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Conserved domains on  [gi|1126724291|ref|NP_001334953|]
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zinc finger protein 606 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-684 2.33e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 293 YDSFLTQHTSTYTAEKPYDYNECGTSFIWSSYLIQHKKTHTGEKPYEC--DKCGKVFRNRSALTKHERTHTGIKPYECNK 370
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 371 CGK------------AFSWNS--------HLIVHKRIHTGEKPYV------CNECGKSFNWNSHLIGHQRTHtgeKPFEC 424
Cdd:COG5048    97 SLPlsnskasssslsSSSSNSndnnllssHSLPPSSRDPQLPDLLsisnlrNNPLPGNNSSSVNTPQSNSLH---PPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 425 TECGKSFSWSSHLIAHMRMHTGEKPFKCDECEKAFRDYSALSKHERTHSGAKPYKCTECGKSF------SWSSHLIAHQR 498
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 499 THTGEKPYNCQECGKAFRERSALTKHEIIHSGI-KPYECNKCGKSCSQMAHLVRHQRT--HTGE--KPYEC--NKCGKSF 571
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLF 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 572 SQSCHLVAHRRIHTGEKPYKCNQCERSF-------NCSSHLIAHRRTHTGEKPYRC--NECGKAFNESSSLIVHLRNHTG 642
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKEKLLNSSSkfspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLS 413

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1126724291 643 EKP--YKCNHCEKAFCKNSSLIIHQRMHSGEKRFICSECGKAFS 684
Cdd:COG5048   414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
KRAB super family cl42959
krueppel associated box;
1-32 5.45e-12

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 61.07  E-value: 5.45e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1126724291    1 MLETYGHLLSVGNQIAKPEVISLLEQGEEPWS 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-684 2.33e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 293 YDSFLTQHTSTYTAEKPYDYNECGTSFIWSSYLIQHKKTHTGEKPYEC--DKCGKVFRNRSALTKHERTHTGIKPYECNK 370
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 371 CGK------------AFSWNS--------HLIVHKRIHTGEKPYV------CNECGKSFNWNSHLIGHQRTHtgeKPFEC 424
Cdd:COG5048    97 SLPlsnskasssslsSSSSNSndnnllssHSLPPSSRDPQLPDLLsisnlrNNPLPGNNSSSVNTPQSNSLH---PPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 425 TECGKSFSWSSHLIAHMRMHTGEKPFKCDECEKAFRDYSALSKHERTHSGAKPYKCTECGKSF------SWSSHLIAHQR 498
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 499 THTGEKPYNCQECGKAFRERSALTKHEIIHSGI-KPYECNKCGKSCSQMAHLVRHQRT--HTGE--KPYEC--NKCGKSF 571
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLF 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 572 SQSCHLVAHRRIHTGEKPYKCNQCERSF-------NCSSHLIAHRRTHTGEKPYRC--NECGKAFNESSSLIVHLRNHTG 642
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKEKLLNSSSkfspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLS 413

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1126724291 643 EKP--YKCNHCEKAFCKNSSLIIHQRMHSGEKRFICSECGKAFS 684
Cdd:COG5048   414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
KRAB smart00349
krueppel associated box;
1-32 5.45e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 61.07  E-value: 5.45e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1126724291    1 MLETYGHLLSVGNQIAKPEVISLLEQGEEPWS 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
548-573 6.32e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 6.32e-05
                          10        20
                  ....*....|....*....|....*.
gi 1126724291 548 HLVRHQRTHTGEKPYECNKCGKSFSQ 573
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 588-637 4.55e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1126724291 588 KPYkCNQCERSFNCSSHLIAHRRTHTgekpYRCNECGKAFNESSSLIVHL 637
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-684 2.33e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 293 YDSFLTQHTSTYTAEKPYDYNECGTSFIWSSYLIQHKKTHTGEKPYEC--DKCGKVFRNRSALTKHERTHTGIKPYECNK 370
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 371 CGK------------AFSWNS--------HLIVHKRIHTGEKPYV------CNECGKSFNWNSHLIGHQRTHtgeKPFEC 424
Cdd:COG5048    97 SLPlsnskasssslsSSSSNSndnnllssHSLPPSSRDPQLPDLLsisnlrNNPLPGNNSSSVNTPQSNSLH---PPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 425 TECGKSFSWSSHLIAHMRMHTGEKPFKCDECEKAFRDYSALSKHERTHSGAKPYKCTECGKSF------SWSSHLIAHQR 498
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 499 THTGEKPYNCQECGKAFRERSALTKHEIIHSGI-KPYECNKCGKSCSQMAHLVRHQRT--HTGE--KPYEC--NKCGKSF 571
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLF 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 572 SQSCHLVAHRRIHTGEKPYKCNQCERSF-------NCSSHLIAHRRTHTGEKPYRC--NECGKAFNESSSLIVHLRNHTG 642
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKEKLLNSSSkfspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLS 413

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1126724291 643 EKP--YKCNHCEKAFCKNSSLIIHQRMHSGEKRFICSECGKAFS 684
Cdd:COG5048   414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
KRAB smart00349
krueppel associated box;
1-32 5.45e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 61.07  E-value: 5.45e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1126724291    1 MLETYGHLLSVGNQIAKPEVISLLEQGEEPWS 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
392-697 6.18e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 6.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 392 KPYVCNECGKSFNWNSHLIGHQRTHTGEKPFECT--ECGKSFSWSSHLIAHMRMHTGEKPFKCDECEKAFRDYSALSKHE 469
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 470 RTHSG-AKPYKCTECGKSFSWSSHLIAHQRTHTGEKPYNCQECGKAFRERSALTKHEIIHSGIkpyeCNKCGKSCSQMAH 548
Cdd:COG5048   112 SSSSNsNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN----SLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 549 LvrHQRTHTGEKPYECNKCGKSFSQSCHLVAHRRIHTGEKPYKCNQCerSFNCSSHLIAHRRTHTGEKPYRCNECGKAFN 628
Cdd:COG5048   188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 629 ESSSLIVHLRNHTG---------EKPYKCNHCEKAFCKNSSLIIHQRM--HSGE--KRFICSE--CGKAFSGHSALLQHQ 693
Cdd:COG5048   264 SLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343


                  ....
gi 1126724291 694 RNHS 697
Cdd:COG5048   344 LLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
548-573 6.32e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 6.32e-05
                          10        20
                  ....*....|....*....|....*.
gi 1126724291 548 HLVRHQRTHTGEKPYECNKCGKSFSQ 573
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-459 3.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.10e-04
                          10        20
                  ....*....|....*....|....
gi 1126724291 436 HLIAHMRMHTGEKPFKCDECEKAF 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 588-637 4.55e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1126724291 588 KPYkCNQCERSFNCSSHLIAHRRTHTgekpYRCNECGKAFNESSSLIVHL 637
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-404 8.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.42e-04
                          10        20
                  ....*....|....*....|....*
gi 1126724291 380 HLIVHKRIHTGEKPYVCNECGKSFN 404
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724291 324 YLIQHKKTHTGEKPYECDKCGKVFRN 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
604-628 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*
gi 1126724291 604 HLIAHRRTHTGEKPYRCNECGKAFN 628
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-432 1.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|....*
gi 1126724291 408 HLIGHQRTHTGEKPFECTECGKSFS 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
576-601 2.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724291 576 HLVAHRRIHTGEKPYKCNQCERSFNC 601
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 2.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|....*
gi 1126724291 352 ALTKHERTHTGIKPYECNKCGKAFS 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-515 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|....
gi 1126724291 492 HLIAHQRTHTGEKPYNCQECGKAF 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
632-655 3.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.33e-03
                          10        20
                  ....*....|....*....|....
gi 1126724291 632 SLIVHLRNHTGEKPYKCNHCEKAF 655
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-488 3.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.60e-03
                          10        20
                  ....*....|....*....|....*
gi 1126724291 464 ALSKHERTHSGAKPYKCTECGKSFS 488
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 338-360 3.84e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.84e-03
                          10        20
                  ....*....|....*....|...
gi 1126724291 338 YECDKCGKVFRNRSALTKHERTH 360
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 439-529 6.00e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724291 439 AHMRMHTGEKPFKCD--ECEKAFRDYSALsKHERTHSgakpykctECGKSFSWSSHLIAHQRTHTGEKPYNCQECGKAFR 516
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGL-KYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409

                          90
                  ....*....|...
gi 1126724291 517 ERSALtKHEIIHS 529
Cdd:COG5189   410 NLNGL-KYHRKHS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 644-698 7.22e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1126724291 644 KPYkCNHCEKAFCKNSSLIIHQRMhsgeKRFICSECGKAFSGHSALLQH-QRNHSE 698
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKA----KHFKCHICHKKLYTAGGLAVHcLQVHKE 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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