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Conserved domains on  [gi|1145522007|ref|NP_001335623|]
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FHF complex subunit HOOK-interacting protein 1A [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RAI16-like pfam10257
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ...
88-411 6.03e-127

Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.


:

Pssm-ID: 370927  Cd Length: 357  Bit Score: 390.15  E-value: 6.03e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007   88 ILEFVVSENIMEKLFLWSLRrEFTDETKIEQLKMYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEEKLVVLLN 167
Cdd:pfam10257    1 CLEYLLQHKILETLCTLGKA-DYPPGMKQEVLKFYNKLLSHERQPLLHHINVHRPLQKLLRSCGEPVGSDVEKELVQLLF 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  168 QLCSILAKDPSILELFFHTSEDQ-----------------GAANFLIFSLLIPFIHREGSVGQQARDALLFIMSLSAENT 230
Cdd:pfam10257   80 GLCVKLRQDPSLLNFFFENKSDQqraellvnpsvefagatGKEDFNLFSLLLPLVHREGRLGVFAREGLLLLMSLASRSP 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  231 MVAHHIVENTYFCPVLATGLSGLYSSLPTKLEE---KGEEW---HCLLKDDWLLLP---SLVQFMNSLEFCNAVIQVAHP 301
Cdd:pfam10257  160 TLATYLIESSDLCPLLATGLGALYSLLPTSLPAptiSSIDWrldHSIAPEDLATFPgkrALDSFLSWLDFCNDLIQVAHS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  302 LIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFILLH-------QHENVHILDTLT 374
Cdd:pfam10257  240 EVADALLDAIYEGFLVPVLYPSLLQTSEGSILAVTAYLDRILRSITSPALLQEFLSFLLGEekspetsDDDGHPLRDTLI 319
                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1145522007  375 SRINTP-FRLCVVSLALFRTLIGLHCEDVMLQLVLRYL 411
Cdd:pfam10257  320 ERCNHLsDELSIVTLRLFETLLQLPCEDILLDLVLRNL 357
DUF5917 pfam19314
Family of unknown function (DUF5917); This short presumed domain is found close to the ...
850-943 4.38e-36

Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins.


:

Pssm-ID: 466037  Cd Length: 94  Bit Score: 131.54  E-value: 4.38e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  850 TGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDF 929
Cdd:pfam19314    1 EGPFLRMLFNKLENLLSQSYEVNLQLTGVISRLASYPQPLLHSYLLNPSLPLQPSVRSLYTVLSSLKEEIEERAASIPDF 80
                           90
                   ....*....|....
gi 1145522007  930 PGLLIQAQQYLLFR 943
Cdd:pfam19314   81 DALLRRARKRLLGR 94
KELAA super family cl44742
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ...
998-1029 2.84e-05

KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named.


The actual alignment was detected with superfamily member pfam19311:

Pssm-ID: 466035  Cd Length: 32  Bit Score: 41.71  E-value: 2.84e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1145522007  998 LPVRNPMLAAALFPEFLKELAALAQEHSILCY 1029
Cdd:pfam19311    1 ERHKNLLEAAIVLEEFCKELAAIAFVKSHHSV 32
 
Name Accession Description Interval E-value
RAI16-like pfam10257
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ...
88-411 6.03e-127

Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.


Pssm-ID: 370927  Cd Length: 357  Bit Score: 390.15  E-value: 6.03e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007   88 ILEFVVSENIMEKLFLWSLRrEFTDETKIEQLKMYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEEKLVVLLN 167
Cdd:pfam10257    1 CLEYLLQHKILETLCTLGKA-DYPPGMKQEVLKFYNKLLSHERQPLLHHINVHRPLQKLLRSCGEPVGSDVEKELVQLLF 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  168 QLCSILAKDPSILELFFHTSEDQ-----------------GAANFLIFSLLIPFIHREGSVGQQARDALLFIMSLSAENT 230
Cdd:pfam10257   80 GLCVKLRQDPSLLNFFFENKSDQqraellvnpsvefagatGKEDFNLFSLLLPLVHREGRLGVFAREGLLLLMSLASRSP 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  231 MVAHHIVENTYFCPVLATGLSGLYSSLPTKLEE---KGEEW---HCLLKDDWLLLP---SLVQFMNSLEFCNAVIQVAHP 301
Cdd:pfam10257  160 TLATYLIESSDLCPLLATGLGALYSLLPTSLPAptiSSIDWrldHSIAPEDLATFPgkrALDSFLSWLDFCNDLIQVAHS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  302 LIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFILLH-------QHENVHILDTLT 374
Cdd:pfam10257  240 EVADALLDAIYEGFLVPVLYPSLLQTSEGSILAVTAYLDRILRSITSPALLQEFLSFLLGEekspetsDDDGHPLRDTLI 319
                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1145522007  375 SRINTP-FRLCVVSLALFRTLIGLHCEDVMLQLVLRYL 411
Cdd:pfam10257  320 ERCNHLsDELSIVTLRLFETLLQLPCEDILLDLVLRNL 357
DUF5917 pfam19314
Family of unknown function (DUF5917); This short presumed domain is found close to the ...
850-943 4.38e-36

Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins.


Pssm-ID: 466037  Cd Length: 94  Bit Score: 131.54  E-value: 4.38e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  850 TGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDF 929
Cdd:pfam19314    1 EGPFLRMLFNKLENLLSQSYEVNLQLTGVISRLASYPQPLLHSYLLNPSLPLQPSVRSLYTVLSSLKEEIEERAASIPDF 80
                           90
                   ....*....|....
gi 1145522007  930 PGLLIQAQQYLLFR 943
Cdd:pfam19314   81 DALLRRARKRLLGR 94
KELAA pfam19311
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ...
998-1029 2.84e-05

KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named.


Pssm-ID: 466035  Cd Length: 32  Bit Score: 41.71  E-value: 2.84e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1145522007  998 LPVRNPMLAAALFPEFLKELAALAQEHSILCY 1029
Cdd:pfam19311    1 ERHKNLLEAAIVLEEFCKELAAIAFVKSHHSV 32
 
Name Accession Description Interval E-value
RAI16-like pfam10257
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ...
88-411 6.03e-127

Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.


Pssm-ID: 370927  Cd Length: 357  Bit Score: 390.15  E-value: 6.03e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007   88 ILEFVVSENIMEKLFLWSLRrEFTDETKIEQLKMYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEEKLVVLLN 167
Cdd:pfam10257    1 CLEYLLQHKILETLCTLGKA-DYPPGMKQEVLKFYNKLLSHERQPLLHHINVHRPLQKLLRSCGEPVGSDVEKELVQLLF 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  168 QLCSILAKDPSILELFFHTSEDQ-----------------GAANFLIFSLLIPFIHREGSVGQQARDALLFIMSLSAENT 230
Cdd:pfam10257   80 GLCVKLRQDPSLLNFFFENKSDQqraellvnpsvefagatGKEDFNLFSLLLPLVHREGRLGVFAREGLLLLMSLASRSP 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  231 MVAHHIVENTYFCPVLATGLSGLYSSLPTKLEE---KGEEW---HCLLKDDWLLLP---SLVQFMNSLEFCNAVIQVAHP 301
Cdd:pfam10257  160 TLATYLIESSDLCPLLATGLGALYSLLPTSLPAptiSSIDWrldHSIAPEDLATFPgkrALDSFLSWLDFCNDLIQVAHS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  302 LIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFILLH-------QHENVHILDTLT 374
Cdd:pfam10257  240 EVADALLDAIYEGFLVPVLYPSLLQTSEGSILAVTAYLDRILRSITSPALLQEFLSFLLGEekspetsDDDGHPLRDTLI 319
                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1145522007  375 SRINTP-FRLCVVSLALFRTLIGLHCEDVMLQLVLRYL 411
Cdd:pfam10257  320 ERCNHLsDELSIVTLRLFETLLQLPCEDILLDLVLRNL 357
DUF5917 pfam19314
Family of unknown function (DUF5917); This short presumed domain is found close to the ...
850-943 4.38e-36

Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins.


Pssm-ID: 466037  Cd Length: 94  Bit Score: 131.54  E-value: 4.38e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522007  850 TGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDF 929
Cdd:pfam19314    1 EGPFLRMLFNKLENLLSQSYEVNLQLTGVISRLASYPQPLLHSYLLNPSLPLQPSVRSLYTVLSSLKEEIEERAASIPDF 80
                           90
                   ....*....|....
gi 1145522007  930 PGLLIQAQQYLLFR 943
Cdd:pfam19314   81 DALLRRARKRLLGR 94
KELAA pfam19311
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ...
998-1029 2.84e-05

KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named.


Pssm-ID: 466035  Cd Length: 32  Bit Score: 41.71  E-value: 2.84e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1145522007  998 LPVRNPMLAAALFPEFLKELAALAQEHSILCY 1029
Cdd:pfam19311    1 ERHKNLLEAAIVLEEFCKELAAIAFVKSHHSV 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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