|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
44-483 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 709.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 44 KVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGSGRLMPWVLGCTPF 123
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 124 IALAYFFLWFLPPFTSLRGLWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIV 203
Cdd:cd17452 81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 204 SGAhrphrceatatpgpvtvspnaahlYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPGLSFLAGLSLTTRHPPY 283
Cdd:cd17452 161 ASA------------------------YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHGPY 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 284 LKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFGIFAMVPFAILLA 363
Cdd:cd17452 217 LKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAACGISWMIPFAIMLV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 364 AVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRHGPGLETIFYSSYVFFTKLSGACALGISTLSLEFSGYK 443
Cdd:cd17452 297 TIPNLIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYE 376
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1099517021 444 AGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILMVGSTPK 483
Cdd:cd17452 377 TGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
46-477 |
3.84e-74 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 240.67 E-value: 3.84e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 46 CYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPWVLGCTPFIA 125
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRT-RTRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 126 LAYFFLWFlPPFTSLRGL--WYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIV 203
Cdd:pfam13347 80 VSFILLFT-PPELGRAPLfiWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 204 sgahrphrceatatpGPVTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERP---DPSAPASGPGLSFLAGLSLTTRH 280
Cdd:pfam13347 159 ---------------LILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVsmrSKEDTGQKEAGSLLDMLKEVFRN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 281 PPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFG--IFAMVPF 358
Cdd:pfam13347 224 RAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILgaLITIAGF 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 359 AILLAAVPTAPVA-YVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhRHGPGLETIFYSSYVFFTKLSGACALGISTLSL 437
Cdd:pfam13347 304 ALALLLGPNNTLLfLVLYIIIGFGYGSSFFLPWSMLADVVDYGEL--RTGKRREGTFFAMWSFISKLATGVGLGVSGLLL 381
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1099517021 438 EFSGYKAGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILM 477
Cdd:pfam13347 382 SAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLY 421
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
34-477 |
5.99e-70 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 230.17 E-value: 5.99e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 34 SRAGRLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRL 113
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRT-RTRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 114 MPWVLGCTPFIALAYFFLWFLPPFTSLRGLWY-TTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGT 192
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYaLVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 193 LMGATVHGLIVSgahrphrceatatpgpvTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASgpglSFLA 272
Cdd:COG2211 161 LLASVLPPPLVA-----------------AFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV----SLKE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 273 GLSLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVL-VSAVLSTPLWEWVLQRFGKKTS--- 348
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRFGKKKAfii 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 349 AFGIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhRHGPGLETIFYSSYVFFTKLSGAC 428
Cdd:COG2211 300 GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEW--KTGRRREGLYFGIFTFAIKLGQAL 377
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1099517021 429 ALGISTLSLEFSGYKAGVcKQAEEVVVTLKVLIGAVPTCMILAGLCILM 477
Cdd:COG2211 378 AGALAGLLLALFGYVAGA-AQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
44-476 |
8.19e-35 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 135.46 E-value: 8.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 44 KVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPWVL-GCTP 122
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRT-RTRWGKFRPWLLiGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 123 FIALAyfFLWFLPPFTSLRG--LWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMtvemagtlMGATVHG 200
Cdd:TIGR00792 80 FSIVL--VLLFTTPDFSGTGklVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRR--------FGATLGG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 201 LIVSGAhrphrceatATPGPVTVSP-NAAHLYCIAAAVVVVTYpVCISLLCL-GVKERPDPSAPASGPGLSFLAGLSLTT 278
Cdd:TIGR00792 150 LLVAVI---------VLPLVSYFGGgDDKFGWFMFALVLALIG-VVSLIICFfGTKERYSEIPKNIEKKLSLKQIFKALF 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 279 RHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFGIFAM--V 356
Cdd:TIGR00792 220 KNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLmvL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 357 PFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhRHGPGLETIFYSSYVFFTKLSGACALGISTLS 436
Cdd:TIGR00792 300 GYLIFFFAGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEW--KTGIRAEGLVYSVRTFVRKLGQALAGFFVGLI 377
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1099517021 437 LEFSGYKAGVcKQAEEVVVTLKVLIGAVPTCMILAGLCIL 476
Cdd:TIGR00792 378 LGIIGYVANA-AQSPITLNGIKILMFAVPALFLLLAAIII 416
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
38-477 |
5.08e-23 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 101.34 E-value: 5.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 38 RLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPWV 117
Cdd:PRK09669 5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRT-RTRHGQFRPYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 118 L-GCTPFiALAYFFLWFLPPFTSLRGLWYT-TFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGtlmg 195
Cdd:PRK09669 84 LwFAIPF-GVVCLLTFYTPDFGATGKIIYAcVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIG---- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 196 atvhGLIVSGAHRPhrceATATPGPVTVSPNAAHLYCIAAAVVVVTYPVCISLlclgVKERPDPSAPASGpglSFLAGLS 275
Cdd:PRK09669 159 ----GLIVSVIALP----LVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFM----TKERYTPEVDNSS---SVWKDLK 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 276 LTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGK-KTSAFGIFA 354
Cdd:PRK09669 224 LLLGNSQWRIMFIFNVVLLTAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRvRAFKWTIVA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 355 MVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLP--WSMLPDVVDdfQLQHRHGPGLETIFYSSYVFFTKLSGACALGI 432
Cdd:PRK09669 304 FVILSALIFFIPPSNVWLIFALNILFNFIQNLTTPlqWSMFSDVVD--YEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAV 381
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1099517021 433 STLSLEFSGYKAGVCKQAEEVVVTLKVLIGAVPtCMILAGLCILM 477
Cdd:PRK09669 382 VGWILAWVDYVGGAAVQSASVLTTINLLFTVIP-GVLFAGMAIIL 425
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
44-483 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 709.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 44 KVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGSGRLMPWVLGCTPF 123
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 124 IALAYFFLWFLPPFTSLRGLWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIV 203
Cdd:cd17452 81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 204 SGAhrphrceatatpgpvtvspnaahlYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPGLSFLAGLSLTTRHPPY 283
Cdd:cd17452 161 ASA------------------------YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHGPY 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 284 LKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFGIFAMVPFAILLA 363
Cdd:cd17452 217 LKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAACGISWMIPFAIMLV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 364 AVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRHGPGLETIFYSSYVFFTKLSGACALGISTLSLEFSGYK 443
Cdd:cd17452 297 TIPNLIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYE 376
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1099517021 444 AGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILMVGSTPK 483
Cdd:cd17452 377 TGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
44-483 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 699.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 44 KVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGSGRLMPWVLGCTPF 123
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQRTGIGRLMPWIVFSTPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 124 IALAYFFLWFLPPFTSLRGLWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIV 203
Cdd:cd17392 81 IILAYFFLWFLPPFTSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 204 SGAHRPHRCEATATPG----PVTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPGLSFLAGLSLTTR 279
Cdd:cd17392 161 GVAHRPRRQDCTATPGtsdhPVTVLPNTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDPLSPASGPGLSYLAGLKLVTG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 280 HPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKK-TSAFGIFAMVPF 358
Cdd:cd17392 241 HPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKtTSFIGISAMVPF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 359 AILLAAVP-TAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRHGPGLETIFYSSYVFFTKLSGACALGISTLSL 437
Cdd:cd17392 321 LILLALVPsNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVDDFQLKNPHCPGLEPIFYSCYVFFTKLGGGLSLGISTLSL 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1099517021 438 EFSGYKAGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILMVGSTPK 483
Cdd:cd17392 401 HFSGYKAGACKQPEEVVVTLKVLIAPVPICLILAGLVLFYVYPINE 446
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
44-477 |
7.76e-134 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 393.79 E-value: 7.76e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 44 KVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGSGRLMPWVLGCTPF 123
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPWTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 124 IALAYFFLWFLPPFTSLRGLWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIV 203
Cdd:cd17451 81 AVLSYFLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 204 SGAhrphrceatatpgpvtvspnaahLYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPGLSFLAGLSLTTRHPPY 283
Cdd:cd17451 161 GMA-----------------------AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLKLVMSHGPY 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 284 LKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSA-FGIFAMVPFAILL 362
Cdd:cd17451 218 IKLITGFLFTSLAFMLLEGNFALFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVyIGISSAVPFLILV 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 363 AAVPTA-PVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRHGPGLETIFYSSYVFFTKLSGACALGISTLSLEFSG 441
Cdd:cd17451 298 VLVESNlIVTYVVSVAAGVSVAAAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAG 377
|
410 420 430
....*....|....*....|....*....|....*.
gi 1099517021 442 YKAGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILM 477
Cdd:cd17451 378 YQTRGCSQPEEVNLTLKMLVSAAPVVLILLGLLLFK 413
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
46-477 |
3.84e-74 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 240.67 E-value: 3.84e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 46 CYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPWVLGCTPFIA 125
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRT-RTRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 126 LAYFFLWFlPPFTSLRGL--WYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIV 203
Cdd:pfam13347 80 VSFILLFT-PPELGRAPLfiWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 204 sgahrphrceatatpGPVTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERP---DPSAPASGPGLSFLAGLSLTTRH 280
Cdd:pfam13347 159 ---------------LILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVsmrSKEDTGQKEAGSLLDMLKEVFRN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 281 PPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFG--IFAMVPF 358
Cdd:pfam13347 224 RAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILgaLITIAGF 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 359 AILLAAVPTAPVA-YVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhRHGPGLETIFYSSYVFFTKLSGACALGISTLSL 437
Cdd:pfam13347 304 ALALLLGPNNTLLfLVLYIIIGFGYGSSFFLPWSMLADVVDYGEL--RTGKRREGTFFAMWSFISKLATGVGLGVSGLLL 381
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1099517021 438 EFSGYKAGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILM 477
Cdd:pfam13347 382 SAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLY 421
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
44-477 |
3.29e-73 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 237.89 E-value: 3.29e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 44 KVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPWVLGCTPF 123
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRT-RSRWGRFRPWLLWGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 124 IALAYFFLWFLPPFTSLRGLWY-TTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLI 202
Cdd:cd17332 80 LALLFVLLFTTPDGSGTGKLIYaLITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 203 VSGAHrphrceatatpgpvtvSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPgLSFLAGLSLTTRHPP 282
Cdd:cd17332 160 VAYFG----------------GGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSK-LPLLKSLKALLKNRP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 283 YLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAF-GIFAMVPFAIL 361
Cdd:cd17332 223 FLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFiGLLLAILGLLL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 362 LAAVPTAPVA--YVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhRHGPGLETIFYSSYVFFTKLSGACALGISTLSLEF 439
Cdd:cd17332 303 LFFLPPGNLVliLVLAVLAGIGYGGANLLPWAMLADVIDYGEL--KTGKRREGIFYSVMTFFRKLGLALAGALVGLILSL 380
|
410 420 430
....*....|....*....|....*....|....*...
gi 1099517021 440 SGYKAGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILM 477
Cdd:cd17332 381 AGYVANAAAQSASALNGIRLLIAVLPAVLLLLALILMS 418
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
34-477 |
5.99e-70 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 230.17 E-value: 5.99e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 34 SRAGRLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRL 113
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRT-RTRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 114 MPWVLGCTPFIALAYFFLWFLPPFTSLRGLWY-TTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGT 192
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYaLVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 193 LMGATVHGLIVSgahrphrceatatpgpvTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASgpglSFLA 272
Cdd:COG2211 161 LLASVLPPPLVA-----------------AFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV----SLKE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 273 GLSLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVL-VSAVLSTPLWEWVLQRFGKKTS--- 348
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRFGKKKAfii 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 349 AFGIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhRHGPGLETIFYSSYVFFTKLSGAC 428
Cdd:COG2211 300 GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEW--KTGRRREGLYFGIFTFAIKLGQAL 377
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1099517021 429 ALGISTLSLEFSGYKAGVcKQAEEVVVTLKVLIGAVPTCMILAGLCILM 477
Cdd:COG2211 378 AGALAGLLLALFGYVAGA-AQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
44-476 |
8.19e-35 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 135.46 E-value: 8.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 44 KVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPWVL-GCTP 122
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRT-RTRWGKFRPWLLiGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 123 FIALAyfFLWFLPPFTSLRG--LWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMtvemagtlMGATVHG 200
Cdd:TIGR00792 80 FSIVL--VLLFTTPDFSGTGklVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRR--------FGATLGG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 201 LIVSGAhrphrceatATPGPVTVSP-NAAHLYCIAAAVVVVTYpVCISLLCL-GVKERPDPSAPASGPGLSFLAGLSLTT 278
Cdd:TIGR00792 150 LLVAVI---------VLPLVSYFGGgDDKFGWFMFALVLALIG-VVSLIICFfGTKERYSEIPKNIEKKLSLKQIFKALF 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 279 RHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFGIFAM--V 356
Cdd:TIGR00792 220 KNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLmvL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 357 PFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhRHGPGLETIFYSSYVFFTKLSGACALGISTLS 436
Cdd:TIGR00792 300 GYLIFFFAGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEW--KTGIRAEGLVYSVRTFVRKLGQALAGFFVGLI 377
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1099517021 437 LEFSGYKAGVcKQAEEVVVTLKVLIGAVPTCMILAGLCIL 476
Cdd:TIGR00792 378 LGIIGYVANA-AQSPITLNGIKILMFAVPALFLLLAAIII 416
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
38-477 |
5.08e-23 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 101.34 E-value: 5.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 38 RLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPWV 117
Cdd:PRK09669 5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRT-RTRHGQFRPYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 118 L-GCTPFiALAYFFLWFLPPFTSLRGLWYT-TFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGtlmg 195
Cdd:PRK09669 84 LwFAIPF-GVVCLLTFYTPDFGATGKIIYAcVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIG---- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 196 atvhGLIVSGAHRPhrceATATPGPVTVSPNAAHLYCIAAAVVVVTYPVCISLlclgVKERPDPSAPASGpglSFLAGLS 275
Cdd:PRK09669 159 ----GLIVSVIALP----LVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFM----TKERYTPEVDNSS---SVWKDLK 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 276 LTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGK-KTSAFGIFA 354
Cdd:PRK09669 224 LLLGNSQWRIMFIFNVVLLTAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRvRAFKWTIVA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 355 MVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLP--WSMLPDVVDdfQLQHRHGPGLETIFYSSYVFFTKLSGACALGI 432
Cdd:PRK09669 304 FVILSALIFFIPPSNVWLIFALNILFNFIQNLTTPlqWSMFSDVVD--YEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAV 381
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1099517021 433 STLSLEFSGYKAGVCKQAEEVVVTLKVLIGAVPtCMILAGLCILM 477
Cdd:PRK09669 382 VGWILAWVDYVGGAAVQSASVLTTINLLFTVIP-GVLFAGMAIIL 425
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
44-476 |
8.95e-15 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 76.14 E-value: 8.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 44 KVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGS-GRLMPWVLGCTP 122
Cdd:cd17491 1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGCGKyGRRKSWHLIGTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 123 FIALAYFFLWFLPPFTS------LRGLWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYR--MTVeMAG-TL 193
Cdd:cd17491 81 CVLLSFPFIFNPCLGCSdstsewAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRyaFTV-IANiTV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 194 MGATVHGLIVSGAHrphrceaTATPGPVTVSPNAAHLyciAAAVVVVTYPVCIsLLCLGVKErPDPSAPASGPGlsfLAG 273
Cdd:cd17491 160 YLIAWLLLQQSSGD-------SVNPTSAQDLPIFRNL---SLIVVGIGFLFSL-LFHLGTKE-PRPPTDLSTTT---NEG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 274 LSLTTRHPPYLKL----------VISFLFISA--AVQVEQSYLVLFCTHASQLH-DHVQGLVLTVLVSAVLSTPLWEWVL 340
Cdd:cd17491 225 EEVTAPEEPRLTWkewlrepqfyQVALLYMCTrlIVNLSQVYIPLYLTETLQLPkESIAIVPLVMYVSGFLTSLVMKPIN 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 341 QRFGKK-----TSAFGIFAMVPFAILLAAVPTAPVaYVVAFVSGVSIAVSLLLPWSMLPDVVddfqlqhrhGPGLET--I 413
Cdd:cd17491 305 KKIGRKityllGLLFVLGFCIWVWFQSGSSRTYEI-YGAAVLLGVGSATLLVTSLSMTADLI---------GTNTESgaF 374
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1099517021 414 FYSSYVFFTKLS-GACALGISTLSLEFSgykagvcKQAEEVVVTLKVLIGAVPTCMILAGLCIL 476
Cdd:cd17491 375 VYGAMSFTDKLSnGIAVLIIQSLHPCNT-------ELDECISYYYRVMVVVAGGVAILAGLLLL 431
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
39-476 |
1.00e-13 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 73.28 E-value: 1.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 39 LSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQrTGSGRLMPWVL 118
Cdd:PRK09848 5 LSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVN-TRWGKFRPFLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 119 -GCTPFIALAYFFLWFLPPFTSLRGLWYTtfYCLFQALAT---FFQVPYTALTMLLTPCPRERDSATAYRMT-VEMAGTL 193
Cdd:PRK09848 84 fGTAPLMIFSVLVFWVPTDWSHSSKVVYA--YLTYMGLGLcysLVNIPYGSLATAMTQQPQSRARLGAARGIaASLTFVC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 194 MGATVHGLIVSGAHRPHRCEATATPGPVTVSPNAAHLYCIAAAVVVVTYPVcisllclgvkERPdpsapasgpglSFLAG 273
Cdd:PRK09848 162 LAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIV----------AQP-----------SLKIS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 274 LSLTTRHPPYLKLVIS---FLFISAAVQVEQSYLVLFCTHASQLHdhVQGLVLTVLVSAVLSTPLWEWVLQRFGKK-TSA 349
Cdd:PRK09848 221 LQTLKRNRPLFMLCIGalcVLISTFAVSASSLFYVRYVLNDTGLF--TVLVLVQNLVGTVASAPLVPGMVARIGKKnTFL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 350 FGIFAMVPFAILLAAVPTA--PVAYVVAFVSGVSIAVSLLLPWSMLPDVVDdfQLQHRHGPGLETIFYSSYVFFTKLSGA 427
Cdd:PRK09848 299 IGALLGTCGYLLFFWVSVWslPVALVALAIASIGQGVTMTVMWALEADTVE--YGEYLTGVRIEGLTYSLFSFTRKCGQA 376
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1099517021 428 CALGISTLSLEFSGYKAGVCkQAEEVVVTLKVLIGAVPTCMILAGLCIL 476
Cdd:PRK09848 377 IGGSIPAFILGLSGYIANQV-QTPEVIMGIRTSIALVPCGFMLLAFVII 424
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
39-485 |
3.99e-12 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 68.04 E-value: 3.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 39 LSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPWVL 118
Cdd:PRK11462 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRT-RSRWGKFRPWVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 119 -GCTPFIALAyfFLWFLPPFTSLRG--LWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMG 195
Cdd:PRK11462 85 fGALPFGIVC--VLAYSTPDLSMNGkmIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 196 ATVHGLIVSgahrphrceatatpgpVTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERPDpsAPASGPglSFLAGLS 275
Cdd:PRK11462 163 TVLMMPLVN----------------LIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVE--APPTTT--SMREDLR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 276 LTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTV----LVSAVLSTPLWEWVLqrfgkKTSAF- 350
Cdd:PRK11462 223 DIWQNDQWRIVGLLTIFNILAVCVRGGAMMYYVTWILGTPEVFVAFLTTYcvgnLIGSALAKPLTDWKC-----KVTIFw 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 351 ---GIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDdfQLQHRHGPGLETIFYSSYVFFTKLSGA 427
Cdd:PRK11462 298 wtnALLAVISLAMFFVPMQASITMFVFIFVIGVLHQLVTPIQWVMMSDTVD--YGEWCNGKRLTGISFAGTLFVLKLGLA 375
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1099517021 428 CALGISTLSLEFSGYKAGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILMVGSTPKTP 485
Cdd:PRK11462 376 FGGALIGWMLAYGGYDAAEKAQNSATISIIIALFTIVPAICYLLSAIIAKRYYSLTTH 433
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
37-475 |
2.64e-09 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 59.34 E-value: 2.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 37 GRLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqRTGSGRLMPW 116
Cdd:PRK10429 1 MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNT-RSRWGKFKPW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 117 VLGCTPFIALAYFFLW--FLPPFTSLRgLWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAY-RMTVEMAGTL 193
Cdd:PRK10429 80 ILIGTLANSVVLFLLFsaHLFEGTAQY-VFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYpRFFASLAGFV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 194 MGATVHGLI--VSGAHRphrceatatpgpvtvspnaAHLYCIAAAVVVVTYPVCISLLCLGVKER--PDPSAPASGPGLS 269
Cdd:PRK10429 159 TAGFTLPFVnyVGGGDR-------------------GFGFQMFTLVLIAFFIVSTIITLRNVHEVysSDNQVSAEGSHLT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 270 FLAGLSLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSA 349
Cdd:PRK10429 220 LKDIVALIYKNDQLSCLLGMALAYNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSRRILW 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 350 FG--IFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWS----MLPDVVD--DFQLQHRHgpglETIFYSSYVFF 421
Cdd:PRK10429 300 AGasIFPVLSCGVLLLMGLAAPHNALLIVIAGILLNIGTALFWVlqviMVADTVDygEYKLGIRC----ESIAYSVQTMV 375
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1099517021 422 TKLSGACALGISTLSLEFSGYKAGVcKQAEEVVVTLKVLIGAVPTCMILAGLCI 475
Cdd:PRK10429 376 VKGGSAFAAFFIGVVLGLIGYVPNV-EQSAQTLLGMQFIMIGLPTLFFMITLVL 428
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
45-432 |
1.82e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 56.48 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 45 VCYGIGGVpnQIASSATAFYLQLFLLDIAqIPAAQVSLVLFggkvsgaaADPVAGFFI-----NRSQRTGS--GRLMPWV 117
Cdd:cd17313 4 LGFGFFGI--EFGWALENSYVPPILQTLG-LSHALIGFVWT--------LGPILGLFVqplvgSLSDRCNSriGRRRPFI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 118 LGCTPFIALAYF-------FLWFLPPFTSLRGLWYTT-FYCLFQALATFFQVPYTALTMLLTPcprERDSATAYRMTVEM 189
Cdd:cd17313 73 LVGAPLAALGLIlipnaadIGLALGDGPRTWALVLFVlGIVLLDFAMNVCQGPVRALLPDLVP---PEQRSKANGIINFM 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 190 AGtlMGATVhGLIVSGAHRPHRCEATATPGPVTVspnaahLYCIAAAVVVVTYPVCISLlclgVKERPD----PSAPASG 265
Cdd:cd17313 150 GG--LGGVL-GYLLGAILWDHNWFGFALGGNLKV------PFYIGAIILLVCVLVTLFF----VKEPPLspeaGEHSENP 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 266 PGLSFLAGL--SLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQ-------------GLVLTVLVSAV 330
Cdd:cd17313 217 SLGEVLKSLlkLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHGTSAAsshygagvrmgawGLLIFSLAFLI 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 331 LSTPLwEWVLQRFG-KKTSAFGIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDfqlqHRHGPG 409
Cdd:cd17313 297 FSLPI-GKLGKKIGrKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSE----SGRGQG 371
|
410 420
....*....|....*....|...
gi 1099517021 410 LETIFYSSYVFFTKLSGACALGI 432
Cdd:cd17313 372 TDTGLLNLAISLAQILVSLLAGP 394
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
55-399 |
2.26e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 55 QIASSATAFYLQLFLLDIAQ---IPAAQVSLVLFGGKVSGAAADPVAGFFinrSQRTGSGRLMpwvLGCTPFIALAYFFL 131
Cdd:COG2814 19 AFLSGLGIGIVLPALPLIAAdlgASPAQAGLVVTAYLLGAALGAPLAGRL---ADRFGRRRVL---LLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 132 WFLPPFTSLrglwytTFYCLFQALAT-FFQVPYTALTMLLTPcPRERDSATAYRMTVEMAGTLMGATVHGLIVSGAHrph 210
Cdd:COG2814 93 ALAPSLWLL------LAARFLQGLGAgALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFG--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 211 rceatatpgpvtvspnaahlyciAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPglsFLAGLSLTTRHPPYLKLVISF 290
Cdd:COG2814 163 -----------------------WRWVFLVNAVLALLALLLLLRLLPESRPAARAR---LRGSLRELLRRPRLLLLLLLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 291 LFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVL-VSAVLSTPLWEWVLQRFG-KKTSAFGIFAMVPFAILLAAVPTA 368
Cdd:COG2814 217 FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFgLGGVLGALLAGRLADRFGrRRLLLIGLLLLALGLLLLALAGSL 296
|
330 340 350
....*....|....*....|....*....|.
gi 1099517021 369 PVAYVVAFVSGVSIAVSLLLPWSMLPDVVDD 399
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-377 |
9.91e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 9.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 49 IGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTgsgRLMpwVLGCTPF-IALA 127
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRK---PVM--LAGLLLRaLGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 128 YFFLWFLPPFTSLrglwyttFYCLFQALATFFQVPYTALTMLLTPcPRERDSATAYRMTVEMAGTLMGATVHGLIVSGah 207
Cdd:cd17329 81 LLGFAHSPWLFAI-------ALVLTGFGGGLFEPASEAMIADVTT-PENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 208 rphrceatatpGPVTVSPNAAHLYCIAAAVVVVTYPvcisllclgvkerPDPSAPASGPGLSFLAGLSLTTRHPPYLKLV 287
Cdd:cd17329 151 -----------SFRLLFLAAAVLFLLAALVLLFLLP-------------ETRPKRRAAEKTEILRGYKIVLRDRAFLLFL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 288 ISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTV--LVSAVLSTPLWEWVLQRFGKKTSAFGIFAMVPFAILLAAV 365
Cdd:cd17329 207 LASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALnaLLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFA 286
|
330
....*....|..
gi 1099517021 366 PTAPVAYVVAFV 377
Cdd:cd17329 287 NTLAVLILAMIV 298
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
49-397 |
2.04e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 49 IGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSqrtgsGRLMPWVLGCTPFiALAY 128
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-----GRRRVLLIGLLLF-ALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 129 FFLWFLPPFTSLRGLWyttfycLFQALAT-FFQVPYTALTMLLTPcPRERDSATAYRMTVEMAGTLMGATVHGLIVSgah 207
Cdd:pfam07690 77 LLLLFASSLWLLLVLR------VLQGLGAgALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLAS--- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 208 rphrceatatpgpvtvSPNAAHLYCIAAAVVVvtypVCISLLCLGVKERPDPSAPASGPGLSFLAGLSLTTRHPPYLKLV 287
Cdd:pfam07690 147 ----------------LFGWRAAFLILAILSL----LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 288 ISFLFISAAVQVEQSYLVLFCTHASqlHDHVQGLVLTVLVSAV--LSTPLWEWVLQRFGKKT----SAFGIFAMVPFAIL 361
Cdd:pfam07690 207 LALLLFGFAFFGLLTYLPLYQEVLG--LSALLAGLLLGLGGLLgaIGRLLLGRLSDRLGRRRrlllALLLLILAALGLLL 284
|
330 340 350
....*....|....*....|....*....|....*.
gi 1099517021 362 LAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVV 397
Cdd:pfam07690 285 LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
233-398 |
2.32e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.25 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 233 IAAAVVVVtypVCISLLCLGVKERPDPSAPASGPGLSFLAGLSLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHAS 312
Cdd:cd17325 154 LVCAALAL---LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 313 QLHDHVQGLVLTVL-VSAVLSTPLWEWVLQRFG-KKTSAFGIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPW 390
Cdd:cd17325 231 GLSPAQIGLLFGAQgLASALSQPPAGKLSDRIGrKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL 310
|
....*...
gi 1099517021 391 SMLPDVVD 398
Cdd:cd17325 311 ALLADIVP 318
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
286-397 |
2.54e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.24 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 286 LVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVL-VSAVLSTPLWEWVLQRFG---KKTSAFGIFAMVPFAIL 361
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPfLAGIVGSLLGGWLSDRLGrrrKLVLAIGLLLAALALLL 264
|
90 100 110
....*....|....*....|....*....|....*.
gi 1099517021 362 LAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVV 397
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
69-437 |
7.27e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 7.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 69 LLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTgsgrlmPWVLGCTPFIALAYFFLWFLPPFtslrgLWYTTF 148
Cdd:cd06174 22 LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRR------PVLLLGLLLFALGALLFAFAPSF-----WLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 149 YCLFQALATFFQVPYTALTMLLTPcPRERDSATAYRMTVEMAGTLMGATVHGLIVSGAHRPHRceatatpgpvtvspnaa 228
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFP-ERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWR----------------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 229 hlycIAAAVVVVTYPVCISLLCLGVKERPDPSAP--ASGPGLSFLAGLSLTTRHPPYLKLVISFLFISAAVQVEQSYLVL 306
Cdd:cd06174 153 ----AVFLIAAALALLAAILLLLVVPDPPESARAknEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099517021 307 FCTHASQLHDHVQGLVLTV-LVSAVLSTPLWEWVLQRFG--KKTSAFGIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIA 383
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLfGLAGALGSLLLGLLSDRLIgrKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1099517021 384 VSLLLPWSMlpdvvddfqLQHRHGPGLETIFYSSYVFFTKLSGACALGISTLSL 437
Cdd:cd06174 309 GLLPLSFAL---------IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
233-380 |
7.51e-03 |
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MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 7.51e-03
10 20 30 40 50 60 70 80
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gi 1099517021 233 IAAAVVVVTYPVcislLCLGVKERPDPSAPASGPGLSFLAGLSLT--TRHPPYLKLVISFLFISAAVQVEQSYLVLFCTH 310
Cdd:cd17355 164 LALLALLVLVPV----LLLLRRRPADLALRAYDDASPASPGSTLKeaLRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD 239
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90 100 110 120 130 140 150
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gi 1099517021 311 ASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFGIFAMVPFAILLAAVPTAPVAYVVAFVSGV 380
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALF 309
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