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Conserved domains on  [gi|1145994687|ref|NP_001335653|]
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zinc finger protein 439 isoform f [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-348 6.98e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 6.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 177 VRRHERTHSRKKL-YECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK 249
Cdd:COG5048   276 NESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 250 --QCGKAFT-----RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLR 318
Cdd:COG5048   356 llNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                         170       180       190
                  ....*....|....*....|....*....|
gi 1145994687 319 IHRRIHTGEKPYECKKCGKaFRYVQNFRFH 348
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-237 1.19e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687  60 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 132
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 133 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 201
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994687 202 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 237
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-348 6.98e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 6.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 177 VRRHERTHSRKKL-YECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK 249
Cdd:COG5048   276 NESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 250 --QCGKAFT-----RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLR 318
Cdd:COG5048   356 llNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                         170       180       190
                  ....*....|....*....|....*....|
gi 1145994687 319 IHRRIHTGEKPYECKKCGKaFRYVQNFRFH 348
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-237 1.19e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687  60 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 132
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 133 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 201
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994687 202 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 237
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
232-257 1.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*.
gi 1145994687 232 SFQRHEKTHSGEKPYKCKQCGKAFTR 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-117 5.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.91e-03
                          10        20
                  ....*....|....*....|..
gi 1145994687  96 HERTHTGEKPYECKQCGKSFSY 117
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-348 6.98e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 6.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 177 VRRHERTHSRKKL-YECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK 249
Cdd:COG5048   276 NESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 250 --QCGKAFT-----RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLR 318
Cdd:COG5048   356 llNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                         170       180       190
                  ....*....|....*....|....*....|
gi 1145994687 319 IHRRIHTGEKPYECKKCGKaFRYVQNFRFH 348
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-237 1.19e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687  60 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 132
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 133 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 201
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994687 202 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 237
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 242-321 5.94e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 5.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 242 GEKPYKCK--QCGKAFTRSGSFRYHeRTHtgekpyecKQCGKAFRSAPNLQLHGRTHTGEKPYQCKECGKAFRSASQLRI 319
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1145994687 320 HR 321
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
77-356 6.70e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 6.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687  77 PYKCKFCGKAFHCLSLYLIHERTHTGEKPYECKQCGKSFSYSATH--RIHERTHIGEKPYEC-QECGKAFHSPRSCHRHE 153
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLelSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 154 RSHMGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQC----------------------GKALSSLTSFQTHIRM 211
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 212 HSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYHERTHTGEKPYECKQCGKAFRSAPNLQL 291
Cdd:COG5048   193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1145994687 292 HGRTHTGE-------KPYQCKECGKAFRSASQLRIHRR--IHTGE--KPYECKK--CGKAFRYVQNFRFHERTQTHKN 356
Cdd:COG5048   273 SSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-337 8.27e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 8.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1145994687 272 KPYECKQCGKAFRSAPNLQLHGRTHTGEKPYQC--KECGKAFRSASQLRIHRRIHTGEKPYECKKCGK 337
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-305 2.18e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994687 225 KGFYSAKSFQRHEKTHSG-EKPYKCKQCGKAFTRSGSFRYHERT--HTGE--KPYEC--KQCGKAFRSAPNLQLHGRTHT 297
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347


                  ....*...
gi 1145994687 298 GEKPYQCK 305
Cdd:COG5048   348 SISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
232-257 1.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*.
gi 1145994687 232 SFQRHEKTHSGEKPYKCKQCGKAFTR 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-285 3.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 1145994687 260 SFRYHERTHTGEKPYECKQCGKAFRS 285
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
317-341 5.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.52e-03
                          10        20
                  ....*....|....*....|....*
gi 1145994687 317 LRIHRRIHTGEKPYECKKCGKAFRY 341
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-117 5.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.91e-03
                          10        20
                  ....*....|....*....|..
gi 1145994687  96 HERTHTGEKPYECKQCGKSFSY 117
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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