAARGLPDAPLDlsalraldaDVRLSADSLKLGGLPLGDLAAHLTLDDGRLDLDPLSAGLyGGTLSGS------L 406
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1079280806 3409 SISSPKvSMPDVELNLKSPKVK-GDL--DIAGP-------NLEGDFKGPKVDIKAP------EVNLNAPDVDVHGPD 3469
Cdd:COG2982    407 TLDARG-DPPRVALKLSLSGVDlGPLlpDLAGFdrlsgtlNGDLDLSGTGNSVAALlaslngSASLSLGDGAISGLN 482
TamB super family cl34519
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3223-3722 6.72e-06

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG2911:

Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 53.12  E-value: 6.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3223 DLDLNLKGPKMKGEVDVS----------LANVEgDLKGPALDIKGP-KIDVDAPDIDI------HGPDAKLKGPKLKMPD 3285
Cdd:COG2911    156 RLDLDAKGEPASLSLALSggldrddggtLSRLD-FLNTGRWGLAAPaTLSYDDGRVTLgplclaGGGSLCLSGTLGGTLD 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3286 MHVNMPKISMPEI------DLNLKGsKLKGDVDVSG----PKLEGDIKAP---SLDIKGPEVDVSGPKLNIEGKSKKSRF 3352
Cdd:COG2911    235 LQLRLKNLPLALLnpflpdDLGLSG-TLNGDADLSGglanPQGDASLSLSgdlTLNDGLGGLPLGLGDLTLNARLANGRL 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3353 KLpkfnfsgskvqtpEVDVKGKKPD-IDITG--PKVDINAPDVEVQGKVKGSKFKMPFLSisspkVSMPDVELNLKSpKV 3429
Cdd:COG2911    314 TL-------------DLTLDGGGLGtLSLSGsvPLADGLPPSAPLDGNLRLDNLDLALLN-----PLLPGVLERLSG-QL 374
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3430 KGDLDIAG----PNLEGDFKGPKVDIKAPEVNLNAPDVDVhgpdwNLKMPKMKmpkFSVSGLKAEGPDVAVDLpKGDINI 3505
Cdd:COG2911    375 NGDLRLSGtlaaPQLNGQLTLDDGRLKLPALGVRLTDINL-----RLRFDGDR---LTLDGLTADSGGGTLTL-SGTVDL 445
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3506 EGPSMNIegpDLNVegpegglKGPKFK---MPDMNIKA-PKIsmpDIDLNLKGPKVKGDVDIslpklegdlkgPEVDIKG 3581
Cdd:COG2911    446 DGLSWPA---DLTL-------KGDNLRvlnPPDYTATVsGDL---TLTGTPDGPTLSGNVTV-----------PRARITL 501
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3582 PKVDINAPDVDvhgpdwhlkmPKVKMpkfsmpgfKGEGPEVDVTLPKADIDISGpNVDVDVP-DVNIEGP--DAKLKGpk 3658
Cdd:COG2911    502 PELPPSAVSLS----------DDVVV--------VNRPPEPVPEEEAAGLPLDL-DLNVNLGdDVRVRGFglDARLGG-- 560
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1079280806 3659 fkmpemnikapkismpdfDLNLKG-----PKMKGDVVVslpkVEGDLK--GPEVDIK-------GPKVDidtPDINIE 3722
Cdd:COG2911    561 ------------------DLRLTGtpggaPRLTGEINL----VRGRYNayGQRLTIErgsitfnGPPLD---PYLDIE 613
TamB super family cl34519
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
192-681 7.07e-06

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG2911:

Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 52.73  E-value: 7.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  192 ISNVDVetQSGKTVIRLpSGSGAASPTGSAVDIRA---GAISASGPELQGaghsklQVTMPGIkvggSGVNVNAKGLDLG 268
Cdd:COG2911     88 LDDLDL--RSGGNRLTL-SGNLSAASLDGDLDLDApdlADLAALLPGLAG------SLSGDGL----DSLSLDADGTLAQ 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  269 GR--GGVQVPAVDISSSLGGRAVEVQGPSLESGDHgkikfptmkvpkfgVSTGREGQTPKAGLRVSAPEVSVGH----KG 342
Cdd:COG2911    155 HRldLDAKGEPASLSLALSGGLDRDDGGTLSRLDF--------------LNTGRWGLAAPATLSYDDGRVTLGPlclaGG 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  343 GKPGLTIQAP---QLEVSVPSANIEGLEGKL-KGPQITGpSLEGDLGLKGakpqghigvDASAPQIGGSITGP-SVEVQA 417
Cdd:COG2911    221 GSLCLSGTLGgtlDLQLRLKNLPLALLNPFLpDDLGLSG-TLNGDADLSG---------GLANPQGDASLSLSgDLTLND 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  418 PDIDVQGPGSKLNVpkmkvpKFSVSGAKGEetgIDVTLPTGEVTVPGVSGDVSLPEIATGglEGKMKGTkvktpemiiqk 497
Cdd:COG2911    291 GLGGLPLGLGDLTL------NARLANGRLT---LDLTLDGGGLGTLSLSGSVPLADGLPP--SAPLDGN----------- 348
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  498 pkISMQDVDLSLGSP-----------KLKGDIKVS----APGVQGDVKGPQVALKGSR--VDIETPNLEGTLTGPR--LG 558
Cdd:COG2911    349 --LRLDNLDLALLNPllpgvlerlsgQLNGDLRLSgtlaAPQLNGQLTLDDGRLKLPAlgVRLTDINLRLRFDGDRltLD 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  559 SPSGKTGTCRISMS----------EVDLNVAA--------PKVKGGVDVTL--------PRVEGKVKVPEVDVRGPKVDV 612
Cdd:COG2911    427 GLTADSGGGTLTLSgtvdldglswPADLTLKGdnlrvlnpPDYTATVSGDLtltgtpdgPTLSGNVTVPRARITLPELPP 506
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1079280806  613 SAPDVEAhgpewNLKMPKMKMPTFSTPGAKGEGPDVHMTLpkgdisISGPKVNVEAPDVNLEgLGGKLK 681
Cdd:COG2911    507 SAVSLSD-----DVVVVNRPPEPVPEEEAAGLPLDLDLNV------NLGDDVRVRGFGLDAR-LGGDLR 563
PDZ_canonical super family cl49608
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
22-56 3.14e-04

canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


The actual alignment was detected with superfamily member cd06716:

Pssm-ID: 483948 [Multi-domain]  Cd Length: 88  Bit Score: 42.65  E-value: 3.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1079280806   22 GLTIAQRDD-----GVFVQEVTQNSPAARTGVVKEGDQIV 56
Cdd:cd06716     18 GLTLCYRTDdeedtGIYVSEVDPNSIAAKDGRIREGDQIL 57
AsmA super family cl34531
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
4532-4945 3.25e-04

Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG2982:

Pssm-ID: 442221 [Multi-domain]  Cd Length: 491  Bit Score: 46.96  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4532 KIKGDMDISVpklegdlkgpkvdvkGPKVGIDTPDIDIHGPEGKLKGPKFKMPDLHLkapkismpEVDLN--LKGpkvkg 4609
Cdd:COG2982     51 TIDGDLSLSL---------------FPWPGVTLGDVTLSNPDGFGGPPLASAERLEL--------DLALLplLSG----- 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4610 dmDISLPKVEgdLKGPEVDI-RDPkvdidvpdvdvQG-PDWHLKMPKvkmpkfsmpgfkgegpdvdvnlPKADIDVSGPK 4687
Cdd:COG2982    103 --ELEVDEIT--LDGPVINLeRDA-----------DGrANWDFLLAA----------------------AAAAADAEASA 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4688 VDVDVPDVNIEGPDAKLKGPKFKMpemsikapKISMPDIDLNLKGPKVKGDVDVTLpkvEGDLKGPEADIKGpKVDINTP 4767
Cdd:COG2982    146 WSLDIGRLEITDGRLVYDDAASGA--------DLTLDDLNLTLSGPSLDGPFRLSG---SGRLNGQPLTLDG-KIGGLLA 213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4768 ------DVDVHGPDWHLKMpkvkMPKFSMPGFKGegpdvDVSLPKADIDVSGPKVDVDIPdvniEGPDAKLKGPkfkmpe 4841
Cdd:COG2982    214 lgpyplKLDLRSGDLRLSL----DGTVDLAGLDG-----QLALSGPSLRDLLALLGVTLP----EPGPFSLSGR------ 274
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4842 INIKAPKISIPDVDLDLKGPKVKGDFDVS---VPKVEGTLKGPEVDLkgPRL---DFEGPDAKLSGPSLKMPSLEISAPK 4915
Cdd:COG2982    275 LTADGDRLRLEDLKGTLGDSDLTGDLSVTggdRPALTGDLASDRLDL--DDLlpaAPAAAAAGAPAAARGLPDAPLDLSA 352
                          410       420       430
                   ....*....|....*....|....*....|
gi 1079280806 4916 VTAPDVDLHLKAPKIGFSGPKLEGGEVDLK 4945
Cdd:COG2982    353 LRALDADVRLSADSLKLGGLPLGDLAAHLT 382
AsmA super family cl37543
AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane ...
4326-4631 1.17e-03

AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.


The actual alignment was detected with superfamily member pfam05170:

Pssm-ID: 428346 [Multi-domain]  Cd Length: 607  Bit Score: 45.55  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4326 MPGFKGEGPDVDVTL---PKADIEISGPKVDIDAPDVSIEGPDAKLKGPKFKMPEMNIKAPKISMPDIDFNLKGPKVKGD 4402
Cdd:pfam05170  105 IDSIRLDGAELALERlkqGNWNWQELIQNQQNQASNAPTQQPQPTWPVAAWSLPIGRIQVSNGQVTIDDKASQKILKDIN 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4403 VDVSLPkvegdlkgpeiDIKGPSLdidtPDVNIEGpEGKLKGPKFKMP---EMNIKAPKISMPDFDLHLKGPKVKGDVDV 4479
Cdd:pfam05170  185 LELQVS-----------TLYGPSF----NWSKITI-SGKGDQDPQSFGsqvNVTILSGEISGEALRGSTSTGGMLLLQTL 248
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4480 SLPKVESDlkgpevdiegpEGKLKGPKFKMPDVHFKSPQISMSDIDLNLKGPKIKGD----MDISVPKLEGDLKGPKVDV 4555
Cdd:pfam05170  249 SSPIYHIN-----------SLKLLNAQLELDGTLWDNLNLSIEDLDLKASGWKSITVnlalTADELDSLANQAELPGANL 317
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4556 kgpkvgIDTPD-IDIHGPEGKLKGPKFKMpDLHLKAPKISMPevDLNLKGPKVKGDMDISL----------PKVEGDLKG 4624
Cdd:pfam05170  318 ------PDTPQnITLGELSLSFKTGRVQV-SGSLNSLTLNLD--YLSFDGKKWVGSSDIDLsnrlpqpqprPKLRGKLSS 388

                   ....*..
gi 1079280806 4625 PEVDIRD 4631
Cdd:pfam05170  389 PELDLDN 395
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
4879-5014 1.28e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4879 KGPEVDLKGPRLD---FEGPDAKLSGPSLKMPSLEISAPKVTAPDV---DLHLKAPKIGFSG---------PKLEGGEVd 4943
Cdd:pfam05109  423 KAPESTTTSPTLNttgFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstaDVTSPTPAGTTSGaspvtpspsPRDNGTES- 501
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1079280806 4944 lKGPKVEAPSLDVHMDSPDINIEGPDVKIPKFKKPKFGFGAKSPKADIKSPSLDVTVPEAELNLETPEISV 5014
Cdd:pfam05109  502 -KAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI 571
 
Name Accession Description Interval E-value
TamB COG2911
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
5109-5658 5.08e-09

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 63.14  E-value: 5.08e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5109 PSPKLEGELQAPDLELSL----PAIHVEGLDIKAKAPKV----KMPDVDISVPKIEGDLKG-PKVQANLGAPDINIEG-L 5178
Cdd:COG2911     27 PLALLRGRLCIDELALSAsldgDRLRLDNLDLDAPEGALsgllDLVQATLDAEGLDLASSAlDDLDLRSGGNRLTLSGnL 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5179 DAKVKTPSFGISAPQVS-IPDVNVNLKGpKIKGDvpsvGLEGPDVDLQGPEAKIKFpkfsmpkigipgvKMEGGGAEVHA 5257
Cdd:COG2911    107 SAASLDGDLDLDAPDLAdLAALLPGLAG-SLSGD----GLDSLSLDADGTLAQHRL-------------DLDAKGEPASL 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5258 QLpSLEGDLRGPDVK-------LEGPDVSLKGPGvdlpSVNLSMPKVSGPDLDLNLKGP-SLKGDLDASVpSMKVHAPGL 5329
Cdd:COG2911    169 SL-ALSGGLDRDDGGtlsrldfLNTGRWGLAAPA----TLSYDDGRVTLGPLCLAGGGSlCLSGTLGGTL-DLQLRLKNL 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5330 NLSGVGgkmQVGGDGVKVPG-IDATTKL--NVGAPDVTLRgPSLQGDLAVSGDIKCPKVSVGAPDLSLEASEGSIKLpkm 5406
Cdd:COG2911    243 PLALLN---PFLPDDLGLSGtLNGDADLsgGLANPQGDAS-LSLSGDLTLNDGLGGLPLGLGDLTLNARLANGRLTL--- 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5407 klpQFGISTPGSD-LHVNAKGPQVSGELKGPGVDVNLKGPRISA-------PNVDFNLEGpKVKGSLGATGEIKGPTVGG 5478
Cdd:COG2911    316 ---DLTLDGGGLGtLSLSGSVPLADGLPPSAPLDGNLRLDNLDLallnpllPGVLERLSG-QLNGDLRLSGTLAAPQLNG 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5479 GL---------PGIGVQGLEGNLQmpgIKSSGCDVNLPGVNVKLPTGQISgpeikggLKGSeVGFHGAAP--DISVKGPA 5547
Cdd:COG2911    392 QLtlddgrlklPALGVRLTDINLR---LRFDGDRLTLDGLTADSGGGTLT-------LSGT-VDLDGLSWpaDLTLKGDN 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5548 FN---------MASPESDFGINLKGPKIKGGADVSGG-VSAPDISLGEGHLS----VKGSGGEWKGPQVSSALNLDTS-- 5611
Cdd:COG2911    461 LRvlnppdytaTVSGDLTLTGTPDGPTLSGNVTVPRArITLPELPPSAVSLSddvvVVNRPPEPVPEEEAAGLPLDLDln 540
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1079280806 5612 -KFAGGLHFSGPKVEGGVkGGQIGLQAPGLSVSGPQGHLESGSGKVTF 5658
Cdd:COG2911    541 vNLGDDVRVRGFGLDARL-GGDLRLTGTPGGAPRLTGEINLVRGRYNA 587
AsmA COG2982
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3050-3469 3.32e-07

Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442221 [Multi-domain]  Cd Length: 491  Bit Score: 56.97  E-value: 3.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3050 DLDVS-GPKVDIDVPDVNIEGPEGKLKGPKFKMPEMnikapkismpDIDLNLkgpkvkgdmdvsLPKVEGDMKVPDVDIK 3128
Cdd:COG2982     55 DLSLSlFPWPGVTLGDVTLSNPDGFGGPPLASAERL----------ELDLAL------------LPLLSGELEVDEITLD 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3129 GPKVDInapDVDVQG-PDWHLKMPKIKMPKismpgfKGEGPEVDVNLPKADLD---------VSGPKVDVDVPDVNIEGP 3198
Cdd:COG2982    113 GPVINL---ERDADGrANWDFLLAAAAAAA------DAEASAWSLDIGRLEITdgrlvyddaASGADLTLDDLNLTLSGP 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3199 D----------AKLKGPKFKMpEMNIKAPKISMP-DLDLNLKGPKMKGEVD--VSLANVEGDLKGPALDIK--GPKIDVD 3263
Cdd:COG2982    184 SldgpfrlsgsGRLNGQPLTL-DGKIGGLLALGPyPLKLDLRSGDLRLSLDgtVDLAGLDGQLALSGPSLRdlLALLGVT 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3264 APDidihGPDAKLKGpklkmpDMHVNMPKISMPEIDLNLKGSKLKGDVDVSG---PKLEGDIKAPSLDIK--GPEVDVSG 3338
Cdd:COG2982    263 LPE----PGPFSLSG------RLTADGDRLRLEDLKGTLGDSDLTGDLSVTGgdrPALTGDLASDRLDLDdlLPAAPAAA 332
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3339 PKLNIEGKSKKSRFKLP---------KFNFSGSKVQTPEVDVKGKKPDIDITGPKVDINAPDVEV-QGKVKGSkfkmpfL 3408
Cdd:COG2982    333 AAGAPAAARGLPDAPLDlsalraldaDVRLSADSLKLGGLPLGDLAAHLTLDDGRLDLDPLSAGLyGGTLSGS------L 406
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1079280806 3409 SISSPKvSMPDVELNLKSPKVK-GDL--DIAGP-------NLEGDFKGPKVDIKAP------EVNLNAPDVDVHGPD 3469
Cdd:COG2982    407 TLDARG-DPPRVALKLSLSGVDlGPLlpDLAGFdrlsgtlNGDLDLSGTGNSVAALlaslngSASLSLGDGAISGLN 482
TamB COG2911
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3223-3722 6.72e-06

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 53.12  E-value: 6.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3223 DLDLNLKGPKMKGEVDVS----------LANVEgDLKGPALDIKGP-KIDVDAPDIDI------HGPDAKLKGPKLKMPD 3285
Cdd:COG2911    156 RLDLDAKGEPASLSLALSggldrddggtLSRLD-FLNTGRWGLAAPaTLSYDDGRVTLgplclaGGGSLCLSGTLGGTLD 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3286 MHVNMPKISMPEI------DLNLKGsKLKGDVDVSG----PKLEGDIKAP---SLDIKGPEVDVSGPKLNIEGKSKKSRF 3352
Cdd:COG2911    235 LQLRLKNLPLALLnpflpdDLGLSG-TLNGDADLSGglanPQGDASLSLSgdlTLNDGLGGLPLGLGDLTLNARLANGRL 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3353 KLpkfnfsgskvqtpEVDVKGKKPD-IDITG--PKVDINAPDVEVQGKVKGSKFKMPFLSisspkVSMPDVELNLKSpKV 3429
Cdd:COG2911    314 TL-------------DLTLDGGGLGtLSLSGsvPLADGLPPSAPLDGNLRLDNLDLALLN-----PLLPGVLERLSG-QL 374
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3430 KGDLDIAG----PNLEGDFKGPKVDIKAPEVNLNAPDVDVhgpdwNLKMPKMKmpkFSVSGLKAEGPDVAVDLpKGDINI 3505
Cdd:COG2911    375 NGDLRLSGtlaaPQLNGQLTLDDGRLKLPALGVRLTDINL-----RLRFDGDR---LTLDGLTADSGGGTLTL-SGTVDL 445
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3506 EGPSMNIegpDLNVegpegglKGPKFK---MPDMNIKA-PKIsmpDIDLNLKGPKVKGDVDIslpklegdlkgPEVDIKG 3581
Cdd:COG2911    446 DGLSWPA---DLTL-------KGDNLRvlnPPDYTATVsGDL---TLTGTPDGPTLSGNVTV-----------PRARITL 501
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3582 PKVDINAPDVDvhgpdwhlkmPKVKMpkfsmpgfKGEGPEVDVTLPKADIDISGpNVDVDVP-DVNIEGP--DAKLKGpk 3658
Cdd:COG2911    502 PELPPSAVSLS----------DDVVV--------VNRPPEPVPEEEAAGLPLDL-DLNVNLGdDVRVRGFglDARLGG-- 560
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1079280806 3659 fkmpemnikapkismpdfDLNLKG-----PKMKGDVVVslpkVEGDLK--GPEVDIK-------GPKVDidtPDINIE 3722
Cdd:COG2911    561 ------------------DLRLTGtpggaPRLTGEINL----VRGRYNayGQRLTIErgsitfnGPPLD---PYLDIE 613
TamB COG2911
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
192-681 7.07e-06

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 52.73  E-value: 7.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  192 ISNVDVetQSGKTVIRLpSGSGAASPTGSAVDIRA---GAISASGPELQGaghsklQVTMPGIkvggSGVNVNAKGLDLG 268
Cdd:COG2911     88 LDDLDL--RSGGNRLTL-SGNLSAASLDGDLDLDApdlADLAALLPGLAG------SLSGDGL----DSLSLDADGTLAQ 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  269 GR--GGVQVPAVDISSSLGGRAVEVQGPSLESGDHgkikfptmkvpkfgVSTGREGQTPKAGLRVSAPEVSVGH----KG 342
Cdd:COG2911    155 HRldLDAKGEPASLSLALSGGLDRDDGGTLSRLDF--------------LNTGRWGLAAPATLSYDDGRVTLGPlclaGG 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  343 GKPGLTIQAP---QLEVSVPSANIEGLEGKL-KGPQITGpSLEGDLGLKGakpqghigvDASAPQIGGSITGP-SVEVQA 417
Cdd:COG2911    221 GSLCLSGTLGgtlDLQLRLKNLPLALLNPFLpDDLGLSG-TLNGDADLSG---------GLANPQGDASLSLSgDLTLND 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  418 PDIDVQGPGSKLNVpkmkvpKFSVSGAKGEetgIDVTLPTGEVTVPGVSGDVSLPEIATGglEGKMKGTkvktpemiiqk 497
Cdd:COG2911    291 GLGGLPLGLGDLTL------NARLANGRLT---LDLTLDGGGLGTLSLSGSVPLADGLPP--SAPLDGN----------- 348
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  498 pkISMQDVDLSLGSP-----------KLKGDIKVS----APGVQGDVKGPQVALKGSR--VDIETPNLEGTLTGPR--LG 558
Cdd:COG2911    349 --LRLDNLDLALLNPllpgvlerlsgQLNGDLRLSgtlaAPQLNGQLTLDDGRLKLPAlgVRLTDINLRLRFDGDRltLD 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  559 SPSGKTGTCRISMS----------EVDLNVAA--------PKVKGGVDVTL--------PRVEGKVKVPEVDVRGPKVDV 612
Cdd:COG2911    427 GLTADSGGGTLTLSgtvdldglswPADLTLKGdnlrvlnpPDYTATVSGDLtltgtpdgPTLSGNVTVPRARITLPELPP 506
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1079280806  613 SAPDVEAhgpewNLKMPKMKMPTFSTPGAKGEGPDVHMTLpkgdisISGPKVNVEAPDVNLEgLGGKLK 681
Cdd:COG2911    507 SAVSLSD-----DVVVVNRPPEPVPEEEAAGLPLDLDLNV------NLGDDVRVRGFGLDAR-LGGDLR 563
AsmA pfam05170
AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane ...
3239-3579 2.12e-04

AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.


Pssm-ID: 428346 [Multi-domain]  Cd Length: 607  Bit Score: 47.86  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3239 VSLANVEgdLKGPAlDIKGPKIDVDAPDIDIHgPDAKLKGpKLKMPDMhvnmpKISMPEIDLNLKGSKlKGDVDVSGPKL 3318
Cdd:pfam05170   66 LSLSDIT--LASPQ-GDATPLVSLEQVKISLS-PLPLLRK-QIEIDSI-----RLDGAELALERLKQG-NWNWQELIQNQ 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3319 EGDIKAPSLDIKGPEVDVSGPKLNIEG-KSKKSRFKLpkfNFSGSKVQTPEVDVKGKKPDIdiTGPKVdinaPDVEVQGK 3397
Cdd:pfam05170  135 QNQASNAPTQQPQPTWPVAAWSLPIGRiQVSNGQVTI---DDKASQKILKDINLELQVSTL--YGPSF----NWSKITIS 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3398 VKGSKFKMPFLS-----ISSPKVSMPDVELNLKSPKVKGDLDIAGP-NLEGDFKGPKVDIKAPEV-----NLNAPDVDVH 3466
Cdd:pfam05170  206 GKGDQDPQSFGSqvnvtILSGEISGEALRGSTSTGGMLLLQTLSSPiYHINSLKLLNAQLELDGTlwdnlNLSIEDLDLK 285
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3467 GPDWNLKMPKMKMPKFSVSGLKAEGPDVAVDLPKGDINIE--GPSMNIEGPDLNVEGPeggLKGPKFKMPDMNIKAPKIS 3544
Cdd:pfam05170  286 ASGWKSITVNLALTADELDSLANQAELPGANLPDTPQNITlgELSLSFKTGRVQVSGS---LNSLTLNLDYLSFDGKKWV 362
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1079280806 3545 -MPDIDLNLKGPKVKgdvdiSLPKLEGDLKGPEVDI 3579
Cdd:pfam05170  363 gSSDIDLSNRLPQPQ-----PRPKLRGKLSSPELDL 393
PDZ2-PDZRN4-like cd06716
PDZ domain 2 of PDZ domain-containing RING finger protein 4 (PDZRN4), PDZRN3-B, and related ...
22-56 3.14e-04

PDZ domain 2 of PDZ domain-containing RING finger protein 4 (PDZRN4), PDZRN3-B, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 1 of PDZRN4, PDZRN3-B, and related domains. PDZRN4 (also known as ligand of numb protein X 4, and SEMACAP3-like protein) contains an N-terminal RING domain and two tandem repeat PDZ domains. It is involved in the progression of cancer, including human liver cancer and breast cancer, and may contribute to the tumorigenesis of rectal adenocarcinoma. Danio rerio PDZRN3-B may participate in neurogenesis: the first PDZ domain of Danio rerio Pdzrn3 interacts with Kidins220 (Kinase D-interacting substrate 220 kD, also named Ankyrin Repeat-Rich Membrane Spanning), a crucial mediator of signal transduction in neural tissues. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PDZRN4-like family PDZ2 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467200 [Multi-domain]  Cd Length: 88  Bit Score: 42.65  E-value: 3.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1079280806   22 GLTIAQRDD-----GVFVQEVTQNSPAARTGVVKEGDQIV 56
Cdd:cd06716     18 GLTLCYRTDdeedtGIYVSEVDPNSIAAKDGRIREGDQIL 57
AsmA COG2982
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
4532-4945 3.25e-04

Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442221 [Multi-domain]  Cd Length: 491  Bit Score: 46.96  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4532 KIKGDMDISVpklegdlkgpkvdvkGPKVGIDTPDIDIHGPEGKLKGPKFKMPDLHLkapkismpEVDLN--LKGpkvkg 4609
Cdd:COG2982     51 TIDGDLSLSL---------------FPWPGVTLGDVTLSNPDGFGGPPLASAERLEL--------DLALLplLSG----- 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4610 dmDISLPKVEgdLKGPEVDI-RDPkvdidvpdvdvQG-PDWHLKMPKvkmpkfsmpgfkgegpdvdvnlPKADIDVSGPK 4687
Cdd:COG2982    103 --ELEVDEIT--LDGPVINLeRDA-----------DGrANWDFLLAA----------------------AAAAADAEASA 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4688 VDVDVPDVNIEGPDAKLKGPKFKMpemsikapKISMPDIDLNLKGPKVKGDVDVTLpkvEGDLKGPEADIKGpKVDINTP 4767
Cdd:COG2982    146 WSLDIGRLEITDGRLVYDDAASGA--------DLTLDDLNLTLSGPSLDGPFRLSG---SGRLNGQPLTLDG-KIGGLLA 213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4768 ------DVDVHGPDWHLKMpkvkMPKFSMPGFKGegpdvDVSLPKADIDVSGPKVDVDIPdvniEGPDAKLKGPkfkmpe 4841
Cdd:COG2982    214 lgpyplKLDLRSGDLRLSL----DGTVDLAGLDG-----QLALSGPSLRDLLALLGVTLP----EPGPFSLSGR------ 274
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4842 INIKAPKISIPDVDLDLKGPKVKGDFDVS---VPKVEGTLKGPEVDLkgPRL---DFEGPDAKLSGPSLKMPSLEISAPK 4915
Cdd:COG2982    275 LTADGDRLRLEDLKGTLGDSDLTGDLSVTggdRPALTGDLASDRLDL--DDLlpaAPAAAAAGAPAAARGLPDAPLDLSA 352
                          410       420       430
                   ....*....|....*....|....*....|
gi 1079280806 4916 VTAPDVDLHLKAPKIGFSGPKLEGGEVDLK 4945
Cdd:COG2982    353 LRALDADVRLSADSLKLGGLPLGDLAAHLT 382
AsmA pfam05170
AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane ...
3431-3911 5.71e-04

AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.


Pssm-ID: 428346 [Multi-domain]  Cd Length: 607  Bit Score: 46.32  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3431 GDLDIAGPNlegDFKGPKVDIKAPEVNLNapdvdvhgPDwNLKMPKMKMPKfsvsgLKAEGPDVAVDLPK-GDINIE--G 3507
Cdd:pfam05170   69 SDITLASPQ---GDATPLVSLEQVKISLS--------PL-PLLRKQIEIDS-----IRLDGAELALERLKqGNWNWQelI 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3508 PSMNIEGPDLNVEGPEGGLKGPKFKMPDMNIKAPKISMPDIDLNLKgpKVKGDVDISLpkLEGDLKGPEVDIKGPKVDIN 3587
Cdd:pfam05170  132 QNQQNQASNAPTQQPQPTWPVAAWSLPIGRIQVSNGQVTIDDKASQ--KILKDINLEL--QVSTLYGPSFNWSKITISGK 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3588 ApDVDVHGPDWHLKMPKVKmPKFSMPGFKGEGPevdVTLPKADIDISGPNVDVDvpdvniegpDAKLKGPKFKMPEMNIK 3667
Cdd:pfam05170  208 G-DQDPQSFGSQVNVTILS-GEISGEALRGSTS---TGGMLLLQTLSSPIYHIN---------SLKLLNAQLELDGTLWD 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3668 APKISMPDFDLNLKGPKMKGDVV----VSLPKVEGDLKGPEVDIkgpkvdIDTPD-INIEGSEGKFKGPKFKIpEMHLKA 3742
Cdd:pfam05170  274 NLNLSIEDLDLKASGWKSITVNLaltaDELDSLANQAELPGANL------PDTPQnITLGELSLSFKTGRVQV-SGSLNS 346
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3743 PKISMPDIDLNLKGPKVKGDVDVSL--------PKMEGDLKGPEVDI------------KGPKVDINAPDVDVQGPDwhl 3802
Cdd:pfam05170  347 LTLNLDYLSFDGKKWVGSSDIDLSNrlpqpqprPKLRGKLSSPELDLdnllpiktavaaKSRAPEWDASGLSADGAN--- 423
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3803 kMPKVKMPKFSmpGFK-GEGPDVDVNLPKadldVSGPKVDIDVPDVNIEGPEGKLKGPKFKMP--------EMNIKAPKI 3873
Cdd:pfam05170  424 -LPLPVEPFLW--GVWqGMDADVSANIDK----VTYSGLPISDLKTKLRSEGGVLQLSRLKGGlyggyleaGAQLDLSKK 496
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 1079280806 3874 SMP-DIDLNLKGPKVKGDM-DVSLPK-VEGDMQVpDLDIKG 3911
Cdd:pfam05170  497 PATyRLKINAKNIPLKPLLpDLFKMFsTDGLLDI-DADLQG 536
AsmA pfam05170
AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane ...
4326-4631 1.17e-03

AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.


Pssm-ID: 428346 [Multi-domain]  Cd Length: 607  Bit Score: 45.55  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4326 MPGFKGEGPDVDVTL---PKADIEISGPKVDIDAPDVSIEGPDAKLKGPKFKMPEMNIKAPKISMPDIDFNLKGPKVKGD 4402
Cdd:pfam05170  105 IDSIRLDGAELALERlkqGNWNWQELIQNQQNQASNAPTQQPQPTWPVAAWSLPIGRIQVSNGQVTIDDKASQKILKDIN 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4403 VDVSLPkvegdlkgpeiDIKGPSLdidtPDVNIEGpEGKLKGPKFKMP---EMNIKAPKISMPDFDLHLKGPKVKGDVDV 4479
Cdd:pfam05170  185 LELQVS-----------TLYGPSF----NWSKITI-SGKGDQDPQSFGsqvNVTILSGEISGEALRGSTSTGGMLLLQTL 248
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4480 SLPKVESDlkgpevdiegpEGKLKGPKFKMPDVHFKSPQISMSDIDLNLKGPKIKGD----MDISVPKLEGDLKGPKVDV 4555
Cdd:pfam05170  249 SSPIYHIN-----------SLKLLNAQLELDGTLWDNLNLSIEDLDLKASGWKSITVnlalTADELDSLANQAELPGANL 317
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4556 kgpkvgIDTPD-IDIHGPEGKLKGPKFKMpDLHLKAPKISMPevDLNLKGPKVKGDMDISL----------PKVEGDLKG 4624
Cdd:pfam05170  318 ------PDTPQnITLGELSLSFKTGRVQV-SGSLNSLTLNLD--YLSFDGKKWVGSSDIDLsnrlpqpqprPKLRGKLSS 388

                   ....*..
gi 1079280806 4625 PEVDIRD 4631
Cdd:pfam05170  389 PELDLDN 395
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
4879-5014 1.28e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4879 KGPEVDLKGPRLD---FEGPDAKLSGPSLKMPSLEISAPKVTAPDV---DLHLKAPKIGFSG---------PKLEGGEVd 4943
Cdd:pfam05109  423 KAPESTTTSPTLNttgFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstaDVTSPTPAGTTSGaspvtpspsPRDNGTES- 501
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1079280806 4944 lKGPKVEAPSLDVHMDSPDINIEGPDVKIPKFKKPKFGFGAKSPKADIKSPSLDVTVPEAELNLETPEISV 5014
Cdd:pfam05109  502 -KAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI 571
 
Name Accession Description Interval E-value
TamB COG2911
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
5109-5658 5.08e-09

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 63.14  E-value: 5.08e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5109 PSPKLEGELQAPDLELSL----PAIHVEGLDIKAKAPKV----KMPDVDISVPKIEGDLKG-PKVQANLGAPDINIEG-L 5178
Cdd:COG2911     27 PLALLRGRLCIDELALSAsldgDRLRLDNLDLDAPEGALsgllDLVQATLDAEGLDLASSAlDDLDLRSGGNRLTLSGnL 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5179 DAKVKTPSFGISAPQVS-IPDVNVNLKGpKIKGDvpsvGLEGPDVDLQGPEAKIKFpkfsmpkigipgvKMEGGGAEVHA 5257
Cdd:COG2911    107 SAASLDGDLDLDAPDLAdLAALLPGLAG-SLSGD----GLDSLSLDADGTLAQHRL-------------DLDAKGEPASL 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5258 QLpSLEGDLRGPDVK-------LEGPDVSLKGPGvdlpSVNLSMPKVSGPDLDLNLKGP-SLKGDLDASVpSMKVHAPGL 5329
Cdd:COG2911    169 SL-ALSGGLDRDDGGtlsrldfLNTGRWGLAAPA----TLSYDDGRVTLGPLCLAGGGSlCLSGTLGGTL-DLQLRLKNL 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5330 NLSGVGgkmQVGGDGVKVPG-IDATTKL--NVGAPDVTLRgPSLQGDLAVSGDIKCPKVSVGAPDLSLEASEGSIKLpkm 5406
Cdd:COG2911    243 PLALLN---PFLPDDLGLSGtLNGDADLsgGLANPQGDAS-LSLSGDLTLNDGLGGLPLGLGDLTLNARLANGRLTL--- 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5407 klpQFGISTPGSD-LHVNAKGPQVSGELKGPGVDVNLKGPRISA-------PNVDFNLEGpKVKGSLGATGEIKGPTVGG 5478
Cdd:COG2911    316 ---DLTLDGGGLGtLSLSGSVPLADGLPPSAPLDGNLRLDNLDLallnpllPGVLERLSG-QLNGDLRLSGTLAAPQLNG 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5479 GL---------PGIGVQGLEGNLQmpgIKSSGCDVNLPGVNVKLPTGQISgpeikggLKGSeVGFHGAAP--DISVKGPA 5547
Cdd:COG2911    392 QLtlddgrlklPALGVRLTDINLR---LRFDGDRLTLDGLTADSGGGTLT-------LSGT-VDLDGLSWpaDLTLKGDN 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5548 FN---------MASPESDFGINLKGPKIKGGADVSGG-VSAPDISLGEGHLS----VKGSGGEWKGPQVSSALNLDTS-- 5611
Cdd:COG2911    461 LRvlnppdytaTVSGDLTLTGTPDGPTLSGNVTVPRArITLPELPPSAVSLSddvvVVNRPPEPVPEEEAAGLPLDLDln 540
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1079280806 5612 -KFAGGLHFSGPKVEGGVkGGQIGLQAPGLSVSGPQGHLESGSGKVTF 5658
Cdd:COG2911    541 vNLGDDVRVRGFGLDARL-GGDLRLTGTPGGAPRLTGEINLVRGRYNA 587
TamB COG2911
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
5166-5658 8.73e-09

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 62.36  E-value: 8.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5166 ANLGAPDINIEG-LDAKVKtpsfgISApQVSIPDVNVNLKgpkIKGDVpSVGLEGPDVDLQGPEAKIKFpkfsmpkigip 5244
Cdd:COG2911    248 NPFLPDDLGLSGtLNGDAD-----LSG-GLANPQGDASLS---LSGDL-TLNDGLGGLPLGLGDLTLNA----------- 306
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5245 gvKMEGGGAEVHAQL-------PSLEGDLRGPDVKLEGP--DVSLKGPGVDLPSVNLSMP----KVSGP-DLDLNLKG-- 5308
Cdd:COG2911    307 --RLANGRLTLDLTLdggglgtLSLSGSVPLADGLPPSAplDGNLRLDNLDLALLNPLLPgvleRLSGQlNGDLRLSGtl 384
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5309 --PSLKGDLDASVPSMKVHAPGLNLSGVGGKMQVGGDGVKVPGIDATT---KLNVGApDVTLRGPSLQGDLAVSGD---- 5379
Cdd:COG2911    385 aaPQLNGQLTLDDGRLKLPALGVRLTDINLRLRFDGDRLTLDGLTADSgggTLTLSG-TVDLDGLSWPADLTLKGDnlrv 463
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5380 IKCPKVSVGA-PDLSLEAS------EGSIKLPK--MKLPQFGISTPGSD---LHVNAKGPQVSGELKGPG-VDVNLkgpR 5446
Cdd:COG2911    464 LNPPDYTATVsGDLTLTGTpdgptlSGNVTVPRarITLPELPPSAVSLSddvVVVNRPPEPVPEEEAAGLpLDLDL---N 540
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5447 ISAPNvDFNLEGPKVKGSLGATGEIKGpTVGGGLpgigvqGLEGNLQMPgiksSGcDVNLPGVNVKLPTGQI--SGPEIK 5524
Cdd:COG2911    541 VNLGD-DVRVRGFGLDARLGGDLRLTG-TPGGAP------RLTGEINLV----RG-RYNAYGQRLTIERGSItfNGPPLD 607
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5525 GGL--------KGSEVGfhgaapdISVKGPAFNM--------ASPESD------FGinlkgpkiKGGADVSGGVSApdiS 5582
Cdd:COG2911    608 PYLdieavrtvDDVTAG-------VRVTGTASNPkitlfsdpALPQDEilslllFG--------RGLDSLSGGDAA---Q 669
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1079280806 5583 LGEGHLSVKGSGGEWKGPQVSSALNLDTSKFAGGLHFSGPKVEGgvkGGQIGlqaPGLSVSGPQGhLESGSGKVTF 5658
Cdd:COG2911    670 LASAAASLLGGGGGGLLGQLGSALGLDDLSIDTGGSGDGTSVTV---GKYLT---DRLYVSYGVG-LFDGLSEVTL 738
TamB COG2911
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
5254-5673 3.27e-08

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 60.44  E-value: 3.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5254 EVHAQLPSLEGDLRGPDVKLEGPDVSLKGPGVDlpsvNLsmpKVSGPDLDLNLKG----PSLKGDLDASVPSMKVHAP-G 5328
Cdd:COG2911     57 DLDAPEGALSGLLDLVQATLDAEGLDLASSALD----DL---DLRSGGNRLTLSGnlsaASLDGDLDLDAPDLADLAAlL 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5329 LNLSGvggkmQVGGDGVKVPGIDATTKLNVGAPDVTLRGPSLQGDLAVSGdikcpkvsvgapDLSLEASEGSIKLPKMKL 5408
Cdd:COG2911    130 PGLAG-----SLSGDGLDSLSLDADGTLAQHRLDLDAKGEPASLSLALSG------------GLDRDDGGTLSRLDFLNT 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5409 PQFGISTPGSdLHVNAKGPQVSG-ELKGPG---VDVNLKGP---RISAPNVDFNL------EGPKVKGSLGATGEIKGPT 5475
Cdd:COG2911    193 GRWGLAAPAT-LSYDDGRVTLGPlCLAGGGslcLSGTLGGTldlQLRLKNLPLALlnpflpDDLGLSGTLNGDADLSGGL 271
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5476 vggGLPGIGVQ-GLEGNLQmpgikssgcdVNLPGVNVKLPTGQISgpeIKGGLKGSEVGFhgaapDISVKGPAFNMASPE 5554
Cdd:COG2911    272 ---ANPQGDASlSLSGDLT----------LNDGLGGLPLGLGDLT---LNARLANGRLTL-----DLTLDGGGLGTLSLS 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5555 SDFGINlkgPKIKGGADVSGGVSAPDISLG-------------EGHLSVKGS-GGEWKGPQVSSALNLDTSKFAG---GL 5617
Cdd:COG2911    331 GSVPLA---DGLPPSAPLDGNLRLDNLDLAllnpllpgvlerlSGQLNGDLRlSGTLAAPQLNGQLTLDDGRLKLpalGV 407
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1079280806 5618 HFSGPKVEGGVKGGQIGLQapGLSVSGPQGHLeSGSGKVTFPKMKIP-KFTFSGREL 5673
Cdd:COG2911    408 RLTDINLRLRFDGDRLTLD--GLTADSGGGTL-TLSGTVDLDGLSWPaDLTLKGDNL 461
AsmA COG2982
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3050-3469 3.32e-07

Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442221 [Multi-domain]  Cd Length: 491  Bit Score: 56.97  E-value: 3.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3050 DLDVS-GPKVDIDVPDVNIEGPEGKLKGPKFKMPEMnikapkismpDIDLNLkgpkvkgdmdvsLPKVEGDMKVPDVDIK 3128
Cdd:COG2982     55 DLSLSlFPWPGVTLGDVTLSNPDGFGGPPLASAERL----------ELDLAL------------LPLLSGELEVDEITLD 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3129 GPKVDInapDVDVQG-PDWHLKMPKIKMPKismpgfKGEGPEVDVNLPKADLD---------VSGPKVDVDVPDVNIEGP 3198
Cdd:COG2982    113 GPVINL---ERDADGrANWDFLLAAAAAAA------DAEASAWSLDIGRLEITdgrlvyddaASGADLTLDDLNLTLSGP 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3199 D----------AKLKGPKFKMpEMNIKAPKISMP-DLDLNLKGPKMKGEVD--VSLANVEGDLKGPALDIK--GPKIDVD 3263
Cdd:COG2982    184 SldgpfrlsgsGRLNGQPLTL-DGKIGGLLALGPyPLKLDLRSGDLRLSLDgtVDLAGLDGQLALSGPSLRdlLALLGVT 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3264 APDidihGPDAKLKGpklkmpDMHVNMPKISMPEIDLNLKGSKLKGDVDVSG---PKLEGDIKAPSLDIK--GPEVDVSG 3338
Cdd:COG2982    263 LPE----PGPFSLSG------RLTADGDRLRLEDLKGTLGDSDLTGDLSVTGgdrPALTGDLASDRLDLDdlLPAAPAAA 332
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3339 PKLNIEGKSKKSRFKLP---------KFNFSGSKVQTPEVDVKGKKPDIDITGPKVDINAPDVEV-QGKVKGSkfkmpfL 3408
Cdd:COG2982    333 AAGAPAAARGLPDAPLDlsalraldaDVRLSADSLKLGGLPLGDLAAHLTLDDGRLDLDPLSAGLyGGTLSGS------L 406
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1079280806 3409 SISSPKvSMPDVELNLKSPKVK-GDL--DIAGP-------NLEGDFKGPKVDIKAP------EVNLNAPDVDVHGPD 3469
Cdd:COG2982    407 TLDARG-DPPRVALKLSLSGVDlGPLlpDLAGFdrlsgtlNGDLDLSGTGNSVAALlaslngSASLSLGDGAISGLN 482
TamB COG2911
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3223-3722 6.72e-06

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 53.12  E-value: 6.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3223 DLDLNLKGPKMKGEVDVS----------LANVEgDLKGPALDIKGP-KIDVDAPDIDI------HGPDAKLKGPKLKMPD 3285
Cdd:COG2911    156 RLDLDAKGEPASLSLALSggldrddggtLSRLD-FLNTGRWGLAAPaTLSYDDGRVTLgplclaGGGSLCLSGTLGGTLD 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3286 MHVNMPKISMPEI------DLNLKGsKLKGDVDVSG----PKLEGDIKAP---SLDIKGPEVDVSGPKLNIEGKSKKSRF 3352
Cdd:COG2911    235 LQLRLKNLPLALLnpflpdDLGLSG-TLNGDADLSGglanPQGDASLSLSgdlTLNDGLGGLPLGLGDLTLNARLANGRL 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3353 KLpkfnfsgskvqtpEVDVKGKKPD-IDITG--PKVDINAPDVEVQGKVKGSKFKMPFLSisspkVSMPDVELNLKSpKV 3429
Cdd:COG2911    314 TL-------------DLTLDGGGLGtLSLSGsvPLADGLPPSAPLDGNLRLDNLDLALLN-----PLLPGVLERLSG-QL 374
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3430 KGDLDIAG----PNLEGDFKGPKVDIKAPEVNLNAPDVDVhgpdwNLKMPKMKmpkFSVSGLKAEGPDVAVDLpKGDINI 3505
Cdd:COG2911    375 NGDLRLSGtlaaPQLNGQLTLDDGRLKLPALGVRLTDINL-----RLRFDGDR---LTLDGLTADSGGGTLTL-SGTVDL 445
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3506 EGPSMNIegpDLNVegpegglKGPKFK---MPDMNIKA-PKIsmpDIDLNLKGPKVKGDVDIslpklegdlkgPEVDIKG 3581
Cdd:COG2911    446 DGLSWPA---DLTL-------KGDNLRvlnPPDYTATVsGDL---TLTGTPDGPTLSGNVTV-----------PRARITL 501
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3582 PKVDINAPDVDvhgpdwhlkmPKVKMpkfsmpgfKGEGPEVDVTLPKADIDISGpNVDVDVP-DVNIEGP--DAKLKGpk 3658
Cdd:COG2911    502 PELPPSAVSLS----------DDVVV--------VNRPPEPVPEEEAAGLPLDL-DLNVNLGdDVRVRGFglDARLGG-- 560
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1079280806 3659 fkmpemnikapkismpdfDLNLKG-----PKMKGDVVVslpkVEGDLK--GPEVDIK-------GPKVDidtPDINIE 3722
Cdd:COG2911    561 ------------------DLRLTGtpggaPRLTGEINL----VRGRYNayGQRLTIErgsitfnGPPLD---PYLDIE 613
TamB COG2911
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
192-681 7.07e-06

Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442155 [Multi-domain]  Cd Length: 766  Bit Score: 52.73  E-value: 7.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  192 ISNVDVetQSGKTVIRLpSGSGAASPTGSAVDIRA---GAISASGPELQGaghsklQVTMPGIkvggSGVNVNAKGLDLG 268
Cdd:COG2911     88 LDDLDL--RSGGNRLTL-SGNLSAASLDGDLDLDApdlADLAALLPGLAG------SLSGDGL----DSLSLDADGTLAQ 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  269 GR--GGVQVPAVDISSSLGGRAVEVQGPSLESGDHgkikfptmkvpkfgVSTGREGQTPKAGLRVSAPEVSVGH----KG 342
Cdd:COG2911    155 HRldLDAKGEPASLSLALSGGLDRDDGGTLSRLDF--------------LNTGRWGLAAPATLSYDDGRVTLGPlclaGG 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  343 GKPGLTIQAP---QLEVSVPSANIEGLEGKL-KGPQITGpSLEGDLGLKGakpqghigvDASAPQIGGSITGP-SVEVQA 417
Cdd:COG2911    221 GSLCLSGTLGgtlDLQLRLKNLPLALLNPFLpDDLGLSG-TLNGDADLSG---------GLANPQGDASLSLSgDLTLND 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  418 PDIDVQGPGSKLNVpkmkvpKFSVSGAKGEetgIDVTLPTGEVTVPGVSGDVSLPEIATGglEGKMKGTkvktpemiiqk 497
Cdd:COG2911    291 GLGGLPLGLGDLTL------NARLANGRLT---LDLTLDGGGLGTLSLSGSVPLADGLPP--SAPLDGN----------- 348
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  498 pkISMQDVDLSLGSP-----------KLKGDIKVS----APGVQGDVKGPQVALKGSR--VDIETPNLEGTLTGPR--LG 558
Cdd:COG2911    349 --LRLDNLDLALLNPllpgvlerlsgQLNGDLRLSgtlaAPQLNGQLTLDDGRLKLPAlgVRLTDINLRLRFDGDRltLD 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806  559 SPSGKTGTCRISMS----------EVDLNVAA--------PKVKGGVDVTL--------PRVEGKVKVPEVDVRGPKVDV 612
Cdd:COG2911    427 GLTADSGGGTLTLSgtvdldglswPADLTLKGdnlrvlnpPDYTATVSGDLtltgtpdgPTLSGNVTVPRARITLPELPP 506
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1079280806  613 SAPDVEAhgpewNLKMPKMKMPTFSTPGAKGEGPDVHMTLpkgdisISGPKVNVEAPDVNLEgLGGKLK 681
Cdd:COG2911    507 SAVSLSD-----DVVVVNRPPEPVPEEEAAGLPLDLDLNV------NLGDDVRVRGFGLDAR-LGGDLR 563
AsmA COG2982
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
5158-5530 1.76e-05

Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442221 [Multi-domain]  Cd Length: 491  Bit Score: 51.19  E-value: 1.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5158 DLKGP---KVQANLGAPdINIEG-LDAKVkTPSFGISAPQVSI--PD--------------VNVNLkGPKIKGD--VPSV 5215
Cdd:COG2982     33 RLRPLierQVSEATGRE-VTIDGdLSLSL-FPWPGVTLGDVTLsnPDgfggpplasaerleLDLAL-LPLLSGEleVDEI 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5216 GLEGPDVDLQ-------------GPEAKIKFPKFSMPKIGIPGVKMEGG-------GAEVHAQLPSLEGDLRGPD----- 5270
Cdd:COG2982    110 TLDGPVINLErdadgranwdfllAAAAAAADAEASAWSLDIGRLEITDGrlvyddaASGADLTLDDLNLTLSGPSldgpf 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5271 -----VKLEGPDVSLKGP-GVDLPSVNLSM-PKVSGPDLDLNLKG----PSLKGDLDASVPSMK-------VHAPGLNLS 5332
Cdd:COG2982    190 rlsgsGRLNGQPLTLDGKiGGLLALGPYPLkLDLRSGDLRLSLDGtvdlAGLDGQLALSGPSLRdllallgVTLPEPGPF 269
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5333 GVGGKMQVGGDGVKVPGIdattKLNVGapDVTLRG---------PSLQGDLAvSGDIKCPK-VSVGAPDLSLEASEGSIK 5402
Cdd:COG2982    270 SLSGRLTADGDRLRLEDL----KGTLG--DSDLTGdlsvtggdrPALTGDLA-SDRLDLDDlLPAAPAAAAAGAPAAARG 342
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 5403 LPKMKLPQFGISTPGSDLHVNAKGPQVSG-ELKGPGVDVNLKGPRISAPNVDFNLEGPKVKGSLGATGEIKGPTVG--GG 5479
Cdd:COG2982    343 LPDAPLDLSALRALDADVRLSADSLKLGGlPLGDLAAHLTLDDGRLDLDPLSAGLYGGTLSGSLTLDARGDPPRVAlkLS 422
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1079280806 5480 LPGIGVQGLEGNLQMPgIKSSGcDVNLpgvNVKLPTGQISGPEIKGGLKGS 5530
Cdd:COG2982    423 LSGVDLGPLLPDLAGF-DRLSG-TLNG---DLDLSGTGNSVAALLASLNGS 468
AsmA pfam05170
AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane ...
3239-3579 2.12e-04

AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.


Pssm-ID: 428346 [Multi-domain]  Cd Length: 607  Bit Score: 47.86  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3239 VSLANVEgdLKGPAlDIKGPKIDVDAPDIDIHgPDAKLKGpKLKMPDMhvnmpKISMPEIDLNLKGSKlKGDVDVSGPKL 3318
Cdd:pfam05170   66 LSLSDIT--LASPQ-GDATPLVSLEQVKISLS-PLPLLRK-QIEIDSI-----RLDGAELALERLKQG-NWNWQELIQNQ 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3319 EGDIKAPSLDIKGPEVDVSGPKLNIEG-KSKKSRFKLpkfNFSGSKVQTPEVDVKGKKPDIdiTGPKVdinaPDVEVQGK 3397
Cdd:pfam05170  135 QNQASNAPTQQPQPTWPVAAWSLPIGRiQVSNGQVTI---DDKASQKILKDINLELQVSTL--YGPSF----NWSKITIS 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3398 VKGSKFKMPFLS-----ISSPKVSMPDVELNLKSPKVKGDLDIAGP-NLEGDFKGPKVDIKAPEV-----NLNAPDVDVH 3466
Cdd:pfam05170  206 GKGDQDPQSFGSqvnvtILSGEISGEALRGSTSTGGMLLLQTLSSPiYHINSLKLLNAQLELDGTlwdnlNLSIEDLDLK 285
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3467 GPDWNLKMPKMKMPKFSVSGLKAEGPDVAVDLPKGDINIE--GPSMNIEGPDLNVEGPeggLKGPKFKMPDMNIKAPKIS 3544
Cdd:pfam05170  286 ASGWKSITVNLALTADELDSLANQAELPGANLPDTPQNITlgELSLSFKTGRVQVSGS---LNSLTLNLDYLSFDGKKWV 362
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1079280806 3545 -MPDIDLNLKGPKVKgdvdiSLPKLEGDLKGPEVDI 3579
Cdd:pfam05170  363 gSSDIDLSNRLPQPQ-----PRPKLRGKLSSPELDL 393
PDZ2-PDZRN4-like cd06716
PDZ domain 2 of PDZ domain-containing RING finger protein 4 (PDZRN4), PDZRN3-B, and related ...
22-56 3.14e-04

PDZ domain 2 of PDZ domain-containing RING finger protein 4 (PDZRN4), PDZRN3-B, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 1 of PDZRN4, PDZRN3-B, and related domains. PDZRN4 (also known as ligand of numb protein X 4, and SEMACAP3-like protein) contains an N-terminal RING domain and two tandem repeat PDZ domains. It is involved in the progression of cancer, including human liver cancer and breast cancer, and may contribute to the tumorigenesis of rectal adenocarcinoma. Danio rerio PDZRN3-B may participate in neurogenesis: the first PDZ domain of Danio rerio Pdzrn3 interacts with Kidins220 (Kinase D-interacting substrate 220 kD, also named Ankyrin Repeat-Rich Membrane Spanning), a crucial mediator of signal transduction in neural tissues. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PDZRN4-like family PDZ2 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467200 [Multi-domain]  Cd Length: 88  Bit Score: 42.65  E-value: 3.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1079280806   22 GLTIAQRDD-----GVFVQEVTQNSPAARTGVVKEGDQIV 56
Cdd:cd06716     18 GLTLCYRTDdeedtGIYVSEVDPNSIAAKDGRIREGDQIL 57
AsmA COG2982
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
4532-4945 3.25e-04

Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442221 [Multi-domain]  Cd Length: 491  Bit Score: 46.96  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4532 KIKGDMDISVpklegdlkgpkvdvkGPKVGIDTPDIDIHGPEGKLKGPKFKMPDLHLkapkismpEVDLN--LKGpkvkg 4609
Cdd:COG2982     51 TIDGDLSLSL---------------FPWPGVTLGDVTLSNPDGFGGPPLASAERLEL--------DLALLplLSG----- 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4610 dmDISLPKVEgdLKGPEVDI-RDPkvdidvpdvdvQG-PDWHLKMPKvkmpkfsmpgfkgegpdvdvnlPKADIDVSGPK 4687
Cdd:COG2982    103 --ELEVDEIT--LDGPVINLeRDA-----------DGrANWDFLLAA----------------------AAAAADAEASA 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4688 VDVDVPDVNIEGPDAKLKGPKFKMpemsikapKISMPDIDLNLKGPKVKGDVDVTLpkvEGDLKGPEADIKGpKVDINTP 4767
Cdd:COG2982    146 WSLDIGRLEITDGRLVYDDAASGA--------DLTLDDLNLTLSGPSLDGPFRLSG---SGRLNGQPLTLDG-KIGGLLA 213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4768 ------DVDVHGPDWHLKMpkvkMPKFSMPGFKGegpdvDVSLPKADIDVSGPKVDVDIPdvniEGPDAKLKGPkfkmpe 4841
Cdd:COG2982    214 lgpyplKLDLRSGDLRLSL----DGTVDLAGLDG-----QLALSGPSLRDLLALLGVTLP----EPGPFSLSGR------ 274
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4842 INIKAPKISIPDVDLDLKGPKVKGDFDVS---VPKVEGTLKGPEVDLkgPRL---DFEGPDAKLSGPSLKMPSLEISAPK 4915
Cdd:COG2982    275 LTADGDRLRLEDLKGTLGDSDLTGDLSVTggdRPALTGDLASDRLDL--DDLlpaAPAAAAAGAPAAARGLPDAPLDLSA 352
                          410       420       430
                   ....*....|....*....|....*....|
gi 1079280806 4916 VTAPDVDLHLKAPKIGFSGPKLEGGEVDLK 4945
Cdd:COG2982    353 LRALDADVRLSADSLKLGGLPLGDLAAHLT 382
AsmA pfam05170
AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane ...
3431-3911 5.71e-04

AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.


Pssm-ID: 428346 [Multi-domain]  Cd Length: 607  Bit Score: 46.32  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3431 GDLDIAGPNlegDFKGPKVDIKAPEVNLNapdvdvhgPDwNLKMPKMKMPKfsvsgLKAEGPDVAVDLPK-GDINIE--G 3507
Cdd:pfam05170   69 SDITLASPQ---GDATPLVSLEQVKISLS--------PL-PLLRKQIEIDS-----IRLDGAELALERLKqGNWNWQelI 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3508 PSMNIEGPDLNVEGPEGGLKGPKFKMPDMNIKAPKISMPDIDLNLKgpKVKGDVDISLpkLEGDLKGPEVDIKGPKVDIN 3587
Cdd:pfam05170  132 QNQQNQASNAPTQQPQPTWPVAAWSLPIGRIQVSNGQVTIDDKASQ--KILKDINLEL--QVSTLYGPSFNWSKITISGK 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3588 ApDVDVHGPDWHLKMPKVKmPKFSMPGFKGEGPevdVTLPKADIDISGPNVDVDvpdvniegpDAKLKGPKFKMPEMNIK 3667
Cdd:pfam05170  208 G-DQDPQSFGSQVNVTILS-GEISGEALRGSTS---TGGMLLLQTLSSPIYHIN---------SLKLLNAQLELDGTLWD 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3668 APKISMPDFDLNLKGPKMKGDVV----VSLPKVEGDLKGPEVDIkgpkvdIDTPD-INIEGSEGKFKGPKFKIpEMHLKA 3742
Cdd:pfam05170  274 NLNLSIEDLDLKASGWKSITVNLaltaDELDSLANQAELPGANL------PDTPQnITLGELSLSFKTGRVQV-SGSLNS 346
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3743 PKISMPDIDLNLKGPKVKGDVDVSL--------PKMEGDLKGPEVDI------------KGPKVDINAPDVDVQGPDwhl 3802
Cdd:pfam05170  347 LTLNLDYLSFDGKKWVGSSDIDLSNrlpqpqprPKLRGKLSSPELDLdnllpiktavaaKSRAPEWDASGLSADGAN--- 423
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 3803 kMPKVKMPKFSmpGFK-GEGPDVDVNLPKadldVSGPKVDIDVPDVNIEGPEGKLKGPKFKMP--------EMNIKAPKI 3873
Cdd:pfam05170  424 -LPLPVEPFLW--GVWqGMDADVSANIDK----VTYSGLPISDLKTKLRSEGGVLQLSRLKGGlyggyleaGAQLDLSKK 496
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 1079280806 3874 SMP-DIDLNLKGPKVKGDM-DVSLPK-VEGDMQVpDLDIKG 3911
Cdd:pfam05170  497 PATyRLKINAKNIPLKPLLpDLFKMFsTDGLLDI-DADLQG 536
AsmA pfam05170
AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane ...
4326-4631 1.17e-03

AsmA family; The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.


Pssm-ID: 428346 [Multi-domain]  Cd Length: 607  Bit Score: 45.55  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4326 MPGFKGEGPDVDVTL---PKADIEISGPKVDIDAPDVSIEGPDAKLKGPKFKMPEMNIKAPKISMPDIDFNLKGPKVKGD 4402
Cdd:pfam05170  105 IDSIRLDGAELALERlkqGNWNWQELIQNQQNQASNAPTQQPQPTWPVAAWSLPIGRIQVSNGQVTIDDKASQKILKDIN 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4403 VDVSLPkvegdlkgpeiDIKGPSLdidtPDVNIEGpEGKLKGPKFKMP---EMNIKAPKISMPDFDLHLKGPKVKGDVDV 4479
Cdd:pfam05170  185 LELQVS-----------TLYGPSF----NWSKITI-SGKGDQDPQSFGsqvNVTILSGEISGEALRGSTSTGGMLLLQTL 248
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4480 SLPKVESDlkgpevdiegpEGKLKGPKFKMPDVHFKSPQISMSDIDLNLKGPKIKGD----MDISVPKLEGDLKGPKVDV 4555
Cdd:pfam05170  249 SSPIYHIN-----------SLKLLNAQLELDGTLWDNLNLSIEDLDLKASGWKSITVnlalTADELDSLANQAELPGANL 317
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4556 kgpkvgIDTPD-IDIHGPEGKLKGPKFKMpDLHLKAPKISMPevDLNLKGPKVKGDMDISL----------PKVEGDLKG 4624
Cdd:pfam05170  318 ------PDTPQnITLGELSLSFKTGRVQV-SGSLNSLTLNLD--YLSFDGKKWVGSSDIDLsnrlpqpqprPKLRGKLSS 388

                   ....*..
gi 1079280806 4625 PEVDIRD 4631
Cdd:pfam05170  389 PELDLDN 395
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
4879-5014 1.28e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079280806 4879 KGPEVDLKGPRLD---FEGPDAKLSGPSLKMPSLEISAPKVTAPDV---DLHLKAPKIGFSG---------PKLEGGEVd 4943
Cdd:pfam05109  423 KAPESTTTSPTLNttgFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstaDVTSPTPAGTTSGaspvtpspsPRDNGTES- 501
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1079280806 4944 lKGPKVEAPSLDVHMDSPDINIEGPDVKIPKFKKPKFGFGAKSPKADIKSPSLDVTVPEAELNLETPEISV 5014
Cdd:pfam05109  502 -KAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI 571
PDZ_canonical cd00136
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
22-56 1.49e-03

canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467153 [Multi-domain]  Cd Length: 81  Bit Score: 40.60  E-value: 1.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1079280806   22 GLTIA---QRDDGVFVQEVTQNSPAARTGVVKEGDQIV 56
Cdd:cd00136     13 GFSIRggkDGGGGIFVSRVEPGGPAARDGRLRVGDRIL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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