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Conserved domains on  [gi|1085962180|ref|NP_001333507|]
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proton-coupled zinc antiporter SLC30A2 isoform 2 [Mus musculus]

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 11492197)

cation transporter of the cation diffusion facilitator (CDF) family that facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

Gene Ontology:  GO:0008324
PubMed:  25896018|17448255
TCDB:  2.A.4

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
1-276 1.94e-90

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 269.48  E-value: 1.94e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:TIGR01297   3 MLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEAIE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHGHShgnsrddssqqqNPSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:TIGR01297  83 RLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLG------------SLALRAAALHVLSDALSSVGVLIGALLI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180 161 YFKpeYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVH 240
Cdd:TIGR01297 151 YFG--WHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGVHDLHIWRIGPGKLFLDVH 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1085962180 241 IAIAQNADAQ----AVLKVARDRLQGKFNFHTMTIQIEKY 276
Cdd:TIGR01297 229 VVVDPDLDLKqahdIALEIEREILKRHPGIEHVTIQVEPC 268
 
Name Accession Description Interval E-value
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
1-276 1.94e-90

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 269.48  E-value: 1.94e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:TIGR01297   3 MLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEAIE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHGHShgnsrddssqqqNPSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:TIGR01297  83 RLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLG------------SLALRAAALHVLSDALSSVGVLIGALLI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180 161 YFKpeYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVH 240
Cdd:TIGR01297 151 YFG--WHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGVHDLHIWRIGPGKLFLDVH 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1085962180 241 IAIAQNADAQ----AVLKVARDRLQGKFNFHTMTIQIEKY 276
Cdd:TIGR01297 229 VVVDPDLDLKqahdIALEIEREILKRHPGIEHVTIQVEPC 268
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
1-274 2.64e-82

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 249.65  E-value: 2.64e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:COG1230    31 MVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANALLLLVVAGYILYEAIQ 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDyEIKGDTMLITSGCAVAVNLIMGLALHqSGHGHSHgnsrddssqqqnpSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:COG1230   111 RLFNPP-PVAGGGMLVVAVIGLVVNLVSAWLLH-RGSKHDL-------------NLRGAYLHVLADALGSVAVIVAALVI 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180 161 YFKPEYkYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVH 240
Cdd:COG1230   176 LFTGWT-WLDPLLSLLIALLILRSAWGLLRESLRILLEGVPDGIDLEEVRAALEALPGVADVHDLHVWSLSSGENALTAH 254
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1085962180 241 IAIAQNADAQAVLKVARDRLQGKFNFHTMTIQIE 274
Cdd:COG1230   255 VVVDDGADADAILDEIRELLAERFGIEHVTIQIE 288
PRK03557 PRK03557
CDF family zinc transporter ZitB;
1-289 4.75e-43

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 149.51  E-value: 4.75e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:PRK03557   32 MLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIE 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDyEIKGDTMLITSGCAVAVNLIMGLALHqsgHGhshgnsrddsSQQQNPSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:PRK03557  112 RFRTPR-PVAGGMMMAIAVAGLLANILSFWLLH---HG----------SEEKNLNVRAAALHVLGDLLGSVGAIIAALII 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180 161 YFKpEYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTV-KNLLLSVDGVEALHSLHIWaLTVAQPVLSV 239
Cdd:PRK03557  178 IWT-GWTPADPILSILVSVLVLRSAWRLLKESVNELLEGAPVSLDIAELkRRLCREIPEVRNVHHVHVW-MVGEKPVMTL 255
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1085962180 240 HIAIAQNADAQAVLKVARDRLQGKFNFHTMTIQIEKYSEDMKNCQACQGP 289
Cdd:PRK03557  256 HVQVIPPHDHDALLDRIQDYLMHHYQIEHATIQMEYQPCHGPDCHLNQGV 305
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
1-197 2.24e-36

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 128.54  E-value: 2.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:pfam01545   3 ALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYESIQ 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHGHShgnsrddssqqqNPSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:pfam01545  83 RLLSPGEEIDPGLALILALVSLLVNLFLLLYLRRAARRIR------------SPALKADALHALSDVLASLGVLISALLI 150
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1085962180 161 YFKPEY--KYVDPICTFLFSILVLGTTLTILRDVILVLM 197
Cdd:pfam01545 151 YLGPITggLLADPLASLLIGLLILYTALRLLKESLSILL 189
 
Name Accession Description Interval E-value
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
1-276 1.94e-90

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 269.48  E-value: 1.94e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:TIGR01297   3 MLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEAIE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHGHShgnsrddssqqqNPSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:TIGR01297  83 RLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLG------------SLALRAAALHVLSDALSSVGVLIGALLI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180 161 YFKpeYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVH 240
Cdd:TIGR01297 151 YFG--WHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGVHDLHIWRIGPGKLFLDVH 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1085962180 241 IAIAQNADAQ----AVLKVARDRLQGKFNFHTMTIQIEKY 276
Cdd:TIGR01297 229 VVVDPDLDLKqahdIALEIEREILKRHPGIEHVTIQVEPC 268
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
1-274 2.64e-82

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 249.65  E-value: 2.64e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:COG1230    31 MVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANALLLLVVAGYILYEAIQ 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDyEIKGDTMLITSGCAVAVNLIMGLALHqSGHGHSHgnsrddssqqqnpSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:COG1230   111 RLFNPP-PVAGGGMLVVAVIGLVVNLVSAWLLH-RGSKHDL-------------NLRGAYLHVLADALGSVAVIVAALVI 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180 161 YFKPEYkYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVH 240
Cdd:COG1230   176 LFTGWT-WLDPLLSLLIALLILRSAWGLLRESLRILLEGVPDGIDLEEVRAALEALPGVADVHDLHVWSLSSGENALTAH 254
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1085962180 241 IAIAQNADAQAVLKVARDRLQGKFNFHTMTIQIE 274
Cdd:COG1230   255 VVVDDGADADAILDEIRELLAERFGIEHVTIQIE 288
PRK03557 PRK03557
CDF family zinc transporter ZitB;
1-289 4.75e-43

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 149.51  E-value: 4.75e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:PRK03557   32 MLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIE 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDyEIKGDTMLITSGCAVAVNLIMGLALHqsgHGhshgnsrddsSQQQNPSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:PRK03557  112 RFRTPR-PVAGGMMMAIAVAGLLANILSFWLLH---HG----------SEEKNLNVRAAALHVLGDLLGSVGAIIAALII 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180 161 YFKpEYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTV-KNLLLSVDGVEALHSLHIWaLTVAQPVLSV 239
Cdd:PRK03557  178 IWT-GWTPADPILSILVSVLVLRSAWRLLKESVNELLEGAPVSLDIAELkRRLCREIPEVRNVHHVHVW-MVGEKPVMTL 255
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1085962180 240 HIAIAQNADAQAVLKVARDRLQGKFNFHTMTIQIEKYSEDMKNCQACQGP 289
Cdd:PRK03557  256 HVQVIPPHDHDALLDRIQDYLMHHYQIEHATIQMEYQPCHGPDCHLNQGV 305
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
1-197 2.24e-36

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 128.54  E-value: 2.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:pfam01545   3 ALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYESIQ 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHGHShgnsrddssqqqNPSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:pfam01545  83 RLLSPGEEIDPGLALILALVSLLVNLFLLLYLRRAARRIR------------SPALKADALHALSDVLASLGVLISALLI 150
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1085962180 161 YFKPEY--KYVDPICTFLFSILVLGTTLTILRDVILVLM 197
Cdd:pfam01545 151 YLGPITggLLADPLASLLIGLLILYTALRLLKESLSILL 189
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
1-227 1.16e-30

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 115.97  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180   1 MIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQ 80
Cdd:COG0053    16 AVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAVLILLAGLFILYEAIE 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085962180  81 RLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHghshgnsrddssQQQNPSVRAAFIHVIGDLLQSVGVLVAAYII 160
Cdd:COG0053    96 RLLHPEPVEPSGLGLAVLLISIVVNEALARYLRRVGK------------KTGSPALKADALHDRSDALTSLGVLIGLLLA 163
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1085962180 161 YFkPEYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHI 227
Cdd:COG0053   164 LL-TGWPWLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVERIRAIILSVPGVIGVHDLRT 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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